Dermal Absorption Models In Toxicology And Pharmacology

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Dermal Absorption Models in Toxicology and Pharmacology

Jim E. Riviere,Nancy A. Monteiro-Riviere
Dermal Absorption Models in Toxicology and Pharmacology Book PDF

Author : Jim E. Riviere,Nancy A. Monteiro-Riviere
Publisher : CRC Press
Page : 392 pages
File Size : 46,6 Mb
Release : 2005-08-24
Category : Medical
ISBN : 0203020820

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Dermal Absorption Models in Toxicology and Pharmacology by Jim E. Riviere,Nancy A. Monteiro-Riviere Pdf

Many experimental methods and mathematical modeling approaches rooted in disciplines outside of toxicology can be effectively applied to estimating dermal absorption. Dermal Absorption Models in Toxicology and Pharmacology explores current approaches and techniques that can be used to quantify dermal absorption with endpoints useful in both toxicology and pharmacology. The book begins with a review of basic principles and the in vitro and in vivo experimental approaches available for assessing dermal absorption of drugs and chemicals. This is followed by coverage of mathematical or in silico models for quantitating percutaneous absorption and the applications of these techniques to the risk assessment process. The remainder of the book explores scenarios where the unique properties of the chemicals being studied or the matrix in which they are exposed must be considered and then wraps up with a comparative analysis of chemical permeability in human and animal skin. Many of the books covering this subject are just too comprehensive and serve primarily as reference works. This book takes a different approach. Jim Riviere's editorial guidance ensures that the information is readable, accessible, authoritative, and concise, making it the perfect resource for familiarizing new researchers and students to the field and updating established scientists.

Dermal Absorption and Toxicity Assessment

Michael S. Roberts
Dermal Absorption and Toxicity Assessment Book PDF

Author : Michael S. Roberts
Publisher : CRC Press
Page : 704 pages
File Size : 44,9 Mb
Release : 2007-12-14
Category : Medical
ISBN : 9780849375927

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Dermal Absorption and Toxicity Assessment by Michael S. Roberts Pdf

The source Dermal Absorption and Toxicity Assessment supplies a state-of-the-art overview of the dermal absorption process, and is divided into six well organized sections. Written by internationally recognized experts in the field, this Second Edition is a complete revised and updated text, covering the wide range of methods used to assess skin ab

Principles and Practice of Skin Toxicology

Robert Chilcott,Shirley Price
Principles and Practice of Skin Toxicology Book PDF

Author : Robert Chilcott,Shirley Price
Publisher : John Wiley & Sons
Page : 392 pages
File Size : 42,9 Mb
Release : 2008-07-31
Category : Science
ISBN : 9780470773086

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Principles and Practice of Skin Toxicology by Robert Chilcott,Shirley Price Pdf

Written by authorities in the field, this book provides a “bottom up” approach to studying skin toxicology. Principles and Practice of Skin Toxicology clearly outlines basic concepts, cites historical and modern references and contains a dictionary for easy reference. The inclusion of global legislation and regulatory aspects on the topic makes this a comprehensive review for every practitioner, clinical researcher in industry and academia, and MSc and PhD student of toxicology. Different sections cover skin structure and function, principles and measurement of skin absorption, clinical aspects of dermal toxicity and in vitro alternatives. A section on regulatory and legislative aspects includes case studies from the UK that fulfill European Union and US FDA requirements. A glossary provides definitions of technical terms, and the chapters contain an introduction, learning boxes and summary section for ease of use. Includes a chapter on drug delivery through the skin. Addresses risk assessment: a key area for the interpretation of skin absorption data that is rarely covered.

Dermal Absorption

J. Kielhorn,Stephanie Melching-Kollmuss,I. Mangelsdorf,World Health Organization
Dermal Absorption Book PDF

Author : J. Kielhorn,Stephanie Melching-Kollmuss,I. Mangelsdorf,World Health Organization
Publisher : World Health Organization
Page : 217 pages
File Size : 54,8 Mb
Release : 2006
Category : Medical
ISBN : 9789241572354

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Dermal Absorption by J. Kielhorn,Stephanie Melching-Kollmuss,I. Mangelsdorf,World Health Organization Pdf

Introduction and definitions -- Skin structure and function -- Skin transport mechanisms and theoretical concepts -- Metabolism in the skin -- In vitro tests for dermal absorption -- In vivo tests for dermal absorption -- Comparative studies -- Data collections -- Estimation/prediction of dermal penetration -- Use of dermal penetration studies in risk assessment -- Controversial topics in the assessment of dermal absorption -- Conclusions and recommendations.

Health Risk Assessment Dermal and Inhalation Exposure and Absorption of Toxicants

Rhoda G.M. Wang,James B. Knaak,Howard I. Maibach
Health Risk Assessment Dermal and Inhalation Exposure and Absorption of Toxicants Book PDF

Author : Rhoda G.M. Wang,James B. Knaak,Howard I. Maibach
Publisher : CRC Press
Page : 930 pages
File Size : 53,8 Mb
Release : 2017-11-22
Category : Medical
ISBN : 9781351361736

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Health Risk Assessment Dermal and Inhalation Exposure and Absorption of Toxicants by Rhoda G.M. Wang,James B. Knaak,Howard I. Maibach Pdf

Health Risk Assessment is a comprehensive reference focusing on dermal absorption, cholinesterase inhibition, adverse reproductive effects, and carcinogenicity. The book features contributions from over 40 top scientists and covers topics such as PBPK modeling, cytochrome P-450 metabolism in skin, percutaneous absorption, adverse effects, new skin models, and the role of epidemiology in assessing the hazards of toxicants. Health Risk Assessment is essential for toxicologists, environmental chemists, pharmacologists, risk assessors, and managers working in industrial, pesticide, and pharmaceutical development. The book will also benefit individuals in environmental, regulatory, and registration affairs, as well as academicians and students.

Predictive Methods in Percutaneous Absorption

Gary P. Moss,Darren R. Gullick,Simon C. Wilkinson
Predictive Methods in Percutaneous Absorption Book PDF

Author : Gary P. Moss,Darren R. Gullick,Simon C. Wilkinson
Publisher : Springer
Page : 199 pages
File Size : 52,8 Mb
Release : 2015-07-01
Category : Medical
ISBN : 9783662473719

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Predictive Methods in Percutaneous Absorption by Gary P. Moss,Darren R. Gullick,Simon C. Wilkinson Pdf

This book sheds new light on the development and use of quantitative models to describe the process of skin permeation. It critically reviews the development of quantitative predictive models of skin absorption and discusses key recommendations for model development. Topics presented include an introduction to skin physiology; the underlying theories of skin absorption; the physical laboratory-based processes used to generate skin absorption data, which is in turn used to construct mathematical models describing the skin permeation process; algorithms of skin permeability including quantitative structure-activity (or permeability) relationships (QSARs or QSPRs); relationships between permeability and molecular properties; the development of formulation-focused approaches to models of skin permeability prediction; the use of artificial membranes, e.g. polydimethylsiloxane as alternatives to mammalian skin; and lastly, the use of novel Machine Learning methods in developing the next generation of predictive skin permeability models. The book will be of interest to all researchers in academia and industry working in pharmaceutical discovery and development, as well as readers from the field of occupational exposure and risk assessment, especially those whose work involves agrochemicals, bulk chemicals and cosmetics.

Methods for Skin Absorption

Barbara W. Kemppainen,William G. Reifenrath
Methods for Skin Absorption Book PDF

Author : Barbara W. Kemppainen,William G. Reifenrath
Publisher : CRC Press
Page : 244 pages
File Size : 54,7 Mb
Release : 1990-06-13
Category : Medical
ISBN : 0849346517

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Methods for Skin Absorption by Barbara W. Kemppainen,William G. Reifenrath Pdf

This up-to-date volume describes the wide variety of available methods concerning percutaneous absorption of drugs and toxins. It discusses in detail the advantages and disadvantages of each method. This unique publication provides a clear, systematic presentation of each aspect which must be considered when designing and performing skin penetration experiments and when interpreting results. It includes specific information regarding necessary supplies and equipment, along with commercial sources for these items. This state-of-the-art book is an ideal instructional manual for investigators uninitiated in performing percutaneous absorption and metabolism studies. Those involved with investigative dermatology, dermatological research, toxicology, and pharmacology will find this reference interesting and indispensable.

Dermal Absorption and Toxicity Assessment

S. Roberts Michael
Dermal Absorption and Toxicity Assessment Book PDF

Author : S. Roberts Michael
Publisher : CRC Press
Page : 808 pages
File Size : 43,7 Mb
Release : 1998-06-23
Category : Medical
ISBN : 0824701542

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Dermal Absorption and Toxicity Assessment by S. Roberts Michael Pdf

This volume examines the dermal absoption process with emphasis on determining the toxicity arising from exposure to pharmaceuticals, cosmetics, and other substances. It serves as a bench resource for scientists seeking effective and timesaving means of estimating risk. Contributors also reveal how environmental hazards such as metal compounds, contaminated soil and water, and sun sensitivity occur and are measured through the skin. Practical information is provided on specific products, from analgesics and anti-inflammatory drugs, to perfumes, sunscreens and hair dyes.

Percutaneous Absorption

Robert L. Bronaugh,Howard I. Maibach
Percutaneous Absorption Book PDF

Author : Robert L. Bronaugh,Howard I. Maibach
Publisher : CRC Press
Page : 992 pages
File Size : 46,5 Mb
Release : 1999-05-28
Category : Science
ISBN : 1420000942

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Percutaneous Absorption by Robert L. Bronaugh,Howard I. Maibach Pdf

Since publication of the Second Edition in 1989, numerous innovations have occurred that affect the way scientists look at issues in the field of percutaneous absorption. Focusing on recent advances as well as updating and expanding the scope of topics covered in the previous edition, Percutaneous Absorption, Third Edition provides thorough coverage of the skin's role as an important portal of entry for chemicals into the body. Assembles the work of nearly 80 experts-30 more than the Second Edition-into a unified, comprehensive volume that contains the latest ideas and research! Complete with nearly 600 drawings, photographs, equations, and tables and more than 1600 bibliographic citations of pertinent literature, Percutaneous Absorption, Third Edition details the applied biology of percutaneous penetration factors that affect skin permeation, such as age, vehicles, metabolism, hydration of skin, and chemical structure in vivo and in vitro techniques for measuring absorption, examining factors influencing methodology such as animal models, volatility of test compound, multiple dosage, and artificial membranes procedures for use in transdermal delivery, exploring topics such as effects of penetration enhancers on absorption, optimizing absorption, and the topical delivery of drugs to muscle tissue And presents new chapters on mathematical models cutaneous metabolism prediction of percutaneous absorption in vitro absorption methodology dermal decontamination concentration of chemicals in skin transdermal drug delivery mechanisms of absorption safety evaluation of cosmetics absorption of drugs and cosmetic ingredients nail penetration Emphasizes human applications-particularly useful for pharmacists, pharmacologists, dermatologists, cosmetic scientists, biochemists, toxicologists, public health officials, manufacturers of cosmetic and toiletry products, and graduate students in these disciplines! An invaluable reference source for readers who need to keep up with the latest developments in the field, Percutaneous Absorption, Third Edition is also an excellent experimental guide for laboratory personnel.

Models for Assessing Drug Absorption and Metabolism

Ronald T. Borchardt,Philip L. Smith,Glynn Wilson
Models for Assessing Drug Absorption and Metabolism Book PDF

Author : Ronald T. Borchardt,Philip L. Smith,Glynn Wilson
Publisher : Springer Science & Business Media
Page : 459 pages
File Size : 40,5 Mb
Release : 2013-06-29
Category : Medical
ISBN : 9781489918635

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Models for Assessing Drug Absorption and Metabolism by Ronald T. Borchardt,Philip L. Smith,Glynn Wilson Pdf

Pharmaceutical scientists in industry and academia will appreciate this single reference for its detailed experimental procedures for conducting biopharmaceutical studies. This well-illustrated guide allows them to establish, validate, and implement commonly used in situ and in vitro model systems. Chapters provide ready access to these methodologies for studies of the intestinal, buccal, nasal and respiratory, vaginal, ocular, and dermal epithelium as well as the endothelial and elimination barriers.

Dermatotoxicology, Eighth Edition

Klaus Peter Wilhelm,Hongbo Zhai,Howard I. Maibach
Dermatotoxicology Eighth Edition Book PDF

Author : Klaus Peter Wilhelm,Hongbo Zhai,Howard I. Maibach
Publisher : CRC Press
Page : 0 pages
File Size : 40,5 Mb
Release : 2012-09-27
Category : Medical
ISBN : 1841848557

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Dermatotoxicology, Eighth Edition by Klaus Peter Wilhelm,Hongbo Zhai,Howard I. Maibach Pdf

The foundational reference in dermal toxicology, this classic text has been completely revised to bring it up to date in the new Eighth Edition, with almost a third of its chapters being newly added. The structure of the text has also been reorganized to enable easier location of a topic of interest. With contributions from leading international experts, this continues the tradition of providing unsurpassed theoretical and practical guidance for all those working on research aspects, on practical clinical issues, and on the regulatory aspects of exposure to toxic substances. This new edition contains updates to each chapter and contributions from leading international experts, provides an in-depth summary of research and regulatory applications related to dermal toxicology and pharmacology, presents many new chapters that describe the latest advances in dermatotoxicology, and addresses various levels of expertise regarding the development and use of dermal exposure data. New chapters include those on safety terminology, pharmacogenetics and dermatology, ethnic differences in skin properties, and the principles and practice of percutaneous absorption.

Health Risk Assessment

Rhoda G. M. Wang,James B. Knaak,Howard I. Maibach
Health Risk Assessment Book PDF

Author : Rhoda G. M. Wang,James B. Knaak,Howard I. Maibach
Publisher : CRC PressI Llc
Page : 527 pages
File Size : 41,7 Mb
Release : 1993-01-01
Category : Health & Fitness
ISBN : 0849373573

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Health Risk Assessment by Rhoda G. M. Wang,James B. Knaak,Howard I. Maibach Pdf

1. Pharmacokinetcs, metabolism, and percutaneous penetration of the skin; 2. Route of exposure and toxicological response; 3. Dose, toxicity, and risk assessment; 4. New models in skin research.

Topical Drug Bioavailability, Bioequivalence, and Penetration

Vinod P. Shah,Howard I. Maibach,John Jenner
Topical Drug Bioavailability Bioequivalence and Penetration Book PDF

Author : Vinod P. Shah,Howard I. Maibach,John Jenner
Publisher : Springer
Page : 393 pages
File Size : 48,5 Mb
Release : 2015-01-30
Category : Medical
ISBN : 9781493912896

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Topical Drug Bioavailability, Bioequivalence, and Penetration by Vinod P. Shah,Howard I. Maibach,John Jenner Pdf

This authoritative volume explores advances in the techniques used to measure percutaneous penetration of drugs and chemicals to assess bioavailability and bioequivalence and discusses how they have been used in clinical and scientific investigations. Seven comprehensive sections examine topics including in vitro drug release, topical drugs products, clinical studies, and guidelines and workshop reports, among others. The book also describes how targeted transdermal drug delivery and more sophisticated mathematical modelling can aid in understanding the bioavailability of transdermal drugs. The first edition of this book was an important reference guide for researchers working to define the effectiveness and safety of drugs and chemicals that penetrated the skin. This second edition contains cutting-edge advances in the field and is a key resource to those seeking to define the bioavailability and bioequivalence of percutaneously active compounds to improve scientific and clinical investigation and regulation.

The Practical Applicability of Toxicokinetic Models in the Risk Assessment of Chemicals

Jacob Krüse,J. Krüse,H. J. M. Verhaar,W.K. de Raat
The Practical Applicability of Toxicokinetic Models in the Risk Assessment of Chemicals Book PDF

Author : Jacob Krüse,J. Krüse,H. J. M. Verhaar,W.K. de Raat
Publisher : Springer Science & Business Media
Page : 216 pages
File Size : 53,5 Mb
Release : 2002-10-31
Category : Medical
ISBN : 1402009348

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The Practical Applicability of Toxicokinetic Models in the Risk Assessment of Chemicals by Jacob Krüse,J. Krüse,H. J. M. Verhaar,W.K. de Raat Pdf

In this conference a vast range of areas were treated in relation to toxicological modeling and risk assessment, such as occupational toxicology and biomonitoring, exposure to organic solvents and crop protection products, dose-response relations in carcinogenicity, regulatory toxicology, estimation of dermal penetration, uptake and disposition of organic chemicals in fish and the possibilities of in vitro methods in hazards and risk assessment and the extrapolation between animal and human species.

Physiologically Based Pharmacokinetic Modeling

Micaela Reddy,R. S. Yang,Melvin E. Andersen,Harvey J. Clewell III
Physiologically Based Pharmacokinetic Modeling Book PDF

Author : Micaela Reddy,R. S. Yang,Melvin E. Andersen,Harvey J. Clewell III
Publisher : John Wiley & Sons
Page : 420 pages
File Size : 52,8 Mb
Release : 2005-06-14
Category : Science
ISBN : 9780471478775

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Physiologically Based Pharmacokinetic Modeling by Micaela Reddy,R. S. Yang,Melvin E. Andersen,Harvey J. Clewell III Pdf

A definitive, single source of information on PBPK modeling Physiologically-based pharmacokinetic (PBPK) modeling is becomingincreasingly important in human health risk assessments and insupporting pharmacodynamic modeling for toxic responses. Organizedby classes of compounds and modeling purposes so users can quicklyaccess information, this is the first comprehensive reference ofits kind. This book presents an overview of the underlying principles of PBPKmodel development. Then it provides a compendium of PBPK modelinginformation, including historical development, specific modelingchallenges, and current practices for: * Halogenated Alkanes * Halogenated Alkenes * Alkene and Aromatic Compounds * Reactive Vapors in the Nasal Cavity * Alkanes, Oxyhydrocarbons, and Related Compounds * Pesticides and Persistent Organic Pollutants * Dioxin and Related Compounds * Metals and Inorganic Compounds * Drugs * Antineoplastic Agents * Perinatal Transfer * Mixtures * Dermal Exposure Models In addition to pinpointing specific information, readers canexplore diverse modeling techniques and applications. Anauthoritative reference for toxicologists, ecotoxicologists, riskassessors, regulators, pharmacologists, pharmacists, and graduatestudents in pharmacokinetics and toxicology, Physiologically-BasedPharmacokinetic Modeling compiles information from leaders in thefield and discusses future directions for PBPK modeling.