Detection Of Drugs And Their Metabolites In Oral Fluid

Author : Robert M. White,Christine M. Moore
Publisher : Elsevier
Page : 141 pages
File Size : 53,5 Mb
Release : 2018-02-23
Category : Medical
ISBN : 9780128145968

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Detection of Drugs and Their Metabolites in Oral Fluid by Robert M. White,Christine M. Moore Pdf

Detection of Drugs and Their Metabolites in Oral Fluid presents the analytical chemistry methods used for the detection and quantification of drugs and their metabolites in human oral fluid. The authors summarize the state of the science, including its strengths, weaknesses, unmet methodological needs, and cutting-edge trends. This volume covers the salient aspects of oral fluid drug testing, including specimen collection and handling, initial testing, point of collection testing (POCT), specimen validity testing (SVT), and confirmatory and proficiency testing. Analytes discussed include amphetamines, cannabinoids, cocaine, opiates, phencyclidine, cannabimimetics, and miscellaneous drugs. This practical guide helps users turn knowledge into practice, moving logically from an outline of the problem, to the evaluation of the appropriateness of oral fluid as a test medium, and finally to a consideration of detection methods and their validation and employment. Compares different collection and testing systems to assist readers involved in clinical or forensic practice in selecting oral fluid as the matrix of choice Provides a sound basis for the detection of drugs and their metabolites in oral fluid and the interpretation of both positive and negative Places the need, or lack thereof, for specimen validity testing and confirmation testing in context with the purposes of oral fluid testing Describes drugs and drug classes that can be tested, along with useful information on a patient/donor’s drug status

Author : Raphael C. Wong,Harley Y. Tse
Publisher : Springer Science & Business Media
Page : 308 pages
File Size : 46,5 Mb
Release : 2007-11-05
Category : Medical
ISBN : 9781592599516

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Drugs of Abuse by Raphael C. Wong,Harley Y. Tse Pdf

A comprehensive review of the science of drug testing in all its aspects, placing emphasis on technologies that use body fluids other than urine for determining the presence of drugs of abuse. The authors discuss the various body fluid specimens suitable for testing for illicit drugs-particularly saliva, sweat, and hair-describe the structural and manufacturing aspects of on-site testing devices based on lateral flow immunoassay, and detail the pitfalls of using these specimens. They also discuss in detail the problem of sample adulteration and its detection. Since oral fluid has the best potential of succeeding urine as the next matrix of choice for drug detection, four popular saliva testing devices are examined: Intercept®, the Drager Drug Test®, Oratect®, and Drugwipe. Political, social, and legal issues are also considered in articles on privacy, the use of drug testing in courts, and the problem of sample adulteration.

Author : Alain G. Verstraete
Publisher : Pharmaceutical Press
Page : 461 pages
File Size : 50,6 Mb
Release : 2011
Category : Drug testing
ISBN : 9780853696940

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Workplace Drug Testing by Alain G. Verstraete Pdf

This comprehensive text provides clear explanations of the effects of drugs on human performance and the need for workplace drug testing. It provides essential information on the regulatory and legal frameworks around the world, how to set policies and coverage of all aspects of drug analysis and the associated interpretation of results.Contents include:* epidemiology of drug use in the working population* the evidence base and guidelines for workplace drug testing* legal, regulatory aspects and policies for drugs and alcohol* urine and alternative sample collection process* analytical techniques and specimen adulteration.Case studies of successful programmes are also included to illustrate the principles discussed.Written by internationally acknowledged experts this informative book will be essential reading for anyone interested in workplace drug testing or setting up such a system including clinical and forensic toxicologists, occupational health physicians, nurses, human resources, drug counselling and treatment providers, analytical chemists and lawyers.Alain Verstraete is Professor at the Department of Clinical Chemistry, Microbiology and Immunology, Ghent University, Ghent, Belgium and Department Head of the Toxicology Laboratory of the Laboratory of Clinical Biology, Ghent University Hospital, Ghent, Belgium.

Author : Amitava Dasgupta
Publisher : Springer Science & Business Media
Page : 441 pages
File Size : 52,9 Mb
Release : 2007-10-23
Category : Medical
ISBN : 9781588297808

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Handbook of Drug Monitoring Methods by Amitava Dasgupta Pdf

Written in a handbook style with specific methods and tips on eliminating false positive and false negative results, this book is a practical guide to the detailed mechanisms of such occurrences.

Author : Amitava Dasgupta
Publisher : Academic Press
Page : 560 pages
File Size : 46,7 Mb
Release : 2019-01-10
Category : Science
ISBN : 9780128156087

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Critical Issues in Alcohol and Drugs of Abuse Testing by Amitava Dasgupta Pdf

Critical Issues in Alcohol and Drugs of Abuse Testing, Second Edition, addresses the general principles and technological advances for measuring drugs and alcohol, along with the pitfalls of drugs of abuse testing. Many designer drugs, for example, are not routinely tested in drugs of abuse panels and may go undetected in a drug test. This updated edition is a must-have for clinical pathologists, toxicologists, clinicians, and medical review officers and regulators, bridging the gap between technical and clinical information. Topics of note include the monitoring of pain management drugs, bath salts, spices (synthetic marijuana), designer drugs and date rape drugs, and more. Serves as a ready resource of information for alcohol and drug testing Ideal resource for making decisions related to the monitoring and interpretation of results Includes concise content for clinical laboratory scientists, toxicologists and clinicians

Author : Carla Marienfeld
Publisher : Springer Nature
Page : 376 pages
File Size : 40,6 Mb
Release : 2020-03-06
Category : Medical
ISBN : 9783030334048

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Absolute Addiction Psychiatry Review by Carla Marienfeld Pdf

This book serves as a tool for general psychiatrists, medical students, residents, and fellows looking for a clinically relevant and high-yield overview of addiction psychiatry in preparation for their board exams – or for everyday clinical practice. Written by expert educators in addiction psychiatry, the text is organized by substances misused and populations affected. This book serves as both a primary learning tool for those new to the field, as well as a reference for those working in addiction treatment. Each chapter begins with summaries of high yield clinical pearls, followed by general information including treatment, and then ends with accompanying board-style review questions. The scope includes understanding substances of misuse and substance use disorders (SUDs), how to evaluate, diagnose, and monitor SUDs, how to treat SUDs both pharmacologically and behaviorally, and critical information for specific populations of patients. Absolute Addiction Psychiatry for Clinical Practice and Review is an excellent resource for all medical students, residents, fellows, and professionals taking certification exams in addiction, including those in psychiatry, addiction medicine, emergency medicine, internal medicine, pain medicine, and others. The chapter "Laboratory Testing for Substance Use Disorders" is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Author : Amanda J. Jenkins
Publisher : Springer Science & Business Media
Page : 186 pages
File Size : 41,8 Mb
Release : 2008-02-10
Category : Medical
ISBN : 9781597453189

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Drug Testing in Alternate Biological Specimens by Amanda J. Jenkins Pdf

Although the specimen of choice in the US drug testing industry is urine, and serum in clinical medicine, interest has recently grown in the use of other matrices as drug testing media. This book provides researchers and forensic toxicologists with a convenient general text summarizing the state of knowledge today. Chapters focus specifically on the application of these practices to drugs of abuse. The up-to-date information provided is complemented with thorough references.

Author : Ann H. Crowe
Publisher : Unknown
Page : 96 pages
File Size : 50,6 Mb
Release : 1998
Category : Drug abuse and crime
ISBN : PURD:32754068495146

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Drug Identification and Testing in the Juvenile Justice System by Ann H. Crowe Pdf

Author : David Dajing Ji,Darryl Sullivan
Publisher : World Scientific
Page : 498 pages
File Size : 52,6 Mb
Release : 2022-04-21
Category : Science
ISBN : 9789811249266

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Dietary Supplement Test Methods: Liquid Chromatography Separation Techniques And Application by David Dajing Ji,Darryl Sullivan Pdf

This book describes the analytical approach to testing over 160 important dietary supplement ingredients. In addition to the methods, there is significant guidance provided on how to develop, modify, and improve testing techniques. The procedures in this book include some of the most modern technologies that are available in the laboratory today. These basic principles of method development and troubleshooting can be implemented for food and food safety testing, drug development research, and agricultural areas. The contents of this book contain a very comprehensive collection of valuable analytical tools.

Author : Pascal Kintz,Alberto Salomone,Marco Vincenti
Publisher : Academic Press
Page : 392 pages
File Size : 42,5 Mb
Release : 2015-06-25
Category : Medical
ISBN : 9780128017104

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Hair Analysis in Clinical and Forensic Toxicology by Pascal Kintz,Alberto Salomone,Marco Vincenti Pdf

Hair Analysis in Clinical and Forensic Toxicology is an essential reference for toxicologists working with, and researching, hair analysis. The text presents a review of the most up-to-date analytical methods in toxicological hair analysis, along with state-of-the-art developments in the areas of hair physiology, sampling, and pre-treatments, as well as discussions of fundamental issues, applications, and results interpretation. Topics addressed include the diagnosis of chronic excessive alcohol drinking by means of ethyl glucuronide (EtG) and fatty acid ethyl esters (FAEE), the early detection of new psychoactive substances, including designer drugs, the development of novel approaches to screening tests based on mass spectrometry, and the detection of prenatal exposure to psychoactive substances from the analysis of newborn hair. Unites an international team of leading experts to provide an update on the cutting-edge advances in the toxicological analysis of hair Demonstrates toxicological techniques relating to a variety of scenarios and exposure types Ideal resource for the further study of the psychoactive substances, drug-facilitated crimes, ecotoxicology, analytical toxicology, occupational toxicology, toxicity testing, and forensic toxicology Includes detailed instructions for the collection, preparation, and handling of hair, and how to best interpret results

Author : Anonim
Publisher : Unknown
Page : 134 pages
File Size : 45,7 Mb
Release : 1986
Category : Drug abuse
ISBN : PURD:32754081426359

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Urine Testing for Drugs of Abuse by Anonim Pdf

Author : Shuguang Ma,Swapan Chowdhury
Publisher : Elsevier Science
Page : 708 pages
File Size : 44,9 Mb
Release : 2020-07-24
Category : Science
ISBN : 9780128200186

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Identification and Quantification of Drugs, Metabolites, Drug Metabolizing Enzymes, and Transporters by Shuguang Ma,Swapan Chowdhury Pdf

Identification and Quantification of Drugs, Metabolites, Drug Metabolizing Enzymes, and Transporters, Second Edition, is completely updated to provide an overview of the last decade's numerous advances in analytical technologies for detection and quantification of drugs, metabolites, and biomarkers. This new edition goes beyond LC-MS and features all-new chapters on how to evaluate drug absorption, distribution, metabolism, and excretion, potential for hepatic and renal toxicity, immunogenicity of biotherapeutics and translational tools for predicting human dosage, safety and efficacy of small molecules and biologics. This book will be an important handbook and desk reference for pharmacologists, toxicologists, clinical scientists, and students interested in the fields of pharmacology, biochemistry, and drug metabolism. Four sections in the book with 24 chapters give readers an overview of state-of-the-art techniques for identifying and quantifying drugs, metabolites and biomarkers, including a chapter on new approaches for quantification of enzymes and transporters in different tissues Focuses on the role of drug metabolism enzymes, transporters in disposition and drug-drug interactions, as well as strategies for evaluating drug metabolism and safety using advanced liver and kidney models. Discussions on immunogenicity risks of biologics and their evaluation methods have been included Includes several chapters on advanced translational sciences to predict human dosage, pharmacokinetics and efficacy for small molecules and biotherapeutics All chapters are written by experts with a wide range of practical experience from the industry and academia

Author : Rodger L. Foltz
Publisher : Unknown
Page : 214 pages
File Size : 44,6 Mb
Release : 1980
Category : Body fluids
ISBN : PURD:32754081426110

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GC/MS Assays for Abused Drugs in Body Fluids by Rodger L. Foltz Pdf

Author : Amanda J. Jenkins,Bruce A. Goldberger
Publisher : Springer Science & Business Media
Page : 312 pages
File Size : 50,9 Mb
Release : 2002-01-28
Category : Business & Economics
ISBN : UOM:39015054279693

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On-Site Drug Testing by Amanda J. Jenkins,Bruce A. Goldberger Pdf

It is at least a decade since scientists turned their imaginations to creating new compact, portable test instruments and self-contained test kits that could be used to analyze urine and saliva for alcohol, drugs, and their metabolites. Although the potential applications for such tests at the site of specimen collection, now called “on-site” or “point-of-care” testing, range far beyond hospital emergency rooms and law enforcement needs, it was catalyzed by the requirements of workplace drug testing and other drugs-of-abuse testing programs. These programs are now a minor national industry in the United States and in some western European countries, and cover populations as diverse as the military, incarcerated criminals, people suspected of driving under the influence of alcohol and other drugs, all athletes from college to professional ranks, and of course the general employed population, which is monitored for illegal drug use and numbers in the millions. It is not surprising, then, that the need for rapid and precise tests, conducted economically by trained professionals, has become a major goal. Current government approved and peer reviewed laboratory methods for urine analysis serve present needs very well and have become remarkably robust over the past twenty years, but the logistics of testing some moving populations, such as the military, the Coast Guard, workers on off-shore oil platforms, and athletes—perhaps the most mobile of these groups—are unacceptably cumbersome.

Author : Pascal Kintz
Publisher : Elsevier
Page : 312 pages
File Size : 47,6 Mb
Release : 2014-03-22
Category : Medical
ISBN : 9780124169692

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Toxicological Aspects of Drug-Facilitated Crimes by Pascal Kintz Pdf

Toxicological Aspects of Drug-Facilitated Crimes provides readers with an overview of the field of DFC: its history, toxicological effects, analysis, interpretation of results, the roles that age, gender and race may play, and clinical presentations of these drugs. The most commonly used drugs in DFC are addressed (alcohol, cannabis, MDMA, and cocaine), as well as an emerging range of pharmaceuticals (benzodiazepines, hypnotics, sedatives, neuroleptics, histamine H1-antagonists, or anesthetics), which are becoming more widely used, but are more difficult to detect. Edited by a world-renowned expert in the field of Forensic and Analytical Toxicology, Pascal Kintz, this book investigates toxicants of emerging concern and brings together a number of experts in the field to address the most recent discoveries on DFC toxicology. Brings together the latest research on the toxicological analysis of drug-facilitated crimes (DFC), with real-life case studies Provides up-to-date analytical techniques for determining toxicity levels in blood, urine, and hair Covers all types of toxicants involved in DFC, including alcohol, cannabis, MDMA, and a wide variety of pharmaceuticals