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Author : Christine Edith Boschen
Publisher : Unknown
Page : 328 pages
File Size : 50,9 Mb
Release : 1998
Category : Amoxicillin
ISBN : UCR:31210010608030
Author : Stuart B. Levy,Robert Verne Miller
Publisher : McGraw-Hill Companies
Page : 458 pages
File Size : 49,5 Mb
Release : 1989
Category : Science
ISBN : UOM:39015014902194
Author : Robert B. Morin,Marvin Gorman
Publisher : Academic Press
Page : 594 pages
File Size : 45,8 Mb
Release : 2014-05-10
Category : Medical
ISBN : 9781483277196
Chemistry and Biology of ?-Lactam Antibiotics, Volume 1: Penicillins and Cephalosporins provides information pertinent to the study of antibiotics containing the ?-lactam moiety. This book discusses the occurrence of a group of ?-lactam antibiotics structurally related to cephalosporin C. Organized into five chapters, this volume begins with an overview of the mechanism of action of ?-lactam antibiotics that caused many microbiologists to develop screening tools for the detection of the ?-lactam moiety. This text then discusses the discovery of the nocardicins, the thienamycins, and olivanic acids. Other chapters provide a summary of the essential penicillin sulfoxide chemistry that gave rise to many compounds. This book discusses as well the ability of chemists to predict the level of biological activity of a compound from knowledge of its structure through theoretical and physicochemical studies. The final chapter deals with quantitative structure–activity relationships. This book is a valuable resource for microbiologists, chemists, and scientists.
Author : Marcelo Larramendy,Sonia Soloneski
Publisher : BoD – Books on Demand
Page : 280 pages
File Size : 43,5 Mb
Release : 2016-06-16
Category : Science
ISBN : 9789535124016
This book, Environmental Health Risk - Hazardous Factors to Living Species, is intended to provide a set of practical discussions and relevant tools for making risky decisions that require actions to reduce environmental health risk against environmental factors that may adversely impact human health or ecological balances. We aimed to compile information from diverse sources into a single volume to give some real examples extending concepts of those hazardous factors to living species that may stimulate new research ideas and trends in the relevant fields.
Author : Bernard Testa,Joachim M. Mayer
Publisher : John Wiley & Sons
Page : 808 pages
File Size : 48,6 Mb
Release : 2003-08
Category : Science
ISBN : 390639025X
Many drugs and other xenobiotics (e.g., preservatives, insecticides, and plastifiers) contain hydrolyzable moieties such as ester or amide groups. In biological media, such foreign compounds are, therefore, important substrates for hydrolytic reactions catalyzed by hydrolases or proceeding non-enzymatically. Despite their significance, until now, no book has been dedicated to hydrolysis and hydrolases in the metabolism of drugs and other xenobiotics. This work fills a gap in the literature and reviews metabolic reactions of hydrolysis and hydarion from the point of views of enzymes, substrates, and reactions.
Author : The Expert Panel on the Potential Socio-Economic Impacts of Antimicrobial Resistance in Canada
Publisher : Council of Canadian Academies
Page : 268 pages
File Size : 47,6 Mb
Release : 2019-11-12
Category : Medical
ISBN : 9781926522753
When Antibiotics Fail examines the current impacts of AMR on our healthcare system, projects the future impact on Canada’s GDP, and looks at how widespread resistance will influence the day-to-day lives of Canadians. The report examines these issues through a One Health lens, recognizing the interconnected nature of AMR, from healthcare settings to the environment to the agriculture sector. It is the most comprehensive report to date on the economic impact of AMR in Canada.
Author : Thomas J. Dougherty,Michael J. Pucci
Publisher : Springer Science & Business Media
Page : 1119 pages
File Size : 43,5 Mb
Release : 2011-12-18
Category : Medical
ISBN : 9781461414001
This volume covers all aspects of the antibiotic discovery and development process through Phase II/III. The contributors, a group of highly experienced individuals in both academics and industry, include chapters on the need for new antibiotic compounds, strategies for screening for new antibiotics, sources of novel synthetic and natural antibiotics, discovery phases of lead development and optimization, and candidate compound nominations into development. Beyond discovery , the handbook will cover all of the studies to prepare for IND submission: Phase I (safety and dose ranging), progression to Phase II (efficacy), and Phase III (capturing desired initial indications). This book walks the reader through all aspects of the process, which has never been done before in a single reference. With the rise of antibiotic resistance and the increasing view that a crisis may be looming in infectious diseases, there are strong signs of renewed emphasis in antibiotic research. The purpose of the handbook is to offer a detailed overview of all aspects of the problem posed by antibiotic discovery and development.
Author : Joint FAO/WHO Expert Committee on Food Additives,Joint FAO/WHO Expert Committee on Food Additives. Meeting
Publisher : World Health Organization
Page : 206 pages
File Size : 41,5 Mb
Release : 2005
Category : Business & Economics
ISBN : 9241660538
The monographs in this volume summarize data on the veterinary drug residues that were evaluated toxicologically by the Committee, which included three antimicrobial agents (cefuroxime, flumequine and pirlimycin), two insecticides (cyhalothrin, and cypermethrin and alpha-cypermethrin) and one production aid (ractopamine). The Committee also evaluated the safety of low levels of the antimicrobial agent chloramphenicol in animal products. This volume and others in the WHO Food Additives Series contain information that is useful to those who produce and use food additives and veterinary drugs and those involved with controlling contaminants in food, government and food regulatory officers, industrial testing laboratories, toxicological laboratories, and universities.
Author : Claudio O. Gualerzi,Letizia Brandi,Attilio Fabbretti,Cynthia L. Pon
Publisher : John Wiley & Sons
Page : 576 pages
File Size : 42,6 Mb
Release : 2013-09-05
Category : Medical
ISBN : 9783527659708
Most of the antibiotics now in use have been discovered more or less by chance, and their mechanisms of action have only been elucidated after their discovery. To meet the medical need for next-generation antibiotics, a more rational approach to antibiotic development is clearly needed. Opening with a general introduction about antimicrobial drugs, their targets and the problem of antibiotic resistance, this reference systematically covers currently known antibiotic classes, their molecular mechanisms and the targets on which they act. Novel targets such as cell signaling networks, riboswitches and bacterial chaperones are covered here, alongside the latest information on the molecular mechanisms of current blockbuster antibiotics. With its broad overview of current and future antibacterial drug development, this unique reference is essential reading for anyone involved in the development and therapeutic application of novel antibiotics.
Author : Gordon W. Gribble,John A. Joule
Publisher : Elsevier
Page : 674 pages
File Size : 49,6 Mb
Release : 2021-01-05
Category : Science
ISBN : 9780323901536
Progress in Heterocyclic Chemistry, Volume 32, the latest in this annual review series commissioned by the International Society of Heterocyclic Chemistry (ISHC), highlights the previous year’s literature on heterocyclic chemistry, along with articles on new developing topics of particular interest to heterocyclic chemists. Chapters highlighted in volume 32 are written by leading researchers in their field, providing a systematic survey of important, original material reported in the literature of heterocyclic chemistry in 2019. As with previous volumes in the series, this release will help academic and industrial chemists and advanced students keep abreast of developments in heterocyclic chemistry. Recognized as the premiere review of heterocyclic chemistry Includes contributions from leading researchers in the field Provides a systematic survey of the important 2019 heterocyclic chemistry literature Presents articles on new and developing topics of interest to heterocyclic chemists
Author : Satoru Suzuki,Amy Pruden,Marko Virta,Tong Zhang
Publisher : Frontiers Media SA
Page : 109 pages
File Size : 54,7 Mb
Release : 2017-04-10
Category : Electronic book
ISBN : 9782889451319
Rivers, lakes and the ocean receive antibiotic resistance genes from human environments. The aquatic environments are a huge reservoir and exchange stage of antibiotic resistance genes.
Author : Helena Guasch,Antoni Ginebreda,Anita Geiszinger
Publisher : Springer Science & Business Media
Page : 270 pages
File Size : 43,8 Mb
Release : 2012-02-21
Category : Science
ISBN : 9783642257223
The enduring changes in the aquatic environment and the increasing influx of contaminants call for novel conceptual and methodological approaches to relating chemical pollution and ecological alterations in ecosystems. This volume highlights the latest advances concerning the sampling, analyses, occurrence, bioavailability, and effects of emerging and priority pollutants in European rivers, the current status of the River Management Plans in Europe, and the applicability of the newly developed techniques for water monitoring purposes. The topics are discussed in the context of the EU Water Framework Directive, evaluating their shortcomings and providing a basis for doing away with them. Linking scientific research and river management practices, this book is an invaluable source of information for environmental chemists, aquatic scientists, ecologists and water managers.
Author : Steeve Giguère,John F. Prescott,Patricia M. Dowling
Publisher : John Wiley & Sons
Page : 704 pages
File Size : 49,7 Mb
Release : 2013-07-25
Category : Medical
ISBN : 9781118675076
The Fifth Edition of Antimicrobial Therapy in Veterinary Medicine, the most comprehensive reference available on veterinary antimicrobial drug use, has been thoroughly revised and updated to reflect the rapid advancements in the field of antimicrobial therapy. Encompassing all aspects of antimicrobial drug use in animals, the book provides detailed coverage of virtually all types of antimicrobials relevant to animal health. Now with a new chapter on antimicrobial therapy in zoo animals, Antimicrobial Therapy in Veterinary Medicine offers a wealth of invaluable information for appropriately prescribing antimicrobial therapies and shaping public policy. Divided into four sections covering general principles of antimicrobial therapy, classes of antimicrobial agents, special considerations, and antimicrobial drug use in multiple animal species, the text is enhanced by tables, diagrams, and photos. Antimicrobial Therapy in Veterinary Medicine is an essential resource for anyone concerned with the appropriate use of antimicrobial drugs, including veterinary practitioners, students, public health veterinarians, and industry and research scientists.
Author : B. Beek
Publisher : Springer
Page : 338 pages
File Size : 53,7 Mb
Release : 2005-09-06
Category : Science
ISBN : 9783540680963
Biodegradation is a key phenomen among environmental processes. Low degradation rates lead to the persistence of chemicals in the environment and, as a consequence, to delayed or long-term effects, which may be even unknown by now. In this volume the editor has pulled together the newest results of research in biodegradation and persistence of potential environmentally harmful substances and the complex process involved. The main focus is on the microbial degradation, the evolution and predictability of the respective pathways and their impact on bioremediation. Additional chapters deal with sewage treatment plants, the impact of toxicants on impaired biodegradation, and with the need of a more realistic view on fate and behaviour of chemicals in the environment.
Author : Klaus Kümmerer
Publisher : Springer Science & Business Media
Page : 521 pages
File Size : 40,6 Mb
Release : 2008-10-10
Category : Science
ISBN : 9783540746645
Following the success of the first edition, this pioneering study of pharmaceuticals in the environment has been updated and greatly extended. It includes the status of research on pharmaceuticals in soil, with attention to terrestrial and aquatic environments as well as new substance categories such as tetracylines and chinolones and the latest results concerning contamination of the environment and risk reduction.