Cytotoxic Payloads For Antibodydrug Conjugates

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Cytotoxic Payloads for AntibodyDrug Conjugates

David E Thurston,Paul J M Jackson
Cytotoxic Payloads for AntibodyDrug Conjugates Book PDF

Author : David E Thurston,Paul J M Jackson
Publisher : Royal Society of Chemistry
Page : 502 pages
File Size : 50,8 Mb
Release : 2019-07-11
Category : Medical
ISBN : 9781788018456

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Cytotoxic Payloads for AntibodyDrug Conjugates by David E Thurston,Paul J M Jackson Pdf

Antibody–drug conjugates (ADCs) represent one of the most promising and exciting areas of anticancer drug discovery. Five ADCs are now approved in the US and EU [i.e., ado-trastuzumab emtansine (KadcylaTM), brentuximab vedotin (AdcetrisTM), inotuzumab ozogamicin (BesponsaTM), gemtuzumab ozogamicin (MylotargTM) and moxetumomab pasudotox-tdfk (Lumoxiti®)] and over 70 others are in various stages of clinical development, with impressive interim results being reported for many. The technology is based on the concept of delivering a cytotoxic payload selectively to cancer cells by attaching it to an antibody targeted to antigens on the cell surfaces. This approach has several advantages including the ability to select patients as likely responders based on the presence of antigen on the surface of their cancer cells and a wider therapeutic index, given that ADC targeting enables a more efficient delivery of cytotoxic agents to cancer cells than can be achieved by conventional chemotherapy, thus minimising systemic toxicity. Although there are many examples of antibodies that have been developed for this purpose, along with numerous linker technologies used to attach the cytotoxic agent to the antibody, there is presently a relatively small number of payload molecules in clinical use. The purpose of this book is to describe the variety of payloads used to date, along with a discussion of their advantages and disadvantages and to provide information on novel payloads at the research stage that may be used clinically in the future.

Cytotoxic Payloads for Antibody–Drug Conjugates

David E Thurston,Paul J M Jackson
Cytotoxic Payloads for Antibody Drug Conjugates Book PDF

Author : David E Thurston,Paul J M Jackson
Publisher : Royal Society of Chemistry
Page : 502 pages
File Size : 45,5 Mb
Release : 2019-07-15
Category : Medical
ISBN : 9781788010771

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Cytotoxic Payloads for Antibody–Drug Conjugates by David E Thurston,Paul J M Jackson Pdf

Antibody–drug conjugates (ADCs) represent one of the most promising and exciting areas of anticancer drug discovery. Five ADCs are now approved in the US and EU [i.e., ado-trastuzumab emtansine (Kadcyla™), brentuximab vedotin (Adcetris™), inotuzumab ozogamicin (Besponsa™), gemtuzumab ozogamicin (Mylotarg™) and moxetumomab pasudotox-tdfk (Lumoxiti®)] and over 70 others are in various stages of clinical development, with impressive interim results being reported for many. The technology is based on the concept of delivering a cytotoxic payload selectively to cancer cells by attaching it to an antibody targeted to antigens on the cell surfaces. This approach has several advantages including the ability to select patients as likely responders based on the presence of antigen on the surface of their cancer cells and a wider therapeutic index, given that ADC targeting enables a more efficient delivery of cytotoxic agents to cancer cells than can be achieved by conventional chemotherapy, thus minimising systemic toxicity. Although there are many examples of antibodies that have been developed for this purpose, along with numerous linker technologies used to attach the cytotoxic agent to the antibody, there is presently a relatively small number of payload molecules in clinical use. The purpose of this book is to describe the variety of payloads used to date, along with a discussion of their advantages and disadvantages and to provide information on novel payloads at the research stage that may be used clinically in the future.

Antibody-Drug Conjugates

Kenneth J. Olivier, Jr.,Sara A. Hurvitz
Antibody Drug Conjugates Book PDF

Author : Kenneth J. Olivier, Jr.,Sara A. Hurvitz
Publisher : John Wiley & Sons
Page : 560 pages
File Size : 49,5 Mb
Release : 2016-11-14
Category : Medical
ISBN : 9781119060802

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Antibody-Drug Conjugates by Kenneth J. Olivier, Jr.,Sara A. Hurvitz Pdf

Providing practical and proven solutions for antibody-drug conjugate (ADC) drug discovery success in oncology, this book helps readers improve the drug safety and therapeutic efficacy of ADCs to kill targeted tumor cells. • Discusses the basics, drug delivery strategies, pharmacology and toxicology, and regulatory approval strategies • Covers the conduct and design of oncology clinical trials and the use of ADCs for tumor imaging • Includes case studies of ADCs in oncology drug development • Features contributions from highly-regarded experts on the frontlines of ADC research and development

Chemical Linkers in Antibody-Drug Conjugates (ADCs)

Floris van Delft,John M. Lambert
Chemical Linkers in Antibody Drug Conjugates ADCs Book PDF

Author : Floris van Delft,John M. Lambert
Publisher : Royal Society of Chemistry
Page : 477 pages
File Size : 40,8 Mb
Release : 2021-12-22
Category : Medical
ISBN : 9781839162633

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Chemical Linkers in Antibody-Drug Conjugates (ADCs) by Floris van Delft,John M. Lambert Pdf

Chemical Linkers in Antibody-Drug Conjugates aims to shine a detailed light on the various key attributes of chemical linkers in ADCs, for drug-to-antibody ratio, for stability, for release mechanism of payload, for pharmacokinetics, for stability determination, and for efficacy and safety.

Antibody-Drug Conjugates and Immunotoxins

Gail Lewis Phillips
Antibody Drug Conjugates and Immunotoxins Book PDF

Author : Gail Lewis Phillips
Publisher : Springer Science & Business Media
Page : 370 pages
File Size : 49,8 Mb
Release : 2012-12-13
Category : Medical
ISBN : 9781461454564

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Antibody-Drug Conjugates and Immunotoxins by Gail Lewis Phillips Pdf

This volume gathers the leading research on antibody-drug conjugates and immunotoxins. Following a rigorous overview, the volume delves into focused sections on all aspects of ADCs and ITs from clinical development through to targeted therapeutic applications and the latest technologies.

Antibody-Drug Conjugates

Laurent Ducry
Antibody Drug Conjugates Book PDF

Author : Laurent Ducry
Publisher : Humana
Page : 0 pages
File Size : 42,5 Mb
Release : 2016-08-23
Category : Medical
ISBN : 1493960261

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Antibody-Drug Conjugates by Laurent Ducry Pdf

Antibody-drug conjugates (ADCs) represent a promising therapeutic approach for cancer patients by combining the antigen-targeting specificity of monoclonal antibodies (mAbs) with the cytotoxic potency of chemotherapeutic drugs. In Antibody-Drug Conjugates, expert researchers provide detailed protocols for many of the key ADC techniques necessary for working in the field. These chapters and methodologies are aimed at the key tasks necessary to identify a suitable target, properly design the mAb, the linker and the payload, as well as to conjugate them in a reproducible and scalable fashion. Written in the highly successful Methods in Molecular BiologyTM format, these detailed chapters include the kind of practical implementation advice that guarantees quality results. Authoritative and timely, Antibody-Drug Conjugates aims to further drive ADC development and thus help toward improving cancer treatments of the future.

Antibody-Drug Conjugates

Laurent Ducry
Antibody Drug Conjugates Book PDF

Author : Laurent Ducry
Publisher : Humana Press
Page : 317 pages
File Size : 55,5 Mb
Release : 2013-08-03
Category : Medical
ISBN : 1627035427

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Antibody-Drug Conjugates by Laurent Ducry Pdf

Antibody-drug conjugates (ADCs) represent a promising therapeutic approach for cancer patients by combining the antigen-targeting specificity of monoclonal antibodies (mAbs) with the cytotoxic potency of chemotherapeutic drugs. In Antibody-Drug Conjugates, expert researchers provide detailed protocols for many of the key ADC techniques necessary for working in the field. These chapters and methodologies are aimed at the key tasks necessary to identify a suitable target, properly design the mAb, the linker and the payload, as well as to conjugate them in a reproducible and scalable fashion. Written in the highly successful Methods in Molecular BiologyTM format, these detailed chapters include the kind of practical implementation advice that guarantees quality results. Authoritative and timely, Antibody-Drug Conjugates aims to further drive ADC development and thus help toward improving cancer treatments of the future.

Next Generation Antibody Drug Conjugates (ADCs) and Immunotoxins

Ulf Grawunder,Stefan Barth
Next Generation Antibody Drug Conjugates ADCs and Immunotoxins Book PDF

Author : Ulf Grawunder,Stefan Barth
Publisher : Springer
Page : 181 pages
File Size : 40,8 Mb
Release : 2017-04-07
Category : Medical
ISBN : 9783319468778

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Next Generation Antibody Drug Conjugates (ADCs) and Immunotoxins by Ulf Grawunder,Stefan Barth Pdf

This book describes the newest developments in antibody drug conjugates and immunotoxins, paving their way to clinical application. Lessons learned from the current state of the art are used to further improve our understanding of their mechanisms of action and off target activities. The book introduces scientists to all of the prerequisites that must be properly addressed, including identification of the right target, specific traits of target binding antibodies, proper selection of the toxic payload, internalization induced by binding, and next generation conjugation and linker technologies. These knowledge-based, revolutionary new drug principles will form the cornerstone of the future standard of care and will lead to major advances in application, as well as improved quality of life and patient survival rates. This book will be of interest to biotech companies and researchers working in the fields of immunology, pharmacology, and oncology.

Antibody-Drug Conjugates

Kenneth J. Olivier, Jr.,Sara A. Hurvitz
Antibody Drug Conjugates Book PDF

Author : Kenneth J. Olivier, Jr.,Sara A. Hurvitz
Publisher : John Wiley & Sons
Page : 572 pages
File Size : 42,6 Mb
Release : 2016-11-14
Category : Medical
ISBN : 9781119060680

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Antibody-Drug Conjugates by Kenneth J. Olivier, Jr.,Sara A. Hurvitz Pdf

Providing practical and proven solutions for antibody-drug conjugate (ADC) drug discovery success in oncology, this book helps readers improve the drug safety and therapeutic efficacy of ADCs to kill targeted tumor cells. • Discusses the basics, drug delivery strategies, pharmacology and toxicology, and regulatory approval strategies • Covers the conduct and design of oncology clinical trials and the use of ADCs for tumor imaging • Includes case studies of ADCs in oncology drug development • Features contributions from highly-regarded experts on the frontlines of ADC research and development

Innovations for Next-Generation Antibody-Drug Conjugates

Marc Damelin
Innovations for Next Generation Antibody Drug Conjugates Book PDF

Author : Marc Damelin
Publisher : Springer
Page : 357 pages
File Size : 40,9 Mb
Release : 2018-05-29
Category : Medical
ISBN : 9783319781549

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Innovations for Next-Generation Antibody-Drug Conjugates by Marc Damelin Pdf

Antibody-drug conjugates (ADCs) stand at the verge of a transformation. Scores of clinical programs have yielded only a few regulatory approvals, but a wave of technological innovation now empowers us to overcome past technical challenges. This volume focuses on the next generation of ADCs and the innovations that will enable them. The book inspires the future by integrating the field’s history with novel strategies and cutting-edge technologies. While the book primarily addresses ADCs for solid tumors, the last chapter explores the emerging interest in using ADCs to treat other diseases. The therapeutic rationale of ADCs is strong: to direct small molecules to the desired site of action (and away from normal tissues) by conjugation to antibodies or other targeting moieties. However, the combination of small and large molecules imposes deep complexity to lead optimization, pharmacokinetics, toxicology, analytics and manufacturing. The field has made significant advances in all of these areas by improving target selection, ADC design, manufacturing methods and clinical strategies. These innovations will inspire and educate scientists who are designing next-generation ADCs with the potential to transform the lives of patients.

Sample Preparation in LC-MS Bioanalysis

Wenkui Li,Wenying Jian,Yunlin Fu
Sample Preparation in LC MS Bioanalysis Book PDF

Author : Wenkui Li,Wenying Jian,Yunlin Fu
Publisher : John Wiley & Sons
Page : 384 pages
File Size : 46,9 Mb
Release : 2019-03-12
Category : Science
ISBN : 9781119274292

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Sample Preparation in LC-MS Bioanalysis by Wenkui Li,Wenying Jian,Yunlin Fu Pdf

Revised and Expanded Handbook Provides Comprehensive Introduction and Complete Instruction for Sample Preparation in Vital Category of Bioanalysis Following in the footsteps of the previously published Handbook of LC-MS Bioanalysis, this book is a thorough and timely guide to all important sample preparation techniques used for quantitative Liquid Chromatography–Mass Spectrometry (LC-MS) bioanalysis of small and large molecules. LC-MS bioanalysis is a key element of pharmaceutical research and development, post-approval therapeutic drug monitoring, and many other studies used in human healthcare. While advances are continually being made in key aspects of LC-MS bioanalysis such as sensitivity and throughput, the value of research/study mentioned above is still heavily dependent on the availability of high-quality data, for which sample preparation plays the critical role. Thus, this text provides researchers in industry, academia, and regulatory agencies with detailed sample preparation techniques and step-by-step protocols on proper extraction of various analyte(s) of interest from biological samples for LC-MS quantification, in accordance with current health authority regulations and industry best practices. The three sections of the book with a total of 26 chapters cover topics that include: Current basic sample preparation techniques (e.g., protein precipitation, liquid-liquid extraction, solid-phase extraction, salting-out assisted liquid-liquid extraction, ultracentrifugation and ultrafiltration, microsampling, sample extraction via electromembranes) Sample preparation techniques for uncommon biological matrices (e.g., tissues, hair, skin, nails, bones, mononuclear cells, cerebrospinal fluid, aqueous humor) Crucial aspects of LC-MS bioanalytical method development (e.g., pre-analytical considerations, derivation strategies, stability, non-specific binding) in addition to sample preparation techniques for challenging molecules (e.g., lipids, peptides, proteins, oligonucleotides, antibody-drug conjugates) Sample Preparation in LC-MS Bioanalysis will prove a practical and highly valuable addition to the reference shelves of scientists and related professionals in a variety of fields, including pharmaceutical and biomedical research, mass spectrometry, and analytical chemistry, as well as practitioners in clinical pharmacology, toxicology, and therapeutic drug monitoring.

Antibody-Drug Conjugates and Immunotoxins

Gail Lewis Phillips
Antibody Drug Conjugates and Immunotoxins Book PDF

Author : Gail Lewis Phillips
Publisher : Springer
Page : 378 pages
File Size : 52,7 Mb
Release : 2012-12-12
Category : Medical
ISBN : 1461454573

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Antibody-Drug Conjugates and Immunotoxins by Gail Lewis Phillips Pdf

This volume gathers the leading research on antibody-drug conjugates and immunotoxins. Following a rigorous overview, the volume delves into focused sections on all aspects of ADCs and ITs from clinical development through to targeted therapeutic applications and the latest technologies.

Antibody-Drug Conjugates

Jeffrey Wang,Wei-Chiang Shen,Jennica L. Zaro
Antibody Drug Conjugates Book PDF

Author : Jeffrey Wang,Wei-Chiang Shen,Jennica L. Zaro
Publisher : Springer
Page : 252 pages
File Size : 54,6 Mb
Release : 2015-03-05
Category : Medical
ISBN : 9783319130811

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Antibody-Drug Conjugates by Jeffrey Wang,Wei-Chiang Shen,Jennica L. Zaro Pdf

This authoritative volume provides a holistic picture of antibody-drug conjugates (ADCs). Fourteen comprehensive chapters are divided into six sections including an introduction to ADCs, the ADC construct, development issues, landscape, IP and pharmacoeconomics, case studies, and the future of the field. The book examines everything from the selection of the antibody, the drug, and the linker to a discussion of developmental issues such as formulations, bio-analysis, pharmacokinetic-pharmacodynamic relationships, and toxicological and regulatory challenges. It also explores pharmacoecomonics and intellectual properties, including recently issued patents and the cost analysis of drug therapy. Case studies are presented for the three ADCs that have received FDA approval: gemtuzumab ozogamicin (Mylotarg®), Brentuximab vedotin (Adcetris®), and ado-trastuzumab emtansine (Kadcyla®), as well as an ADC in late-stage clinical trials, glembatumumab vedotin (CDX-011). Finally, the volume presents a perspective by the editors on the future directions of ADC development and clinical applications. Antibody-Drug Conjugates is a practical and systematic resource for scientists, professors, and students interested in expanding their knowledge of cutting-edge research in this exciting field.

Biologics, Biosimilars, and Biobetters

Iqbal Ramzan
Biologics Biosimilars and Biobetters Book PDF

Author : Iqbal Ramzan
Publisher : John Wiley & Sons
Page : 328 pages
File Size : 46,5 Mb
Release : 2021-02-03
Category : Medical
ISBN : 9781119564652

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Biologics, Biosimilars, and Biobetters by Iqbal Ramzan Pdf

A comprehensive primer and reference, this book provides pharmacists and health practitioners the relevant science and policy concepts behind biologics, biosimilars, and biobetters from a practical and clinical perspective. Explains what pharmacists need to discuss the equivalence, efficacy, safety, and risks of biosimilars with physicians, health practitioners, and patients about Guides regulators on pragmatic approaches to dealing with these drugs in the context of rapidly evolving scientific and clinical evidence Balances scientific information on complex drugs with practical information, such as a checklist for pharmacists

Enzyme-Mediated Ligation Methods

Timo Nuijens,Marcel Schmidt
Enzyme Mediated Ligation Methods Book PDF

Author : Timo Nuijens,Marcel Schmidt
Publisher : Springer Nature
Page : 369 pages
File Size : 45,9 Mb
Release : 2019-06-03
Category : Science
ISBN : 9781493995462

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Enzyme-Mediated Ligation Methods by Timo Nuijens,Marcel Schmidt Pdf

This volume discusses different enzyme-catalyzed ligation methodologies for a variety of different chemical transformations. This book wants readers to view enzymes as a powerful tool in both academic and industrial research. Chapters in this book cover topics such as sortase A-mediated generation of site-specifically conjugated antibody-drug conjugates; omniligase-catalyzed inter- and intramolecular ligation; ligation catalyzed by microbial transglutaminase; peptide cyclization mediated by cyanobactin macrocyclases, butelase 1 and sortase A; using BioID as a tool for protein proximity labeling in living cells; and inducible, selective labeling of proteins via enzymatic oxidation of tyrosine. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Enzyme-Mediated Ligation Methods is a valuable resource for students and scientists from different disciplines who are interested in using enzymatic strategies to answer their research questions.