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Janeway's Immunobiology by Kenneth Murphy,Paul Travers,Mark Walport,Peter Walter Pdf
The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.
Intestinal Immune System by Soichiro Miura,Ryota Hokari,Shunsuke Komoto Pdf
These negative regulatory mechanisms of the intestinal immune system are disturbed in certain disease conditions, causing the immunocompetent cells to respond to food components and commensal bacteria by becoming activated and to overproduce inflammatory cytokines and chemokines. These disease conditions include food allergies, such as celiac disease, and the inflammatory bowel diseases, such as ulcerative colitis and Crohn's disease, although their exact etiological mechanisms remain to be revealed. --Book Jacket.
Local Immune Responses Of The Gut by Timothy J. Newby,Christopher R. Stokes Pdf
First published in 1984: The main interest of this book is immunological. The first chapter deals with the nature of the local immune system and discusses it within the context of the normal physiology of the gut.
Principles of Mucosal Immunology by Phillip D. Smith,Richard S. Blumberg,Thomas T. MacDonald,Society for Mucosal Immunology Pdf
This respected graduate-level textbook provides comprehensive and accessible coverage of the basic and clinical aspects of the mucosal immune system, addressing the major components of the mucosal barrier ̶ gastrointestinal, upper and lower respiratory, ocular, and genitourinary mucosal immune systems ̶ in a highly user-friendly style. The editors of and contributors to the book, all internationally-recognized leaders, present the current principles, concepts, and basic processes involved in mucosal immunology, mucosal diseases, and host defense at mucosal surfaces. Topics discussed include the development and structure of the mucosal immune system and its cellular constituents, host-microbe relationships, infection, mucosal diseases, and vaccines. The second edition has been carefully updated throughout to reflect the latest developments from clinical research and key literature has been fully updated.
Ontogeny of the Immune System of the Gut by Thomas T. MacDonald Pdf
The book highlights studies on the development of the mucosal immune system in the human fetus, the factors important in the development of the various compartments of this system, and the mechanisms by which the human neonate protects itself against gut allergy and infection. Other topics include the development of the gut immune system in rodents and other veterinary species in which important areas such as the intestinal uptake of the maternal immunoglobulins have been characterized, as well as immunocompetence of the human fetus. The book provides essential reference material for immunologists, pediatricians, and other researchers interested in the features unique to the development of the gut immune system in utero and post-natally in different species.
Immunophysiology of the Gut by W. Allan Walker,Paul R. Harmatz,Barry K. Wershil Pdf
Bristol-Myers Squibb/Mead Johnson Nutrition Symposia, Volume 11: Immunophysiology of the Gut represents a comprehensive and systematic coverage of the immunophysiology of the gut, compiling research that integrates the mucosal immune system and intestinal physiology. This book discusses the immunological regulation of epithelial function, fibroblastic sheath, pathways of arachidonic acid metabolism, and gastric response to mucosal anaphylaxis. The implications for inflammatory diarrhea, role of breast milk in neonatal host defense, and milk-borne peptide growth factors in human and bovine milk are also elaborated. This publication likewise covers the immunopathologic features of celiac disease, immune responses in protein-energy malnutrition, and bacterial translocation. This volume is suitable for experts and clinicians from the disciplines of mucosal immunology, intestinal physiology, and enteric neurophysiology.
Immune Mechanisms in Inflammatory Bowel Disease by Richard Blumberg,Markus F. Neurath Pdf
Immune Mechanisms in Inflammatory Bowel Disease is a highly, concise update of the most recent advances in the immunobiology, genetics and microbiology related to Inflammatory Bowel Disease. This book broadly treats the topics that lead to understanding of the pathogenesis of this disease in an organized, systematic approach.
Inflammatory Bowel Disease by Derek J. Chadwick,Jamie A. Goode Pdf
Inflammatory bowel disease (IBD) comprises a group of idiopathic diseases of the intestine characterized by chronic inflammation of the bowel with periods of exacerbation and remission. Although the exact cause of IBD remains undetermined, the condition appears to be related to a combination of genetic and environmental factors resulting in an aberrant activation of the mucosal immune system. This book contains a series of interdisciplinary discussions between clinical and basic scientists focusing on key issues such as: Epithelial cell and molecular biology, including apoptosis, necrosis and cell survival The role of bacterial milieu and mucosal bacteria in the IBD and of prebiotic and probiotic therapy The progress towards the identification of susceptibility genes and phenotype-determining genes The pharmacogenetics of IBD Mucosal immunology and therapeutic strategies stemming therefrom
The Suckling and Weaned Piglet by Chantal Farmer Pdf
The last books discussing the neonatal or weaned pig were published over 15 years ago. This new book provides up to date information on the suckling and weaned piglet. It covers novel and important topics such as microbiota development in piglets and management of hyperprolific litters. It also discusses topics such as weaning age and its long term influence on piglet heath and performance. The developments of lean and fat tissues and of the intestinal immune system in young pigs are described in detail. Emphasis is put on well-being with chapters focussing on husbandry interventions in suckling piglets as well as consequences of the lactational environment on behavioural disturbances of pigs after weaning. The multiple stressors encountered at and post-weaning are also discussed. Updates on essential subjects such as neonatal mortality, creep feeding of suckling piglets, feeding strategies for weaned pigs, housing systems post-weaning and diseases of piglets are provided. The information covered in this book should be of great assistance to animal scientists, nutritionists, veterinarians and swine producers. They will be made aware of most recent knowledge that will assist in improving the performance and welfare of suckling and weaned piglets.
Diet, immunity and inflammation by P. Brandtzaeg Pdf
The intestinal immune system has generated two arms of adaptive anti-inflammatory defense which normally preserve the epithelial barrier: (i) immune exclusion performed by secretory IgA (SIgA) (and SIgM) antibodies to control surface colonization of micro-organisms and dampen penetration of potentially harmful antigens; and (ii) suppressive mechanisms to avoid hypersensitivity to innocuous antigens, particularly food proteins and the commensal microbiota. The latter phenomenon (‘oral tolerance’) largely depends on regulatory T (Treg) cells induced in mesenteric lymph nodes to which mucosal dendritic cells carry exogenous antigens and become conditioned for stimulation of Treg cells. Polymeric Ig receptor (pIgR/SC) knock-out mice that lack SIgA and SIgM show decreased epithelial barrier function and increased uptake of antigens from food and commensal bacteria. They therefore have a hyper-reactive immune system which is counteracted by enhanced intestinal tolerance induction as a homeostatic back-up mechanism.
Neuro-Immuno-Gastroenterology by Cris S. Constantinescu,Rāzvan I. Arsenescu,Violeta Arsenescu Pdf
This book addresses important issues regarding the interaction between the nervous system, the immune system, and the digestive system. Gut flora has a profound influence on the shaping of the immune response, not only in the gastrointestinal system but also in the nervous system. Fascinatingly, manipulation of intestinal immune responses can be used to modulate neurological disease. Conversely, the nervous system and the psyche have significant effects on the functioning of the gut and liver. After introductory chapters on the neurology, the immunology and microbiology of the gut, the effects of the gut immune system and gut flora and its manipulation on neurological disease are discussed, followed by molecular mimicry and immune tolerance in neuroimmune diseases. Additionally, several chapters deal with gastrointestinal manifestations of neurological diseases. Neuro-Immuno-Gastroenterology is aimed at neurologists, gastroenterologists, and immunologists.
Immunological Aspects of Gastroenterology by Y.R. Mahida Pdf
Diseases of the gastrointestinal tract are common. There is increasing appreciation of the importance of the immune system in the pathogenesis of a number of these diseases. This book covers basic aspects of innate and adaptive immunity in the gastrointestinal tract, oral tolerance, and cellular and molecular mechanisms of acute and chronic inflammation. Specific disease covered include bacterial infections, human immunodeficiency virus (HIV) infection, coeliac disease, and inflammatory bowel disease. Other topics include mucosal immunisation and intestinal transplantation immunology. The readership of this book includes clinicians, scientists, and students interested in the gastrointestinal tract.
Principles of Mucosal Immunology by 0 Society for Mucosal Immunology Pdf
Principles of Mucosal Immunology is designed for graduate students and postdoctoral fellows, researchers in immunology and microbiology, and medical and dental students. It presents the basic and clinical aspects of the mucosal immune system, focusing on the major components of the mucosal barrier the gastrointestinal, upper and lower respiratory,
Understanding Crohn's Disease: Immunity, Genes and Microbes by Amélia Sarmento,Fernando Magro,Nair Campos Pdf
Crohn's disease (CD) is a chronic, relapsing, inflammatory bowel disease resulting in considerable morbidity and reduced quality of life. Although still under intense debate, CD seems to result from an enhanced and uncontrolled immune response to the gut microbiota. CD is thought to be multifactorial depending on genetic and environmental determinants. In recent years, nearly 100 single nucleotide polymorphisms (SNPs) were associated with increased risk of developing CD (some of the SNPs also associated with susceptibility to ulcerative colitis, another type of IBD). These SNPs are mostly located in genes involved in innate and adaptive immunity mechanisms, such as autophagy, expression of pattern-recognition receptors and citokine signaling. Epigenetics is also probably playing a role in CD susceptibility, as it is sensitive to environmental conditions and may mediate gene-environment interactions. Environmental factors possibly involved in CD development include diet, gut microbiota composition and infection with specific pathogens, of which the most consistently associated to CD are Mycobacterium avium subsp. paratuberculosis and adherent-invasive Escherichia coli. This Topic aimed at bringing together contributions covering different genetic, epigenetic, immunological and microbial processes involved in the development of CD, helping to drive forward the understanding of CD immunopahtology.
Crohn's Disease and Ulcerative Colitis by Daniel C. Baumgart Pdf
This new edition is a unique combined resource for physicians and scientists addressing the needs of both groups. In addition to stimulating exchange and collaboration and shortening the path between discovery and application of new knowledge, the book helps clinicians understand new therapeutic concepts from their origins. The volume serves as a comprehensive guide to the current diagnostic modalities, including enhanced imaging techniques such as MRI and CT enterography, virtual colonoscopy, ultrasound, and endomicroscopy, as well as conventional and complex immunomodulatory principles. The latest edition also includes revised chapters from the previous edition, as well as new chapters reflecting current developments in the field. Written by experts in their field, Crohn’s Disease and Ulcerative Colitis: From Epidemiology and Immunobiology to a Rational Diagnostic and Therapeutic Approach, Second Edition is of great value to gastroenterologists, surgeons, internists, pediatricians and gynecologists trainees, as well as all those involved in Crohn’s disease, ulcerative colitis, and related autoimmune disorders.