Copeland And Afshari S Principles And Practice Of Cornea
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Copeland and Afshari's Principles and Practice of Cornea by Robert A. Copeland,Natalie Afshari,Claes H. Dohlman Pdf
The cornea is the transparent front part of the eye covering the iris and the pupil, allowing light to enter and covering two thirds of the eye’s focusing tasks. This two volume set is a comprehensive guide to the latest research and techniques for the cornea. Beginning with basic science, examination techniques and epidemiology, the following chapters discuss the diagnosis and the medical and surgical treatment of numerous different conditions and diseases that may affect the cornea. Written by an extensive international editor and author team, this manual features more than 1300 full colour clinical and histopathological images, as well as a DVD demonstrating a multitude of surgical techniques described in the book. Key points Comprehensive two volume set describing diagnosis and treatment of numerous corneal disorders Features more than 1300 colour images and illustrations Includes a DVD demonstrating surgical techniques and procedures Extensive international author and editor team
Mastering Corneal Surgery by Amar Agarwal,Thomas John Pdf
Mastering Corneal Surgery: Recent Advances and Current Techniques comprehensively covers all the recent advances in the existing techniques for common and rare corneal conditions, as well as presents the potential intraoperative circumstances the surgeon can face with their patients. Mastering Corneal Surgery: Recent Advances and Current Techniques by Drs. Amar Agarwal and Thomas John, along with more than 50 contributors, cover the most recent innovations in corneal surgery, including corneal procedures in combination with IOL implantation in eyes with deficient capsules, and combining endothelial keratoplasty with IOL repositioning. Bonus! Extensive high-quality video demonstrations of the techniques discussed inside Mastering Corneal Surgery: Recent Advances and Current Techniques enhances the written text, creating a superior companion website resource. The 28 videos, combined with the written text, clinical photographs and pictures, furthers the learning process more than learning from text or video alone. Mastering Corneal Surgery: Recent Advances and Current Techniques covers all the recent advances in the existing techniques for common and rare corneal conditions and presents the potential intraoperative circumstances the surgeon can encounter with their patients. The general ophthalmologist and cornea specialist will welcome the novel surgical methods and their differences from the existing techniques highlighted inside this cutting-edge resource.
Inhibitors of corneal inflammation and angiogenesis by Pierfrancesco Mirabelli Pdf
Pathologic angiogenesis is involved in cancer and several blinding conditions such as wet age-related macular degeneration, proliferative retinopathies and corneal neovascularization. In these dieseases, the angiogenic triggers are hypoxia and inflammation, and both involve the main angiogenic mediator, which is Vascular Endothelial Growth Factor (VEGF). Among available treatments, anti-VEGF often shows limited or temporary efficacy, while steroids are potentially responsible for many side-effects. This thesis presents a series of linked studies aimed at elucidating the early pathologic changes leading to inflammation and corneal neovascularization, and how various treatments affect this process. In this thesis, anti-inflammatory and anti-angiogenic treatments are applied in corneal neovascularization models, to identify VEGF-independent pathways and other novel factors as future therapy targets, as well as to investigate the endogenous modulation of angiogenesis. A model of experimental neovascularization in the rat cornea was used as main model, where the neovascular response is triggered by a surgical suture placed into the cornea. Investigational treatments (anti-Vegf, dexamethasone, IMD0354, Gap27, or control substances) were then given topically, with the exception of IMD0354, which was given systemically. The effects in the cornea were studied in vivo with slit lamp photography to assess and quantify macroscopic vessel growth and using in vivo confocal microscopy (IVCM) to study cell infiltration and limbal vessel dilation and detect microscopic vessel sprouts; these examinations were performed longitudinally. Genomic analysis with RNA microarray, selected gene expression with q-RT-PCR, and selected protein expression in tissue (immunohistochemistry, immunofluorescence, Western blot) were performed at different time-points. Moreover, other experiments on cell cultures (HUVEC and HCEC), organ cultures (human corneas), ex vivo models (aortic rings) and in vivo studies (zebrafish vasculogenesis) were performed. Dexamethasone suppressed limbal vasodilation and corneal neovascularization more than anti-Vegf, despite no difference in inflammatory cell infiltration into the cornea. Five-hundred eleven fewer genes were differentially expressed in dexamethasone-treated corneas relative to naïve corneas, compared to anti-Vegf. Among them, several major pro-angiogenic and pro-inflammatory factors and chemokines were suppressed only by dexamethasone and represent novel candidate factors to target in order to improve anti-VEGF treatment. On the other hand, selective inhibition of a single inflammatory pathway (NF-?B), despite showing similar early effects as dexamethasone in suppressing tissue inflammation, was not effective enough to suppress new vessel growth. The same factors suppressed by dexamethasone are also inhibited in endogenous modulation of angiogenesis. Surprisingly, dexamethasone activated several complement factors, which could possibly be beneficial in the anti-angiogenic response. In a different therapeutic approach, promoting cell migration to accelerate epithelial wound closure similarly was not sufficient to avoid inflammation and angiogenesis in the cornea. In conclusion, new and more effective treatments are needed for corneal inflammation and neovascularization with fewer side-effects. In this thesis, several novel factors and mechanisms related to inflammation are identified, factors that are not addressed by anti-Vegf therapy, and therefore represent interesting objects for further study, as they have the potential to be targets for adjuvant therapy. Specific anti-inflammatory treatment as well as therapeutic activation of endogenous regulatory pathways, and potentially complement modulation, might represent new strategies to improve anti-angiogenic therapy, but when used alone they do not seem to avoid corneal neovascularization.
Practical Cytopathology by Huihong Xu,Xiaohua Qian,He Wang Pdf
This book provides a comprehensive, practical, and state-of-the art review addressing the major issues and challenges in cytopathology practice using a question and answer format. Making an accurate diagnosis, especially on a limited cytology sample obtained by minimally invasive procedures, is often challenging, yet crucial to patient care. Using the most current and evidence-based approaches, this book: 1) focuses on frequently asked questions in day-to-day practice of cytopathology as well as surgical pathology; 2) provides quick, accurate, and useful answers; 3) emphasizes the importance of clinical, radiological, and cytological correlation, as well as cyto-histological correlation; and 4) delineates how to judiciously use immunohistochemistry, molecular tests, flow cytometry, cytogenetics, and other established ancillary studies including next generation sequencing and computer-assisted diagnostics. Chapters are written by experts in their fields and provide the most up-to-date information in the field of cytopathology. Practical Cytopathology: Frequently Asked Questions serves as a practical resource and guide to relevant references for trainees, cytotechnologists, and cytopathologists at various skill levels.
Refractive Surgery by Howard V. Gimbel,Ellen E. Anderson Penno Pdf
Drs. Gimbel and Penno provide a comprehensive look at a wide variety of refractive surgery techniques in their new book. Specific techniques are discussed along with preoperative assessments, counseling, and informed consent. In addition to chapters on the commonly performed techniques of LASIK and PRK, there are chapters on intracorneal ring segments, phakic IOL implants, refractive lensectomy, and retreatments. The authors take a practical and concise approach to a wide scope of modern refractive surgery techniques which makes this reference valuable for both the experienced and beginning surgeon. Patient examples are featured illustrating the fundamental principles of assessment and choosing the appropriate refractive surgery technique for an individual patient. The inclusion of co-management principles emphasizes integrated care during the assessment and preoperative work-up, as well as during the postoperative period. This book is an important source that covers many refractive surgery approaches to help you choose the best procedure for your patients and achieve the best results possible.
Textbook on Clinical Ocular Pharmacology & Therapeutics by Renu Agarwal,Sushma Srivastava Pdf
This book is a comprehensive guide to ocular pharmacology for trainees and practising ophthalmologists. Beginning with the basic physiological aspects of ocular pharmacology and ophthalmic drug administration, the following sections discuss different types of drugs used in the treatment of eye disease. The final sections examine contact lens care systems, nutritional supplements and adverse effects of systematically administered drugs into the eye. This useful, quick reference text is highly illustrated with more than 145 images and tables. Key points Comprehensive guide to ocular pharmacology for trainees and practising ophthalmologists Covers different drugs for treatment of eye diseases Includes section on adverse effects of systematically administered drugs Highly illustrated with more than 145 images and tables
Cornea E-Book by Mark J Mannis,Edward J Holland Pdf
Highly praised in its first three editions, Cornea has become a market-leading cornerstone text and the immediate go-to resource for anyone working in this hugely popular and evolving sub-specialty. Offered over two volumes and featuring the knowledge of over 200 experts worldwide, it presents state-of-the-art coverage of the expanding range of contemporary corneal surgery, new diagnostic technology, and medical management of corneal and external disease as well as ocular surface disease. This updated edition includes 20 brand-new chapters, while an enhanced focus on images provides key visual guidance in this challenging field. Exceptionally clear illustrations, diagnostic images, and step-by-step surgical photographs offer superb visual guidance. Expert Consult eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, images, videos, and references from the book on a variety of devices. 20 brand-new chapters cover the latest advances in the field, such as DMEK, Ultra-Thin DSEK and DSAEK techniques; endothelial cell transplantation; keratoplasty and prosthokeratoplasty techniques; collagen cross-linking; and new refractive surgical techniques (presbyopic implants and SMILE surgery). 60 video clips on Expert Consult show new footage of the latest corneal surgery techniques, including Boston Keratoprosthesis, corneal inlay surgery, and lenticule extraction. Boasts over 170 chapters with unique, cutting-edge content, as well as 2,300 clear illustrations – 670 of which are new to this edition. Presents a detailed exposition of the growing number of techniques for lamellar keratoplasty, including outcomes. Includes new sections on the latest developments in the management of ocular surface disease. Key point overviews in each chapter offer easier access to crucial information.
Author : Richard Elander,Larry F. Rich,Jeffrey B. Robin Publisher : Saunders Page : 712 pages File Size : 45,6 Mb Release : 1997 Category : Medical ISBN : UOM:39015040690516
Principles and Practice of Refractive Surgery by Richard Elander,Larry F. Rich,Jeffrey B. Robin Pdf
Introducing the first comprehensive textbook covering all aspects of refractive surgery. Provides the reader with a broad, in-depth description of the principles, theories, methods, instrumentation, and economics involved with incisional, lamellar, and laser surgery correction of refractive errors. Includes contributions from international authorities, and provides comprehensive coverage of currently available instrumentations.
"DSEK: What You Need to Know About Endothelial Keratoplasty provides a comprehensive background of EK, where it is today, and where it is headed in the future. Francis W. Price, MD. who was the first to complete DSEK in the United States, along with Marianne Price, PhD, have designed this text to offer a special emphasis on how to perform surgeries along with preventing and managing complications. In addition, a diverse group of contributing authors provides a wide array of insights and tips for better patient outcomes."--BOOK JACKET.
Mastering Endothelial Keratoplasty by Soosan Jacob Pdf
Volume 1 of this edited book covers basics of endothelial keratoplasty and various surgical techniques currently in use. Chapters on DSAEK, DMEK, big bubble, air pump-assisted and endoilluminator assisted DMEK/PDEK, pre-Descemet’s endothelial keratoplasty (PDEK), and Descemet’s membrane endothelial transfer (DMET) complete the topics on various surgical procedures. Complex situations and complications have been covered in volume 2 of Mastering Endothelial Keratoplasty. Endothelial keratoplasty is a field of great interest to all corneal surgeons. It is an exciting and evolving field in corneal transplantation as the newer techniques of DSAEK, DMEK, E-DMEK and PDEK have inherent advantages that make them supersede the older techniques by far. Hence, in today's scenario with the clearly superior results that these techniques offer, it is imperative for all corneal surgeons to learn them and know everything about managing the patient from the pre-operative to the postoperative period. This two-volume book is a must-read for the beginner as well as the established ophthalmologist with interest in corneal transplantation. It is also a must-have for educational institutions, hospital- based libraries and for post-graduate students, fellows and residents who want to expand their knowledge.
Developmental and Reproductive Toxicology by Ronald D. Hood,Ronald D Hood Pdf
Completely revised and updated, Developmental and Reproductive Toxicology: A Practical Approach, Second Edition draws together valuable information typically scattered throughout the literature, plus some not previously published, into one complete resource. In addition to the traditional aspects of developmental toxicity testing, the book covers evaluating and interpreting data. Originally titled Handbook of Developmental Toxicology, the second edition's new name reflects significant changes in its content and scope. New coverage in the Second Edition: Genomics and proteomics Tests for endocrine disruptors Testing for male and female reproductive toxicity Extensive treatment of the significance, reliability, and interpretation of developmental and reproductive toxicity data Toxicity testing in neonatal and juvenile animals Postnatal developmental milestones FDA perspective on risk assessment Extensive glossaries of developmental defect terminology Previous books on this subject have largely been academically oriented and not intended to guide the practicing developmental or reproductive toxicologist. Useful and informative, this book blends the theoretical foundation with insights gained from hands-on experience. It includes tables of comparative developmental milestones - both pre- and postnatal, glossaries of descriptive terms used in developmental toxicity evaluation, and both US and international regulatory guidelines. Bridging the gap between theory and application, this is a handy single-source of essential information to use in planning, conducting, and interpreting studies.
