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Author : Fabio Cominelli,Theresa T. Pizarro,Charles Dinarello
Publisher : Frontiers Media SA
Page : 142 pages
File Size : 41,6 Mb
Release : 2021-08-10
Category : Medical
ISBN : 9782889711680
Author : Kenneth Murphy,Paul Travers,Mark Walport,Peter Walter
Publisher : Garland Science
Page : 128 pages
File Size : 48,9 Mb
Release : 2010-06-22
Category : Medical
ISBN : 0815344570
The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.
Author : 0 Society for Mucosal Immunology
Publisher : Garland Science
Page : 553 pages
File Size : 40,9 Mb
Release : 2012-04-18
Category : Medical
ISBN : 9781136665141
Principles of Mucosal Immunology is designed for graduate students and postdoctoral fellows, researchers in immunology and microbiology, and medical and dental students. It presents the basic and clinical aspects of the mucosal immune system, focusing on the major components of the mucosal barrier the gastrointestinal, upper and lower respiratory,
Author : W. Allan Walker,Paul R. Harmatz,Barry K. Wershil
Publisher : Academic Press
Page : 475 pages
File Size : 51,7 Mb
Release : 2013-10-22
Category : Health & Fitness
ISBN : 9781483273495
Bristol-Myers Squibb/Mead Johnson Nutrition Symposia, Volume 11: Immunophysiology of the Gut represents a comprehensive and systematic coverage of the immunophysiology of the gut, compiling research that integrates the mucosal immune system and intestinal physiology. This book discusses the immunological regulation of epithelial function, fibroblastic sheath, pathways of arachidonic acid metabolism, and gastric response to mucosal anaphylaxis. The implications for inflammatory diarrhea, role of breast milk in neonatal host defense, and milk-borne peptide growth factors in human and bovine milk are also elaborated. This publication likewise covers the immunopathologic features of celiac disease, immune responses in protein-energy malnutrition, and bacterial translocation. This volume is suitable for experts and clinicians from the disciplines of mucosal immunology, intestinal physiology, and enteric neurophysiology.
Author : Soichiro Miura,Ryota Hokari
Publisher : Biota Publishing
Page : 124 pages
File Size : 51,6 Mb
Release : 2011-08-01
Category : Medical
ISBN : 9781615041459
In the intestine, a unique immunological system that is different from the systemic immune system exists to provide adaptive immunity in response to luminal bacteria and dietary antigens. There are many lymphoid cell aggregates called gut-associated lymphoid tissue (GALT) including Peyer’s patches (PPs), which function as important induction sites for the mucosal immune response. M-cells are present in the epithelium of PPs, having a specialized structure for uptake of macromolecules such as bacteria. In addition to GALT, there are abundant lymphoid cells in the intestinal lamina propria, where they mainly play a role as immune effector cells. A strong innate immune system that mainly consists of dendritic cells, macrophages, and γδT lymphocytes also exists in the intestinal mucosa to assist the barrier function of intestinal epithelial cells. The intestinal mucosa thus shows a unique morphological structure with many immune cells being present under physiological conditions. This condition is known as "controlled inflammation." These abundant immune cells also have characteristic functions: they are "negatively regulated" and have been educated not to overreact unnecessarily to the intestinal luminal milieu. Main players that control inflammation of the intestinal mucosa include regulatory cytokines and regulatory T cells which induce oral tolerance to intestinal bacteria and food antigens, and the secretory IgA system. The maintenance of unique immunological activity in the intestine is also related to an organized, orchestrated lymphocyte migratory mechanism called the "common mucosal immune system." These negative regulatory mechanisms of the intestinal immune system are disturbed in certain disease conditions, causing the immunocompetent cells to respond to food components and commensal bacteria by becoming activated and to overproduce inflammatory cytokines and chemokines. These disease conditions include food allergies, such as celiac disease, and the inflammatory bowel diseases, such as ulcerative colitis and Crohn’s disease, although their exact etiological mechanisms remain to be revealed. Table of Contents: Introduction / GALT: Its Structure and Formation / Intestinal Epithelial Cells and Their Immune Function / Innate Immunity in the Intestinal Mucosa / Intraepithelial Lymphocytes (IELs) / Lymphoid Cell Trafficking in Intestinal Immunology / Site of Induction of Mucosal Immunity and Antigen Presentation by Dendritic Cells / Production of Secretory IgA (SIgA) / Effector Site of Acquired Immunity and T Helper Cell Subpopulation / Immune Regulatory System and Oral Tolerance / Food Allergy and Celiac Disease / Inflammatory Bowel Diseases / Enteric Infection with Pathogenic Microbes and Mucosal Immunity / References
Author : Jessica Borger,Joanna Kirman,Graham Le Gros
Publisher : Frontiers Media SA
Page : 191 pages
File Size : 48,9 Mb
Release : 2020-08-06
Category : Electronic
ISBN : 9782889639250
We acknowledge the initiation and support of this Research Topic by the InternationalUnion of Immunological Societies (IUIS). We hereby state publicly that the IUIS hashad no editorial input in articles included in this Research Topic, thus ensuring that allaspects of this Research Topic are evaluated objectively, unbiased by any specific policyor opinion of the IUIS.
Author : Claudio Fiocchi
Publisher : Unknown
Page : 270 pages
File Size : 55,6 Mb
Release : 1996
Category : Cytokines
ISBN : 3540603263
The pathogenesis of both forms of inflammatory bowel disease, Crohn's disease and ulcerative colitis, depends on complex immune abnormalities, and the investigation of cytokines has become critical to basic, clinical and therapeutic aspects of these enigmatic entities. This book offers clear, concise, state-of-the-art information on the role of various immunoregulatory and pro-inflammatory mediators in Crohn's disease and ulcerative colitis. Each cytokine is analyzed in regard to pathogenic and clinical implications, taking advantage of information derived from patients, animal models, as well as immunological and molecular in vitro systems. This volume is of interest to gastroenterologists, clinical investigators, immunologists, cell biologists and any professional interested in mucosal immunity and inflammation.
Author : Jiri Mestecky,Warren Strober,Michael W. Russell,Hilde Cheroutre,Bart N. Lambrecht,Brian L Kelsall
Publisher : Academic Press
Page : 2540 pages
File Size : 45,7 Mb
Release : 2015-03-06
Category : Medical
ISBN : 9780124159754
Mucosal Immunology, now in its fourth edition, is the only comprehensive reference covering the basic science and clinical manifestations of mucosal immunology. Most infectious agents enter the body through the various mucous membranes, and many common infections take place in or on mucous membranes, making this subject an area of singular importance in the field of immunology. This book contains new research data, exceptional illustrations, original theory, a new perspective, and excellent organization. It covers immune system topics, such as inductive and effector tissues and cells, and development and physiology of the mucosal barrier; diseases in the digestive system, respiratory tract, and genitourinary tract; and immunodeficiency. The most comprehensive text on mucosal immunology from internationally recognized experts in the field Includes exceptional color illustrations, new research data, original theory and information on all mucosal diseases Contains nine new chapters and an expanded appendix
Author : Anonim
Publisher : Academic Press
Page : 304 pages
File Size : 47,7 Mb
Release : 2010-11-26
Category : Medical
ISBN : 0123813018
Advances in Immunology, a long-established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for future. Contributions from leading authorities and industry experts Informs and updates on all the latest developments in the field
Author : Phillip D. Smith,Richard S. Blumberg,Thomas T. MacDonald,Society for Mucosal Immunology
Publisher : Garland Science
Page : 957 pages
File Size : 55,5 Mb
Release : 2020-04-21
Category : Medical
ISBN : 9781000754612
This respected graduate-level textbook provides comprehensive and accessible coverage of the basic and clinical aspects of the mucosal immune system, addressing the major components of the mucosal barrier ̶ gastrointestinal, upper and lower respiratory, ocular, and genitourinary mucosal immune systems ̶ in a highly user-friendly style. The editors of and contributors to the book, all internationally-recognized leaders, present the current principles, concepts, and basic processes involved in mucosal immunology, mucosal diseases, and host defense at mucosal surfaces. Topics discussed include the development and structure of the mucosal immune system and its cellular constituents, host-microbe relationships, infection, mucosal diseases, and vaccines. The second edition has been carefully updated throughout to reflect the latest developments from clinical research and key literature has been fully updated.
Author : P. Brandtzaeg
Publisher : Elsevier Inc. Chapters
Page : 760 pages
File Size : 44,7 Mb
Release : 2013-09-30
Category : Medical
ISBN : 9780128086940
The intestinal immune system has generated two arms of adaptive anti-inflammatory defense which normally preserve the epithelial barrier: (i) immune exclusion performed by secretory IgA (SIgA) (and SIgM) antibodies to control surface colonization of micro-organisms and dampen penetration of potentially harmful antigens; and (ii) suppressive mechanisms to avoid hypersensitivity to innocuous antigens, particularly food proteins and the commensal microbiota. The latter phenomenon (‘oral tolerance’) largely depends on regulatory T (Treg) cells induced in mesenteric lymph nodes to which mucosal dendritic cells carry exogenous antigens and become conditioned for stimulation of Treg cells. Polymeric Ig receptor (pIgR/SC) knock-out mice that lack SIgA and SIgM show decreased epithelial barrier function and increased uptake of antigens from food and commensal bacteria. They therefore have a hyper-reactive immune system which is counteracted by enhanced intestinal tolerance induction as a homeostatic back-up mechanism.
Author : S. Challacombe,P. Bland,C. Stokes,A. Heatley,A. Mowat
Publisher : Springer Science & Business Media
Page : 941 pages
File Size : 45,9 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9789400918481
The immunology of mucosal surfaces is one of the most exciting and relevant areas of medical veterinary and dental research since it applies basic research to tissues in volved in everyday defence against microbes and against environmental and food antigens. This book is based on the contributions presented at the International Con gress of Mucosal Immunology, held in London in July 1989 and organised by the Mu cosal Immunology Affinity Group of the British Society for Immunology. The meet ing was attended by over 500 delegates from 27 countries, including virtually all of the leading investigators in the field. The contents give comprehensive and up-to date information on such topics as antigen presentation and processing in the gut, mucosal vaccines in man and animals, HIV infection in the gut, the role of yo T cells in the gut epithelium, recent advances in inflammatory bowel disease and coeliac dis ease, the role of cytokines in the regulation of the IgA response, mucosal mast cells and cell migration. The contributions reflect the rapid pace of research in mucosal immunology, and the great strides which are taking place in the understanding of the immunology, molecular biology and biochemistry of host response at mucosal sur faces.
Author : Britta Siegmund,Moritz Leppkes,Christoph Becker
Publisher : Frontiers Media SA
Page : 159 pages
File Size : 51,6 Mb
Release : 2018-10-18
Category : Electronic
ISBN : 9782889456185
Author : Martin F. Kagnoff,Hiroshi Kiyono
Publisher : Academic Press
Page : 633 pages
File Size : 46,7 Mb
Release : 1996-08-01
Category : Medical
ISBN : 9780080531243
Essentials of Mucosal Immunology presents basic concepts as well as new and exciting advances in mucosal immunology and inflammation, the development of mucosal vaccines, and the role of the immune system in mucosal disease. Specific chapters highlight novel approaches to the treatment of autoimmune disease, including the use of oral tolerance; approaches to and vectors for new vaccines; and current concepts in mucosal inflammation and its role in inflammatory bowel disease and ulcer disease. Contains the most current research on mucosal immunology and is comprehensive in scope Includes ideal coverage of both the basic and clinical aspects of the mucosal immune system Provides an understanding of the mucosal immune system with regard to new treatments and preventative methods, including vaccine development Includes contributions from an international team of experts
Author : Richard Blumberg,Markus F. Neurath
Publisher : Springer Science & Business Media
Page : 262 pages
File Size : 48,5 Mb
Release : 2007-02-26
Category : Medical
ISBN : 9780387337784
Immune Mechanisms in Inflammatory Bowel Disease is a highly, concise update of the most recent advances in the immunobiology, genetics and microbiology related to Inflammatory Bowel Disease. This book broadly treats the topics that lead to understanding of the pathogenesis of this disease in an organized, systematic approach.
