Cytokines And The Cns

Author : Richard M. Ransohoff,Etty N. Benveniste
Publisher : CRC Press
Page : 384 pages
File Size : 54,9 Mb
Release : 2005-10-31
Category : Medical
ISBN : 9781420039849

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Cytokines and the CNS by Richard M. Ransohoff,Etty N. Benveniste Pdf

Provides Insight into How Cytokine Action Impacts the Physiology and Pathology of the CNS. As with the first edition of Cytokines and the CNS, this completely updated and revised edition introduces neurobiologists to cytokine biology and immunologists to the unique functions of cytokines in CNS physiology. The dramatically accelerating interest in cytokines and cytokine/chemokine signaling over the past several years has encouraged an explosion of literature on cytokines. The similarity between factors involved in inflammation or immunity, and those implicated in neural development, physiology, and repair has become so apparent that familiarity with cytokines must now be considered an essential element in the neurobiologist’s cognitive tool-kit. Conversely, for immunobiologists, the concepts elaborated by neurobiologists to understand developmental patterning and networked organ function continue to evolve in such a way that comprehension of cytokine action in the CNS can only enhance a further understanding of immune system function. Cytokines and the CNS, Second Edition is patterned after the first edition; however, the wealth of knowledge now available adds a tremendous amount of insight and new implications. To guarantee a fresh perspective, the editors made a conscious choice to utilize an entirely new set of contributors, all experts in various aspects of cytokine research. Cytokines and the CNS, Second Edition starts with a chapter on the CNS, focusing on pathological reactions to insult. Next, come three chapters on cytokine biology, followed by four chapters that integrate cytokine biology into basic CNS processes (development; inflammation; immunity; degeneration/repair), after which five chapters apply this body of knowledge to disease or pathology. The book closes with a look at the application of cytokine biology to the treatment of disease, a brand new area of research.

Author : Nancy J. Rothwell
Publisher : Springer Science & Business Media
Page : 216 pages
File Size : 48,7 Mb
Release : 2013-03-09
Category : Medical
ISBN : 9781461596950

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Cytokines in the Nervous System by Nancy J. Rothwell Pdf

Author : Anonim
Publisher : Elsevier
Page : 608 pages
File Size : 44,6 Mb
Release : 2008-06-18
Category : Science
ISBN : 0080559352

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Cytokines and the Brain by Anonim Pdf

This book opens a new page of neuro-immunobiology providing substantive experimental and clinical data to support current understanding in the field, and potential applications of this knowledge in the treatment of disease. The volume is a collection of complex, new data drawn from multiple areas of investigation in the field. The contents summarize current understanding on the presence and function of CNS cytokines and their receptors in a variety of CNS cells during health and disease. The chapters are a collection of complex, new data demonstrating the presence and synthesis of cytokines in brain cells, as well as their receptors on cell membranes in health and disease. The strength of the volume are the descriptions of the authors own investigations, together with those of others in the field pertaining to a large number of cytokines in brain function, as well as mechanisms involved in the development of CNS disorders, including multiple sclerosis and Alzheimer’s disease. Also included are novel approaches to the treatment of CNS disorders based on new experimental data. The contributors to this volume are internationally known scientists and clinical researchers in their respective fields of investigation and treatment. *Opens a new page of neuro-immunobiology and provides substantive evidence for the promise of this field in the treatment of disease *Summarizes current understanding on the presence and function of central nervous system (CNS) cytokines and their receptors in a variety of CNS cells during health and disease *Includes novel approaches to the treatment of CNS disorders based on new experimental data *Offers new insight into triggers for the development of autoimmune diseases in the brain and the possibilities for treatment

Author : Nancy Rothwell
Publisher : Chapman & Hall
Page : 207 pages
File Size : 54,5 Mb
Release : 1996-01-01
Category : Science
ISBN : 1570593922

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Cytokines in the Nervous System by Nancy Rothwell Pdf

Author : Giora Z. Feuerstein,A. Jaqueline Hunter,Brian W. Metcalf,George Poste,Robert R. Ruffolo, Jr.
Publisher : CRC Press
Page : 541 pages
File Size : 51,9 Mb
Release : 2003-09-02
Category : Medical
ISBN : 9780203304242

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Inflammatory Cells and Mediators in CNS Disease by Giora Z. Feuerstein,A. Jaqueline Hunter,Brian W. Metcalf,George Poste,Robert R. Ruffolo, Jr. Pdf

This book looks at the causes and long-term effects of inflammation in the CNS as a result of various conditions, and the therapeutic opportunities presented in each case. Each chapter is written by an acknowledged leader in the field

Author : Errol B. De Souza
Publisher : Academic Press
Page : 369 pages
File Size : 42,9 Mb
Release : 2013-10-22
Category : Medical
ISBN : 9781483217550

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Neurobiology of Cytokines by Errol B. De Souza Pdf

Neurobiology of Cytokines, Part A provides an overview of the effects of cytokines in the brain and in the endocrine system. The book discusses the general aspects of cytokines, including the endogenous agonists and antagonists, their receptors, their second messengers, and transport mechanisms for cytokines across the blood-brain barrier. The text also describes the anatomical localization of cytokines, cytokine receptors, and their respective mRNA in brain and in endocrine tissues. The methods for evaluating the in vivo as well as in vitro actions of cytokines on hormone secretion are also considered. The book further tackles the synthesis and release of cytokines and their central nervous system actions; and the methodology for studying the role of cytokines in human neuropathological conditions.

Author : Nancy J. Rothwell
Publisher : Elsevier
Page : 216 pages
File Size : 52,6 Mb
Release : 2013-10-22
Category : Science
ISBN : 9781483287768

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Interleukin-1 in the Brain by Nancy J. Rothwell Pdf

Interest in interleukin-1 (IL-1) has increased dramatically over the last decade, but has been largely restricted to immunologists, cell biologists and those studying inflammation and cancer. However, it has recently been recognized that the brain directly controls or modulates many aspects of immune function, while molecules classically associated with the immune system, such as interleukin-1, are synthesised within the brain and act directly on the central nervous system to modify local and systemic functions. Thus, this topic is relatively new to neurobiologists, and this book is the first comprehensive description of current knowledge on interleukin-1 in the brain, including its location, synthesis and receptors, actions on behaviour, fever, metabolism, neuroendocrine function, electrical activity of the brain, nerve growth factor, and relationship to clinical indications. The book is organised into three sections. The first reviews the data available on the neural localisation of IL-1 and the nature of its central receptors. The main part of the book examines the different neural effects of IL-1 and the mechanisms which are involved in these actions, comparing IL-1 where possible to other inflammatory cytokines which also have neurotrophic effects. The final section evaluates the possible role of IL-1 in neural plasticity and neuronal degeneration.

Author : Errol B. DeSouza
Publisher : Academic Press
Page : 310 pages
File Size : 53,7 Mb
Release : 2013-10-22
Category : Science
ISBN : 9781483288314

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Neurobiology of Cytokines, Part B by Errol B. DeSouza Pdf

Recent data suggest a critical role for cytokines in the regulation of brain and endocrine function under normal physiological conditions. The aim of this volume and its companion Volume 16 is to provide an overview of the effects of cytokines in the brain and in the endocrine system. Methods presented for easy adaptation to new systems Comprehensive protocols included for: The synthesis and release of cytokines; The study of their central nervous system actions; Studying the role of cytokines in human neuropathological conditions

Author : L.R. Watkins,S.F. Maier
Publisher : Springer
Page : 232 pages
File Size : 51,9 Mb
Release : 2013-03-08
Category : Medical
ISBN : 9783034887496

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Cytokines and Pain by L.R. Watkins,S.F. Maier Pdf

Within the past few years, it has become recognized that the immune system communicates to the brain. Substances released from activated immune cells (cytokines) stimulate peripheral nerves, thereby signaling the brain and spinal cord that infection/inflammation has occurred. Additionally, peripheral infection/inflammation leads to de novo synthesis and release of cytokines within the brain and spinal cord. Thus, cytokines effect neural activation both peripherally and centrally. Through this communication pathway, cytokines such as interleukin-1, interleukin-6 and tumor necrosis factor markedly alter brain function, physiology and behavior. One important but underrecognized aspect of this communication is the dramatic impact that immune activation has on pain modulation. The purpose of this book is to examine, for the first time, immune-to-brain communication from the viewpoint of its effect on pain processing. It is aimed both at the basic scientist and health care providers, in order to clarify the major role that substances released by immune cells play in pain modulation. This book contains chapters contributed by all of the major laboratories focused on understanding how cytokines modulate pain. These chapters provide a unique vantage point from which to examine this question, as the summarized work ranges from evolutionary approaches across diverse species, to the basics of the immune response, to the effect of cytokines on peripheral and central nervous system sites, to therapeutic potential in humans.

Author : Donald W. Pfaff,Nora D. Volkow
Publisher : Springer
Page : 0 pages
File Size : 55,5 Mb
Release : 2016-10-27
Category : Medical
ISBN : 1493934732

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Neuroscience in the 21st Century by Donald W. Pfaff,Nora D. Volkow Pdf

Edited and authored by a wealth of international experts in neuroscience and related disciplines, this key new resource aims to offer medical students and graduate researchers around the world a comprehensive introduction and overview of modern neuroscience. Neuroscience research is certain to prove a vital element in combating mental illness in its various incarnations, a strategic battleground in the future of medicine, as the prevalence of mental disorders is becoming better understood each year. Hundreds of millions of people worldwide are affected by mental, behavioral, neurological and substance use disorders. The World Health Organization estimated in 2002 that 154 million people globally suffer from depression and 25 million people from schizophrenia; 91 million people are affected by alcohol use disorders and 15 million by drug use disorders. A more recent WHO report shows that 50 million people suffer from epilepsy and 24 million from Alzheimer’s and other dementias. Because neuroscience takes the etiology of disease—the complex interplay between biological, psychological, and sociocultural factors—as its object of inquiry, it is increasingly valuable in understanding an array of medical conditions. A recent report by the United States’ Surgeon General cites several such diseases: schizophrenia, bipolar disorder, early-onset depression, autism, attention deficit/ hyperactivity disorder, anorexia nervosa, and panic disorder, among many others. Not only is this volume a boon to those wishing to understand the future of neuroscience, it also aims to encourage the initiation of neuroscience programs in developing countries, featuring as it does an appendix full of advice on how to develop such programs. With broad coverage of both basic science and clinical issues, comprising around 150 chapters from a diversity of international authors and including complementary video components, Neuroscience in the 21st Century in its second edition serves as a comprehensive resource to students and researchers alike.

Author : Robert Dantzer,Emmanuelle E. Wollmann,Raz Yirmiya
Publisher : Springer Science & Business Media
Page : 334 pages
File Size : 45,9 Mb
Release : 1999-07-31
Category : Medical
ISBN : 9780306461354

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Cytokines, Stress, and Depression by Robert Dantzer,Emmanuelle E. Wollmann,Raz Yirmiya Pdf

Until a few years ago, cytokines were only known to immunologists; now these molecules have burst upon neurosciences and permeated several avenues of current research. This book examines the possible role of cytokines in mental depression, based on recent clinical and experimental data, and constitutes the first attempt to make a synthesis between the exciting new developments in cytokine research and their implications for the pathophysiology of mental disorders.

Author : Ziad Kronfol
Publisher : Springer Science & Business Media
Page : 436 pages
File Size : 47,5 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461503231

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Cytokines and Mental Health by Ziad Kronfol Pdf

Cytokines and Mental Health explores the relationship between cytokines, neural circuitry and mental health. It is interdisciplinary and "translational", bringing together information that spans the spectrum from the molecular and cellular levels to the patient and the clinic. Content includes chapters that discuss cytokine pathways in the brain, the neurochemical and neuroendocrine effects of cytokines, and the behavioral effects of cytokines including sickness behavior. These chapters in basic research are followed by a more clinical section that discusses the role of cytokines in neuropsychiatric disorders such as major depression, schizophrenia and Alzheimer's disease. The book offers different things to different people. It should be of great interest to neuroscientists and immunologists working in the field of psychoneuroimmunology. It would also greatly benefit mental health professionals including psychiatrists, psychologists and clinicians of diverse background who are interested in mind-body medicine.

Author : Thomas E. Lane,Monica Carson,Conni Bergmann,Tony Wyss-Coray
Publisher : Springer Science & Business Media
Page : 318 pages
File Size : 50,5 Mb
Release : 2007-12-24
Category : Medical
ISBN : 9780387738949

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Central Nervous System Diseases and Inflammation by Thomas E. Lane,Monica Carson,Conni Bergmann,Tony Wyss-Coray Pdf

Edited and authored by top names in the field, this book provides a succinct reference on inflammatory central nervous system disease. It focuses on current areas of investigation in the fields of neuroimmunology, virology, pharmacology, and disease. Sections focus on specific categories of diseases, examining the pharmacological, virological, and immunological effects of and on the disease. This book’s unique organization provides a concise overview of inflammatory CNS disease.

Author : Paul Murrell
Publisher : Unknown
Page : 301 pages
File Size : 42,7 Mb
Release : 2006
Category : Electronic
ISBN : OCLC:1087667215

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R Graphics by Paul Murrell Pdf

Author : Michael Schäfer,Christoph Stein
Publisher : Springer
Page : 206 pages
File Size : 44,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783034880398

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Mind over Matter - Regulation of Peripheral Inflammation by the CNS by Michael Schäfer,Christoph Stein Pdf

Several new developments in the field of neuroimmunology with focus on the brain-to-immune system communication have been the incentive for this PIR volume. It covers topics such as brain-immune interactions, the impact of stress on the immune response, pain and immunosuppression, the modulation of inflammation and pain by the sympathetic nervous system, consequences of nerve injury for the immune system, neuronal mechanisms of immune cell recruitment, and the modulation of the immune response by corticotropin-releasing hormone or adenosine. The authors are a unique group of scientists who are all interested in brain-to-immune interactions; however, each from a different perspective. The volume will serve both neurobiologists and immunologists to understand the influence of the central nervous system on peripheral inflammation. Many aspects of this book will also be stimulating for researchers in the pain field.