Crispr In Animals And Animal Models

Author : Anonim
Publisher : Academic Press
Page : 148 pages
File Size : 45,6 Mb
Release : 2017-11-10
Category : Science
ISBN : 9780128125076

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CRISPR in Animals and Animal Models by Anonim Pdf

CRISPR in Animals and Animal Models, Volume 152, the latest release in the Progress in Molecular Biology and Translational Science series, explores the genome editing CRISPR system in cells and animal models, its applications, the uses of the CRISPR system, and the past, present and future of CRISPR genome editing. Topics of interest in this updated volume include a section on CRISPR history, The genome editing revolution, Programming CRISPR and its applications, CRISPR Delivery methods, CRISPR libraries and screening, CRISPR investigation in haploid cells, CRISPR in the generation of transgenic animals, CRISPR therapeutics, and Promising strategies and present challenges. Accessible to students and researchers alike Written by leading authorities in the field

Author : Jun Song,Bradford Daigneault,Zhanjun Li,Huaqiang Yang
Publisher : Frontiers Media SA
Page : 186 pages
File Size : 53,8 Mb
Release : 2022-02-18
Category : Science
ISBN : 9782889744428

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Genome Editing Applications in Animal Research by Jun Song,Bradford Daigneault,Zhanjun Li,Huaqiang Yang Pdf

Author : Yongye Huang,Jacek Z. Kubiak,Lin Yuan,Sen Wu,Feng Yue
Publisher : Frontiers Media SA
Page : 155 pages
File Size : 41,6 Mb
Release : 2023-06-21
Category : Science
ISBN : 9782832526880

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Applying large animals for developmental study and disease modeling by Yongye Huang,Jacek Z. Kubiak,Lin Yuan,Sen Wu,Feng Yue Pdf

Author : Anonim
Publisher : Academic Press
Page : 226 pages
File Size : 51,8 Mb
Release : 2019-07-30
Category : Medical
ISBN : 9780128165744

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Cellular and Animal Models in Human Genomics Research by Anonim Pdf

Cellular and Animal Models in Human Genomics Research provides an indispensable resource for applying comparative genomics in the annotation of disease-gene associated variants that are identified by human genomic sequencing. The book presents a thorough overview of effective protocols for the use of cellular and animal modeling methods to turn lists of plausible genes into causative biomarkers. With chapters written by international experts, the book first addresses the fundamental aspects of using cellular and animal models in genetic and genomic studies, including in-depth examples of specific models and their utility, i.e., yeast, worms, flies, fish, mice and large animals. Protocols for properly conducting model studies, genomic technology, modeling candidate genes vs. genetic variants, integrative modeling, utilizing induced pluripotent stem cells, and employing CRISPR-Cas9 are also discussed in-depth. Provides a thorough, accessible resource that helps researchers and students employ cellular and animal models in their own genetic and genomic studies Offers guidance on how to effectively interpret the results and significance of genetic and genomic model studies for human health Features chapters from international experts in the use of specific cellular and animal models, including yeast, worms, flies, fish, mice, and large animals, among other organisms

Author : Lucas M. Chaible,Denise Kinoshita,Marcus A. Finzi Corat,Maria L. Zaidan Dagli
Publisher : Elsevier Inc. Chapters
Page : 1108 pages
File Size : 46,6 Mb
Release : 2013-05-29
Category : Medical
ISBN : 9780128072233

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Animal Models for the Study of Human Disease by Lucas M. Chaible,Denise Kinoshita,Marcus A. Finzi Corat,Maria L. Zaidan Dagli Pdf

Genetically modified animals were created about 30 years ago, and are considered good models of human diseases. In this chapter, the types of genetically engineered mice, such as transgenic, knockout conditional knockout, and knockin animals, and the general techniques on how to obtain them are described. In addition, the available genetically modified models for genetic diseases, multifactorial and polygenic (complex) disorders, neurodegenerative, inflammatory diseases, besides cancer models, are presented. The aim of the chapter is to help investigators to find out the best models for their studies.

Author : Anonim
Publisher : Unknown
Page : 218 pages
File Size : 41,5 Mb
Release : 2003
Category : Commerce
ISBN : CHI:63990601

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Transgenic Animal Models by Anonim Pdf

Author : Kathrin Herrmann,Kimberley Jayne
Publisher : BRILL
Page : 749 pages
File Size : 46,9 Mb
Release : 2019-04-30
Category : Philosophy
ISBN : 9789004391192

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Animal Experimentation: Working Towards a Paradigm Change by Kathrin Herrmann,Kimberley Jayne Pdf

Animal experimentation has been one of the most controversial areas of animal use, mainly due to the intentional harms inflicted upon animals for the sake of hoped-for benefits in humans. Despite this rationale for continued animal experimentation, shortcomings of this practice have become increasingly more apparent and well-documented. However, these limitations are not yet widely known or appreciated, and there is a danger that they may simply be ignored. The 51 experts who have contributed to Animal Experimentation: Working Towards a Paradigm Change critically review current animal use in science, present new and innovative non-animal approaches to address urgent scientific questions, and offer a roadmap towards an animal-free world of science.

Author : National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Roundtable on Science and Welfare in Laboratory Animal Use
Publisher : National Academies Press
Page : 123 pages
File Size : 44,9 Mb
Release : 2019-08-26
Category : Science
ISBN : 9780309488518

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Care, Use, and Welfare of Marmosets as Animal Models for Gene Editing-Based Biomedical Research by National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Roundtable on Science and Welfare in Laboratory Animal Use Pdf

The marmoset, a type of small monkey native to South America, is a research model of increasing importance for biomedical research in the United States and globally. Marmosets offer a range of advantages as animal models in neuroscience, aging, infectious diseases, and other fields of study. They may be particularly useful for the development of new disease models using genetic engineering and assisted reproductive technologies. However, concerns have been voiced with respect to the development of new marmoset-based models of disease, ethical considerations for their use, the supply of marmosets available for research, and gaps in guidance for their care and management. To explore and address these concerns, the Roundtable on Science and Welfare in Laboratory Animal Use hosted a public workshop on October 22-23, 2018, in Washington, DC. The workshop focused on the availability of marmosets in the United States and abroad; animal welfare and ethical considerations stemming from the use of wildtype and genetically modified marmosets; and standards of housing and care, dietary needs, and feeding requirements for marmosets in captivity. This publication summarizes the presentations and discussions from the workshop.

Author : Izuho Hatada
Publisher : Humana
Page : 0 pages
File Size : 53,5 Mb
Release : 2024-02-26
Category : Science
ISBN : 1071630180

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Genome Editing in Animals by Izuho Hatada Pdf

This second edition provides new and updated protocols that can be used for generation of knockout animals. Chapters guide the reader through basic protocols for three genome editing technologies, target design tools, and specific protocols for each animal. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Genome Editing in Animals: Methods and Protocols, Second Edition aims to be a useful practical guide to researches to help further their study in this field.

Author : Vladimir Korinek
Publisher : Unknown
Page : 273 pages
File Size : 54,9 Mb
Release : 2021
Category : Electronic
ISBN : 3036512772

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Animal Modeling in Cancer by Vladimir Korinek Pdf

Dear Readers, Understanding the pathological mechanisms involved in human diseases and their possible treatment has been historically based on comparative analysis of diverse animal species that share a similar genetic, physiological and behavioural composition. The ancient Greeks were the first to use animals as models for anatomy and physiology, and this was consequently adopted by other cultures and led to important discoveries. In recent years, there have been many efforts to understand and fight cancer through new revolutionary personalized treatments and wider screenings that help diagnose and treat cancer. A fundamental part of this effort is to develop suitable cancer animal models that simulate the different disease variants and their progression. Ranging from tumor-derived xenografts to genetically engineered models, a wide variety of systems are applied for this purpose, and many technological breakthroughs are changing the way cancer is studied and analyzed. In this Special Issue, we collected a set of research articles and reviews that focus on the generation of cancer animal models that are used for understanding the disease and contribute to designing and testing new drugs for cancer prevention or treatment. Vladimir Korinek Collection Editor.

Author : George M Church,Edward Regis
Publisher : Basic Books
Page : 305 pages
File Size : 47,5 Mb
Release : 2014-04-08
Category : Science
ISBN : 9780465038657

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Regenesis by George M Church,Edward Regis Pdf

A Harvard biologist and master inventor explores how new biotechnologies will enable us to bring species back from the dead, unlock vast supplies of renewable energy, and extend human life. In Regenesis, George Church and science writer Ed Regis explore the possibilities of the emerging field of synthetic biology. Synthetic biology, in which living organisms are selectively altered by modifying substantial portions of their genomes, allows for the creation of entirely new species of organisms. These technologies-far from the out-of-control nightmare depicted in science fiction-have the power to improve human and animal health, increase our intelligence, enhance our memory, and even extend our life span. A breathtaking look at the potential of this world-changing technology, Regenesis is nothing less than a guide to the future of life.

Author : Ranbir Chander Sobti
Publisher : Academic Press
Page : 504 pages
File Size : 53,9 Mb
Release : 2021-12-08
Category : Science
ISBN : 9780323910446

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Advances in Animal Experimentation and Modeling by Ranbir Chander Sobti Pdf

Exploration in Laboratory Animal Sciences Understanding Life Phenomena updates our knowledge about the newer technologies such as molecular biology, genomics including sequencing, proteomics, transcriptomics, cell culture, stem cell culture, transgenesis and their translation to understand systematics and phylogeny of laboratory animals at molecular level. In seven sections Exploration in Laboratory Animal Sciences Understanding Life Phenomena resolves issues of conservation, applications in environment monitoring, production of drugs and others. Comparative research has enabled use of domestic animal models that translate the advances in basic biosciences to the schemes for human welfare including medicine. Molecular geneticists are unravelling the complexities of mammalian genes and the field of biotechnology is maturing at a fast pace. Additionally, research focused on immunology and animal behavior offer new insight into ways of enhancing animal welfare. The rise in consumption of animal proteins in addition to the challenges of sustaining our natural resources has given animal scientists a vast array of opportunities to engage in integrative systems-based research for meeting the challenges that behold us. Exploration in Laboratory Animal Sciences Understanding Life Phenomena also discusses the manipulation of animals as factories for the production of safe foods, drugs, and sensors and others to meet the contemporary challenges faced by mankind in the new world order created by pandemic of Covid 19. It also includes several chapters on the causation and management of certain diseases and impact of microbes on life. Provides insight to newer and futuristic technologies to understand disease process and drug design by animal models Addresses a wide variety of species and covers a wide variety of topics (such as animal species, the laboratory setting, regulatory guidelines, and ethical considerations) to fully prepare for work with all types of animals Gives a perspective on laboratory animal use that allows to explain the benefits of animal use as required by veterinary technology program accreditation procedure Includes examples of animal bio-technological techniques (including stem cell and tissue engineering) for their applications to humanity Offers new insight into ways of enhancing animal welfare by the inclusion of research results focused on immunology and laboratory animal behavior

Author : P. Michael Conn
Publisher : Academic Press
Page : 1108 pages
File Size : 45,7 Mb
Release : 2013-05-29
Category : Science
ISBN : 9780124159129

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Animal Models for the Study of Human Disease by P. Michael Conn Pdf

Animal Models for the Study of Human Disease identifies important animal models and assesses the advantages and disadvantages of each model for the study of human disease. The first section addresses how to locate resources, animal alternatives, animal ethics and related issues, much needed information for researchers across the biological sciences and biomedicine.The next sections of the work offers models for disease-oriented topics, including cardiac and pulmonary diseases, aging, infectious diseases, obesity, diabetes, neurological diseases, joint diseases, visual disorders, cancer, hypertension, genetic diseases, and diseases of abuse. Organized by disease orientation for ease of searchability Provides information on locating resources, animal alternatives and animal ethics Covers a broad range of animal models used in research for human disease

Author : Rodolphe Barrangou,John van der Oost
Publisher : Springer Science & Business Media
Page : 300 pages
File Size : 54,7 Mb
Release : 2012-12-13
Category : Science
ISBN : 9783642346576

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CRISPR-Cas Systems by Rodolphe Barrangou,John van der Oost Pdf

CRISPR/Cas is a recently described defense system that protects bacteria and archaea against invasion by mobile genetic elements such as viruses and plasmids. A wide spectrum of distinct CRISPR/Cas systems has been identified in at least half of the available prokaryotic genomes. On-going structural and functional analyses have resulted in a far greater insight into the functions and possible applications of these systems, although many secrets remain to be discovered. In this book, experts summarize the state of the art in this exciting field.

Author : Yuan-Chuan Chen,Shiu-Jau Chen
Publisher : BoD – Books on Demand
Page : 110 pages
File Size : 47,6 Mb
Release : 2019-05-29
Category : Medical
ISBN : 9781789845082

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Gene Editing by Yuan-Chuan Chen,Shiu-Jau Chen Pdf

Gene-editing technologies (e.g., ZFNs, TALENs, and CRISPRs/Cas9) have been extensively used as tools in basic research. They are further applied in manufacturing agricultural products, food, industrial products, medicinal products, etc. Particularly, the discovery of medicinal products using gene-editing technologies will open a new era for human therapeutics. Though there are still many technical and ethical challenges ahead of us, more and more products based on gene-editing technologies have been approved for marketing. These technologies are promising for multiple applications. Their development and implications should be explored in the broadest context possible. Future research directions should also be highlighted. In this book, the applications, perspectives, and challenges of gene-editing technologies are significantly demonstrated and discussed.