Cross Talk Between Lymph Node Lymphatic Endothelial Cells And T Cells In Inflammation And Cancer

Author : Sonia Elhadad,Silvia Della Bella
Publisher : Frontiers Media SA
Page : 102 pages
File Size : 46,9 Mb
Release : 2017-12-06
Category : Electronic book
ISBN : 9782889453511

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Cross Talk between Lymph Node Lymphatic Endothelial Cells and T Cells in Inflammation and Cancer by Sonia Elhadad,Silvia Della Bella Pdf

Lymphocytes constantly survey the lymph nodes in search for potential infection by a pathogen. They enter the afferent lymphatic vessel that serves as a conduit to transport the motile lymphocytes to the draining lymph node. Lymphatic vessels (LVs) are present in most vascularized tissues. They are traditionally regarded as passive conduits for soluble antigens and leukocytes. Afferent LVs begin as blind ended capillaries, which give rise to collecting vessels that merge and connect with draining lymph nodes (dLNs). Initial lymphatic capillaries are composed of Lymphatic Endothelial Cells (LECs) connected by discontinuous cell junctions, which join to form larger collecting lymphatic vessels, and ultimately feed into the LN subcapsular sinus. Within the LN, LECs are localized to the subcapsular, cortical, and medullary sinuses, where they interact with incoming and exiting leukocytes. LECs, and in general LN stromal cells, have emerged in the recent years as active players in the immune response. In support to this,studies have shown that the immune response generated during inflammation and under pathologic conditions is accompanied by modeling of the LVs and generation of new lymphatics, a process known as lymphangiogenesis. These facts strongly suggest that LECs and stromal LN cells in general, are not inert players but rather are part of the immune response by organizing immune cells movement, exchanging information and supplying survival factors. The purpose of this research topic is to review the role of the LECs during immune homeostasis and cancer. Considering the critical role of lymphangiogenesis in many pathologies like chronic and acute inflammation, autoimmunity, wound healing, graft rejection, and tumor metastasis, it is important to understand the molecular mechanisms that govern the cross talks between the LECs and immune cells during homeostasis and inflammation.

Author : Bharat B. Aggarwal,Bokyung Sung,Subash Chandra Gupta
Publisher : Springer
Page : 490 pages
File Size : 40,5 Mb
Release : 2014-05-12
Category : Medical
ISBN : 9783034808378

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Inflammation and Cancer by Bharat B. Aggarwal,Bokyung Sung,Subash Chandra Gupta Pdf

This volume examines in detail the role of chronic inflammatory processes in the development of several types of cancer. Leading experts describe the latest results of molecular and cellular research on infection, cancer-related inflammation and tumorigenesis. Further, the clinical significance of these findings in preventing cancer progression and approaches to treating the diseases are discussed. Individual chapters cover cancer of the lung, colon, breast, brain, head and neck, pancreas, prostate, bladder, kidney, liver, cervix and skin as well as gastric cancer, sarcoma, lymphoma, leukemia and multiple myeloma.

Author : Burkhard Ludewig,Mark Christopher Coles,Paul Kaye,Christopher G Mueller
Publisher : Frontiers E-books
Page : 162 pages
File Size : 44,7 Mb
Release : 2014-12-17
Category : Allergy
ISBN : 9782889193622

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Emerging immune functions of non-hematopoietic stromal cells by Burkhard Ludewig,Mark Christopher Coles,Paul Kaye,Christopher G Mueller Pdf

The development and function of the immune system is dependent on interactions between haematopoietic cells and non-hematopoietic stromal cells. The non-hematopoietic stromal cells create the microenvironment in which the immune system operates, providing an architectural landscape for hematopoietic cell-cell interactions and molecular cues governing haematopoietic cell positioning, growth and survival. Not surprisingly, therefore, aberrant stromal cell function has recently been shown to play a key role in the development of disease pathologies associated with immune dysfunction. For example, remodelling of lymphoid tissue stroma and the development of ectopic tertiary lymphoid tissues are characteristic of many infectious and inflammatory diseases and stromal cells have a recognised role in lymphoma and tumour development and resistance to therapy. An increased understanding of the molecular basis of stromal cell differentiation and function in these varied contexts will provide new tools to promote research on stromal cell biology and immune dysfunction, and potential new targets for therapeutic intervention in diseases with a major impact on public health. The importance of stromal cells and the molecular mechanisms of stromal cell function in the regulation of immune responses have only recently been appreciated and thus represent an exciting new area in immunology.

Author : Barrett Rollins
Publisher : Springer Science & Business Media
Page : 314 pages
File Size : 47,6 Mb
Release : 1999-04-09
Category : Medical
ISBN : 9781592597017

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Chemokines and Cancer by Barrett Rollins Pdf

Chemokines and Cancer synthesizes a state-of-the-art understanding of the role that chemokines and their receptors play in the pathophysiology of malignancy. It examines the influence of chemokines on a broad array of malignant cells, including their effects on such intrinsic properties as growth and movement, as well as exploring their influence on the host's response to a growing tumor. The authors also demonstrate the physiological consequences of chemokine expression and suggest how chemokines can be used to regulate tumor growth in vivo, including their direct effects on tumor growth, on tumor destruction by host inflammatory cells, and on tumor angiogenesis. The only book available that relates chemokines to cancer, Chemokines and Cancer holds out the promise of novel therapeutic approaches to malignancy through the manipulation of chemokines and/or their receptors.

Author : Marie-Caroline Dieu-Nosjean
Publisher : Humana
Page : 289 pages
File Size : 52,6 Mb
Release : 2019-09-07
Category : Medical
ISBN : 1493993720

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Tertiary Lymphoid Structures by Marie-Caroline Dieu-Nosjean Pdf

This volume explores the various methods used to study tertiary lymphoid structures (TLS) in pathological situations. Pre-clinical models are also discussed in detail to show how TLS structure, development, and maintenance can be targeted and studied in vivo. The chapters in this book cover topics such as humans and mice; strategies to quantify TLS in order to use it in stained tissue sections; classifying a gene signature form fixed and paraffin-embedded tissues; and development of murine inflammatory models to help look at TLS in the context of infection or malignancy. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and thorough, Tertiary Lymphoid Structures: Methods and Protocols is a valuable resource that increases the reader’s knowledge on immune functions and how they will pave the way to future therapeutic applications.

Author : Helen Michelle McGettrick,Sian M. Henson,Vicky L. Morrison,Ronen Sumagin
Publisher : Frontiers Media SA
Page : 172 pages
File Size : 54,5 Mb
Release : 2022-02-04
Category : Medical
ISBN : 9782889742851

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Targeting Leukocyte Trafficking: Insights and Future Directions by Helen Michelle McGettrick,Sian M. Henson,Vicky L. Morrison,Ronen Sumagin Pdf

Author : Wu Qi,Lucillia Bezu,Peng Liu,Annalisa Del Prete,Houjun Xia
Publisher : Frontiers Media SA
Page : 138 pages
File Size : 50,6 Mb
Release : 2022-12-22
Category : Science
ISBN : 9782832509470

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Tissue-resident immune cells in tumor immunity and immunotherapy by Wu Qi,Lucillia Bezu,Peng Liu,Annalisa Del Prete,Houjun Xia Pdf

Author : Gillian M. Griffiths,Jürg Tschopp
Publisher : Springer
Page : 224 pages
File Size : 45,7 Mb
Release : 2011-12-25
Category : Medical
ISBN : 3642794165

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Pathways for Cytolysis by Gillian M. Griffiths,Jürg Tschopp Pdf

At first glance the destruction of a target cell by a killer cell seems to be a simple endeavor. A closer look, however, reveals the complex mechanisms underlying this task. Killer cells are able to specifically recognize altered or infected cells. A transient contract with target cells has to be established to allow the delivery of lethal molecules or signals. The killer cell then disengages from the damaged cell and moves away to kill other target cells. After the eradication of the target cells, the number or activity of activated killer cells has to be reduced to avoid nonspecific killing of innocent cells. In 1992, Herman Eisen concluded, in his introductory remarks in the most recent volume on lymphocyte cytotoxicity (EISEN 1993): "Given the immense amount of effort made in the past decade to understand these (lytic) mechanisms, it seems surprising that a consensus about the principal mechanisms has not been reached." Since that time, advances made in the field of cell-mediated cytolysis are so significant that our knowledge regarding the lytic mechanisms has been considerably augmented. Much of this is due to studies with transfectants and mutants-either naturally occurring or generated by gene targeting. It is now clear that there are two predominant pathways which act hand in hand and lead to efficienttarget cell destruction.

Author : Santiago Cal,Alvaro J. Obaya
Publisher : Humana Press
Page : 352 pages
File Size : 45,5 Mb
Release : 2018-01-10
Category : Medical
ISBN : 1493975943

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Proteases and Cancer by Santiago Cal,Alvaro J. Obaya Pdf

This volume explores the role of proteases in various catalytic classes and cellular processes associated with cancer. The chapters in this book cover topics such as encoding proteolytic enzymes, cleavage sites of proteases, functional catalytic domains of MMPs, zymography, angiogenesis and lymphangiogenesis, genetic and epigenetic alterations of metallopeptidases, and methods to target metalloproteinases. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and cutting edge, Proteases and Cancer: Methods and Protocols is a valuable resource for clinical researchers across numerous fields such as molecular and cellular biology, oncology, biochemistry, and chemistry. This book is also useful for PhD students in the various disciples of health sciences.

Author : G. Marone,F. Granata
Publisher : Karger Medical and Scientific Publishers
Page : 244 pages
File Size : 49,8 Mb
Release : 2013-10-21
Category : Medical
ISBN : 9783318024814

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Angiogenesis, Lymphangiogenesis and Clinical Implications by G. Marone,F. Granata Pdf

Angiogenesis, the formation of new blood vessels, is fundamental for physiological processes such as embryonic and postnatal development, wound repair, and reproductive functions. Angiogenesis plays a major role in tumor growth and in several autoimmune and allergic disorders. Lymphangiogenesis, the formation of new lymphatic vessels, is also important for tumor growth, the formation of metastasis, and chronic inflammatory diseases. Judah Folkman, a pioneer in the study of angiogenesis, first proposed that macrophages and mast cells could be a relevant source of angiogenic factors. Since then, much effort has gone into the elucidation of the role of immune cells in the modulation of angiogenesis and lymphangiogenesis. There is now compelling evidence that several components of the innate and adaptive immune system are implicated in inflammatory and neoplastic angiogenesis and lymphangiogenesis. Articles in this volume deal with the emerging, intriguing possibility that immune cells are both a source and a target of angiogenic and lymphangiogenic factors. Therefore, cells of the immune system might play a role in inflammatory and neoplastic angiogenesis/lymphangiogenesis through the expression of several angiogenic factors and their receptors and co-receptors. The important new findings in this volume will be of special interest to vascular biologists, basic and clinical immunologists, oncologists and to specialists in allergic and immune disorders.

Author : You Zhou,Tao Huang,Tianbao Li,Jing Sun
Publisher : Frontiers Media SA
Page : 514 pages
File Size : 53,7 Mb
Release : 2022-04-26
Category : Science
ISBN : 9782889745678

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RNA Modification in Human Cancers: Roles and Therapeutic Implications by You Zhou,Tao Huang,Tianbao Li,Jing Sun Pdf

Author : Beth A. Jirón Tamburini,Amanda W. Lund,Timothy P. Padera
Publisher : Frontiers Media SA
Page : 205 pages
File Size : 51,8 Mb
Release : 2020-01-22
Category : Electronic
ISBN : 9782889633258

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Regulation of Immune Function by the Lymphatic Vasculature by Beth A. Jirón Tamburini,Amanda W. Lund,Timothy P. Padera Pdf

Author : Richard T. Smith
Publisher : Elsevier
Page : 552 pages
File Size : 52,5 Mb
Release : 2012-12-02
Category : Nature
ISBN : 9780323146265

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Immune Surveillance by Richard T. Smith Pdf

Immune Surveillance deals with the issues regarding tumor immunology and surveillance, in which the central theme is all about the life span of the mammalian host that is depleted by the environment with mutagenic agents and solutions. The book is divided into six chapters. It includes discussions on the organization and modulation of cell membrane receptors, as well as the origin and expression of membrane antigens. It also covers the topics on the triggering mechanisms for and effector mechanisms activated by the cellular recognition. These topics analyze and evaluate alternatives for the recognition and destruction mechanisms in the knowledge of cell cooperation and requirements for immune recognition. A chapter provides discourse on a solution for the paradox of thriving tumors based on the demonstrable in vitro host immunity. Another discusses the generation of antibody diversity and the theory of self-tolerance. The last chapter explains the evaluation of the evidence for immune surveillance. This reference will be invaluable to those who specialize in immunology.

Author : David Shepro
Publisher : Elsevier
Page : 1353 pages
File Size : 45,5 Mb
Release : 2005-11-03
Category : Medical
ISBN : 9780126395105

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Microvascular Research: Biology and Pathology, Two-Volume Set by David Shepro Pdf

The microvasculature refers to the smallest blood vessels, arterial and venous, that nurture the tissues of each organ. Apart from transport, they also contribute to the systematic regulation of the body. In everyday terminology, the microcirculation is "where the action is." Microcirculation is directly involved in such disease states as Alzheimers, inflammation, tumor growth, diabetic retinopathy, and wound healing- plus cardiovascular fitness is directly related to the formation of new capillaries in large muscles. Microvascular Research is the first book devoted exclusively to this vital systemic component of the cardiovascular system and provides up to date mini-reviews of normal functions and clinical states. The contributing authors are senior scientists with international reputation in their given disciplines. This two-volume set is a broad, interdisciplinary work that encompasses basic research and clinical applications equally. * Broad coverage of both basic and clinical aspects of microvasculature research * Contains 167 chapters from over 300 international authors * Each chapter includes key figures and annotated references

Author : Changjun Yin,Andreas J.R. Habenicht,Sarajo Mohanta,Pasquale Maffia
Publisher : Frontiers Media SA
Page : 237 pages
File Size : 51,9 Mb
Release : 2017-05-22
Category : Electronic book
ISBN : 9782889451807

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Tertiary Lymphoid Organs (TLOs): Powerhouses of Disease Immunity by Changjun Yin,Andreas J.R. Habenicht,Sarajo Mohanta,Pasquale Maffia Pdf

The immune system employs TLOs to elicit highly localized and forceful responses to unresolvable peripheral tissue inflammation. Current data indicate that TLOs are protective but they may also lead to collateral tissue injury and serve as nesting places to generate autoreactive lymphocytes. A better comprehension of these powerhouses of disease immunity will likely facilitate development to unprecedented and specific therapies to fight chronic inflammatory diseases.