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A thought-provoking exploration of deleterious mutations in the human genome and their effects on human health and wellbeing Despite all of the elaborate mechanisms that a cell employs to handle its DNA with the utmost care, a newborn human carries about 100 new mutations, originated in their parents, about 10 of which are deleterious. A mutation replacing just one of the more than three billion nucleotides in the human genome may lead to synthesis of a dysfunctional protein, and this can be inconsistent with life or cause a tragic disease. Several percent of even young people suffer from diseases that are caused, exclusively or primarily, by pre?]existing and new mutations in their genomes, including both a wide variety of genetically simple Mendelian diseases and diverse complex diseases such as birth anomalies, diabetes, and schizophrenia. Milder, but still substantial, negative effects of mutations are even more pervasive. As of now, we possess no means of reducing the rate at which mutations appear spontaneously. However, the recent flood of genomic data made possible by next-generation methods of DNA sequencing, enabled scientists to explore the impacts of deleterious mutations on humans with previously unattainable precision and begin to develop approaches to managing them. Written by a leading researcher in the field of evolutionary genetics, Crumbling Genome reviews the current state of knowledge about deleterious mutations and their effects on humans for those in the biological sciences and medicine, as well as for readers with only a general scientific literacy and an interest in human genetics. Provides an extensive introduction to the fundamentals of evolutionary genetics with an emphasis on mutation and selection Discusses the effects of pre-existing and new mutations on human genotypes and phenotypes Provides a comprehensive review of the current state of knowledge in the field and considers crucial unsolved problems Explores key ethical, scientific, and social issues likely to become relevant in the near future as the modification of human germline genotypes becomes technically feasible Crumbling Genome is must-reading for students and professionals in human genetics, genomics, bioinformatics, evolutionary biology, and biological anthropology. It is certain to have great appeal among all those with an interest in the links between genetics and evolution and how they are likely to influence the future of human health, medicine, and society.
A thought-provoking exploration of deleterious mutations in the human genome and their effects on human health and wellbeing Despite all of the elaborate mechanisms that a cell employs to handle its DNA with the utmost care, a newborn human carries about 100 new mutations, originated in their parents, about 10 of which are deleterious. A mutation replacing just one of the more than three billion nucleotides in the human genome may lead to synthesis of a dysfunctional protein, and this can be inconsistent with life or cause a tragic disease. Several percent of even young people suffer from diseases that are caused, exclusively or primarily, by pre ]existing and new mutations in their genomes, including both a wide variety of genetically simple Mendelian diseases and diverse complex diseases such as birth anomalies, diabetes, and schizophrenia. Milder, but still substantial, negative effects of mutations are even more pervasive. As of now, we possess no means of reducing the rate at which mutations appear spontaneously. However, the recent flood of genomic data made possible by next-generation methods of DNA sequencing, enabled scientists to explore the impacts of deleterious mutations on humans with previously unattainable precision and begin to develop approaches to managing them. Written by a leading researcher in the field of evolutionary genetics, Crumbling Genome reviews the current state of knowledge about deleterious mutations and their effects on humans for those in the biological sciences and medicine, as well as for readers with only a general scientific literacy and an interest in human genetics. Provides an extensive introduction to the fundamentals of evolutionary genetics with an emphasis on mutation and selection Discusses the effects of pre-existing and new mutations on human genotypes and phenotypes Provides a comprehensive review of the current state of knowledge in the field and considers crucial unsolved problems Explores key ethical, scientific, and social issues likely to become relevant in the near future as the modification of human germline genotypes becomes technically feasible Crumbling Genome is must-reading for students and professionals in human genetics, genomics, bioinformatics, evolutionary biology, and biological anthropology. It is certain to have great appeal among all those with an interest in the links between genetics and evolution and how they are likely to influence the future of human health, medicine, and society.
The Society of Genes by Itai Yanai,Lercher Martin Pdf
Since Dawkins popularized the notion of the selfish gene, the question of how these selfish genes work together to construct an organism remained a mystery. Now, standing atop a wealth of new research, Itai Yanai and Martin Lercher—pioneers in the field of systems biology—provide a vision of how genes cooperate and compete in the struggle for life.
Genetic testing has provided important clues to understanding our health, but it has also raised many ethical, legal, and medical questions and concerns. This book explores the breadth of genetic testing, its possibilities, and the controversies that surround its use. The mapping of the human genome has paved the way for a variety of genetic tests. Expectant mothers can have their fetus screened for a variety of genetic abnormalities, and couples worried that they might be carriers for a genetic disorder can be tested before deciding to have children. Women can be screened for the BRCA2 gene that has been linked to increased risk of breast cancer. Individuals curious about their ancestry can find out more about their heritage. Genetic testing can also be used to establish paternity and help solve crimes. Part of Greenwood's Health and Medical Issues Today series, this book is divided into three sections. Part I explores the history of genetic testing, including the rise of direct-to-consumer tests, and outlines the current applications and contexts in which genetic testing is performed. Part II delves deep into the ethical, legal, financial, medical, and psychological issues and controversies that surround genetic testing. Part III provides a variety of useful materials, including case studies, a timeline of critical events, and a directory of resources.
Unsolved Problems in Ecology by Andrew Dobson,David Tilman,Robert D. Holt Pdf
Leading ecologists discuss some of the most compelling open questions in the field today Unsolved Problems in Ecology brings together many of the world's leading ecologists to discuss the most fundamental research questions confronting the field today. This diverse and thought-provoking collection of essays spans virtually all of the key subfields of the discipline, from behavioral and evolutionary ecology to population biology, community ecology, ecosystem ecology, disease ecology, and conservation biology. These essays are intended to stoke curiosity, challenge prevailing wisdom, and provoke new ways of thinking about ecology in light of new technologies and unprecedented environmental challenges brought on by climate and land-use change. Authoritative and accessible, Unsolved Problems in Ecology is ideal for graduate students in the early stages of their scientific careers and an essential resource for seasoned ecologists looking for exciting new directions to take their research. Sheds light on modern ecology's most important and compelling open questions Features thought-provoking contributions from more than two dozen world-class ecologists Covers behavior, evolution, communities, ecosystems, resource management, and more Discusses ways to raise the financial and intellectual profile of the discipline An invaluable resource for graduate students as well as seasoned ecologists
2019 PEN/E.O. Wilson Literary Science Writing Award Finalist "Science book of the year"—The Guardian One of New York Times 100 Notable Books for 2018 One of Publishers Weekly's Top Ten Books of 2018 One of Kirkus's Best Books of 2018 One of Mental Floss's Best Books of 2018 One of Science Friday's Best Science Books of 2018 “Extraordinary”—New York Times Book Review "Magisterial"—The Atlantic "Engrossing"—Wired "Leading contender as the most outstanding nonfiction work of the year"—Minneapolis Star-Tribune Celebrated New York Times columnist and science writer Carl Zimmer presents a profoundly original perspective on what we pass along from generation to generation. Charles Darwin played a crucial part in turning heredity into a scientific question, and yet he failed spectacularly to answer it. The birth of genetics in the early 1900s seemed to do precisely that. Gradually, people translated their old notions about heredity into a language of genes. As the technology for studying genes became cheaper, millions of people ordered genetic tests to link themselves to missing parents, to distant ancestors, to ethnic identities... But, Zimmer writes, “Each of us carries an amalgam of fragments of DNA, stitched together from some of our many ancestors. Each piece has its own ancestry, traveling a different path back through human history. A particular fragment may sometimes be cause for worry, but most of our DNA influences who we are—our appearance, our height, our penchants—in inconceivably subtle ways.” Heredity isn’t just about genes that pass from parent to child. Heredity continues within our own bodies, as a single cell gives rise to trillions of cells that make up our bodies. We say we inherit genes from our ancestors—using a word that once referred to kingdoms and estates—but we inherit other things that matter as much or more to our lives, from microbes to technologies we use to make life more comfortable. We need a new definition of what heredity is and, through Carl Zimmer’s lucid exposition and storytelling, this resounding tour de force delivers it. Weaving historical and current scientific research, his own experience with his two daughters, and the kind of original reporting expected of one of the world’s best science journalists, Zimmer ultimately unpacks urgent bioethical quandaries arising from new biomedical technologies, but also long-standing presumptions about who we really are and what we can pass on to future generations.
Human Evolutionary Demography by Oskar Burger,Ronald Lee,Rebecca Sear Pdf
Human evolutionary demography is an emerging field blending natural science with social science. This edited volume provides a much-needed, interdisciplinary introduction to the field and highlights cutting-edge research for interested readers and researchers in demography, the evolutionary behavioural sciences, biology, and related disciplines. By bridging the boundaries between social and biological sciences, the volume stresses the importance of a unified understanding of both in order to grasp past and current demographic patterns. Demographic traits, and traits related to demographic outcomes, including fertility and mortality rates, marriage, parental care, menopause, and cooperative behavior are subject to evolutionary processes. Bringing an understanding of evolution into demography therefore incorporates valuable insights into this field; just as knowledge of demography is key to understanding evolutionary processes. By asking questions about old patterns from a new perspective, the volume—composed of contributions from established and early-career academics—demonstrates that a combination of social science research and evolutionary theory offers holistic understandings and approaches that benefit both fields. Human Evolutionary Demography introduces an emerging field in an accessible style. It is suitable for graduate courses in demography, as well as upper-level undergraduates. Its range of research is sure to be of interest to academics working on demographic topics (anthropologists, sociologists, demographers), natural scientists working on evolutionary processes, and disciplines which cross-cut natural and social science, such as evolutionary psychology, human behavioral ecology, cultural evolution, and evolutionary medicine. As an accessible introduction, it should interest readers whether or not they are currently familiar with human evolutionary demography.
The Past is a Future Country by Edward Dutton,J.O.A. Rayner-Hilles Pdf
Since the 1960s, the West has moved ever-leftwards. 'Equality' and ‘feelings' are central to the New Religion that rejects all traditional values. Yet beneath the institutionally dominant ‘Left' stews a growing and restless ‘Right’. How has this fractured situation come about? What will the future hold? In The Past is a Future Country, the authors trace it back to the Industrial Revolution. Darwinian selection massively weakened, meaning that, for the first time in history, the selfish, sick and stupid could survive and reproduce, undermining our religious, group-oriented culture. Now the West is scourged by an epidemic of narcissists, competing to signal their individuality and moral superiority. But their ‘fight for equality’ is really a fight for self-promotion. Reflecting this runaway individualism, Westerners increasingly don’t have children, save for those who are genetically resistant to this onslaught — the staunchly conservative and religious: the eventual inheritors of the earth. But there is a dark storm brewing in the demographic data that the authors have analysed. There is a burgeoning growth in the population of exceptionally unintelligent and antisocial people that social welfare systems cannot sustain for much longer. The developed world will pass away, and the global population that depends on it will crash, in the greatest Malthusian Collapse of all time. Yet all is not lost. The authors show how a resistant class of intelligent, religious conservatives will band together to preserve enclaves of civilization that may survive most of the coming apocalypse, and from its ashes rebuild a new world: A Neo-Byzantium.
HISTORY & MATHEMATICS by Leonid Grinin,Andrey Korotayev Pdf
The present Yearbook (which is the eighth in the series) is subtitled Investigating Past and Future. It is devoted to three problems: the analysis of the aspects of past and present in the light of formal methods; singularity, i.e. forthcoming abrupt shift in development, the approach (or even presence) of which we already feel; the aspects of the cosmic future of human race. This issue consists of four sections: (I) History, Technologies, Politics, and Mathematics includes five articles on different directions of factual or theoretical content: history, technology, politics, and studies covering past, present, and future; (II) Singularity includes two contributions and is devoted to a rather interesting phenomenon of singularity. They suggest that indeed the hyperbolic planetary evolutionary trend observed since the origins of life on the Earth cannot continue beyond the forthcoming singularity, whereas the post-singular evolutionary trend should be qualitatively different from what has been observed before; (III) Beyond the Earth also consists of two very different articles, but they are united by their interest in the future of human race in terms of their interaction with the space; (IV) Reviews and Notes. We hope that this issue will be interesting and useful both for historians and mathematicians, as well as for all those dealing with various social and natural sciences.
The Oxford Handbook of Evolutionary Medicine by Martin Brüne,Wulf Schiefenhövel Pdf
Medicine is grounded in the natural sciences, among which biology stands out with regard to the understanding of human physiology and conditions that cause dysfunction. Ironically though, evolutionary biology is a relatively disregarded field. One reason for this omission is that evolution is deemed a slow process. Indeed, macroanatomical features of our species have changed very little in the last 300,000 years. A more detailed look, however, reveals that novel ecological contingencies, partly in relation to cultural evolution, have brought about subtle changes pertaining to metabolism and immunology, including adaptations to dietary innovations, as well as adaptations to the exposure to novel pathogens. Rapid pathogen evolution and evolution of cancer cells cause major problems for the immune system to find adequate responses. In addition, many adaptations to past ecologies have turned into risk factors for somatic disease and psychological disorder in our modern worlds (i.e. mismatch), among which epidemics of autoimmune diseases, cardiovascular diseases, diabetes and obesity, as well as several forms of cancer stand out. In addition, depression, anxiety and other psychiatric conditions add to the list. The Oxford Handbook of Evolutionary Medicine is a compilation of cutting edge insights into the evolutionary history of ourselves as a species, and how and why our evolved design may convey vulnerability to disease. Written in a classic textbook style emphasising physiology and pathophysiology of all major organ systems, the Oxford Handbook of Evolutionary Medicine will be valuable for students as well as scholars in the fields of medicine, biology, anthropology and psychology.
Modernity and Cultural Decline by Matthew Alexandar Sarraf,Michael Anthony Woodley of Menie,Colin Feltham Pdf
This book argues that despite the many real advantages that industrial modernity has yielded—including large gains in wealth, longevity, and (possibly) happiness—it has occurred together with the appearance of a variety of serious problems. Chief among these are probable losses in subjective existential purpose and increases in psychopathology. A highly original theory of the ultimate basis of these trends is advanced, which unites prior work in psychometrics and evolutionary science. This theory builds on the social epistasis amplification model to argue that genetic and epigenetic changes in modernizing and modernized populations, stemming from shifts in selective pressures related to industrialization, have lowered human fitness and wellness.
This is a book about baseball’s true “replacement players.” During the four seasons the U.S. was at war in World War II (1942-1945), 533 players made their major-league debuts. There were 67 first-time major leaguers under the age of 21 (Joe Nuxhall the youngest at 15 in 1944). More than 60 percent of the players in the 1941 Opening Day lineups departed for the service. The 1944 Dodgers had only Dixie Walker and Mickey Owen as the two regulars from their 1941 pennant-winning team. The owners brought in not only first-timers but also many oldsters. Hod Lisenbee pitched 80 innings for the Reds in 1945 at the age of 46. He had last pitched in the major leagues in 1936. War veteran and former POW Bert Shepard, with an artificial leg, pitched in one game for the 1945 Senators, and one-armed outfielder Pete Gray played for the St. Louis Browns. The war years featured firsts and lasts. The St. Louis Browns won their first (and last) pennant in 1944 — a feat made more amazing by the fact that they had not finished in the first division since 1929. The 1944 team featured 13 players classified as 4-F. The Chicago Cubs appeared in the 1945 World Series but have not made it back since. Some 53 members of the Society for American Baseball Research (SABR) have contributed to this volume. We invite you to sit back and relax as you learn Who's on First? Includes contributions by: Alan Cohen, Ashlie Christian And Armand Peterson, Bill Nowlin, Bob Brady, Bob Lemoine, Bob Mayer, Bob Webster, Charles Faber, Charlie Weatherby, Chris Rainey, Cort Vitty, David Finoli, David M. Jordan, David Raglin And Barb Mantegani, David W. Pugh, Don Zminda, Duke Goldman, Greg Erion, Gregg Omoth, Gregory H. Wolf, J. G. Preston, James D. Smith, Iii, Jay Hurd, Jeff Marlett, Jeff Obermeyer, Jim Sweetman, Joanne Hulbert, John Shannahan, Leslie Heaphy, Lyle Spatz, Marc Lancaster, Marc Z Aaron, Mark S. Sternman, Mel Marmer, Merrie A. Fidler, Michael Huber, Michael Huber And Rachel Hamelers, Mike Mcclary, Peter C. Bjarkman, Rex Hamann, Rich Bogovich, Richard Cuicchi, Richard Moraski, Rory Costello And Lou Hernández, Seamus Kearney, Sidney Davis, Steve Smith, Thomas Ayers, Tom Hawthorn, Walter Leconte Table of Contents: Introduction MARC Z AARON The Business of Baseball During World War II JEFF OBERMEYER “But Where is Pearl Harbor?” Baseball and the Day the World Changed, December 7, 1941 BOB LEMOINE The Tri-Cornered War Bond Baseball Game MICHAEL HUBER AND RACHEL HAMELERS NATIONAL LEAGUE Boston Braves How the Boston Braves Survived the War But Lost the Battle for Boston BOB BRADY Ben Cardoni BY MARK S. STERNMAN Buck Etchison BY ALAN COHEN Butch Nieman BY SIDNEY DAVIS Mystery Member of the ‘45 Braves BOB BRADY Brooklyn Dodgers The Brooklyn Dodgers in Wartime MICHAEL HUBER John “Fats” D’Antonio RICHARD CUICCHI Bill Hart BOB LEMOINE Lee Pfund BOB WEBSTER Chicago Cubs The Cubs in Wartime THOMAS AYERS Jorge Comellas RICH BOGOVICH Billy Holm BILL NOWLIN Walter Signer GREGORY H. WOLF Cincinnati Reds The Cincinnati Reds During World War II JAY HURD Tomás de la Cruz PETER C. BJARKMAN Buck Fausett J. G. PRESTON Dick Sipek CHARLES FABER New York Giants The New York Giants in Wartime BOB MAYER Al Gardella CHARLIE WEATHERBY Frank Seward JEFF MARLETT Roy Zimmerman JOANNE HULBERT Philadelphia Phillies The Phillies in Wartime SEAMUS KEARNEY Chet Covington STEVE SMITH Hilly Flitcraft JIM SWEETMAN Lee Riley MEL MARMER Pittsburgh Pirates The Pirates in Wartime DAVID FINOLI Xavier Rescigno DAVID FINOLI Len Gilmore DAVID FINOLI Frankie Zak DAVID FINOLI St. Louis Cardinals The Cardinals in Wartime GREGORY H. WOLF Jack Creel GREGORY H. WOLF Gene Crumling GREGORY H. WOLF Bob Keely GREGORY H. WOLF AMERICAN LEAGUE Boston Red Sox The Red Sox in Wartime BILL NOWLIN Otey Clark BILL NOWLIN Ty LaForest BILL NOWLIN Stan Partenheimer JOHN SHANNAHAN The Frostbite League: Spring Training 1943 - 1945 BILL NOWLIN The 1944 Red Sox: What Could Have Been DUKE GOLDMAN Chicago White Sox The White Sox in Wartime DON ZMINDA Vince Castino DAVID RAGLIN AND BARB MANTEGANI Guy Curtright DON ZMINDA Floyd Speer REX HAMANN Cleveland Indians World War II and the Cleveland Indians DAVID W. PUGH Otto Denning CHRIS RAINEY Jim McDonnell ASHLIE CHRISTIAN AND ARMAND PETERSON Mickey Rocco GREGG OMOTH Detroit Tigers The Tigers in Wartime MIKE MCCLARY Chuck Hostetler MARC LANCASTER Bobby Maier MARC LANCASTER Charlie Metro TOM HAWTHORN New York Yankees The Yankees in Wartime MARC Z AARON Joe Buzas MARC Z AARON Mike Garbark MARC Z AARON Bud Metheny MARC Z AARON Philadelphia Athletics The Wartime Philadelphia Athletics DAVID M. JORDAN Orie Arntzen GREGORY H. WOLF Jim Tyack ALAN COHEN Woody Wheaton ALAN COHEN St. Louis Browns The St. Louis Browns in World War II GREG ERION Milt Byrnes GREG ERION Charley Fuchs GREG ERION Pete Gray MEL MARMER Washington Senators The Washington Senators in Wartime RICHARD MORASKI Ed Butka CORT VITTY Jug Thesenga BOB LEMOINE Tony Zardón RORY COSTELLO AND LOU HERNÁNDEZ Senators Who Died in Combat RICHARD MORASKI OTHER ESSAYS The All-Star Games in the War Years LYLE SPATZ Wartime Baseball: Minor Leagues, Major Changes (San Diego to Buffalo) JAMES D. SMITH, III Impact of WWII on the Negro Leagues LESLIE HEAPHY Baseball’s Women on the Field During WWII MERRIE A. FIDLER In-season Exhibition Games During Wartime WALTER LECONTE The Double Victory Campaign and the Campaign to Integrate Baseball DUKE GOLDMAN
“Over a decade after its publication, one book on dating has people firmly in its grip.” —The New York Times We already rely on science to tell us what to eat, when to exercise, and how long to sleep. Why not use science to help us improve our relationships? In this revolutionary book, psychiatrist and neuroscientist Dr. Amir Levine and Rachel Heller scientifically explain why some people seem to navigate relationships effortlessly, while others struggle. Discover how an understanding of adult attachment—the most advanced relationship science in existence today—can help us find and sustain love. Pioneered by psychologist John Bowlby in the 1950s, the field of attachment posits that each of us behaves in relationships in one of three distinct ways: • Anxious people are often preoccupied with their relationships and tend to worry about their partner's ability to love them back. • Avoidant people equate intimacy with a loss of independence and constantly try to minimize closeness. • Secure people feel comfortable with intimacy and are usually warm and loving. Attached guides readers in determining what attachment style they and their mate (or potential mate) follow, offering a road map for building stronger, more fulfilling connections with the people they love.
Dragons at Crumbling Castle by Terry Pratchett Pdf
New York Times best-selling author Terry Pratchett's irreverent and irresistible tales for children in a lavishly designed and extensively illustrated volume.
The Glattfelders in America by Jeanine Hartman Pdf
The Glattfelder etc. families originally of Switzerland. Casper Glattfelder (1709-1774/75) and his brother, Johannes Peter Glattfelder (1700-1742), were sons of Felix Glattfelder and Barbara Gorius, both born in Glattfelden, Eglisau, Zurich, Switzwerland. Casper married (1) Elizabeth Lauffer (1711-1743/46) in 1731 in Switzerland, and (2) Anna Maria? (d. 1775) about 1745 in Pennsylvania. He died in Codorus Twp., York Co., Pa. Johannes Peter Glattfelder married Salomea AmBerg (b. 1704) 1721 in Glattfelden. Hons Heinrich Glattfelder (1671-1734) was also born in Glattfelden, where he married Dorothea Gorius (d. 1719) in 1693. Descendants live in York Co., Pa., Davidson Co., N.C., Tennessee, Ohio, Indiana, Illinois, Kansas, Missouri, California, Switzerland and elsewhere.
