Dermatotoxicology Sixth Edition

Author : Hongbo Zhai,Howard I. Maibach
Publisher : CRC Press
Page : 1232 pages
File Size : 48,7 Mb
Release : 2004-02-25
Category : Medical
ISBN : 0415288622

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Dermatotoxicology, Sixth Edition by Hongbo Zhai,Howard I. Maibach Pdf

For twenty-five years, Dermatotoxicology has stood as the definitive reference book in the field. A generation of toxicologists and dermatologists has consulted this volume throughout their careers, finding within it a wealth of theoretical and practical guidance. Updated and expanded to reflect the latest developments in skin toxicology, Dermatotoxicology, Sixth Edition includes fundamental information on the mechanisms of action of toxic substances on the skin, as well as practical information on the various methods to evaluating dermal toxicity. It is unparalleled in its coverage, and this new edition broadens its scope to include chapters on: * Barrier Creams * Cosmetic Reactions * UV Radiation Exposure * Electron Paramagnetic Resonance * Powdered Human Stratum Corneum * Iontophoresis * Permeability of Skin for Metal Compounds * Current Trends in Skin Cancer Research * Tape Stripping Method v. Stratum Corneum * Hazardous Substances from Soil and Water * Isolated Perfused Porcine Skin Flap * Physiologically-based Pharmacokinetic Models This completely revised and reworked edition constitutes a major contribution to the field of dermatotoxicology. Presenting the most modern concepts and methods in use today, researchers and clinicians will find this an invaluable resource time and time again.

Author : Klaus Peter Wilhelm,Hongbo Zhai,Howard I. Maibach
Publisher : CRC Press
Page : 1044 pages
File Size : 43,5 Mb
Release : 2007-11-26
Category : Medical
ISBN : 9781420009774

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Dermatotoxicology by Klaus Peter Wilhelm,Hongbo Zhai,Howard I. Maibach Pdf

Reflecting the embryonic state of the field, the first edition of Dermatoxicology, published in 1977, numbered 567 pages. Now the foundational reference in dermal toxicology, this seventh edition consists of 1,032 pages and defines what was once a largely intuitive field but has evolved into an established science of metrics and mechanisms. Updated

Author : Klaus Peter Wilhelm,Hongbo Zhai,Howard I. Maibach
Publisher : CRC Press
Page : 0 pages
File Size : 52,7 Mb
Release : 2012-09-27
Category : Medical
ISBN : 1841848557

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Dermatotoxicology, Eighth Edition by Klaus Peter Wilhelm,Hongbo Zhai,Howard I. Maibach Pdf

The foundational reference in dermal toxicology, this classic text has been completely revised to bring it up to date in the new Eighth Edition, with almost a third of its chapters being newly added. The structure of the text has also been reorganized to enable easier location of a topic of interest. With contributions from leading international experts, this continues the tradition of providing unsurpassed theoretical and practical guidance for all those working on research aspects, on practical clinical issues, and on the regulatory aspects of exposure to toxic substances. This new edition contains updates to each chapter and contributions from leading international experts, provides an in-depth summary of research and regulatory applications related to dermal toxicology and pharmacology, presents many new chapters that describe the latest advances in dermatotoxicology, and addresses various levels of expertise regarding the development and use of dermal exposure data. New chapters include those on safety terminology, pharmacogenetics and dermatology, ethnic differences in skin properties, and the principles and practice of percutaneous absorption.

Author : Hongbo Zhai,Howard I. Maibach
Publisher : CRC Press
Page : 1232 pages
File Size : 49,9 Mb
Release : 2004-02-25
Category : Medical
ISBN : 9780203426272

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Dermatotoxicology by Hongbo Zhai,Howard I. Maibach Pdf

For twenty-five years, Dermatotoxicology has stood as the definitive reference book in the field. A generation of toxicologists and dermatologists has consulted this volume throughout their careers, finding within it a wealth of theoretical and practical guidance. Updated and expanded to reflect the latest developments in skin toxicology, De

Author : A. Wallace Hayes,Claire L. Kruger
Publisher : CRC Press
Page : 2186 pages
File Size : 46,8 Mb
Release : 2014-10-10
Category : Medical
ISBN : 9781842145364

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Hayes' Principles and Methods of Toxicology, Sixth Edition by A. Wallace Hayes,Claire L. Kruger Pdf

Hayes’ Principles and Methods of Toxicology has long been established as a reliable reference to the concepts, methodologies, and assessments integral to toxicology. The new sixth edition has been revised and updated while maintaining the same high standards that have made this volume a benchmark resource in the field. With new authors and new chapters that address the advances and developments since the fifth edition, the book presents everything toxicologists and students need to know to understand hazards and mechanisms of toxicity, enabling them to better assess risk. The book begins with the four basic principles of toxicology—dose matters, people differ, everything transforms, and timing is crucial. The contributors discuss various agents of toxicity, including foodborne, solvents, crop protection chemicals, radiation, and plant and animal toxins. They examine various methods for defining and measuring toxicity in a host of areas, including genetics, carcinogenicity, toxicity in major body systems, and the environment. This new edition contains an expanded glossary reflecting significant changes in the field. New topics in this edition include: The importance of dose–response Systems toxicology Food safety The humane use and care of animals Neurotoxicology The comprehensive coverage and clear writing style make this volume an invaluable text for students and a one-stop reference for professionals.

Author : Christopher Sudhakar
Publisher : BoD – Books on Demand
Page : 212 pages
File Size : 42,6 Mb
Release : 2012-02-22
Category : Medical
ISBN : 9789535100553

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Infection Control by Christopher Sudhakar Pdf

Health care associated infection is coupled with significant morbidity and mortality. Prevention and control of infection is indispensable part of health care delivery system. Knowledge of Preventing HAI can help health care providers to make informed and therapeutic decisions thereby prevent or reduce these infections. Infection control is continuously evolving science that is constantly being updated and enhanced. The book will be very useful for all health care professionals to combat with health care associated infections.

Author : Sean Ekins
Publisher : John Wiley & Sons
Page : 855 pages
File Size : 46,5 Mb
Release : 2007-06-30
Category : Science
ISBN : 9780470145883

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Computational Toxicology by Sean Ekins Pdf

A comprehensive analysis of state-of-the-art molecular modeling approaches and strategies applied to risk assessment for pharmaceutical and environmental chemicals This unique volume describes how the interaction of molecules with toxicologically relevant targets can be predicted using computer-based tools utilizing X-ray crystal structures or homology, receptor, pharmacophore, and quantitative structure activity relationship (QSAR) models of human proteins. It covers the in vitro models used, newer technologies, and regulatory aspects. The book offers a complete systems perspective to risk assessment prediction, discussing experimental and computational approaches in detail, with: * An introduction to toxicology methods and an explanation of computational methods * In-depth reviews of QSAR methods applied to enzymes, transporters, nuclear receptors, and ion channels * Sections on applying computers to toxicology assessment in the pharmaceutical industry and in the environmental arena * Chapters written by leading international experts * Figures that illustrate computational models and references for further information This is a key resource for toxicologists and scientists in the pharmaceutical industry and environmental sciences as well as researchers involved in ADMET, drug discovery, and technology and software development.

Author : Francis Nicholas Marzulli,Howard I. Maibach
Publisher : Hemisphere Pub
Page : 604 pages
File Size : 53,7 Mb
Release : 1977
Category : Contact dermatitis
ISBN : UOM:39015003227629

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Dermatotoxicology and Pharmacology by Francis Nicholas Marzulli,Howard I. Maibach Pdf

Author : Peter A. McAnulty,Anthony D. Dayan,Niels-Christian Ganderup,Kenneth L. Hastings
Publisher : CRC Press
Page : 713 pages
File Size : 40,5 Mb
Release : 2011-12-19
Category : Medical
ISBN : 9781439811184

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The Minipig in Biomedical Research by Peter A. McAnulty,Anthony D. Dayan,Niels-Christian Ganderup,Kenneth L. Hastings Pdf

The Minipig in Biomedical Research is a comprehensive resource for research scientists on the potential and use of the minipig in basic and applied biomedical research, and the development of drugs and chemicals. Written by acknowledged experts in the field, and drawing on the authors’ global contacts and experience with regulatory authorities and the pharmaceutical and other industries, this accessible manual ranges widely over the biological, scientific, and practical uses of the minipig in the laboratory. Its coverage extends from the minipig’s origins, anatomy, genetics, immunology, and physiology to its welfare, health, and husbandry; practical dosing and examination procedures; surgical techniques; and all areas of toxicity testing and the uses of the minipig as a disease model. Regulatory aspects of its use are considered. The reader will find an extensive amount of theoretical and practical information in the pharmacology; ADME and toxicology chapters which will help scientists and managers when deciding which species to use in basic research; drug discovery and pharmacology; and toxicology studies of chemicals, biotechnology products and devices. The book discusses regulatory uses of minipigs in the evaluation of human and veterinary pharmaceuticals, medical devices, and other classes of xenobiotics. It describes features of normal health, normal laboratory values, and common diseases. It also carefully elucidates ethical and legal considerations in their supply, housing, and transport. The result is an all-inclusive and up to date manual about the experimental uses of the minipig that describes ‘How to’ and ‘Why’ and ’What to expect in the normal’, combining enthusiasm and experience with critical assessment of its values and potential problems.

Author : Miranda A. Farage,Howard I. Maibach
Publisher : CRC Press
Page : 346 pages
File Size : 51,7 Mb
Release : 2016-04-19
Category : Medical
ISBN : 9781420005318

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The Vulva by Miranda A. Farage,Howard I. Maibach Pdf

Addressing common misconceptions concerning the dermatologic composition and assessment of vulvular skin, this book is a unique compilation of current research and information on the anatomy, physiology, toxicology, microbiology, and diagnosis of the vulva and surrounding anatomical structures. A must-have source for anyone treating female patients, this source considers age and ethnicity factors and analyzes a wide range of symptoms, skin conditions, and diseases that physicians may encounter when caring for female patients.

Author : Anonim
Publisher : Unknown
Page : 1576 pages
File Size : 48,8 Mb
Release : 2004
Category : Environmental health
ISBN : RUTGERS:39030033377435

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Environmental Health Perspectives by Anonim Pdf

Author : Michael S. Roberts
Publisher : CRC Press
Page : 704 pages
File Size : 44,8 Mb
Release : 2007-12-14
Category : Medical
ISBN : 9780849375927

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Dermal Absorption and Toxicity Assessment by Michael S. Roberts Pdf

The source Dermal Absorption and Toxicity Assessment supplies a state-of-the-art overview of the dermal absorption process, and is divided into six well organized sections. Written by internationally recognized experts in the field, this Second Edition is a complete revised and updated text, covering the wide range of methods used to assess skin ab

Author : A. Wallace Hayes,Tetyana Kobets
Publisher : CRC Press
Page : 2143 pages
File Size : 46,9 Mb
Release : 2023-07-03
Category : Medical
ISBN : 9781000875775

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Hayes' Principles and Methods of Toxicology by A. Wallace Hayes,Tetyana Kobets Pdf

Hayes’ Principles and Methods of Toxicology has long been established as a reliable and informative reference for the concepts, methodologies, and assessments integral to toxicology. The new edition contains updated and new chapters with the addition of new authors while maintaining the same high standards that have made this book a benchmark resource in the field. Key Features: The comprehensive yet concise coverage of various aspects of fundamental and applied toxicology makes this book a valuable resource for educators, students, and professionals. Questions provided at the end of each chapter allow readers to test their knowledge and understanding of the material covered. All chapters have been updated and over 60 new authors have been added to reflect the dynamic nature of toxicological sciences New topics in this edition include Safety Assessment of Cosmetics and Personal Care Products, The Importance of the Dose/Rate Response, Novel Approaches and Alternative Models, Epigenetic Toxicology, and an Expanded Glossary. The volume is divided into 4 major sections, addressing fundamental principles of toxicology (Section I. "Principles of Toxicology"), major classes of established chemical hazards (Section II. "Agents"), current methods used for the assessment of various endpoints indicative of chemical toxicity (Section III. "Methods"), as well as toxicology of specific target systems and organs (Section IV. "Organ- and System-Specific Toxicology"). This volume will be a valuable tool for the audience that wishes to broaden their understanding of hazards and mechanisms of toxicity and to stay on top of the emerging methods and concepts of the rapidly advancing field of toxicology and risk assessment.

Author : Byung-Mu Lee,Sam Kacew
Publisher : CRC Press
Page : 389 pages
File Size : 46,5 Mb
Release : 2012-09-21
Category : Medical
ISBN : 9781841849546

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Lu's Basic Toxicology by Byung-Mu Lee,Sam Kacew Pdf

This new edition of our bestselling book, Lu's Basic Toxicology, provides a number of key benefits that make it a must-read for toxicology specialists worldwide, including:Revision of a Bestseller - the new Sixth Edition provides the critical updates toxicologists need to keep up with the changing timesNew Information - on over-the-counter preparat

Author : Nina Dragicevic,Howard I. Maibach
Publisher : Springer
Page : 414 pages
File Size : 40,8 Mb
Release : 2017-05-04
Category : Medical
ISBN : 9783662532706

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Percutaneous Penetration Enhancers Drug Penetration Into/Through the Skin by Nina Dragicevic,Howard I. Maibach Pdf

Percutaneous Penetration Enhancers in a mini-series format comprising five volumes, represents the most comprehensive reference on enhancement methods – both well established and recently introduced – in the field of dermal/transdermal drug delivery. In detail the broad range of both chemical and physical methods used to enhance the skin delivery of drugs is described. All aspects of drug delivery and measurement of penetration are covered, and the latest findings are provided on skin structure and function, mathematics in skin permeation, and modern analytical techniques adapted to assess and measure penetration. In offering a detailed description of the methods currently in use for penetration enhancement, this book will be of value for researchers, pharmaceutical scientists, practitioners, students and dermatological scientists or dermatologists​.