Frontiers In Cardiovascular Drug Discovery

Author : Atta-ur-Rahman,M. Iqbal Choudhary
Publisher : Bentham Science Publishers
Page : 406 pages
File Size : 52,9 Mb
Release : 2016-11-01
Category : Medical
ISBN : 9781681081632

Get Book

Frontiers in Cardiovascular Drug Discovery by Atta-ur-Rahman,M. Iqbal Choudhary Pdf

Frontiers in Cardiovascular Drug Discovery is an eBook series devoted to publishing the latest advances in cardiovascular drug design and discovery. Each volume brings reviews on the biochemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, recent important patents, and structure-activity relationships of molecules used in cardiovascular therapy. The eBook series should prove to be of great interest to all medicinal chemists and pharmaceutical scientists involved in preclinical and clinical research in cardiology. The third volume of the series covers the following topics: - P2Y12 receptor agonists -Heart failure pharmacotherapy -Vasopressin and the cardiovascular system -Cerebral small vessel disease -Complement blocking therapeutic strategies -New antiplatelet and anticoagulating agents for gastrointestinal treatments

Author : Atta-ur-Rahman,M. Iqbal Choudhary
Publisher : Bentham Science Publishers
Page : 278 pages
File Size : 55,7 Mb
Release : 2020-10-02
Category : Medical
ISBN : 9789811413230

Get Book

Frontiers in Cardiovascular Drug Discovery: Volume 5 by Atta-ur-Rahman,M. Iqbal Choudhary Pdf

Frontiers in Cardiovascular Drug Discovery is a book series devoted to publishing the latest advances in cardiovascular drug design and discovery. Each volume brings reviews on the biochemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, recent important patents, and structure-activity relationships of molecules used in cardiovascular therapy. The book series should prove to be of great interest to all medicinal chemists and pharmaceutical scientists involved in preclinical and clinical research in cardiology. The fifth volume of the series covers the following topics: -The Lipid Hypothesis: From Resins to Proprotein Convertase Subtilisin/Kexin Type-9 Inhibitors -The Role of SGLT2i in the Prevention and Treatment of Heart Failure -Natural Products and Semi-Synthetic Compounds as Antithrombotics: A Review of the Last Ten Years (2009-2019) -Transient Receptor Potential Channels: Therapeutic Targets for Cardiometabolic Diseases? -Treatment of Raynaud’s Phenomenon -Traditional Medicine Based Cardiovascular Therapeutics -Cardiovascular Disease: A Systems Biology Approach

Author : M. Iqbal Choudhary
Publisher : Bentham Science Publishers
Page : 256 pages
File Size : 54,5 Mb
Release : 2022-11-11
Category : Medical
ISBN : 9789815036916

Get Book

Frontiers in Cardiovascular Drug Discovery: Volume 6 by M. Iqbal Choudhary Pdf

Frontiers in Cardiovascular Drug Discovery is a book series devoted to publishing the latest advances in cardiovascular drug design and discovery. Each volume brings reviews on the biochemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, recent important patents, and structure-activity relationships of molecules used in cardiovascular therapy. The book series should prove to be of great interest to all medicinal chemists and pharmaceutical scientists involved in preclinical and clinical research in cardiology. Volume 6 covers the following topics: - Cardiovascular effects of ranolazine and the scope for translational research: a current review of literature - Rho/Rho kinase signaling pathway and disease: - Hibernation or transformation? Challenges in cardiovascular drug development - New approaches in P2Y12 receptor blocker drugs use - Pathophysiological links between diabetes and cardiovascular diseases: at the biochemical and molecular levels

Author : Atta-ur-Rahman,M. Iqbal Choudhary
Publisher : Unknown
Page : 128 pages
File Size : 44,8 Mb
Release : 2016-01-01
Category : Electronic
ISBN : 1681081644

Get Book

Frontiers in Cardiovascular Drug Discovery by Atta-ur-Rahman,M. Iqbal Choudhary Pdf

Frontiers in Cardiovascular Drug Discovery is an eBook series devoted to publishing the latest advances in cardiovascular drug design and discovery. Each volume brings reviews on the biochemistry, in-silico drug design, combinatorial chemistry, high-throu

Author : M. Iqbal Choudhary
Publisher : Frontiers in Cardiovascular Dr
Page : 0 pages
File Size : 47,8 Mb
Release : 2022-11-11
Category : Medical
ISBN : 9815036920

Get Book

Frontiers in Cardiovascular Drug Discovery: Volume 6 by M. Iqbal Choudhary Pdf

Frontiers in Cardiovascular Drug Discovery is a book series devoted to publishing the latest advances in cardiovascular drug design and discovery. Each volume brings reviews on the biochemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, recent important patents, and structure-activity relationships of molecules used in cardiovascular therapy. The book series should prove to be of great interest to all medicinal chemists and pharmaceutical scientists involved in preclinical and clinical research in cardiology. Volume 6 covers the following topics: - Cardiovascular effects of ranolazine and the scope for translational research: a current review of literature - Rho/Rho kinase signaling pathway and disease: - Hibernation or transformation? Challenges in cardiovascular drug development - New approaches in P2Y12 receptor blocker drugs use - Pathophysiological links between diabetes and cardiovascular diseases: at the biochemical and molecular levels

Author : Atta-ur- Rahman
Publisher : Unknown
Page : 348 pages
File Size : 49,5 Mb
Release : 2010
Category : Cardiovascular agents
ISBN : 1608056686

Get Book

Frontiers in cardiovascular drug discovery 1 by Atta-ur- Rahman Pdf

Author : Atta-ur-Rahman,M. Iqbal Choudhary
Publisher : Bentham Science Publishers
Page : 206 pages
File Size : 49,5 Mb
Release : 2019-04-05
Category : Medical
ISBN : 9781681084008

Get Book

Frontiers in Cardiovascular Drug Discovery: Volume 4 by Atta-ur-Rahman,M. Iqbal Choudhary Pdf

Frontiers in Cardiovascular Drug Discovery is an eBook series devoted to publishing the latest advances in cardiovascular drug design and discovery. Each volume brings reviews on the biochemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, recent important patents, and structure-activity relationships of molecules used in cardiovascular therapy. The eBook series should prove to be of great interest to all medicinal chemists and pharmaceutical scientists involved in preclinical and clinical research in cardiology. The fourth volume of the series covers the following topics: -Aspirin administration -Adenosine receptor targeting for cardiovascular therapy -Drug treatment of patients with coronary stenting -Immunosuppressive drugs in heart transplantation -PCSK9 inhibition for lowering LDL-C levels.

Author : Michael K. Pugsley
Publisher : Humana Press
Page : 431 pages
File Size : 45,6 Mb
Release : 2003-07-30
Category : Medical
ISBN : 1588290972

Get Book

Cardiac Drug Development Guide by Michael K. Pugsley Pdf

Cardiac Drug Development Guide outlines, in detail, the therapeutics of cardiac medicine currently at the cutting edge of scientific research and development around the world. This volume integrates basic and clinical cardiac pharmacology by c- bining, for the first time, both classical and molecular aspects of therapeutic drug development. The chapters comprise a broad spectrum of therapeutic areas and hence involve a comprehensive discussion of molecular, biochemical, and electrophy- ological concepts based on years of in vitro as well as in vivo pharmacological st- ies. In addition, the latter part of the book includes comprehensive clinical cardiac chapters that describe important topics in molecular medicine. These chapters also discuss current clinical therapeutic trends in medicine and provide an evaluation of the efficacy of novel drugs in these areas. Cardiac Drug Development Guide has many distinctive and outstanding features that set it apart from other cardiac pharmacology books. This book introduces topics in an easily understandable format for researchers in many varying disciplines by integrating and thereby simplifying concepts not usually discussed across a broad range of cardiac disciplines and in a highly technical field. Each chapter not only introduces and describes the physiology, pharmacology, and pathophysiology of the disease, but also overviews the clinical implications of drug development, what stages these areas are currently in, and also reviews some of the methodologies involved in drug discovery and development. As a result, this book provides a comprehensive overview of the most advanced procedures in cardiac pharmacology today.

Author : Mohamed Boutjdir,Pietro Enea Lazzerini,Robert Murray Hamilton
Publisher : Frontiers Media SA
Page : 263 pages
File Size : 43,7 Mb
Release : 2020-01-30
Category : Electronic
ISBN : 9782889633975

Get Book

 Cardioimmunology: Inflammation and Immunity in Cardiovascular Disease by Mohamed Boutjdir,Pietro Enea Lazzerini,Robert Murray Hamilton Pdf

Author : Yuhei Nishimura,Hideaki Hara
Publisher : Frontiers Media SA
Page : 153 pages
File Size : 53,9 Mb
Release : 2019-01-11
Category : Electronic
ISBN : 9782889456963

Get Book

Drug Repositioning: Current Advances and Future Perspectives by Yuhei Nishimura,Hideaki Hara Pdf

Drug repositioning is the process of identifying new indications for existing drugs. At present, the conventional de novo drug discovery process requires an average of about 14 years and US$2.5 billion to approve and launch a drug. Drug repositioning can reduce the time and cost of this process because it takes advantage of drugs already in clinical use for other indications or drugs that have cleared phase I safety trials but have failed to show efficacy in the intended diseases. Historically, drug repositioning has been realized through serendipitous clinical observations or improved understanding of disease mechanisms. However, recent technological advances have enabled a more systematic approach to drug repositioning. This eBook collects 16 articles from 112 authors, providing readers with current advances and future perspectives of drug repositioning.

Author : Steffen Erhard Petersen,Karim Lekadir,Alistair A. Young,Tim Leiner
Publisher : Frontiers Media SA
Page : 138 pages
File Size : 51,6 Mb
Release : 2020-10-09
Category : Medical
ISBN : 9782889660582

Get Book

Current and Future Role of Artificial Intelligence in Cardiac Imaging by Steffen Erhard Petersen,Karim Lekadir,Alistair A. Young,Tim Leiner Pdf

This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Author : Jun-ichi Abe,Anil K. Sood,James Martin
Publisher : Frontiers Media SA
Page : 113 pages
File Size : 40,9 Mb
Release : 2019-05-17
Category : Electronic
ISBN : 9782889458752

Get Book

Cardio-Oncology: From Bench to Bedside by Jun-ichi Abe,Anil K. Sood,James Martin Pdf

Cardio-oncology is a medical subspecialty concerned with the diagnosis and treatment of cardiovascular disease (CVD) and organ failure mediated by micro- to macro-circulation defects in cancer patients and survivors. The risk of CVD in cancer survivors is eight times higher than the general population, and the relative risk of coronary artery disease and heart failure (HF) is 10 times and 15 times higher, respectively, compared to their siblings without cancer. It is important to note that cancer treatments including chemotherapy and radiation can lead to both short- (< 1 year) and long-term (> 5 years) cardiovascular complications. Previously, Dr. Edward T.H. Yeh initiated the MD Anderson Practice (MAP) project, and published 16 MAPs to provide the current best practice we considered at UT MD Anderson. As shown in these MAPs, one of the key issues of cardio-oncology practice and science is how we can allow cancer patients to receive maximum and uninterrupted treatments for cancer while protecting them from cancer therapy-mediated cardiovascular complications. Therefore, it is crucial to understand not only pathophysiology of CVD, but also mechanistic insights of how each cancer treatment can control cancer growth and metastasis. Without having the profound knowledge in the pathophysiological, clinical and epidemiologic aspects of cardiovascular complications of existing cancer therapy, it is impossible to establish the strong evidence-based strategies and approaches for both short- and long-term cardiovascular complications after cancer treatment. In addition, we believe that cardio-oncology science should not be restricted to deal with the side effects of each specific cancer drug, because many common cardiovascular phenotypes among the different cancer treatments are also observed. This Research Topic provides a comprehensive overview from both of the current research and practice, and a platform for obtaining the logical and up-to-date treatment and prevention of CVD in cancer patients and survivors.

Author : Filippo Drago,Rafael Maldonado
Publisher : Frontiers Media SA
Page : 588 pages
File Size : 55,6 Mb
Release : 2021-10-14
Category : Science
ISBN : 9782889714858

Get Book

Drug Repurposing for COVID-19 Therapy by Filippo Drago,Rafael Maldonado Pdf

Author : Apostolos Zarros,Tilli Tansey
Publisher : Frontiers Media SA
Page : 137 pages
File Size : 51,9 Mb
Release : 2019-11-27
Category : Electronic
ISBN : 9782889632237

Get Book

Pharmaceutical Innovation After World War II: From Rational Drug Discovery to Biopharmaceuticals by Apostolos Zarros,Tilli Tansey Pdf

This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Author : Alfonso Pompella,Alessandro Corti
Publisher : Frontiers Media SA
Page : 144 pages
File Size : 52,7 Mb
Release : 2015-07-17
Category : Pharmacology
ISBN : 9782889195954

Get Book

The Changing Faces of Glutathione, a Cellular Protagonist by Alfonso Pompella,Alessandro Corti Pdf

Glutathione (GSH) has been described for a long time just as a defensive reagent against the action of toxic xenobiotics (drugs, pollutants, carcinogens), both directly and as a cofactor for GSH transferases. As a prototype antioxidant, it has been involved in cell protection from the noxious effect of excess oxidant stress, both directly and as a cofactor of glutathione peroxidases. In addition, it has long been known that GSH is capable of forming disulfide bonds with cysteine residues of proteins, and the relevance of this mechanism ("S-glutathionylation") in regulation of protein function has been well documented in a number of research fields. Rather paradoxically, it has also been highlighted that GSH—and notably its catabolites, as originated by metabolism by gamma-glutamyltransferase—can promote oxidative processes, by participating in metal ion-mediated reactions eventually leading to formation of reactive oxygen species and free radicals. Also, a fundamental role of GSH has been recognized in the storage and transport of nitric oxide (NO), in the form of S-nitrosoglutathione (GSNO). The significance of GSH as a major factor in regulation of cell life, proliferation, and death, can be regarded as the integrated result of all these roles, as well as of more which are emerging in diverse fields of biology and pathophysiology. Against this background, modulation of GSH levels and GSH-related enzyme activities represents a fertile field for experimental pharmacology in numerous and diverse perspectives of animal, plant and microbiologic research. This research topic includes 14 articles, i.e. 4 Opinion Articles, 6 Reviews, and 4 Original Research Articles. The contributions by several distinguished research groups, each from his own standpoint of competence and expertise, provide a comprehensive and updated view over the diverse roles, the changing faces of GSH and GSH-related enzymes in cell’s health, disease and death.