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Author : Jun Song,Bradford Daigneault,Zhanjun Li,Huaqiang Yang
Publisher : Frontiers Media SA
Page : 186 pages
File Size : 54,9 Mb
Release : 2022-02-18
Category : Science
ISBN : 9782889744428
Author : The Royal Society,National Academy of Sciences,National Academy of Medicine,International Commission on the Clinical Use of Human Germline Genome Editing
Publisher : National Academies Press
Page : 239 pages
File Size : 52,7 Mb
Release : 2021-01-16
Category : Medical
ISBN : 9780309671132
Heritable human genome editing - making changes to the genetic material of eggs, sperm, or any cells that lead to their development, including the cells of early embryos, and establishing a pregnancy - raises not only scientific and medical considerations but also a host of ethical, moral, and societal issues. Human embryos whose genomes have been edited should not be used to create a pregnancy until it is established that precise genomic changes can be made reliably and without introducing undesired changes - criteria that have not yet been met, says Heritable Human Genome Editing. From an international commission of the U.S. National Academy of Medicine, U.S. National Academy of Sciences, and the U.K.'s Royal Society, the report considers potential benefits, harms, and uncertainties associated with genome editing technologies and defines a translational pathway from rigorous preclinical research to initial clinical uses, should a country decide to permit such uses. The report specifies stringent preclinical and clinical requirements for establishing safety and efficacy, and for undertaking long-term monitoring of outcomes. Extensive national and international dialogue is needed before any country decides whether to permit clinical use of this technology, according to the report, which identifies essential elements of national and international scientific governance and oversight.
Author : National Academies of Sciences, Engineering, and Medicine,National Academy of Medicine,National Academy of Sciences,Committee on Human Gene Editing: Scientific, Medical, and Ethical Considerations
Publisher : National Academies Press
Page : 329 pages
File Size : 47,6 Mb
Release : 2017-08-13
Category : Medical
ISBN : 9780309452885
Genome editing is a powerful new tool for making precise alterations to an organism's genetic material. Recent scientific advances have made genome editing more efficient, precise, and flexible than ever before. These advances have spurred an explosion of interest from around the globe in the possible ways in which genome editing can improve human health. The speed at which these technologies are being developed and applied has led many policymakers and stakeholders to express concern about whether appropriate systems are in place to govern these technologies and how and when the public should be engaged in these decisions. Human Genome Editing considers important questions about the human application of genome editing including: balancing potential benefits with unintended risks, governing the use of genome editing, incorporating societal values into clinical applications and policy decisions, and respecting the inevitable differences across nations and cultures that will shape how and whether to use these new technologies. This report proposes criteria for heritable germline editing, provides conclusions on the crucial need for public education and engagement, and presents 7 general principles for the governance of human genome editing.
Author : National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Roundtable on Science and Welfare in Laboratory Animal Use
Publisher : National Academies Press
Page : 123 pages
File Size : 55,6 Mb
Release : 2019-08-26
Category : Science
ISBN : 9780309488518
The marmoset, a type of small monkey native to South America, is a research model of increasing importance for biomedical research in the United States and globally. Marmosets offer a range of advantages as animal models in neuroscience, aging, infectious diseases, and other fields of study. They may be particularly useful for the development of new disease models using genetic engineering and assisted reproductive technologies. However, concerns have been voiced with respect to the development of new marmoset-based models of disease, ethical considerations for their use, the supply of marmosets available for research, and gaps in guidance for their care and management. To explore and address these concerns, the Roundtable on Science and Welfare in Laboratory Animal Use hosted a public workshop on October 22-23, 2018, in Washington, DC. The workshop focused on the availability of marmosets in the United States and abroad; animal welfare and ethical considerations stemming from the use of wildtype and genetically modified marmosets; and standards of housing and care, dietary needs, and feeding requirements for marmosets in captivity. This publication summarizes the presentations and discussions from the workshop.
Author : Izuho Hatada
Publisher : Humana
Page : 0 pages
File Size : 52,5 Mb
Release : 2024-02-26
Category : Science
ISBN : 1071630180
This second edition provides new and updated protocols that can be used for generation of knockout animals. Chapters guide the reader through basic protocols for three genome editing technologies, target design tools, and specific protocols for each animal. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Genome Editing in Animals: Methods and Protocols, Second Edition aims to be a useful practical guide to researches to help further their study in this field.
Author : Sukanta Mondal,Ram Lakhan Singh
Publisher : Academic Press
Page : 340 pages
File Size : 50,7 Mb
Release : 2020-11-25
Category : Science
ISBN : 9780128206126
Advances in Animal Genomics provides an outstanding collection of integrated strategies involving traditional and modern - omics (structural, functional, comparative and epigenomics) approaches and genomics-assisted breeding methods which animal biotechnologists can utilize to dissect and decode the molecular and gene regulatory networks involved in the complex quantitative yield and stress tolerance traits in livestock. Written by international experts on animal genomics, this book explores the recent advances in high-throughput, next-generation whole genome and transcriptome sequencing, array-based genotyping, and modern bioinformatics approaches which have enabled to produce huge genomic and transcriptomic resources globally on a genome-wide scale. This book is an important resource for researchers, students, educators and professionals in agriculture, veterinary and biotechnology sciences that enables them to solve problems regarding sustainable development with the help of current innovative biotechnologies. Integrates basic and advanced concepts of animal biotechnology and presents future developments Describes current high-throughput next-generation whole genome and transcriptome sequencing, array-based genotyping, and modern bioinformatics approaches for sustainable livestock production Illustrates integrated strategies to dissect and decode the molecular and gene regulatory networks involved in complex quantitative yield and stress tolerance traits in livestock Ensures readers will gain a strong grasp of biotechnology for sustainable livestock production with its well-illustrated discussion
Author : Izuho Hatada
Publisher : Springer Nature
Page : 396 pages
File Size : 46,6 Mb
Release : 2023-02-11
Category : Science
ISBN : 9781071630167
This second edition provides new and updated protocols that can be used for generation of knockout animals. Chapters guide the reader through basic protocols for three genome editing technologies, target design tools, and specific protocols for each animal. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Genome Editing in Animals: Methods and Protocols, Second Edition aims to be a useful practical guide to researches to help further their study in this field.
Author : Anonim
Publisher : Academic Press
Page : 148 pages
File Size : 53,8 Mb
Release : 2017-11-10
Category : Science
ISBN : 9780128125076
CRISPR in Animals and Animal Models, Volume 152, the latest release in the Progress in Molecular Biology and Translational Science series, explores the genome editing CRISPR system in cells and animal models, its applications, the uses of the CRISPR system, and the past, present and future of CRISPR genome editing. Topics of interest in this updated volume include a section on CRISPR history, The genome editing revolution, Programming CRISPR and its applications, CRISPR Delivery methods, CRISPR libraries and screening, CRISPR investigation in haploid cells, CRISPR in the generation of transgenic animals, CRISPR therapeutics, and Promising strategies and present challenges. Accessible to students and researchers alike Written by leading authorities in the field
Author : Rodolphe Barrangou,John van der Oost
Publisher : Springer Science & Business Media
Page : 300 pages
File Size : 48,6 Mb
Release : 2012-12-13
Category : Science
ISBN : 9783642346576
CRISPR/Cas is a recently described defense system that protects bacteria and archaea against invasion by mobile genetic elements such as viruses and plasmids. A wide spectrum of distinct CRISPR/Cas systems has been identified in at least half of the available prokaryotic genomes. On-going structural and functional analyses have resulted in a far greater insight into the functions and possible applications of these systems, although many secrets remain to be discovered. In this book, experts summarize the state of the art in this exciting field.
Author : Kathrin Herrmann,Kimberley Jayne
Publisher : Unknown
Page : 0 pages
File Size : 48,7 Mb
Release : 2019
Category : Animal experimentation
ISBN : 9004356185
Animal Experimentation: Working Towards a Paradigm Change critically appraises current animal use in science and discusses ways in which we can contribute to a paradigm change towards human-biology based approaches.
Author : Dineshkumar Pandian
Publisher : Dineshkumar Pandian
Page : 52 pages
File Size : 55,7 Mb
Release : 2023-03-14
Category : Science
ISBN : 8210379456XXX
"Gene Editing 101: Principles and Applications" is an essential guide for anyone interested in understanding the fundamentals of gene editing and its applications. This e-book provides a comprehensive overview of the principles and technologies used in gene editing, including the CRISPR-Cas9 system, TALENs, and zinc finger nucleases. It also covers the ethical considerations and potential risks associated with gene editing, as well as the current regulations governing its use. The e-book includes real-world examples of gene editing applications, such as genetic engineering of crops, gene therapy for genetic diseases, and editing of animal genomes for research purposes. It also explores the potential for gene editing to address global challenges, such as climate change, food insecurity, and disease outbreaks. With clear explanations and engaging illustrations, "Gene Editing 101" is the perfect resource for students, researchers, and anyone interested in the cutting-edge field of gene editing. Whether you're a beginner or an expert in the field, this e-book is an indispensable guide to the science, ethics, and applications of gene editing.
Author : Yuan-Chuan Chen,Shiu-Jau Chen
Publisher : BoD – Books on Demand
Page : 110 pages
File Size : 47,9 Mb
Release : 2019-05-29
Category : Medical
ISBN : 9781789845082
Gene-editing technologies (e.g., ZFNs, TALENs, and CRISPRs/Cas9) have been extensively used as tools in basic research. They are further applied in manufacturing agricultural products, food, industrial products, medicinal products, etc. Particularly, the discovery of medicinal products using gene-editing technologies will open a new era for human therapeutics. Though there are still many technical and ethical challenges ahead of us, more and more products based on gene-editing technologies have been approved for marketing. These technologies are promising for multiple applications. Their development and implications should be explored in the broadest context possible. Future research directions should also be highlighted. In this book, the applications, perspectives, and challenges of gene-editing technologies are significantly demonstrated and discussed.
Author : Kui Li,Bingyuan Wang
Publisher : Elsevier
Page : 444 pages
File Size : 40,7 Mb
Release : 2024-04-26
Category : Technology & Engineering
ISBN : 9780128191002
Livestock Genome Editing Tools introduces applications and improvements to a series of new genome editing techniques in livestock, such as pigs, cattle, and sheep. These tools include zinc finger nucleases (ZFN), transcription activator-like effector nucleases (TALEN), and the clustered regularly interspaced short palindromic repeats (CRISPR/Cas9) system, as well as the traditional gene targeting tools. The book also summarizes a series of genome editing-related techniques including microinjection and somatic cell nuclear transfer. Written by international experts who have been working on livestock genetic editing field for more than 30 years, this book provides extensively theoretical and practical experience for readers to master the latest developments. This book explores the importance of research and application, as well as operation procedures, of livestock genetic editing tools. The writing of operation details makes this book an accessible read. Livestock Genome Editing Tools is an important resource for researchers interested in genome-edited animals, scientists and technicians in breeding institutions, and is also of interest to students major in animal reproduction and biological engineering. Provides operable experimental procedures of pigs, cattle, and sheep genome editing tools Introduces the evaluation, breeding process, and application of each of the latest and most effective tools Examines the importance of livestock germplasm innovation, breed improvement, and human disease model generation
Author : Andrea Boggio,Cesare P. R. Romano,Jessica Almqvist
Publisher : Cambridge University Press
Page : 681 pages
File Size : 51,6 Mb
Release : 2020-01-09
Category : Law
ISBN : 9781108499873
A survey of the regulation of human germline genome modification in eighteen countries and the emerging international standards.
Author : Bernard E. Rollin
Publisher : Cambridge University Press
Page : 260 pages
File Size : 54,7 Mb
Release : 1995-06-30
Category : Business & Economics
ISBN : 0521478073
This book is unlike others on the emotionally charged subject of the moral and social issues raised by genetically engineering animals. Nontechnical and anecdotal, it attempts to inform, not inflame, the reader about the problems society must address.