Angiogenesis Lymphangiogenesis And Clinical Implications

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Angiogenesis, Lymphangiogenesis and Clinical Implications

G. Marone,F. Granata
Angiogenesis Lymphangiogenesis and Clinical Implications Book PDF

Author : G. Marone,F. Granata
Publisher : Karger Medical and Scientific Publishers
Page : 246 pages
File Size : 41,9 Mb
Release : 2013-10-21
Category : Medical
ISBN : 9783318024814

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Angiogenesis, Lymphangiogenesis and Clinical Implications by G. Marone,F. Granata Pdf

Angiogenesis, the formation of new blood vessels, is fundamental for physiological processes such as embryonic and postnatal development, wound repair, and reproductive functions. Angiogenesis plays a major role in tumor growth and in several autoimmune and allergic disorders. Lymphangiogenesis, the formation of new lymphatic vessels, is also important for tumor growth, the formation of metastasis, and chronic inflammatory diseases. Judah Folkman, a pioneer in the study of angiogenesis, first proposed that macrophages and mast cells could be a relevant source of angiogenic factors. Since then, much effort has gone into the elucidation of the role of immune cells in the modulation of angiogenesis and lymphangiogenesis. There is now compelling evidence that several components of the innate and adaptive immune system are implicated in inflammatory and neoplastic angiogenesis and lymphangiogenesis. Articles in this volume deal with the emerging, intriguing possibility that immune cells are both a source and a target of angiogenic and lymphangiogenic factors. Therefore, cells of the immune system might play a role in inflammatory and neoplastic angiogenesis/lymphangiogenesis through the expression of several angiogenic factors and their receptors and co-receptors. The important new findings in this volume will be of special interest to vascular biologists, basic and clinical immunologists, oncologists and to specialists in allergic and immune disorders.

The Textbook of Angiogenesis and Lymphangiogenesis: Methods and Applications

Enrique Zudaire,Frank Cuttitta
The Textbook of Angiogenesis and Lymphangiogenesis Methods and Applications Book PDF

Author : Enrique Zudaire,Frank Cuttitta
Publisher : Springer Science & Business Media
Page : 436 pages
File Size : 40,7 Mb
Release : 2012-11-29
Category : Medical
ISBN : 9789400745810

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The Textbook of Angiogenesis and Lymphangiogenesis: Methods and Applications by Enrique Zudaire,Frank Cuttitta Pdf

Angiogenesis and lymphangiogenesis have become attractive targets for drug therapy because of their key roles in a broad spectrum of pathological disease states ranging from macular degeneration to tumor growth and metastasis. A substantial increase in the research effort over the past decade has deepened our understanding of the basic mechanisms underlying angiogenesis and lymphangiogenesis, promoting the development of promising therapeutics for the clinical management of vascular-related diseases. These extraordinary advancements have been built upon a vast array of diverse analytical techniques developed globally throughout the field. Over the years, these methods have evolved to suit the specific needs of different researchers and experimental scenarios, resulting in a myriad of technical variants of basic assay approaches. "The Textbook of Angiogenesis and Lymphangiogenesis: Methods and Applications" is an up-to-date comprehensive textbook on angiogenesis and lymphangiogenesis techniques and applications. This volume is designed to embody the collective works of experts in the clinical as well as the basic research arenas who have significantly contributed to the development and application of techniques in all areas of angiogenesis and lymphangiogenesis. Each chapter introduces and discusses one or a group of closely related techniques and convey step-by-step protocol information and detailed technical guidance to the reader. Emphasis has been placed on explanatory illustrations, critical technical steps as well as divulging information on the benefits and caveats of specific practices related to the methods discussed. This manual is intended to serve as a written guide for both newcomers and established professionals in the field.

Angiogenesis

Napoleone Ferrara
Angiogenesis Book PDF

Author : Napoleone Ferrara
Publisher : CRC Press
Page : 280 pages
File Size : 45,8 Mb
Release : 2006-08-15
Category : Medical
ISBN : 9781420004373

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Angiogenesis by Napoleone Ferrara Pdf

Why a new book on angiogenesis and why now? For the first time concepts proposed over 30 years ago have found clinical validation. In the last two years the first antiangiogenic agents have been approved by the FDA for the treatment of cancer and age-related macular degeneration. Not surprisingly, this clinical success has raised a new set of basic

The Textbook of Angiogenesis and Lymphangiogenesis: Methods and Applications

Enrique Zudaire,Frank Cuttitta
The Textbook of Angiogenesis and Lymphangiogenesis Methods and Applications Book PDF

Author : Enrique Zudaire,Frank Cuttitta
Publisher : Springer
Page : 440 pages
File Size : 53,5 Mb
Release : 2012-11-28
Category : Medical
ISBN : 940074580X

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The Textbook of Angiogenesis and Lymphangiogenesis: Methods and Applications by Enrique Zudaire,Frank Cuttitta Pdf

Angiogenesis and lymphangiogenesis have become attractive targets for drug therapy because of their key roles in a broad spectrum of pathological disease states ranging from macular degeneration to tumor growth and metastasis. A substantial increase in the research effort over the past decade has deepened our understanding of the basic mechanisms underlying angiogenesis and lymphangiogenesis, promoting the development of promising therapeutics for the clinical management of vascular-related diseases. These extraordinary advancements have been built upon a vast array of diverse analytical techniques developed globally throughout the field. Over the years, these methods have evolved to suit the specific needs of different researchers and experimental scenarios, resulting in a myriad of technical variants of basic assay approaches. "The Textbook of Angiogenesis and Lymphangiogenesis: Methods and Applications" is an up-to-date comprehensive textbook on angiogenesis and lymphangiogenesis techniques and applications. This volume is designed to embody the collective works of experts in the clinical as well as the basic research arenas who have significantly contributed to the development and application of techniques in all areas of angiogenesis and lymphangiogenesis. Each chapter introduces and discusses one or a group of closely related techniques and convey step-by-step protocol information and detailed technical guidance to the reader. Emphasis has been placed on explanatory illustrations, critical technical steps as well as divulging information on the benefits and caveats of specific practices related to the methods discussed. This manual is intended to serve as a written guide for both newcomers and established professionals in the field.

Lymphangiogenesis in Cancer Metastasis

Steven A. Stacker,Marc G. Achen
Lymphangiogenesis in Cancer Metastasis Book PDF

Author : Steven A. Stacker,Marc G. Achen
Publisher : Springer Science & Business Media
Page : 255 pages
File Size : 40,5 Mb
Release : 2009-09-30
Category : Medical
ISBN : 9789048122479

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Lymphangiogenesis in Cancer Metastasis by Steven A. Stacker,Marc G. Achen Pdf

Lymphangiogenesis and Cancer Metastasis introduces the new field of lymphatic vessel growth and development, and its relationship to the metastatic spread of cancer cells. The book covers all aspects of this new field from the fundamental role that protein growth factors and their receptors play in lymphangiogenesis to the potential application of these advances to cancer diagnosis and treatment. Other clinical aspects explored include the mechanisms and importance of lymph node metastasis, the role of the lymphatics in lymphangioleiomyomatosis and Kaposi’s sarcoma, and approaches for imaging lymphatics in cancer. The book also covers the innovative approaches taken by researchers to explore new roles for lymphatic vessel biology in the context of cancer. The information presented in this volume, which describes the revolutionary concepts of tumor lymphangiogenesis, will be of interest to all students, scientists and oncologists who are seeking to understand the complexities of tumor metastasis. Key Features: Presents fundamental concepts of tumor lymphangiogenesis and the molecules which control this process Provides a comprehensive summary of current research in this ground breaking area Provides a book which links progress in basic tumor and developmental biology with current and future oncology practise Is an essential text for molecular biologists, cell biologists and oncologists seeking to understand the implications of this rapidly developing area.

Adrenomedullin

Alfredo Martínez,Frank Cuttitta
Adrenomedullin Book PDF

Author : Alfredo Martínez,Frank Cuttitta
Publisher : IOS Press
Page : 410 pages
File Size : 49,9 Mb
Release : 1998
Category : Adrenomedullin
ISBN : 9051993609

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Adrenomedullin by Alfredo Martínez,Frank Cuttitta Pdf

Adrenomedullin is a recently discovered peptide hormone which involved in many physiological and pathological processes. This book reviews all the information available on this intriguing molecule, covering topics as diverse as blood pressure regulation, growth of tumours and normal cells, the central nervous system, and comparative studies from sharks to mammals. An international group of experts has contributed to this volume which will be of interest to professionals, researchers, and those who will benefit from a broad review of the literature and the main trends in adrenomedullin research.

Hypoxia and Cancer Metastasis

Daniele M. Gilkes
Hypoxia and Cancer Metastasis Book PDF

Author : Daniele M. Gilkes
Publisher : Springer
Page : 160 pages
File Size : 44,9 Mb
Release : 2019-06-14
Category : Medical
ISBN : 9783030127343

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Hypoxia and Cancer Metastasis by Daniele M. Gilkes Pdf

The present book is an attempt to provide a detailed review of studies that clarify our current understanding of the role of hypoxia in the progression of primary cancer to metastatic disease. It will enable researchers to discover the critical cellular changes that occur under hypoxic conditions and play a role in metastatic dissemination, from the activation of hypoxia-inducible factors, HIF-1 and HIF-2, to the transcriptional profile changes that occur in cancer cells and promote cancer cell survival under detrimental conditions. Readers will discover the methods and challenges involved in imaging and quantifying the degree of hypoxia in a primary tumor. We will provide an understanding of the hypoxia-induced phenotypes that influence heterogeneity, alter the secretome and tumor microenvironment, modify cellular metabolism, and promote immune suppression and resistance to chemotherapy. Finally, we will uncover the therapeutic strategies that are being devised to target the hypoxic microenvironment in the hopes of preventing metastasis and improving the efficacy of standard-of-care cancer treatments. This work is an up to date source of information on the challenges and complexity of the hypoxic tumor microenvironment. Basic and translational scientists, post-doctoral fellows, graduate students, and those interested in how tumors metastasize will find this book a reference that details how hypoxia influences metastatic disease.

Angiogenesis Assays

Carolyn A. Staton,Claire Lewis,Roy Bicknell
Angiogenesis Assays Book PDF

Author : Carolyn A. Staton,Claire Lewis,Roy Bicknell
Publisher : John Wiley & Sons
Page : 410 pages
File Size : 50,5 Mb
Release : 2007-01-11
Category : Medical
ISBN : 9780470029343

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Angiogenesis Assays by Carolyn A. Staton,Claire Lewis,Roy Bicknell Pdf

Angiogenesis, the development of new blood vessels from the existing vasculature, is essential for physiological growth and over 18,000 research articles have been published describing the role of angiogenesis in over 70 different diseases, including cancer, diabetic retinopathy, rheumatoid arthritis and psoriasis. One of the most important technical challenges in such studies has been finding suitable methods for assessing the effects of regulators of eh angiogenic response. While increasing numbers of angiogenesis assays are being described both in vitro and in vivo, it is often still necessary to use a combination of assays to identify the cellular and molecular events in angiogenesis and the full range of effects of a given test protein. Although the endothelial cell - its migration, proliferation, differentiation and structural rearrangement - is central to the angiogenic process, it is not the only cell type involved. the supporting cells, the extracellular matrix and the circulating blood with its cellular and humoral components also contribute. In this book, experts in the use of a diverse range of assays outline key components of these and give a critical appraisal of their strengths and weaknesses. Examples include assays for the proliferation, migration and differentiation of endothelial cells in vitro, vessel outgrowth from organ cultures, assessment of endothelial and mural cell interactions, and such in vivo assays as the chick chorioallantoic membrane, zebrafish, corneal, chamber and tumour angiogenesis models. These are followed by a critical analysis of the biological end-points currently being used in clinical trials to assess the clinical efficacy of anti-angiogenic drugs, which leads into a discussion of the direction future studies should take. This valuable book is of interest to research scientists currently working on angiogenesis in both the academic community and in the biotechnology and pharmaceutical industries. Relevant disciplines include cell and molecular biology, oncology, cardiovascular research, biotechnology, pharmacology, pathology and physiology.

Physiologic and Pathologic Angiogenesis

Dan Simionescu,Agneta Simionescu
Physiologic and Pathologic Angiogenesis Book PDF

Author : Dan Simionescu,Agneta Simionescu
Publisher : BoD – Books on Demand
Page : 466 pages
File Size : 48,7 Mb
Release : 2017-04-05
Category : Medical
ISBN : 9789535130239

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Physiologic and Pathologic Angiogenesis by Dan Simionescu,Agneta Simionescu Pdf

The purpose of this book is to highlight novel advances in the field and to incentivize scientists from a variety of fields to pursue angiogenesis as a research avenue. Blood vessel formation and maturation to capillaries, arteries, or veins is a fascinating area which can appeal to multiple scientists, students, and professors alike. Angiogenesis is relevant to medicine, engineering, pharmacology, and pathology and to the many patients suffering from blood vessel diseases and cancer, among others. We are hoping that this book will become a source of inspiration and novel ideas for all.

Molecular Mechanisms of Angiogenesis

Jean-Jacques Feige,Gilles Pagès,Fabrice Soncin
Molecular Mechanisms of Angiogenesis Book PDF

Author : Jean-Jacques Feige,Gilles Pagès,Fabrice Soncin
Publisher : Springer
Page : 501 pages
File Size : 40,9 Mb
Release : 2014-05-27
Category : Science
ISBN : 9782817804668

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Molecular Mechanisms of Angiogenesis by Jean-Jacques Feige,Gilles Pagès,Fabrice Soncin Pdf

Angiogenesis is a multi-stage process that drives the generation of new blood and lymphatic vessels from pre-existing ones. It is highly active during embryogenesis, largely inactive during adulthood but reactivated during wound healing and under a number of pathological conditions including cancer and ocular diseases. In addition to endothelial cells, which line the walls of the vessels, several other cell types (pericytes, macrophages, progenitor cells...) also contribute to angiogenesis. A number of signaling pathways are activated and very finely tune the delicate morphogenetic events that ultimately lead to the formation of stable blood proof neovessels. This book reviews recent advances in our understanding of the molecular and cellular mechanisms of angiogenesis, with a focus on how to integrate these observations into the context of developmental, post-natal and pathological neovascularization. The book was published under the auspices of the French Angiogenesis Society. Most contributors are prominent members of this Society or international researchers who have actively contributed to the Annual Meetings of the Society.

Angiogenesis

William D. Figg,Judah Folkman
Angiogenesis Book PDF

Author : William D. Figg,Judah Folkman
Publisher : Springer Science & Business Media
Page : 592 pages
File Size : 50,9 Mb
Release : 2008-05-24
Category : Medical
ISBN : 9780387715186

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Angiogenesis by William D. Figg,Judah Folkman Pdf

Dr. Judah Folkman is considered the "father of angiogenesis." Because of Folkman's discovery and research, the possibilities of angiogenic therapy have broadened beyond cancer to many noncancerous diseases. Angiogenesis: An Integrative Approach from Science to Medicine is a comprehensive, concise summary of tumor angiogenesis. It is an up-to-date and authoritative reference for the angiogenesis field as it relates to oncology. This book represents the first collection in a volume of which Folkman is co-editor. Folkman has authored nearly 400 original papers and more than 100 book chapters.

Vascular Development

Derek J. Chadwick,Jamie A. Goode
Vascular Development Book PDF

Author : Derek J. Chadwick,Jamie A. Goode
Publisher : John Wiley & Sons
Page : 260 pages
File Size : 42,5 Mb
Release : 2007-08-20
Category : Science
ISBN : 9780470319420

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Vascular Development by Derek J. Chadwick,Jamie A. Goode Pdf

The formation of blood vessels is an essential aspect of embryogenesis in vertebrates. It is a central feature of numerous post-embryonic processes, including tissue and organ growth and regeneration. It is also part of the pathology of tumour formation and certain inflammatory conditions. In recent years, comprehension of the molecular genetics of blood vessel formation has progressed enormously and studies in vertebrate model systems, especially the mouse and the zebrafish, have identified a common set of molecules and processes that are conserved throughout vertebrate embryogenesis while, in addition, highlighting aspects that may differ between different animal groups. The discovery in the past decade of the crucial role of new blood vessel formation for the development of cancers has generated great interest in angiogenesis (the formation of new blood vessels from pre-existing ones), with its major implications for potential cancer-control strategies. In addition, there are numerous situations where therapeutic treatments either require or would be assisted by vasculogenesis (the de novo formation of blood vessels). In particular, post-stroke therapies could include treatments that stimulate neovascularization of the affected tissues. The development of such treatments, however, requires thoroughly understanding the developmental properties of endothelial cells and the basic biology of blood vessel formation. While there are many books on angiogenesis, this unique book focuses on exactly this basic biology and explores blood vessel formation in connection with tissue development in a range of animal models. It includes detailed discussions of relevant cell biology, genetics and embryogenesis of blood vessel formation and presents insights into the cross-talk between developing blood vessels and other tissues. With contributions from vascular biologists, cell biologists and developmental biologists, a comprehensive and highly interdisciplinary volume is the outcome.

Vascularization for Tissue Engineering and Regenerative Medicine

Wolfgang Holnthoner,Andrea Banfi,James Kirkpatrick,Heinz Redl
Vascularization for Tissue Engineering and Regenerative Medicine Book PDF

Author : Wolfgang Holnthoner,Andrea Banfi,James Kirkpatrick,Heinz Redl
Publisher : Springer
Page : 0 pages
File Size : 54,7 Mb
Release : 2021-06-09
Category : Technology & Engineering
ISBN : 3319545841

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Vascularization for Tissue Engineering and Regenerative Medicine by Wolfgang Holnthoner,Andrea Banfi,James Kirkpatrick,Heinz Redl Pdf

This reference work presents the basic principles of angiogenesis induction, including the roles of signaling factors such as hypoxia-inducible factors, biophysical stimulation and angiogenic cells. The book also covers lymphogenesis induction. Both the established fundamentals in the field as well as new trends in the vascularization of engineered tissues are discussed. These include pre-vascularization strategies using preparation of channeled scaffolds and preparation of decellularized blood vessel trees, approaches to inducing formation of microvasculature and approaches to inducing the growth of vascular networks. The authors expand on these concepts with current studies of dual-level approaches to engineer vascularized tissue composites. The book concludes with a discussion of current clinical approaches and the use of vascular grafts in the context of providing clinical practice with new tissue engineering strategies.

Tumour Angiogenesis

R. John Bicknell,Claire E. Lewis,Napoleone Ferrara
Tumour Angiogenesis Book PDF

Author : R. John Bicknell,Claire E. Lewis,Napoleone Ferrara
Publisher : Unknown
Page : 416 pages
File Size : 51,8 Mb
Release : 1997
Category : Neovascularization
ISBN : UOM:39015041324271

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Tumour Angiogenesis by R. John Bicknell,Claire E. Lewis,Napoleone Ferrara Pdf

Tumour Angiogenesis is the first comprehensive book to cover all areas of this rapidly expanding research area. Each chapter is written by world experts in the field and topics covered include in vivo models, mechanisms, inhibition, and the role of macrophages, cytokines, proteases,extracellular matrix components, nitric oxide, prostanoids and oncogenes/tumour suppressor genes in angiogenesis. Other chapters examine the role of specific growth factors in angiogenesis - these include vascular endothelial growth factor, the basic fibroblast growth factor family, transforminggrowth factor-beta, tumour necrosis factor-alpha, platelet-derived endothelial cell growth factor/thymidine phosphorylase and pleiotrophin and related molecules. Clinical issues are addressed in chapters that deal with the prognostic and predictive value of tumour microvessel density and thetherapeutic significance of microregional blood flow. The two final chapters examine the feasibility of targeting tumour vasculature using either antibodies or gene therapy.

Antiangiogenic Agents in Cancer Therapy

Beverly A. Teicher,Lee M. Ellis
Antiangiogenic Agents in Cancer Therapy Book PDF

Author : Beverly A. Teicher,Lee M. Ellis
Publisher : Springer Science & Business Media
Page : 559 pages
File Size : 41,5 Mb
Release : 2008-01-08
Category : Medical
ISBN : 9781597451840

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Antiangiogenic Agents in Cancer Therapy by Beverly A. Teicher,Lee M. Ellis Pdf

This volume represents a compendium of scientific findings and approaches to the study of angiogenesis in cancer. The second edition of Antiangiogenic Agents in Cancer Therapy is intended to give a current perspective on the state-of-the-art of angiogenensis and therapy directed at this process. Antiangiogenesis is a dynamic and evolving field in oncology. New therapeutic targets continue to emerge followed by the rapid development of new therapeutic agents to be investigated in clinical trials. Optimizing the therapeutic potential of antiangiogenic agents in combination with the other therapies in the armamentarium to fight cancer will be an on-going challenge.