Coronary Artery Disease Therapeutics And Drug Discovery

Coronary Artery Disease Therapeutics And Drug Discovery Book in PDF, ePub and Kindle version is available to download in english. Read online anytime anywhere directly from your device. Click on the download button below to get a free pdf file of Coronary Artery Disease Therapeutics And Drug Discovery book. This book definitely worth reading, it is an incredibly well-written.

Coronary Artery Disease: Therapeutics and Drug Discovery

Miao Wang
Coronary Artery Disease Therapeutics and Drug Discovery Book PDF

Author : Miao Wang
Publisher : Springer Nature
Page : 345 pages
File Size : 41,6 Mb
Release : 2020-04-03
Category : Medical
ISBN : 9789811525179

Get Book

Coronary Artery Disease: Therapeutics and Drug Discovery by Miao Wang Pdf

This book provides an overview of the etiology of coronary artery disease and focuses on the main therapies and drug interventions currently available. It highlights drug pharmacology and therapeutic challenges, with a special emphasis on the underlying principles of available therapeutics and the on-going development of drugs for coronary artery disease. The book is divided into eight chapters, the first of which describes the classical mechanism of coronary artery disease and its clinical presentations. Chapter 2 lists the principles of and related evidence on the prevention and treatment of coronary artery disease. This includes diet and lifestyle management, and guidelines for the treatment of acute coronary syndrome and stable coronary artery disease. In turn, Chapter 3 describes revascularization treatments, covering percutaneous coronary interventions, coronary artery bypass grafts and thrombolysis. This chapter also addresses the main therapeutic challenges. The following chapters provide an overview of three major categories of coronary artery disease drugs, which target thrombosis (Chapter 4), lipid metabolism (Chapter 5), and hypertension (Chapter 6). Heart failure constitutes the major health burden in the late stage of coronary artery disease; accordingly, current heart failure therapeutics and related drug pharmacology are described in Chapter 7. In closing, Chapter 8 provides a summary of on-going clinical trials for coronary artery disease drug development and discusses a number of promising areas in which intensive research into new therapeutics is being pursued. Given its scope, the book will be of interest to clinicians, medical students and research scientists, as well as to pharmaceutical professionals who are seeking new therapies and drugs for coronary artery disease and related disorders.

Frontiers in Cardiovascular Drug Discovery

Atta-ur- Rahman,M. Iqbal Choudhary
Frontiers in Cardiovascular Drug Discovery Book PDF

Author : Atta-ur- Rahman,M. Iqbal Choudhary
Publisher : Bentham Science Publishers
Page : 359 pages
File Size : 54,9 Mb
Release : 2011-08-11
Category : Medical
ISBN : 9781608051601

Get Book

Frontiers in Cardiovascular Drug Discovery by Atta-ur- Rahman,M. Iqbal Choudhary Pdf

"Frontiers in Cardiovascular Drug Discovery" is an Ebook series devoted to publishing the latest and the most important advances in Cardiovascular drug design and discovery. Eminent scientists write contributions on all areas of rational drug design and d

Frontiers in Cardiovascular Drug Discovery: Volume 5

Atta-ur-Rahman,M. Iqbal Choudhary
Frontiers in Cardiovascular Drug Discovery Volume 5 Book PDF

Author : Atta-ur-Rahman,M. Iqbal Choudhary
Publisher : Bentham Science Publishers
Page : 278 pages
File Size : 45,6 Mb
Release : 2020-10-02
Category : Medical
ISBN : 9789811413230

Get Book

Frontiers in Cardiovascular Drug Discovery: Volume 5 by Atta-ur-Rahman,M. Iqbal Choudhary Pdf

Frontiers in Cardiovascular Drug Discovery is a book series devoted to publishing the latest advances in cardiovascular drug design and discovery. Each volume brings reviews on the biochemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, recent important patents, and structure-activity relationships of molecules used in cardiovascular therapy. The book series should prove to be of great interest to all medicinal chemists and pharmaceutical scientists involved in preclinical and clinical research in cardiology. The fifth volume of the series covers the following topics: -The Lipid Hypothesis: From Resins to Proprotein Convertase Subtilisin/Kexin Type-9 Inhibitors -The Role of SGLT2i in the Prevention and Treatment of Heart Failure -Natural Products and Semi-Synthetic Compounds as Antithrombotics: A Review of the Last Ten Years (2009-2019) -Transient Receptor Potential Channels: Therapeutic Targets for Cardiometabolic Diseases? -Treatment of Raynaud’s Phenomenon -Traditional Medicine Based Cardiovascular Therapeutics -Cardiovascular Disease: A Systems Biology Approach

Cardiac Drug Development Guide

Michael K. Pugsley
Cardiac Drug Development Guide Book PDF

Author : Michael K. Pugsley
Publisher : Springer Science & Business Media
Page : 427 pages
File Size : 43,6 Mb
Release : 2008-02-06
Category : Medical
ISBN : 9781592594047

Get Book

Cardiac Drug Development Guide by Michael K. Pugsley Pdf

Cardiac Drug Development Guide outlines, in detail, the therapeutics of cardiac medicine currently at the cutting edge of scientific research and development around the world. This volume integrates basic and clinical cardiac pharmacology by c- bining, for the first time, both classical and molecular aspects of therapeutic drug development. The chapters comprise a broad spectrum of therapeutic areas and hence involve a comprehensive discussion of molecular, biochemical, and electrophy- ological concepts based on years of in vitro as well as in vivo pharmacological st- ies. In addition, the latter part of the book includes comprehensive clinical cardiac chapters that describe important topics in molecular medicine. These chapters also discuss current clinical therapeutic trends in medicine and provide an evaluation of the efficacy of novel drugs in these areas. Cardiac Drug Development Guide has many distinctive and outstanding features that set it apart from other cardiac pharmacology books. This book introduces topics in an easily understandable format for researchers in many varying disciplines by integrating and thereby simplifying concepts not usually discussed across a broad range of cardiac disciplines and in a highly technical field. Each chapter not only introduces and describes the physiology, pharmacology, and pathophysiology of the disease, but also overviews the clinical implications of drug development, what stages these areas are currently in, and also reviews some of the methodologies involved in drug discovery and development. As a result, this book provides a comprehensive overview of the most advanced procedures in cardiac pharmacology today.

Cardiovascular Drug Development

John Somberg
Cardiovascular Drug Development Book PDF

Author : John Somberg
Publisher : CRC Press
Page : 259 pages
File Size : 48,9 Mb
Release : 1998-11-04
Category : Medical
ISBN : 9780824746315

Get Book

Cardiovascular Drug Development by John Somberg Pdf

These multidisciplinary presentations provide information essential to devising effective drug protocols in cardiovascular drug development, facilitating the approval process. Guides researchers and developers through the government drug approval process, facilitating development, minimizing costs, and harmonizing international standards employed in the creation of vital new cardiovascular therapies! Cardiovascular Drug Development explores the delicate balance of efficacy and safety that cardiovascular therapy must achieve to gain regulatory approval discusses the search for surrogates and the need in some areas for natural history endpoints reviews optimum strategies for protocol design in the development of drugs to treat hypertension, cardiac arrhythmias, heart failure, coronary artery disease, and hypercholesterolemia and other lipid disorders compares and contrasts the varying standards of evidence for drug approval in the United States, Europe, and Asia and more! Cardiovascular Drug Development will prove to be a valuable asset for cardiologists, pharmacologists and pharmacists, regulatory affairs specialists, and directors of research and development for pharmaceutical companies.

Cardiovascular Diseases

Y. Robert Li
Cardiovascular Diseases Book PDF

Author : Y. Robert Li
Publisher : John Wiley & Sons
Page : 501 pages
File Size : 45,9 Mb
Release : 2015-04-06
Category : Medical
ISBN : 9780470915370

Get Book

Cardiovascular Diseases by Y. Robert Li Pdf

Written in an accessible style and consistent format, the book covers both the fundamentals and advances in the pharmacology of cardiovascular drugs, as well as their integrated applications in the management of individual cardiovascular diseases. • Integrates fundamentals and recent advances regarding cardiovascular drugs, blending basic and clinical sciences needed to effectively understand and treat cardiovascular diseases • Facilitates understanding of drug action and mechanism by covering physiology / pathophysiology and pharmacology • Includes guidelines and algorithms for pharmacotherapeutic management of cardiovascular diseases • Uses case presentations and study questions to enhance understanding of the material • Serves as a resource for pharmaceutical and medical students and researchers interested in cardiovascular issues

Translational Research in Coronary Artery Disease

Wilbert S. Aronow,John Arthur McClung
Translational Research in Coronary Artery Disease Book PDF

Author : Wilbert S. Aronow,John Arthur McClung
Publisher : Academic Press
Page : 244 pages
File Size : 55,6 Mb
Release : 2015-10-29
Category : Medical
ISBN : 9780128026052

Get Book

Translational Research in Coronary Artery Disease by Wilbert S. Aronow,John Arthur McClung Pdf

Translational Research in Coronary Artery Disease: Pathophysiology to Treatment covers the entire spectrum of basic science, genetics, drug treatment, and interventions for coronary artery disease. With an emphasis on vascular biology, this reference fully explains the fundamental aspects of coronary artery disease pathophysiology. Included are important topics, including endothelial function, endothelial injury, and endothelial repair in various disease states, vascular smooth muscle function and its interaction with the endothelium, and the interrelationship between inflammatory biology and vascular function. By providing this synthesis of current research literature, this reference allows the cardiovascular scientist and practitioner to access everything they need from one source. Provides a concise summary of recent developments in coronary and vascular research, including previously unpublished data Summarizes in-depth discussions of the pathobiology and novel treatment strategies for coronary artery disease Provides access to an accompanying website that contains photos and videos of noninvasive diagnostic modalities for evaluation of coronary artery disease

Frontiers in Cardiovascular Drug Discovery: Volume 6

M. Iqbal Choudhary
Frontiers in Cardiovascular Drug Discovery Volume 6 Book PDF

Author : M. Iqbal Choudhary
Publisher : Bentham Science Publishers
Page : 256 pages
File Size : 55,6 Mb
Release : 2022-11-11
Category : Medical
ISBN : 9789815036916

Get Book

Frontiers in Cardiovascular Drug Discovery: Volume 6 by M. Iqbal Choudhary Pdf

Frontiers in Cardiovascular Drug Discovery is a book series devoted to publishing the latest advances in cardiovascular drug design and discovery. Each volume brings reviews on the biochemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, recent important patents, and structure-activity relationships of molecules used in cardiovascular therapy. The book series should prove to be of great interest to all medicinal chemists and pharmaceutical scientists involved in preclinical and clinical research in cardiology. Volume 6 covers the following topics: - Cardiovascular effects of ranolazine and the scope for translational research: a current review of literature - Rho/Rho kinase signaling pathway and disease: - Hibernation or transformation? Challenges in cardiovascular drug development - New approaches in P2Y12 receptor blocker drugs use - Pathophysiological links between diabetes and cardiovascular diseases: at the biochemical and molecular levels

Pathophysiology and Pharmacotherapy of Cardiovascular Disease

Gowraganahalli Jagadeesh,Pitchai Balakumar,Khin Maung-U
Pathophysiology and Pharmacotherapy of Cardiovascular Disease Book PDF

Author : Gowraganahalli Jagadeesh,Pitchai Balakumar,Khin Maung-U
Publisher : Springer
Page : 1342 pages
File Size : 41,7 Mb
Release : 2015-05-06
Category : Medical
ISBN : 9783319159614

Get Book

Pathophysiology and Pharmacotherapy of Cardiovascular Disease by Gowraganahalli Jagadeesh,Pitchai Balakumar,Khin Maung-U Pdf

The present book covers the basic principles of cardiovascular physiology, pathophysiology and advanced pharmacology with particular emphasis on cellular mechanisms of drug action. It provides an update on the progress made in several aspects of cardiovascular diseases so that it might kindle scientists and clinicians alike in furthering basic and translational research. In addition, the book is expected to fill imperative gaps in understanding and optimally treating cardiovascular disease.

Cardiovascular Therapeutics

Elliott M. Antman
Cardiovascular Therapeutics Book PDF

Author : Elliott M. Antman
Publisher : Elsevier Health Sciences
Page : 973 pages
File Size : 44,6 Mb
Release : 2007-01-01
Category : Medical
ISBN : 9781416033585

Get Book

Cardiovascular Therapeutics by Elliott M. Antman Pdf

Manage cardiovascular problems more effectively with the most comprehensive resource available! A trusted companion to Braunwald's Heart Disease, Cardiovascular Therapeutics, 4th Edition addresses pharmacological, interventional, and surgical management approaches for each type of cardiovascular disease. This practical and clinically focused cardiology reference offers a balanced, complete approach to all of the usual and unusual areas of cardiovascular disease and specific therapies in one concise volume, equipping you to make the best choices for every patient. Understand current approaches to treating and managing cardiovascular patients for long-term health, for complex problems, and for unusual cardiac events. Benefit from the substantial experience of Elliott M. Antman, MD, Marc S. Sabatine, MD, and a host of other respected authorities, who provide practical, evidence-based rationales for all of today's clinical therapies. Expand your knowledge beyond pharmacologic interventions with complete coverage of the most effective interventional and device therapies being used today. Easily reference Braunwald's Heart Disease, 9th Edition for further information on topics of interest. Make the best use of the latest genetic and molecular therapies as well as advanced therapies for heart failure. Cut right to the answers you need with an enhanced focus on clinically relevant information and a decreased emphasis on pathophysiology. Stay current with ACC/AHA/ESC guidelines and the best ways to implement them in clinical practice. Get an enhanced visual perspective with an all-new, full-color design throughout. Access the complete contents online and download images at www.expertconsult.com.

Atherosclerosis Drug Discovery

Charles Day
Atherosclerosis Drug Discovery Book PDF

Author : Charles Day
Publisher : Springer Science & Business Media
Page : 456 pages
File Size : 54,9 Mb
Release : 2013-11-22
Category : Medical
ISBN : 9781461446187

Get Book

Atherosclerosis Drug Discovery by Charles Day Pdf

Although atherosclerosis is the leading cause of death in the so-called affluent societies, there is presently no drug in our pharmacologic armamentarium against disease to either prevent or reverse this insidious killer and debilitant of human lives. Because of this void the First Brook Lodge Symposium on Anti Atherosclerosis Drug Discovery was convened at Brook Lodge in Augusta, Michigan, August 13-15, 1975. The symposium was sponsored by The Upjohn Company and was international in scope, with investi gators attending from such countries as England, Japan, Belgium, and Italy. The symposium focused on the problems associated with the discovery and evaluation of new drugs effective in preventing or reversing atherosclerosis. The thrust of material is centered around animal models useful as tools in the search and evaluation of new drugs. Broadly categorized, the models are nonhuman primates, rabbits, rodents, quail, and tissue culture. The material is a mix of studies on serum lipids and, more importantly, of studies on the artery, irrespective of serum lipid levels. The prevention of arterial lesions, not reduction of serum lipids, is emphasized. A review of all anti-atherosclerotic agents, with the exception of hypolipidemic agents, is included in this volume of the proceedings of the symposium.

Landmark Papers in Cardiovascular Medicine

Aung Myat,Tony Gershlick
Landmark Papers in Cardiovascular Medicine Book PDF

Author : Aung Myat,Tony Gershlick
Publisher : OUP Oxford
Page : 520 pages
File Size : 49,5 Mb
Release : 2012-09-27
Category : Medical
ISBN : 9780191637865

Get Book

Landmark Papers in Cardiovascular Medicine by Aung Myat,Tony Gershlick Pdf

Landmark Papers in Cardiovascular Medicine provides a thorough and wide-ranging analysis of core examples of novel research, clinical trials and seminal papers published in the medical literature that have paved the way for breakthroughs in the management of the entire spectrum of cardiovascular disease. These papers may have produced positive, negative or equivocal findings but are regarded by the experts as having either stimulated a paradigm shift in therapeutic strategy or been the catalyst for new and improved methods of research, diagnosis or drug development. Our aim is to provide both a benchmark and inspiration for future work in the field of cardiovascular medicine and also to give the reader an insight into the mechanics and infrastructure of how high-quality evidence-based medicine has been produced. Each trial summary is punctuated by sections on 'strengths and limitations', 'impact on the field', 'learning points' and 'further reading' suggestions that allow for a completely holistic analysis of the data. The experts also give their views on what research is currently underway, their hopes for the future and what advances they predict will occur in each subspecialty field of cardiovascular medicine, making this book essential reading for all those individuals with an interest in the field.

Cardiovascular Disability

Institute of Medicine,Board on the Health of Select Populations,Committee on Social Security Cardiovascular Disability Criteria
Cardiovascular Disability Book PDF

Author : Institute of Medicine,Board on the Health of Select Populations,Committee on Social Security Cardiovascular Disability Criteria
Publisher : National Academies Press
Page : 304 pages
File Size : 44,6 Mb
Release : 2010-12-04
Category : Medical
ISBN : 9780309156981

Get Book

Cardiovascular Disability by Institute of Medicine,Board on the Health of Select Populations,Committee on Social Security Cardiovascular Disability Criteria Pdf

The Social Security Administration (SSA) uses a screening tool called the Listing of Impairments to identify claimants who are so severely impaired that they cannot work at all and thus immediately qualify for benefits. In this report, the IOM makes several recommendations for improving SSA's capacity to determine disability benefits more quickly and efficiently using the Listings.

Drugs in the Management of Heart Disease

A. Breckenridge
Drugs in the Management of Heart Disease Book PDF

Author : A. Breckenridge
Publisher : Springer Science & Business Media
Page : 240 pages
File Size : 53,5 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9789400948761

Get Book

Drugs in the Management of Heart Disease by A. Breckenridge Pdf

In any textbook, basic scientific knowledge, and the art of clinical practice should be brought together in a rational manner and this volume on cardio vascular therapy attempts to achieve this aim. It deals with five selected areas - hypertension, angina and coronary artery disease, heart failure and anticoa gulant therapy. Clearly not all branches of cardiovascular therapeutics could be included; a separate section on anti-arrhythmic drugs is noticeably absent but it is proposed that this omission will be rectified in other volumes in the series. In general, textbooks on therapeutics tend to be ephemeral; as new discoveries are made and evaluated, medical practice changes. This volume then summarizes current opinion up to mid 1984 and gives, we believe, a reasoned account of present views. The contributors are all clinical pharma cologists with a wealth of clinical experience. The therapeutic advice given is well founded and the underlying scientific basis is clearly explained. The book is aimed at postgraduates, but should the undergraduate care to dip into it, we hope he will be informed and thereby educated. A. Breckenridge vii Series Editor's Note The last few decades have seen an explosion in our knowledge of cardiovas cular disease as a result of research in many disciplines. The tempo of research is ever increasing, so that it is becoming more and more difficult for one person to encompass the whole spectrum of the advances taking place on many fronts.

Prevention of Disease Progression Throughout the Cardiovascular Continuum

L.E. Ryden
Prevention of Disease Progression Throughout the Cardiovascular Continuum Book PDF

Author : L.E. Ryden
Publisher : Springer Science & Business Media
Page : 147 pages
File Size : 41,6 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642565250

Get Book

Prevention of Disease Progression Throughout the Cardiovascular Continuum by L.E. Ryden Pdf

Despite remarkable therapeutic achievements in medicine, cardiovascular diseases remain the major cause of death in the new millennium. The cardiovascular disease continuum starts with risk factors such as hypertension, diabetes mellitus and lipid disorders, leading to coronary artery disease or left ventricular hypertrophy. Left ventricular dysfunction and remodelling follow after initial myocardial damage (e.g. myocardial infarction), finally leading to the development of heart failure. This book gives an overview of the effects of antiadrenergic treatment in the different stages of the cardiovascular continuum, with a particular emphasis on heart failure, authored by a faculty of leading international clinical cardiologists.