Current Challenges In Modeling Cellular Metabolism

Author : Daniel Machado,Kai H. Zhuang,Nikolaus Sonnenschein,Markus J. Herrgård
Publisher : Frontiers Media SA
Page : 117 pages
File Size : 47,7 Mb
Release : 2016-01-21
Category : Biology (General)
ISBN : 9782889197545

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Current Challenges in Modeling Cellular Metabolism by Daniel Machado,Kai H. Zhuang,Nikolaus Sonnenschein,Markus J. Herrgård Pdf

Mathematical and computational models play an essential role in understanding the cellular metabolism. They are used as platforms to integrate current knowledge on a biological system and to systematically test and predict the effect of manipulations to such systems. The recent advances in genome sequencing techniques have facilitated the reconstruction of genome-scale metabolic networks for a wide variety of organisms from microbes to human cells. These models have been successfully used in multiple biotechnological applications. Despite these advancements, modeling cellular metabolism still presents many challenges. The aim of this Research Topic is not only to expose and consolidate the state-of-the-art in metabolic modeling approaches, but also to push this frontier beyond the current edge through the introduction of innovative solutions. The articles presented in this e-book address some of the main challenges in the field, including the integration of different modeling formalisms, the integration of heterogeneous data sources into metabolic models, explicit representation of other biological processes during phenotype simulation, and standardization efforts in the representation of metabolic models and simulation results.

Author : Debmalya Barh,Vasco Azevedo
Publisher : Academic Press
Page : 420 pages
File Size : 50,8 Mb
Release : 2018-02-28
Category : Science
ISBN : 9780128158715

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Omics Technologies and Bio-engineering by Debmalya Barh,Vasco Azevedo Pdf

Omics Technologies and Bio-Engineering: Towards Improving Quality of Life, Volume 2 is a unique reference that brings together multiple perspectives on omics research, providing in-depth analysis and insights from an international team of authors. The book delivers pivotal information that will inform and improve medical and biological research by helping readers gain more direct access to analytic data, an increased understanding on data evaluation, and a comprehensive picture on how to use omics data in molecular biology, biotechnology and human health care. Covers various aspects of biotechnology and bio-engineering using omics technologies Focuses on the latest developments in the field, including biofuel technologies Provides key insights into omics approaches in personalized and precision medicine Provides a complete picture on how one can utilize omics data in molecular biology, biotechnology and human health care

Author : Jian Yu,Zhizhuang Joe Zhao,Hubing Shi,Manoj Kumar Kashyap
Publisher : Frontiers Media SA
Page : 140 pages
File Size : 52,9 Mb
Release : 2022-12-05
Category : Medical
ISBN : 9782832508695

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Linking Cellular Metabolism to Hematological Malignancies by Jian Yu,Zhizhuang Joe Zhao,Hubing Shi,Manoj Kumar Kashyap Pdf

Author : Pullan Andrew,Buist Martin L,Cheng Leo K
Publisher : World Scientific Publishing Company
Page : 448 pages
File Size : 55,7 Mb
Release : 2005-09-07
Category : Science
ISBN : 9789813106567

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Mathematically Modelling The Electrical Activity Of The Heart: From Cell To Body Surface And Back Again by Pullan Andrew,Buist Martin L,Cheng Leo K Pdf

This book on modelling the electrical activity of the heart is an attempt to describe continuum based modelling of cardiac electrical activity from the cell level to the body surface (the forward problem), and back again (the inverse problem). Background anatomy and physiology is covered briefly to provide a suitable context for understanding the detailed modelling that is presented herein. The questions of what is mathematical modelling and why one would want to use mathematical modelling are addressed to give some perspective to the philosophy behind our approach. Our view of mathematical modelling is broad — it is not simply about obtaining a solution to a set of mathematical equations, but includes some material on aspects such as experimental and clinical validation.

Author : Osbaldo Resendis-Antonio,Christian Diener
Publisher : Frontiers Media SA
Page : 144 pages
File Size : 48,6 Mb
Release : 2017-11-23
Category : Electronic
ISBN : 9782889453337

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Systems Biology and the Challenge of Deciphering the Metabolic Mechanisms Underlying Cancer by Osbaldo Resendis-Antonio,Christian Diener Pdf

Since the discovery of the Warburg effect in the 1920s cancer has been tightly associated with the genetic and metabolic state of the cell. One of the hallmarks of cancer is the alteration of the cellular metabolism in order to promote proliferation and undermine cellular defense mechanisms such as apoptosis or detection by the immune system. However, the strategies by which this is achieved in different cancers and sometimes even in different patients of the same cancer is very heterogeneous, which hinders the design of general treatment options. Recently, there has been an ongoing effort to study this phenomenon on a genomic scale in order to understand the causality underlying the disease. Hence, current “omics” technologies have contributed to identify and monitor different biological pieces at different biological levels, such as genes, proteins or metabolites. These technological capacities have provided us with vast amounts of clinical data where a single patient may often give rise to various tissue samples, each of them being characterized in detail by genomescale data on the sequence, expression, proteome and metabolome level. Data with such detail poses the imminent problem of extracting meaningful interpretations and translating them into specific treatment options. To this purpose, Systems Biology provides a set of promising computational tools in order to decipher the mechanisms driving a healthy cell’s metabolism into a cancerous one. However, this enterprise requires bridging the gap between large data resources, mathematical analysis and modeling specifically designed to work with the available data. This is by no means trivial and requires high levels of communication and adaptation between the experimental and theoretical side of research.

Author : Gerhard A. Holzapfel,Ray W. Ogden
Publisher : Springer Science & Business Media
Page : 351 pages
File Size : 49,9 Mb
Release : 2009-06-05
Category : Technology & Engineering
ISBN : 9783211958759

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Biomechanical Modelling at the Molecular, Cellular and Tissue Levels by Gerhard A. Holzapfel,Ray W. Ogden Pdf

Author : Isabelle Queinnec,Sophie Tarbouriech,Germain Garcia,Silviu-Iulian Niculescu
Publisher : Springer
Page : 342 pages
File Size : 48,6 Mb
Release : 2007-08-07
Category : Technology & Engineering
ISBN : 9783540719885

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Biology and Control Theory: Current Challenges by Isabelle Queinnec,Sophie Tarbouriech,Germain Garcia,Silviu-Iulian Niculescu Pdf

Creating some links between control feedback and biology modeling communities based on similarities in modeling, observing and perceiving alive structures, and analyzing interconnections between biological structures and subsystems was the main objective of this volume. In this context, biology systems need appropriate analysis tools due to their structure and hierarchy, complexity and environment interference, and we believe that these aspects may generate interesting research topics in control area. Indeed, several works, raising the potential impact of control developments to bring some beginning of answers in the context of biological systems, have been published in the recent years. The idea of this book was conceived in the context mentioned above with the objective to help in claiming many of the problems for control researchers, starting discussions and opening interactive debates between the control and biology communities, and, finally, to alert graduate students to the many interesting ideas at the frontier between control feedback theory and biology.

Author : Junjie Xiao
Publisher : Springer Nature
Page : 338 pages
File Size : 50,9 Mb
Release : 2022-12-01
Category : Medical
ISBN : 9789811956423

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Genome Editing in Cardiovascular and Metabolic Diseases by Junjie Xiao Pdf

This book provides the latest research progress on genome editing in cardiovascular and metabolic diseases and includes bioinformatics research methodology of genome editing. Genome editing is a genetic engineering technique precisely modified specific target genes of organism genome, which has been applied to basic theoretical research and production applications from plants and animals to gene therapy of human beings. Cardiovascular and metabolic diseases have become major factors affecting human health worldwide. This book contains information about bioinformatics, genome editing in cardiovascular diseases, genome editing in metabolic diseases and therapeutic effects. It will be useful for biologist, cardiologist, cardiovascular surgeons, endocrinologist, internists, nurses, undergraduate and graduate students in medicine and cell biology and others interested in cardiovascular and metabolic medicine.

Author : Anonim
Publisher : Elsevier
Page : 4876 pages
File Size : 52,5 Mb
Release : 2019-07-17
Category : Science
ISBN : 9780444640475

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Comprehensive Biotechnology by Anonim Pdf

Comprehensive Biotechnology, Third Edition, Six Volume Set unifies, in a single source, a huge amount of information in this growing field. The book covers scientific fundamentals, along with engineering considerations and applications in industry, agriculture, medicine, the environment and socio-economics, including the related government regulatory overviews. This new edition builds on the solid basis provided by previous editions, incorporating all recent advances in the field since the second edition was published in 2011. Offers researchers a one-stop shop for information on the subject of biotechnology Provides in-depth treatment of relevant topics from recognized authorities, including the contributions of a Nobel laureate Presents the perspective of researchers in different fields, such as biochemistry, agriculture, engineering, biomedicine and environmental science

Author : Stanislav Kopriva,Dibyendu Talukdar,Hideki Takahashi,Rüdiger Hell,Agnieszka Sirko,Stanislaus F. D' Souza,Tulika Talukdar
Publisher : Frontiers Media SA
Page : 370 pages
File Size : 40,6 Mb
Release : 2016-09-07
Category : Botany
ISBN : 9782889199037

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Frontiers of Sulfur Metabolism in Plant Growth, Development, and Stress Response by Stanislav Kopriva,Dibyendu Talukdar,Hideki Takahashi,Rüdiger Hell,Agnieszka Sirko,Stanislaus F. D' Souza,Tulika Talukdar Pdf

Growing plants have a constitutive demand for sulfur to synthesize proteins, sulfolipids and other essential sulfur containing molecules for growth and development. The uptake and subsequent distribution of sulfate is regulated in response to demand and environmental cues. The importance of sulfate for plant growth and vigor and hence crop yield and nutritional quality for human and animal diets has been clearly recognized. The acquisition of sulfur by plants, however, has become an increasingly important concern for the agriculture due to the decreasing S-emissions from industrial sources and the consequent limitation of inputs from atmospheric deposition. Molecular characterization involving transcriptomics, proteomics and metabolomics in Arabidopsis thaliana as well as in major crops revealed that sulfate uptake, distribution and assimilation are finely regulated depending on sulfur status and demand, and that these regulatory networks are integrated with cell cycle, photosynthesis, carbohydrate metabolism, hormonal signaling, uptake and assimilation of other nutrients, etc., to enable plant growth, development, and reproduction even under different biotic and abiotic stresses. This knowledge can be used to underpin approaches to enhance plant growth and nutritional quality of major food crops around the world. Although considerable progress has been made regarding the central role of sulfur metabolism in plant growth, development and stress response, several frontiers need to be explored to reveal the mechanisms of the cross-talk between sulfur metabolism and these processes. In this research topic the knowledge on plant sulfur metabolism is reviewed and updated. Focus is put not only on molecular mechanisms of control of sulfur metabolism but also on its integration with other vital metabolic events. The topic covers 4 major areas of sulfur research: sulfate uptake, assimilation and metabolism, regulation, and role in stress response. We hope that the topic will promote interaction between researchers with different expertise and thus contribute to a more integrative approach to study sulfur metabolism in plants.

Author : Sybille Mazurek,Maria Shoshan
Publisher : Springer
Page : 374 pages
File Size : 46,6 Mb
Release : 2015-01-19
Category : Medical
ISBN : 9783709118245

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Tumor Cell Metabolism by Sybille Mazurek,Maria Shoshan Pdf

The four sections of this book cover cell and molecular biology of tumor metabolism, metabolites, tumor microenvironment, diagnostics and epigenetics. Written by international experts, it provides a thorough insight into and understanding of tumor cell metabolism and its role in tumor biology. The book is intended for scientists in cancer cell and molecular biology, scientists in drug and diagnostic development, as well as for clinicians and oncologists.

Author : Christoph Wittmann,Sang Yup Lee
Publisher : Springer Science & Business Media
Page : 391 pages
File Size : 48,9 Mb
Release : 2012-06-15
Category : Medical
ISBN : 9789400745346

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Systems Metabolic Engineering by Christoph Wittmann,Sang Yup Lee Pdf

Systems Metabolic Engineering is changing the way microbial cell factories are designed and optimized for industrial production. Integrating systems biology and biotechnology with new concepts from synthetic biology enables the global analysis and engineering of microorganisms and bioprocesses at super efficiency and versatility otherwise not accessible. Without doubt, systems metabolic engineering is a major driver towards bio-based production of chemicals, materials and fuels from renewables and thus one of the core technologies of global green growth. In this book, Christoph Wittmann and Sang-Yup Lee have assembled the world leaders on systems metabolic engineering and cover the full story – from genomes and networks via discovery and design to industrial implementation practises. This book is a comprehensive resource for students and researchers from academia and industry interested in systems metabolic engineering. It provides us with the fundaments to targeted engineering of microbial cells for sustainable bio-production and stimulates those who are interested to enter this exiting research field.

Author : Dongya Jia,Yapeng Su,Mingyang Lu,Xuefei Li
Publisher : Frontiers Media SA
Page : 153 pages
File Size : 43,7 Mb
Release : 2023-06-21
Category : Medical
ISBN : 9782832526965

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Systems Biology and Single-cell Analysis of Cancer Metabolism and its Role in Cancer Emergent Properties by Dongya Jia,Yapeng Su,Mingyang Lu,Xuefei Li Pdf

Author : Anonim
Publisher : ScholarlyEditions
Page : 1037 pages
File Size : 43,9 Mb
Release : 2012-01-09
Category : Medical
ISBN : 9781464965159

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Issues in Reproductive Medicine Research: 2011 Edition by Anonim Pdf

Issues in Reproductive Medicine Research / 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Reproductive Medicine Research. The editors have built Issues in Reproductive Medicine Research: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Reproductive Medicine Research in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Reproductive Medicine Research: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Author : Hui Zhang,Yung-Fu Chang,Jianzhu Liu
Publisher : Frontiers Media SA
Page : 137 pages
File Size : 52,5 Mb
Release : 2022-07-12
Category : Medical
ISBN : 9782889765454

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Regulation of Mitochondrial Function on Animal Diseases by Hui Zhang,Yung-Fu Chang,Jianzhu Liu Pdf