Design And Strategy In Organic Synthesis

Design And Strategy In Organic Synthesis Book in PDF, ePub and Kindle version is available to download in english. Read online anytime anywhere directly from your device. Click on the download button below to get a free pdf file of Design And Strategy In Organic Synthesis book. This book definitely worth reading, it is an incredibly well-written.

Design and Strategy in Organic Synthesis

Stephen Hanessian,Simon Giroux,Bradley L. Merner
Design and Strategy in Organic Synthesis Book PDF

Author : Stephen Hanessian,Simon Giroux,Bradley L. Merner
Publisher : Wiley-VCH
Page : 0 pages
File Size : 45,6 Mb
Release : 2013-09-03
Category : Science
ISBN : 3527319646

Get Book

Design and Strategy in Organic Synthesis by Stephen Hanessian,Simon Giroux,Bradley L. Merner Pdf

This long-awaited graduate level book, written by one of the world's leading organic chemists in collaboration with two of his former and present coworkers, adopts a refreshingly unique approach to synthesis planning and execution. Following an introductory look at the concept of synthesis, the authors discuss the Why, What, and How of organic synthesis as they apply to natural products. Although emphasis is on the Chiron Approach utilizing amino-acids, carbohydrates, hydroxy acids, terpenes, lactones and other naturally occurring small molecules as starting materials, catalytic asymmetric methods are also included as a corollary whenever relevant. A must-have source of first class information for everyone working in organic synthesis, be it in academia or industry. With a foreword by Larry E. Overman and David W. C. MacMillan

Design and Strategy in Organic Synthesis

Stephen Hanessian,Simon Giroux,Bradley L. Merner
Design and Strategy in Organic Synthesis Book PDF

Author : Stephen Hanessian,Simon Giroux,Bradley L. Merner
Publisher : Wiley-VCH
Page : 0 pages
File Size : 52,9 Mb
Release : 2013-09-03
Category : Science
ISBN : 3527333916

Get Book

Design and Strategy in Organic Synthesis by Stephen Hanessian,Simon Giroux,Bradley L. Merner Pdf

Following an introductory look at the concept of synthesis, this text goes on to discuss sources of enantiomerically pure compounds, the Chiron approach, locating the various substructures, synthesis with the various precursors and computer-aided synthesis--

Design and Optimization in Organic Synthesis

Rolf Carlson,Johan E. Carlson
Design and Optimization in Organic Synthesis Book PDF

Author : Rolf Carlson,Johan E. Carlson
Publisher : Elsevier
Page : 594 pages
File Size : 43,7 Mb
Release : 2005-04-08
Category : Science
ISBN : 9780080455273

Get Book

Design and Optimization in Organic Synthesis by Rolf Carlson,Johan E. Carlson Pdf

Revised, and updated Design and Optimization in Organic Synthesis presents strategies to explore experimental conditions and methodologies for systematic studies of entire reaction systems (substrates, reagent(s), catalyst(s), and solvents). Chemical phenomena are not usually the result of a single factor and this book describes how statistically designed methods can be used to analyse and evaluate synthetic procedures. The methodology is based on multivariate statistical techniques. The accompanying CD contains data tables and programmes. This book is essential reading for anyone working in process design and development in fine chemicals or the pharmaceutical industry, and is suitable for those with no experience in the field. * Contains recalculated models and redrawn figures, as well as new chapters on for example, the design of combinatorial libraries * Presents strategies to explore experimental conditions and methodologies * Enables the analysis and prediction of the best synthetic procedures

The Algebra of Organic Synthesis

John Andraos
The Algebra of Organic Synthesis Book PDF

Author : John Andraos
Publisher : CRC Press
Page : 1221 pages
File Size : 47,5 Mb
Release : 2016-04-19
Category : Science
ISBN : 9781420093292

Get Book

The Algebra of Organic Synthesis by John Andraos Pdf

The Algebra of Organic Synthesis combines the aims, philosophies, and efforts involved in organic synthesis, reaction optimization, and green chemistry with techniques for determining quantitatively just how "green" synthesis plans are. It provides the first complete quantitative description of synthesis strategy analysis in the context of green ch

Organic Chemistry in Action

F. Serratosa
Organic Chemistry in Action Book PDF

Author : F. Serratosa
Publisher : Elsevier
Page : 418 pages
File Size : 46,5 Mb
Release : 2013-10-22
Category : Science
ISBN : 9781483290928

Get Book

Organic Chemistry in Action by F. Serratosa Pdf

Contrary to all other books in the field of organic synthesis, this volume combines Corey's methodology, which is based on the concept of synthon and retrosynthetic analysis, with Evans' methodology based on the `Lapworth model' of alternating polarities. Using this approach, the formation of carbon-carbon bonds and the manipulation of functional groups are treated together, whereas the stereochemical aspects are considered separately. Emphasis is laid on the importance of rigid structures, whether in the starting materials, the synthetic intermediates or the transition states, as a means of controlling the stereochemistry of the organic compounds. Enclosed with the book is a copy of a miniprogram (CHAOS) for an IBM PC, or fully compatible computers, which is an interactive program, affording the beginner a fast and easy way of learning, exploring and looking for new synthetic schemes of molecules of moderate complexity. As a textbook on organic synthesis, this volume will be of immense value at university level.

Design and Optimization in Organic Synthesis

Rolf Carlson,Johan E. Carlson
Design and Optimization in Organic Synthesis Book PDF

Author : Rolf Carlson,Johan E. Carlson
Publisher : Elsevier Science Limited
Page : 574 pages
File Size : 44,6 Mb
Release : 2005
Category : Science
ISBN : 0444515275

Get Book

Design and Optimization in Organic Synthesis by Rolf Carlson,Johan E. Carlson Pdf

Revised, and updated Design and Optimization in Organic Synthesis presents strategies to explore experimental conditions and methodologies for systematic studies of entire reaction systems (substrates, reagent(s), catalyst(s), and solvents). Chemical phenomena are not usually the result of a single factor and this book describes how statistically designed methods can be used to analyse and evaluate synthetic procedures. The methodology is based on multivariate statistical techniques. The accompanying CD contains data tables and programmes. This book is essential reading for anyone working in process design and development in fine chemicals or the pharmaceutical industry, and is suitable for those with no experience in the field. * Contains recalculated models and redrawn figures, as well as new chapters on for example, the design of combinatorial libraries * Presents strategies to explore experimental conditions and methodologies * Enables the analysis and prediction of the best synthetic procedures

Design and Optimization in Organic Synthesis

R. Carlson
Design and Optimization in Organic Synthesis Book PDF

Author : R. Carlson
Publisher : Elsevier
Page : 553 pages
File Size : 52,7 Mb
Release : 1991-11-21
Category : Science
ISBN : 9780080868356

Get Book

Design and Optimization in Organic Synthesis by R. Carlson Pdf

This is the first general textbook on experimental design and optimization in organic synthesis. The book presents a unified methodology for carrying out systematic studies when the objective is to develop efficient and optimum synthetic methods. Strategies are included both for exploring the experimental conditions and for systematic studies of entire reaction systems (substrates, reagent(s) and solvents). The methodology is based on multivariate statistical techniques. The following topics are treated in depth: classical two-level designs for screening experiments, gradient methods (steepest ascent, simplex methods) as well as response surface techniques for optimization, principal components analysis and PLS modelling. The book is intended as a hands-on text for chemists and engineers engaged in developing synthetic methods in industrial research, e.g. in fine chemicals and pharmaceuticals production, as well as for advanced undergraduate students, graduate students, and researchers in an academic environment.

Designing Organic Syntheses

Stuart Warren
Designing Organic Syntheses Book PDF

Author : Stuart Warren
Publisher : John Wiley & Sons
Page : 298 pages
File Size : 41,5 Mb
Release : 1991-01-08
Category : Science
ISBN : 0471996122

Get Book

Designing Organic Syntheses by Stuart Warren Pdf

Teaches students to use the language of sythesis directly (utilizing the grammar of synthon and disconnection) rather than translating it into that of organic chemistry.

Strategies and Tactics in Organic Synthesis

Erik J. Sorensen,David A. Siler,Jeffrey D. Mighion
Strategies and Tactics in Organic Synthesis Book PDF

Author : Erik J. Sorensen,David A. Siler,Jeffrey D. Mighion
Publisher : Elsevier Inc. Chapters
Page : 344 pages
File Size : 55,8 Mb
Release : 2013-07-29
Category : Science
ISBN : 9780128056127

Get Book

Strategies and Tactics in Organic Synthesis by Erik J. Sorensen,David A. Siler,Jeffrey D. Mighion Pdf

This chapter defines risk-taking in organic synthesis as the deliberate pursuit of strategies that do not have near neighbors in the chemical literature. In these ventures into the unknown, chemical behavior can be difficult to predict. The literature of organic chemistry is replete with examples of powerful, bond-forming strategies that had little or no precedent when they were developed. This essay addresses some of those examples in an effort to demonstrate the merits of creative risk-taking in the planning and execution of organic syntheses.

Strategies for Organic Drug Synthesis and Design

Daniel Lednicer
Strategies for Organic Drug Synthesis and Design Book PDF

Author : Daniel Lednicer
Publisher : John Wiley & Sons
Page : 700 pages
File Size : 46,8 Mb
Release : 2009-03-04
Category : Science
ISBN : 0470399597

Get Book

Strategies for Organic Drug Synthesis and Design by Daniel Lednicer Pdf

This book examines and evaluates the strategies utilized to design and synthesize pharmaceutically active agents. Significant updates over the last 10 years since the publication of the 1st edition include synthesis of enantiomerically pure isomers, novel chemical methodologies, and new pharmaceutical agents targeted at novel biological endpoints. Written by an experienced successful author, this book meets the needs of a growing community of researchers in pharmaceutical R &D, as well as medical professionals, by providing a useful guide for designing and synthesizing pharmaceutical agents. Additionally, it is a useful text for medicinal chemistry students.

Introduction to Strategies for Organic Synthesis

Laurie S. Starkey
Introduction to Strategies for Organic Synthesis Book PDF

Author : Laurie S. Starkey
Publisher : John Wiley & Sons
Page : 360 pages
File Size : 54,6 Mb
Release : 2012-01-18
Category : Science
ISBN : 9781118180853

Get Book

Introduction to Strategies for Organic Synthesis by Laurie S. Starkey Pdf

The stepping-stone text for students with a preliminary knowledge of organic chemistry looking to move into organic synthesis research and graduate-level coursework Organic synthesis is an advanced but important field of organic chemistry, however resources for advanced undergraduates and graduate students moving from introductory organic chemistry courses to organic synthesis research are scarce. Introduction to Strategies for Organic Synthesis is designed to fill this void, teaching practical skills for making logical retrosynthetic disconnections, while reviewing basic organic transformations, reactions, and reactivities. Divided into seven parts that include sections on Retrosynthesis and Protective Groups; Overview of Organic Transformations; Synthesis of Monofunctional Target Molecules; Synthesis of Target Molecules with Two Functional Groups; Synthesis of Aromatic Target Molecules; Synthesis of Compounds Containing Rings; and Predicting and Controlling Stereochemistry, the book covers everything students need to successfully perform retrosynthetic analyses of target molecule synthesis. Starting with a review of functional group transformations, reagents, and reaction mechanisms, the book demonstrates how to plan a synthesis, explaining functional group analysis and strategic disconnections. Incorporating a review of the organic reactions covered, it also demonstrates each reaction from a synthetic chemist's point of view, to provide students with a clearer understanding of how retrosynthetic disconnections are made. Including detailed solutions to over 300 problems, worked-through examples and end-of-chapter comprehension problems, Introduction to Strategies for Organic Synthesis serves as a stepping stone for students with an introductory knowledge of organic chemistry looking to progress to more advanced synthetic concepts and methodologies.

The Way of Synthesis

Tomas Hudlicky,Josephine W. Reed
The Way of Synthesis Book PDF

Author : Tomas Hudlicky,Josephine W. Reed
Publisher : Wiley-VCH
Page : 1032 pages
File Size : 43,7 Mb
Release : 2007-09-04
Category : Science
ISBN : UVA:X030338033

Get Book

The Way of Synthesis by Tomas Hudlicky,Josephine W. Reed Pdf

This two-colored textbook presents not only synthetic ways to design organic compounds, it also contains a compilation of the most important total synthesis of the last 50 years with a comparative view of multiple designs for the same targets. It explains different tactics and strategies, making it easy to apply to many problems, regardless of the synthetic question in hand. Following a historical view of the evolution of synthesis, the book goes on to look at principles and issues impacting synthesis and design as well as principles and issues of methods. The sections on comparative design cover classics in terpenes and alkaloid synthesis, while a further section covers such miscellaneous syntheses as Maytansine, Palytoxin, Brevetoxin B and Indinavir. The whole is rounded off with a look at future perspectives and, what makes this textbook extraordinairy, with personal recollections of the chemists, who synthesized these fascinating compounds. With its attractive layout highlighting key parts and tactics using a second color, this is a useful tool for organic chemists, lecturers and students in chemistry, as well as those working in the chemical industry. "I think, as will many organic chemists, that the Hudlicky book will be the Bible of synthetic organic chemistry, the past, the present and the future. A hallmark publication." (Victor Snieckus)

Solid-Phase Organic Synthesis

Patrick H. Toy,Yulin Lam
Solid Phase Organic Synthesis Book PDF

Author : Patrick H. Toy,Yulin Lam
Publisher : John Wiley & Sons
Page : 560 pages
File Size : 53,7 Mb
Release : 2012-01-10
Category : Science
ISBN : 9781118141632

Get Book

Solid-Phase Organic Synthesis by Patrick H. Toy,Yulin Lam Pdf

Presents both the fundamental concepts and the most recent applications in solid-phase organic synthesis With its emphasis on basic concepts, Solid-Phase Organic Synthesis guides readers through all the steps needed to design and perform successful solid-phase organic syntheses. The authors focus on the fundamentals of heterogeneous supports in the synthesis of organic molecules, explaining the use of a solid material to facilitate organic synthesis. This comprehensive text not only presents the fundamentals, but also reviews the most recent research findings and applications, offering readers everything needed to conduct their own state-of-the-art science experiments. Featuring chapters written by leading researchers in the field, Solid-Phase Organic Synthesis is divided into two parts: Part One, Concepts and Strategies, discusses the linker groups used to attach the synthesis substrate to the solid support, colorimetric tests to identify the presence of functional groups, combinatorial synthesis, and diversity-oriented synthesis. Readers will discover how solid-phase synthesis is currently used to facilitate the discovery of new molecular functionality. The final chapter discusses how using a support can change or increase reaction selectivity. Part Two, Applications, presents examples of the solid-phase synthesis of various classes of organic molecules. Chapters explore general asymmetric synthesis on a support, strategies for heterocyclic synthesis, and synthesis of radioactive organic molecules, dyes, dendrimers, and oligosaccharides. Each chapter ends with a set of conclusions that underscore the key concepts and methods. References in each chapter enable readers to investigate any topic in greater depth. With its presentation of basic concepts as well as recent findings and applications, Solid-Phase Organic Synthesis is the ideal starting point for students and researchers in organic, medicinal, and combinatorial chemistry who want to take full advantage of current solid-phase synthesis techniques.

Strategic Applications of Named Reactions in Organic Synthesis

Laszlo Kurti,Barbara Czako
Strategic Applications of Named Reactions in Organic Synthesis Book PDF

Author : Laszlo Kurti,Barbara Czako
Publisher : Elsevier
Page : 808 pages
File Size : 48,9 Mb
Release : 2005-04-29
Category : Science
ISBN : 9780080575414

Get Book

Strategic Applications of Named Reactions in Organic Synthesis by Laszlo Kurti,Barbara Czako Pdf

Kurti and Czako have produced an indispensable tool for specialists and non-specialists in organic chemistry. This innovative reference work includes 250 organic reactions and their strategic use in the synthesis of complex natural and unnatural products. Reactions are thoroughly discussed in a convenient, two-page layout--using full color. Its comprehensive coverage, superb organization, quality of presentation, and wealth of references, make this a necessity for every organic chemist. * The first reference work on named reactions to present colored schemes for easier understanding* 250 frequently used named reactions are presented in a convenient two-page layout with numerous examples* An opening list of abbreviations includes both structures and chemical names * Contains more than 10,000 references grouped by seminal papers, reviews, modifications, and theoretical works * Appendices list reactions in order of discovery, group by contemporary usage, and provide additional study tools* Extensive index quickly locates information using words found in text and drawings

Strategies and Tactics In Organic Synthesis

Thomas Lindberg
Strategies and Tactics In Organic Synthesis Book PDF

Author : Thomas Lindberg
Publisher : Elsevier
Page : 385 pages
File Size : 52,5 Mb
Release : 2012-12-02
Category : Science
ISBN : 9780323152938

Get Book

Strategies and Tactics In Organic Synthesis by Thomas Lindberg Pdf

Strategies and Tactics in Organic Synthesis presents the chronological development of ideas and experimentation in organic synthesis. This book is organized into 13 chapters that explore the synthetic pathways of various organic compounds. The first four chapters describe the variations in the synthesis of superphane, gibberellic acid, prostaglandin, and alkaloids. The following chapters cover the organic synthesis and biosynthesis of tylonolide, endiandric acids A-G, dodecahedrane, fomannosin, and illudol. A chapter focuses on the evolution of the total synthesis of jatrophone, an architecturally interesting macrocyclic diterpene extracted from Jatropha gossypiifolia. Another chapter discusses the heuristic principle for the stereorationale design of alkaloid syntheses. The remaining chapters discuss the approach to the total synthesis of steroids, streptonigrin, methynolide, and Prelog-Djerassi lactonic acid. Organic chemists, teachers, and students will find this book of great value.