Percutaneous Absorption

Author : Robert L. Bronaugh,Howard I. Maibach
Publisher : CRC Press
Page : 992 pages
File Size : 51,7 Mb
Release : 1999-05-28
Category : Science
ISBN : 1420000942

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Percutaneous Absorption by Robert L. Bronaugh,Howard I. Maibach Pdf

Since publication of the Second Edition in 1989, numerous innovations have occurred that affect the way scientists look at issues in the field of percutaneous absorption. Focusing on recent advances as well as updating and expanding the scope of topics covered in the previous edition, Percutaneous Absorption, Third Edition provides thorough coverage of the skin's role as an important portal of entry for chemicals into the body. Assembles the work of nearly 80 experts-30 more than the Second Edition-into a unified, comprehensive volume that contains the latest ideas and research! Complete with nearly 600 drawings, photographs, equations, and tables and more than 1600 bibliographic citations of pertinent literature, Percutaneous Absorption, Third Edition details the applied biology of percutaneous penetration factors that affect skin permeation, such as age, vehicles, metabolism, hydration of skin, and chemical structure in vivo and in vitro techniques for measuring absorption, examining factors influencing methodology such as animal models, volatility of test compound, multiple dosage, and artificial membranes procedures for use in transdermal delivery, exploring topics such as effects of penetration enhancers on absorption, optimizing absorption, and the topical delivery of drugs to muscle tissue And presents new chapters on mathematical models cutaneous metabolism prediction of percutaneous absorption in vitro absorption methodology dermal decontamination concentration of chemicals in skin transdermal drug delivery mechanisms of absorption safety evaluation of cosmetics absorption of drugs and cosmetic ingredients nail penetration Emphasizes human applications-particularly useful for pharmacists, pharmacologists, dermatologists, cosmetic scientists, biochemists, toxicologists, public health officials, manufacturers of cosmetic and toiletry products, and graduate students in these disciplines! An invaluable reference source for readers who need to keep up with the latest developments in the field, Percutaneous Absorption, Third Edition is also an excellent experimental guide for laboratory personnel.

Author : Robert L. Bronaugh,Howard I. Maibach
Publisher : Unknown
Page : 688 pages
File Size : 53,6 Mb
Release : 1989
Category : Medical
ISBN : UOM:39015014490109

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Percutaneous Absorption by Robert L. Bronaugh,Howard I. Maibach Pdf

Author : Robert L. Bronaugh,Howard I. Maibach
Publisher : CRC Press
Page : 290 pages
File Size : 52,8 Mb
Release : 2023-06-14
Category : Medical
ISBN : 9781000946628

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In Vitro Percutaneous Absorption by Robert L. Bronaugh,Howard I. Maibach Pdf

This book covers all major areas of interest in the rapidly expanding field of in vitro methods for percutaneous absorption studies. Specific areas discussed include diffusion cell design, receptor fluid, preparation of skin, and temperature. The book covers experimental methodology, as well as the underlying principles and fundamentals that help professionals and students gain an understanding of the basis for currently used methodology.

Author : Hans Schaefer,Thomas E. Redelmeier
Publisher : S. Karger AG (Switzerland)
Page : 336 pages
File Size : 54,6 Mb
Release : 1996
Category : Medical
ISBN : UOM:39015038525732

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Skin Barrier by Hans Schaefer,Thomas E. Redelmeier Pdf

Skin Barrier is the first book to be written exclusively by researchers for researchers as a convenient desktop reference. It focuses on several key aspects of the skin barrier including composition and structure and a description of the properties governing the diffusion of compounds across the skin. Although there has been a large number of laboratories involved in measuring percutaneous absorption over the past 15 to 20 years, it is only recently that there has been a general consensus in the scientific community regarding the development of standard protocols. Recognizing the importance of this, the authors have included two chapters detailing the protocol used in measuring and predicting percutaneous absorption and a discussion on the practical application of these techniques to solve associated problems. In order to provide the researcher and especially the student with access to more detailed information, the book features a comprehensive listing of references published over the past 10 years. Skin Barrier is the only desktop reference for dermatologists, cosmetologists, biochemists, biologists, and those in the pharmaceutics industry, who need detailed and accurate information about the skin barrier on a daily basis. No R & D department should be without a copy.

Author : Nina Dragićević,Howard Maibach
Publisher : CRC Press
Page : 1008 pages
File Size : 42,5 Mb
Release : 2021-07-30
Category : Medical
ISBN : 9780429511561

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Percutaneous Absorption by Nina Dragićević,Howard Maibach Pdf

Updating and expanding the scope of topics covered in the previous edition, Percutaneous Absorption: Drugs, Cosmetics, Mechanisms, Methods, Fifth Edition supplies new chapters on topics currently impacting the field including cutaneous metabolism, skin contamination, exposure to protein allergens, in vitro absorption methodology and the percutaneous absorption of chemical mixtures. Complete with studies on the role of the skin as a key portal of entry for chemicals into the body, this book serves as a detailed reference source for recent advances in the field, as well as an experimental guide for laboratory personnel. Key Features: Details in vivo and in vitro methods for measuring absorption, dermal decontamination, mechanisms of transdermal delivery, and the relationship of transepidermal water loss to percutaneous absorption Considers a range of mathematical models, the safety evaluation of cosmetic ingredients, the absorption of hair dyes, nanoparticles for drug delivery, and other novel methods of drug delivery Discusses topics including skin metabolism, the skin reservoir, and the effects of desquamation on absorption

Author : Michael S. Roberts
Publisher : CRC Press
Page : 704 pages
File Size : 43,9 Mb
Release : 2007-12-14
Category : Medical
ISBN : 9780849375927

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Dermal Absorption and Toxicity Assessment by Michael S. Roberts Pdf

The source Dermal Absorption and Toxicity Assessment supplies a state-of-the-art overview of the dermal absorption process, and is divided into six well organized sections. Written by internationally recognized experts in the field, this Second Edition is a complete revised and updated text, covering the wide range of methods used to assess skin ab

Author : Robert L. Bronaugh,Howard I. Maibach
Publisher : CRC Press
Page : 920 pages
File Size : 42,7 Mb
Release : 2005-07-25
Category : Medical
ISBN : 1574448692

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Percutaneous Absorption by Robert L. Bronaugh,Howard I. Maibach Pdf

Updating and expanding the scope of topics covered in the previous edition, this Fourth Edition supplies new chapters on topics currently impacting the field including cutaneous metabolism, skin contamination, exposure to protein allergens, in vitro absorption methodology, the percutaneous absorption of chemical mixtures, the penetration of chemicals through the hair follicles, dermal drug delivery, mechanisms of absorption, nanoparticles and dermal absorption, the absorption of drugs and cosmetic ingredients, nail penetration, and other current research.

Author : Barbara W. Kemppainen,William G. Reifenrath
Publisher : CRC Press
Page : 244 pages
File Size : 47,7 Mb
Release : 1990-06-13
Category : Medical
ISBN : 0849346517

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Methods for Skin Absorption by Barbara W. Kemppainen,William G. Reifenrath Pdf

This up-to-date volume describes the wide variety of available methods concerning percutaneous absorption of drugs and toxins. It discusses in detail the advantages and disadvantages of each method. This unique publication provides a clear, systematic presentation of each aspect which must be considered when designing and performing skin penetration experiments and when interpreting results. It includes specific information regarding necessary supplies and equipment, along with commercial sources for these items. This state-of-the-art book is an ideal instructional manual for investigators uninitiated in performing percutaneous absorption and metabolism studies. Those involved with investigative dermatology, dermatological research, toxicology, and pharmacology will find this reference interesting and indispensable.

Author : Gary P. Moss,Darren R. Gullick,Simon C. Wilkinson
Publisher : Springer
Page : 199 pages
File Size : 44,8 Mb
Release : 2015-07-01
Category : Medical
ISBN : 9783662473719

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Predictive Methods in Percutaneous Absorption by Gary P. Moss,Darren R. Gullick,Simon C. Wilkinson Pdf

This book sheds new light on the development and use of quantitative models to describe the process of skin permeation. It critically reviews the development of quantitative predictive models of skin absorption and discusses key recommendations for model development. Topics presented include an introduction to skin physiology; the underlying theories of skin absorption; the physical laboratory-based processes used to generate skin absorption data, which is in turn used to construct mathematical models describing the skin permeation process; algorithms of skin permeability including quantitative structure-activity (or permeability) relationships (QSARs or QSPRs); relationships between permeability and molecular properties; the development of formulation-focused approaches to models of skin permeability prediction; the use of artificial membranes, e.g. polydimethylsiloxane as alternatives to mammalian skin; and lastly, the use of novel Machine Learning methods in developing the next generation of predictive skin permeability models. The book will be of interest to all researchers in academia and industry working in pharmaceutical discovery and development, as well as readers from the field of occupational exposure and risk assessment, especially those whose work involves agrochemicals, bulk chemicals and cosmetics.

Author : Robert L. Bronaugh,Howard I. Maibach
Publisher : Unknown
Page : 878 pages
File Size : 43,7 Mb
Release : 2010
Category : Skin
ISBN : OCLC:1065693554

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Percutaneous Absorption by Robert L. Bronaugh,Howard I. Maibach Pdf

Author : Vinod P. Shah,Howard I. Maibach,John Jenner
Publisher : Springer
Page : 402 pages
File Size : 52,7 Mb
Release : 2015-01-30
Category : Medical
ISBN : 9781493912896

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Topical Drug Bioavailability, Bioequivalence, and Penetration by Vinod P. Shah,Howard I. Maibach,John Jenner Pdf

This authoritative volume explores advances in the techniques used to measure percutaneous penetration of drugs and chemicals to assess bioavailability and bioequivalence and discusses how they have been used in clinical and scientific investigations. Seven comprehensive sections examine topics including in vitro drug release, topical drugs products, clinical studies, and guidelines and workshop reports, among others. The book also describes how targeted transdermal drug delivery and more sophisticated mathematical modelling can aid in understanding the bioavailability of transdermal drugs. The first edition of this book was an important reference guide for researchers working to define the effectiveness and safety of drugs and chemicals that penetrated the skin. This second edition contains cutting-edge advances in the field and is a key resource to those seeking to define the bioavailability and bioequivalence of percutaneously active compounds to improve scientific and clinical investigation and regulation.

Author : Francis N. Marzulli,Howard I. Maibach
Publisher : CRC Press
Page : 420 pages
File Size : 49,9 Mb
Release : 2019-05-07
Category : Medical
ISBN : 1439805873

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Dermatotoxicology Methods by Francis N. Marzulli,Howard I. Maibach Pdf

This work presents and evaluates methods employed to identify the potential of certain types of chemicals to adversely affect the skin. A variety of test methods are included such as tests for skin penetration, metabolism, irritation, the skin immune system, photo effects, skin cancer, and topical effects of retinoids and depigmenting chemicals. Tests for chemicals that affect the reproductive and nervous system are also included. Both animal and human tests that have been standardised and tests that are under development and employ animal alternatives are addressed in this book. Besides different testing methods, a rationale for accepting non-animal models and a review of some regulatory agency discussions about animal alternative tests are included.

Author : Zacarías León González
Publisher : Springer Science & Business Media
Page : 216 pages
File Size : 41,9 Mb
Release : 2013-12-24
Category : Science
ISBN : 9783319011899

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Percutaneous Absorption of UV Filters Contained in Sunscreen Cosmetic Products by Zacarías León González Pdf

Zacarías León's thesis describes the development and validation of analytical methods to estimate the processes set in motion by percutaneous absorption of UV filters in sunscreen cosmetic products. León describes these methods in both in vitro and non-invasive in vivo methodologies. Currently dermatologists recommend the use of sunscreen products not only under conditions of extreme exposure to the sun but also in daily situations. However the chemical compounds in these products contain may lead to undesired processes and cause induced toxicity, estrogenic effects and endocrine activity. León establishes methods to investigate these effects and provides valuable information on the undesired side effects associated with the use of UV filters found in sunscreen products. The work in this thesis has led to a number of publications in renowned analytical chemistry journals.

Author : Robert L. Bronaugh,Howard I. Maibach
Publisher : CRC-Press
Page : 288 pages
File Size : 42,9 Mb
Release : 1991-07-24
Category : Medical
ISBN : 0849347483

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In Vitro Percutqaneous Absorption by Robert L. Bronaugh,Howard I. Maibach Pdf

This book covers all major areas of interest in the rapidly expanding field of in vitro methods for percutaneous absorption studies. Specific areas discussed include diffusion cell design, receptor fluid, preparation of skin, and temperature. The book covers experimental methodology, as well as the underlying principles and fundamentals that help professionals and students gain an understanding of the basis for currently used methodology.

Author : Jim E. Riviere,Nancy A. Monteiro-Riviere
Publisher : CRC Press
Page : 392 pages
File Size : 44,8 Mb
Release : 2005-08-24
Category : Medical
ISBN : 0203020820

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Dermal Absorption Models in Toxicology and Pharmacology by Jim E. Riviere,Nancy A. Monteiro-Riviere Pdf

Many experimental methods and mathematical modeling approaches rooted in disciplines outside of toxicology can be effectively applied to estimating dermal absorption. Dermal Absorption Models in Toxicology and Pharmacology explores current approaches and techniques that can be used to quantify dermal absorption with endpoints useful in both toxicology and pharmacology. The book begins with a review of basic principles and the in vitro and in vivo experimental approaches available for assessing dermal absorption of drugs and chemicals. This is followed by coverage of mathematical or in silico models for quantitating percutaneous absorption and the applications of these techniques to the risk assessment process. The remainder of the book explores scenarios where the unique properties of the chemicals being studied or the matrix in which they are exposed must be considered and then wraps up with a comparative analysis of chemical permeability in human and animal skin. Many of the books covering this subject are just too comprehensive and serve primarily as reference works. This book takes a different approach. Jim Riviere's editorial guidance ensures that the information is readable, accessible, authoritative, and concise, making it the perfect resource for familiarizing new researchers and students to the field and updating established scientists.