Dengue And Zika Control And Antiviral Treatment Strategies

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Dengue and Zika: Control and Antiviral Treatment Strategies

Author : Rolf Hilgenfeld,Subhash G. Vasudevan
Publisher : Springer
Page : 375 pages
File Size : 42,6 Mb
Release : 2018-05-29
Category : Medical
ISBN : 9789811087271

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Dengue and Zika: Control and Antiviral Treatment Strategies by Rolf Hilgenfeld,Subhash G. Vasudevan Pdf

This contributed volume contains 25 chapters from leading international scientists working on dengue and Zika viruses, who came together in Praia do Tofo in Mozambique to discuss the latest developments in the fields of epidemiology, pathogenesis, structural virology, immunology, antiviral drug discovery and development, vaccine efficacy, and mosquito control programs. The meeting venue offered an opportunity to discuss current research on these flaviviruses in an idyllic setting, and also to develop first-hand appreciation of the issues in infectious diseases facing developing countries and of the research gaps in Africa. For readers, who should include basic and clinical researchers in the field and public health professionals, the chapters are organized to provide a comprehensive overview of the various topics in current dengue and Zika virus research. A unique feature of the proceedings of this meeting is the inclusion of the discussions that took place following presentations. These have been transcribed and appended to the end of the relevant chapters, and they form the “salt in the soup” of this book.

New Treatment Strategies for Dengue and Other Flaviviral Diseases

Author : Gregory R. Bock,Jamie A. Goode
Publisher : John Wiley & Sons
Page : 276 pages
File Size : 42,7 Mb
Release : 2006-10-02
Category : Science
ISBN : 9780470058015

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New Treatment Strategies for Dengue and Other Flaviviral Diseases by Gregory R. Bock,Jamie A. Goode Pdf

Dengue virus is a member of the Flaviviridae family, which includes viruses associated with human diseases such as yellow fever, Japanese encephalitis and hepatitis C. Dengue fever is transmitted by mosquitoes, principally Aedes aegypti. There are four serotypes of dengue virus, of which DENV-2 has been the most prevalent in many recent epidemics. Following primary infection, lifelong immunity develops, preventing repeated assault by the same serotype. However, the non-neutralizing antibodies from a previous infection or maternally acquired antibodies are thought to form complexes with a different serotype during a subsequent infection and cause dengue haemorrhagic fever/dengue shock syndrome, which can be fatal. There is no treatment or vaccine available today that can combat this emerging and uncontrolled disease. This book features contributions from the world’s leading researchers working on dengue and related flaviviruses who examine the current state of the art in the molecular biology of the dengue virus. Particular emphasis is placed on the structure and function of the virus and the targeting of virus proteins by potential antiviral agents. The pathogenesis of dengue and dengue haemorrhagic fever are discussed in detail, especially the target cells and the specific receptors on these cells, thereby developing a clear overview of host and viral factors that contribute to dengue haemorrhagic fever. Finally, the book reviews the therapeutic options, paying particular attention to ways in which vector, host and environment can play a critical role in the spread of this disease. With dengue fever and other emerging viral diseases becoming increasingly prevalent around the world, this book provides valuable insight into the virus that causes this disease and potential ways to manage it. It is essential reading for all those working in tropical diseases, public health and virology. Praise from the reviews: "The book provides an excellent summary of dengue/flavivirus research and is important for individuals and institutions interested in emerging infectious diseases." MICROBIOLOGY TODAY

Disease Control Priorities, Third Edition (Volume 9)

Author : Dean T. Jamison,Hellen Gelband,Susan Horton,Prabhat Jha,Charles N. Mock,Rachel Nugent
Publisher : World Bank Publications
Page : 426 pages
File Size : 54,9 Mb
Release : 2017-12-06
Category : Medical
ISBN : 9781464805288

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Disease Control Priorities, Third Edition (Volume 9) by Dean T. Jamison,Hellen Gelband,Susan Horton,Prabhat Jha,Charles N. Mock,Rachel Nugent Pdf

As the culminating volume in the DCP3 series, volume 9 will provide an overview of DCP3 findings and methods, a summary of messages and substantive lessons to be taken from DCP3, and a further discussion of cross-cutting and synthesizing topics across the first eight volumes. The introductory chapters (1-3) in this volume take as their starting point the elements of the Essential Packages presented in the overview chapters of each volume. First, the chapter on intersectoral policy priorities for health includes fiscal and intersectoral policies and assembles a subset of the population policies and applies strict criteria for a low-income setting in order to propose a "highest-priority" essential package. Second, the chapter on packages of care and delivery platforms for universal health coverage (UHC) includes health sector interventions, primarily clinical and public health services, and uses the same approach to propose a highest priority package of interventions and policies that meet similar criteria, provides cost estimates, and describes a pathway to UHC.

Dengue

Author : World Health Organization
Publisher : World Health Organization
Page : 159 pages
File Size : 55,6 Mb
Release : 2009
Category : Medical
ISBN : 9789241547871

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Dengue by World Health Organization Pdf

This publication is intended to contribute to prevention and control of the morbidity and mortality associated with dengue and to serve as an authoritative reference source for health workers and researchers. These guidelines are not intended to replace national guidelines but to assist in the development of national or regional guidelines. They are expected to remain valid for five years (until 2014), although developments in research could change their validity.--Publisher's description.

CDC Yellow Book 2018: Health Information for International Travel

Author : Centers for Disease Control and Prevention CDC
Publisher : Oxford University Press
Page : 672 pages
File Size : 51,7 Mb
Release : 2017-04-17
Category : Medical
ISBN : 9780190628635

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CDC Yellow Book 2018: Health Information for International Travel by Centers for Disease Control and Prevention CDC Pdf

THE ESSENTIAL WORK IN TRAVEL MEDICINE -- NOW COMPLETELY UPDATED FOR 2018 As unprecedented numbers of travelers cross international borders each day, the need for up-to-date, practical information about the health challenges posed by travel has never been greater. For both international travelers and the health professionals who care for them, the CDC Yellow Book 2018: Health Information for International Travel is the definitive guide to staying safe and healthy anywhere in the world. The fully revised and updated 2018 edition codifies the U.S. government's most current health guidelines and information for international travelers, including pretravel vaccine recommendations, destination-specific health advice, and easy-to-reference maps, tables, and charts. The 2018 Yellow Book also addresses the needs of specific types of travelers, with dedicated sections on: · Precautions for pregnant travelers, immunocompromised travelers, and travelers with disabilities · Special considerations for newly arrived adoptees, immigrants, and refugees · Practical tips for last-minute or resource-limited travelers · Advice for air crews, humanitarian workers, missionaries, and others who provide care and support overseas Authored by a team of the world's most esteemed travel medicine experts, the Yellow Book is an essential resource for travelers -- and the clinicians overseeing their care -- at home and abroad.

Viral Infections and Antiviral Therapies

Author : Amal Kumar Dhara,Amit Kumar Nayak
Publisher : Academic Press
Page : 810 pages
File Size : 55,5 Mb
Release : 2022-11-10
Category : Science
ISBN : 9780323972420

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Viral Infections and Antiviral Therapies by Amal Kumar Dhara,Amit Kumar Nayak Pdf

Viral Infections and Antiviral Therapies provides comprehensive coverage of viral infections and their transmission. Coverage includes antiviral agents, therapeutics, their mechanisms and treatment strategies. The book is organized into four sections, including an introduction to antiviral therapies, viral infections and their transmission, antiviral agents and therapeutics, and a market overview and future developments. The chapters in each section of the book discuss various key topics that are contributed to by an international group of leading experts. Covers emerging and sexually transmitted viruses, including mode of transmission and pathophysiology of viral infections Describes antiviral agents and therapeutics for viruses such as rotaviruses, enteroviruses and coronaviruses Discusses strategies for the delivery of antiviral agents and vaccinations

Hazardous Environmental Micro-pollutants, Health Impacts and Allied Treatment Technologies

Author : Toqeer Ahmed,Muhammad Zaffar Hashmi
Publisher : Springer Nature
Page : 401 pages
File Size : 46,5 Mb
Release : 2022-06-27
Category : Science
ISBN : 9783030965235

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Hazardous Environmental Micro-pollutants, Health Impacts and Allied Treatment Technologies by Toqeer Ahmed,Muhammad Zaffar Hashmi Pdf

This volume discusses hazardous environmental micropollutants, their impacts on human health, and possible means to mitigate their associated risks. The book features chapters that cover a variety of topics related to environmental micropollutants, which include dusts, infectious particles, heavy metals, organophosphates, atmospheric toxic organic micropollutants, fungal spores, pollutants from E-waste, antibiotic waste, and more. In addition impacts on human health and the environment, economic issues are addressed, with potential policy solutions offered. This work is timely, as hazardous micropollutants in soil, water and air are becoming more common, and this environmental contamination is leading to increasing instances of suboptimal human health outcomes. The book will be of interest to students and researchers in environmental pollution and remediation technology, microbiologists, and environmental regulators.

Dengue Fever

Author : Jorge Abelardo Falcón-Lezama,Miguel Betancourt-Cravioto,Roberto Tapia-Conyer
Publisher : BoD – Books on Demand
Page : 182 pages
File Size : 48,5 Mb
Release : 2019-01-30
Category : Medical
ISBN : 9781789849998

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Dengue Fever by Jorge Abelardo Falcón-Lezama,Miguel Betancourt-Cravioto,Roberto Tapia-Conyer Pdf

For over 70 years, dengue fever has challenged health systems in every region of the World. It has evolved from a benign febrile illness from the tropics to a major concern in urban settlements, overwhelming health infrastructure with large outbreaks, as it continues to teach us important lessons with its complexities. This book intends to review the latest updates on dengue fever, the tools available for its study and control, and promising technologies currently in the pipeline. With this work, the editors wish to provide students with an updated reference text on the basics of this disease as well as researchers and academics, with a useful document to understand the current outlook and the perspectives for the future.

New Drug Development for Known and Emerging Viruses

Author : Helga Rübsamen-Schaeff,Helmut Buschmann
Publisher : John Wiley & Sons
Page : 530 pages
File Size : 52,6 Mb
Release : 2022-01-31
Category : Medical
ISBN : 9783527343379

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New Drug Development for Known and Emerging Viruses by Helga Rübsamen-Schaeff,Helmut Buschmann Pdf

Discusses how to fight Ebola, SARS Corona, and other known or emerging human viruses by building on the successes in antiviral therapy of the past decades Written by leading medicinal chemists from academia and industry, this book discusses the entire field of antiviral drug discovery and development from a medicinal chemistry perspective, focusing on antiviral drugs, targets, and viral disease mechanisms. It provides an outlook on emerging pathogens such as Ebola, Zika, West Nile, Lassa, and includes a chapter on SARS Coronoavirus-2 causing the present pandemic. New Drug Development for Known and Emerging Viruses describes the discovery and development process for antiviral agents for different classes of viruses and targets based on the experiences from the nine human viruses for which approved drugs are on the market (HIV, HCV, Influenza, RSV, HBV, HPV, HCMV, HSV, and VZV). It covers the properties and potential of 20 classes of currently approved antivirals, including combination drugs, and looks at novel antiviral strategies against emerging viruses. Covers the entire field of antiviral drug discovery and development Addresses the need for antiviral drugs to combat major health threats such as Ebola, Zika, West Nile, and SARS Coronavirus-2 Summarizes the successes of the past 15 years in developing ground-breaking medicines against 9 major human viruses, both from the medicinal chemistry and the pharmacological angle Discusses practical and strategic challenges in the drug discovery and development process, including screening technologies, latency, and toxicity issues New Developments in Antiviral Drugs is an important book for medicinal chemists, pharmaceutical chemists, virologists, and epidemiologists, and will be of great interest to those in the pharmaceutical industry and public health agencies.

Genome Editing Tools and Gene Drives

Author : Reagan Mudziwapasi,Ringisai Chekera,Clophas Zibusiso Ncube,Irvonnie Shoko,Berlinda Ncube,Thandanani Moyo,Jeffrey Godfrey Chimbo,Jemethious Dube,Farai Faustos Mashiri,Moira Amanda Mubani,Duncan Maruta,Charity Chimbo,Mpumuzi Masuku,Ryman Shoko,Rutendo Patricia Nyamusamba,Fortune Ntengwa Jomane
Publisher : CRC Press
Page : 177 pages
File Size : 51,9 Mb
Release : 2021-10-18
Category : Medical
ISBN : 9781000463101

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Genome Editing Tools and Gene Drives by Reagan Mudziwapasi,Ringisai Chekera,Clophas Zibusiso Ncube,Irvonnie Shoko,Berlinda Ncube,Thandanani Moyo,Jeffrey Godfrey Chimbo,Jemethious Dube,Farai Faustos Mashiri,Moira Amanda Mubani,Duncan Maruta,Charity Chimbo,Mpumuzi Masuku,Ryman Shoko,Rutendo Patricia Nyamusamba,Fortune Ntengwa Jomane Pdf

Genome-editing methods are becoming routine tools for molecular and cell biologists. Such tools include ZFNs, CRISPR, megaTALs and TALENs. These tools are revolutionizing the creation of precisely manipulated genomes to modify the characteristics of organisms or cells. Additionally, gene drives have altered the way we understand inheritance laws. They give us the ability to have total control of the inheritance of traits of choice and importance. This succinct volume summarizes the history, principles and applications – as well as the advantages and disadvantages – of each of these tools and various kinds of gene drives. The book is part of a program to produce books helpful to students and faculties of science at colleges and universities. This volume in the Pocket Guides to Biomedical Sciences series will help demystify these technologies. The book fills the gap between established conventional methods and the novel and exciting newly introduced tools of genome editing and gene drives. It will help young scientists understand the emerging genome-editing tools and gene drives, thereby promoting related research and adoption. Key Features Extensively reviews the current genome-editing tools and gene drives Clarifies the targeting mechanisms and specificity of genome-editing tools Details many different types of natural and synthetic gene drives Highlights concerns with gene drives and genome-editing tools Related Titles Brown, T. A. Genomes 4 (ISBN 978-0-8153-4508-4) Samuelsson, T. The Human Genome in Health and Disease: A Story in Four Letters (ISBN 978-0-8153-4591-6) Soh, J., et al. Genome Annotation (ISBN 978-1-4398-4117-4)

Immunological Methods in Microbiology

Author : Anonim
Publisher : Academic Press
Page : 410 pages
File Size : 48,9 Mb
Release : 2020-04-29
Category : Science
ISBN : 9780128208120

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Immunological Methods in Microbiology by Anonim Pdf

Immunological Methods in Microbiology, Volume 47 in the Methods in Microbiology series, highlights new advances in the field, with this new volume presenting interesting chapters on Immunological Techniques in the Clinical laboratory, Immunologic Diagnosis of HIV and Opportunistic Infections, Combining Antigen Detection and Serology for the Diagnosis of Selected Infectious Diseases, Immunologic Detection of Lyme Disease and Related Borrelioses, Immunodetection of Bacteria Causing Brucellosis, Immunological Diagnostic Techniques Used to Identify and Type Pasteurella, Immunological Tests for Diarrhea caused by Diarrheagenic Escherichia coli Targeting Their Main Virulence Factors, and much more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Methods in Microbiology series Includes the latest information on Immunological Methods in Microbiology

Virus as Populations

Author : Esteban Domingo
Publisher : Academic Press
Page : 426 pages
File Size : 44,9 Mb
Release : 2019-11-06
Category : Science
ISBN : 9780128163320

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Virus as Populations by Esteban Domingo Pdf

Virus as Composition, Complexity, Quasispecies, Dynamics, and Biological Implications, Second Edition, explains the fundamental concepts surrounding viruses as complex populations during replication in infected hosts. Fundamental phenomena in virus behavior, such as adaptation to changing environments, capacity to produce disease, and the probability to be transmitted or respond to treatment all depend on virus population numbers. Concepts such as quasispecies dynamics, mutations rates, viral fitness, the effect of bottleneck events, population numbers in virus transmission and disease emergence, and new antiviral strategies are included. The book's main concepts are framed by recent observations on general virus diversity derived from metagenomic studies and current views on the origin and role of viruses in the evolution of the biosphere. Features current views on key steps in the origin of life and origins of viruses Includes examples relating ancestral features of viruses with their current adaptive capacity Explains complex phenomena in an organized and coherent fashion that is easy to comprehend and enjoyable to read Considers quasispecies as a framework to understand virus adaptability and disease processes

Global Health Impacts of Vector-Borne Diseases

Author : National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Global Health,Forum on Microbial Threats
Publisher : National Academies Press
Page : 397 pages
File Size : 47,6 Mb
Release : 2016-10-21
Category : Medical
ISBN : 9780309377591

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Global Health Impacts of Vector-Borne Diseases by National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Global Health,Forum on Microbial Threats Pdf

Pathogens transmitted among humans, animals, or plants by insects and arthropod vectors have been responsible for significant morbidity and mortality throughout recorded history. Such vector-borne diseases â€" including malaria, dengue, yellow fever, and plague â€" together accounted for more human disease and death in the 17th through early 20th centuries than all other causes combined. Over the past three decades, previously controlled vector-borne diseases have resurged or reemerged in new geographic locations, and several newly identified pathogens and vectors have triggered disease outbreaks in plants and animals, including humans. Domestic and international capabilities to detect, identify, and effectively respond to vector-borne diseases are limited. Few vaccines have been developed against vector-borne pathogens. At the same time, drug resistance has developed in vector-borne pathogens while their vectors are increasingly resistant to insecticide controls. Furthermore, the ranks of scientists trained to conduct research in key fields including medical entomology, vector ecology, and tropical medicine have dwindled, threatening prospects for addressing vector-borne diseases now and in the future. In June 2007, as these circumstances became alarmingly apparent, the Forum on Microbial Threats hosted a workshop to explore the dynamic relationships among host, pathogen(s), vector(s), and ecosystems that characterize vector-borne diseases. Revisiting this topic in September 2014, the Forum organized a workshop to examine trends and patterns in the incidence and prevalence of vector-borne diseases in an increasingly interconnected and ecologically disturbed world, as well as recent developments to meet these dynamic threats. Participants examined the emergence and global movement of vector-borne diseases, research priorities for understanding their biology and ecology, and global preparedness for and progress toward their prevention, control, and mitigation. This report summarizes the presentations and discussions from the workshop.

Carbohydrates 2018

Author : Amélia Pilar Rauter,Nuno Manuel Xavier
Publisher : MDPI
Page : 172 pages
File Size : 41,6 Mb
Release : 2020-03-25
Category : Medical
ISBN : 9783039283163

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Carbohydrates 2018 by Amélia Pilar Rauter,Nuno Manuel Xavier Pdf

This book contains original papers and reviews on carbohydrate research in medicine, authored by participants of the 29th International Carbohydrate Symposium, where this topic had a special emphasis. The focus on biological events involving carbohydrates and glycoconjugates has delivered reliable approaches for disease treatment and diagnosis. Research on carbohydrate-based compounds for therapeutic applications is illustrated in various contributions, namely those covering the development of novel agents against Alzheimer’s disease, e.g. the neuroprotective C-glucosylated flavones and the isonucleoside-based cholinesterase inhibitors. New imino sugar glucosidase inhibitors are also disclosed, a class of compounds with potential for diabetes, Gaucher disease or cancer treatment. Also the development of a useful synthetic method towards multivalent glycoclusters of biomedical interest is here highlighted. The relevance of glycomimetics in drug discovery and the progress on carbohydrates in early diagnosis and cancer treatment are reviewed. Noteworthy is the chitosan-based delivery system for drug oral administration, a new biomaterial-based approach to improve bioavailability. Another study on the conformation of Streptococcus capsular polysaccharide backbones by molecular modelling provides useful information for bacterial immunotherapeutic approaches. All original contributions and reviews clearly demonstrate the potential of glycosciences for innovation in medicinal (glyco)chemistry and pharmaceutical research.

Pandemic Influenza Preparedness and Response

Author : World Health Organization,World Health Organization. Global Influenza Programme
Publisher : World Health Organization
Page : 62 pages
File Size : 42,5 Mb
Release : 2009
Category : Medical
ISBN : 9789241547680

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Pandemic Influenza Preparedness and Response by World Health Organization,World Health Organization. Global Influenza Programme Pdf

This guidance is an update of WHO global influenza preparedness plan: the role of WHO and recommendations for national measures before and during pandemics, published March 2005 (WHO/CDS/CSR/GIP/2005.5).