Developmental Neurotoxicology

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Handbook of Developmental Neurotoxicology

William Slikker, Jr.,Merle G. Paule,Cheng Wang
Handbook of Developmental Neurotoxicology Book PDF

Author : William Slikker, Jr.,Merle G. Paule,Cheng Wang
Publisher : Academic Press
Page : 616 pages
File Size : 51,5 Mb
Release : 2018-01-04
Category : Science
ISBN : 9780128093948

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Handbook of Developmental Neurotoxicology by William Slikker, Jr.,Merle G. Paule,Cheng Wang Pdf

Handbook of Developmental Neurotoxicology, Second Edition, provides a comprehensive view of the fundamental aspects of neurodevelopment, the pathways and agents that affect them, relevant clinical syndromes, and risk assessment procedures for developmental neurotoxicants. The editors and chapter authors are internationally recognized experts whose collaboration heralds a remarkable advance in the field, bridging developmental neuroscience with the principles of neurotoxicology. The book features eight new chapters with newly recruited authors, making it an essential text for students and professionals in toxicology, neurotoxicology, developmental biology, pharmacology, and neuroscience. Presents a comprehensive, up-to-date resource on developmental neurotoxicology with updated chapters from the first edition Contains new chapters that focus on subjects recent to the field Includes well-illustrated material, with diagrams, charts, and tables Contains compelling case studies and chapters written by world experts

Developmental Neurotoxicology

G Jean Harry
Developmental Neurotoxicology Book PDF

Author : G Jean Harry
Publisher : CRC Press
Page : 202 pages
File Size : 42,6 Mb
Release : 1994-07-13
Category : Medical
ISBN : 1439805504

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Developmental Neurotoxicology by G Jean Harry Pdf

Developmental Neurotoxicology addresses a number of basic principles underlying the vulnerability of the developing nervous system to environmental toxicant exposure. Evidence of functional alterations, induced at levels of chemical exposure that fail to produce structural teratological alterations, indicates that the evaluation of the functional capacity of exposed animals may indeed offer a sensitive evaluation of developmental toxicity. The contributing authors discuss the basic principles of development in structure and functional components and present information covering various methodological approaches, as well as evidence for the value of examining the developing nervous system for environmentally induced perturbations. The final chapter covers how this type of data is used to evaluate human risk potential.

Developmental Neurotoxicology Research

Cheng Wang,William Slikker, Jr
Developmental Neurotoxicology Research Book PDF

Author : Cheng Wang,William Slikker, Jr
Publisher : John Wiley & Sons
Page : 819 pages
File Size : 55,7 Mb
Release : 2011-04-12
Category : Science
ISBN : 9780470922743

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Developmental Neurotoxicology Research by Cheng Wang,William Slikker, Jr Pdf

This book describes how systems biology, pharmacogenomic and behavioral approaches, as applied to neurodevelopmental toxicology, provide a structure to arrange information in a biological model. Authors review and discuss approaches that can be used as effective tools to dissect mechanisms underlying pharmacological and toxicological phenomena associated with the exposure to drugs or environmental toxicants during development. This book presents cross-cutting research tools and animal models, along with applications to the studies associated with potential anesthetic-induced developmental neurotoxicity; the developmental basis of adolescent or adult onset of disease; risk assessment of methyl mercury and its effects on neurodevelopment; challenges in the field to identify environmental factors of relevance to autism; and the strategy and progress of epilepsy research.

Developmental Neurotoxicology

G Jean Harry
Developmental Neurotoxicology Book PDF

Author : G Jean Harry
Publisher : CRC Press
Page : 192 pages
File Size : 54,5 Mb
Release : 1994-07-13
Category : Medical
ISBN : 0849344271

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Developmental Neurotoxicology by G Jean Harry Pdf

Developmental Neurotoxicology addresses a number of basic principles underlying the vulnerability of the developing nervous system to environmental toxicant exposure. Evidence of functional alterations, induced at levels of chemical exposure that fail to produce structural teratological alterations, indicates that the evaluation of the functional capacity of exposed animals may indeed offer a sensitive evaluation of developmental toxicity. The contributing authors discuss the basic principles of development in structure and functional components and present information covering various methodological approaches, as well as evidence for the value of examining the developing nervous system for environmentally induced perturbations. The final chapter covers how this type of data is used to evaluate human risk potential.

Environmental Neurotoxicology

National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Board on Environmental Studies and Toxicology,Committee on Neurotoxicology and Models for Assessing Risk
Environmental Neurotoxicology Book PDF

Author : National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Board on Environmental Studies and Toxicology,Committee on Neurotoxicology and Models for Assessing Risk
Publisher : National Academies Press
Page : 167 pages
File Size : 45,6 Mb
Release : 1992-02-01
Category : Science
ISBN : 9780309045315

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Environmental Neurotoxicology by National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Board on Environmental Studies and Toxicology,Committee on Neurotoxicology and Models for Assessing Risk Pdf

Scientists agree that exposure to toxic agents in the environment can cause neurological and psychiatric illnesses ranging from headaches and depression to syndromes resembling parkinsonism. It can even result in death at high exposure levels. The emergence of subclinical neurotoxicity-the concept that long-term impairments can escape clinical detection-makes the need for risk assessment even more critical. This volume paves the way toward definitive solutions, presenting the current consensus on risk assessment and environmental toxicants and offering specific recommendations. The book covers: The biologic basis of neurotoxicity. Progress in the application of biologic markers. Reviews of a wide range of in vitro and in vivo testing techniques. The use of surveillance and epidemiology to identify neurotoxic hazards that escape premarket screening. Research needs. This volume will be an important resource for policymakers, health specialists, researchers, and students.

Role of Inflammation in Environmental Neurotoxicity

Anonim
Role of Inflammation in Environmental Neurotoxicity Book PDF

Author : Anonim
Publisher : Academic Press
Page : 352 pages
File Size : 43,5 Mb
Release : 2019-02-15
Category : Science
ISBN : 9780128157176

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Role of Inflammation in Environmental Neurotoxicity by Anonim Pdf

Role of Inflammation in Environmental Neurotoxicity, Volume Three, in this comprehensive serial, addresses contemporary advances in neurotoxicology by providing authoritative review articles on key issues in the field. Edited by leading subject experts, topics of note in this new release include Neuroinflammation (Introduction), Organophosphates, Lead, Manganese, Drugs of abuse, Peripheral vs central inflammation, Air pollution, Developmental neurotoxicity, Ethanol, and the Blood brain barrier, amongst other topics. Provides a unique, first of its kind resource Contributed to by world leaders in neurotoxicology Contains a diversity of topics (from molecular to epidemiology) in neurotoxicology

Neurotoxicology

Louis W. Chang,William Slikker Jr.
Neurotoxicology Book PDF

Author : Louis W. Chang,William Slikker Jr.
Publisher : Elsevier
Page : 875 pages
File Size : 50,7 Mb
Release : 1995-04-20
Category : Science
ISBN : 9780080537474

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Neurotoxicology by Louis W. Chang,William Slikker Jr. Pdf

Neurotoxicology: Approaches and Methods provides a unique and comprehensive presentation of the current concepts and state-of-the-art methods for the assessment of neurotoxicity. The book analyzes various techniques available and discusses their strengths and weaknesses. This volume will serve as an excellent desk companion and laboratory guide for all investigators, researchers, clinicians, and students interested in neurotoxicology. The internationally knowngroup of editors divide the book into seven sections: Neuromorphological and Neuropathological Approaches; Neurophysiological Approaches; Neurobehavioral Toxicology; Neurochemical and Biomolecular Approaches; In-Vitro Models; Clinical Neurotoxicology; and Risk Assessment of Neurotoxicity. Each section yields the most up-to-date information by experts in their fields. Meticulously organized and edited, Neurotoxicology: Approaches and Methods is the most authoritative and well-planned neurotoxicology book on the market. Discusses neurobehavioral testing methods for assessment of neural dysfunctions Explains state-of-the-art diagnostic methods, such as clinico-neuropsychological and neurophysiological methods, for patients confronted by neurotoxic problems Discusses In Vitro methods, including aggregating brain cell methods, organotypic cultures, and the use of human neuronal cell lines for the assessment of neurotoxicity Presents step-by-step procedures for many methods Provides state-of-the-art neuromorphological and biomolecular methods and approaches for neurotoxicity investigation

Behavioral Toxicology

Bernard Weiss
Behavioral Toxicology Book PDF

Author : Bernard Weiss
Publisher : Springer Science & Business Media
Page : 475 pages
File Size : 44,5 Mb
Release : 2013-03-09
Category : Science
ISBN : 9781468428599

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Behavioral Toxicology by Bernard Weiss Pdf

Behavioral toxicology is a young discipline in the United States; so young, in fact, that this is one of its first books. Behavioral questions are bound to play a major role in future scientific work and governmental decisions involving the health effects of environmental contaminants and other chemicals. This role springs from two key problems that face scientists and public agencies required to set acceptable exposure standards or to determine criteria for the toxicity of therapeutic chemicals: How do you evaluate effects that may show up only as subtle functional disturbances? And how do you de tect toxic effects early enough so that they may still be reversible, before they produce major damage? The contributions in this book come from a collection of scientists whose interests span a wide variety of problem areas. The focus is largely on me thodological issues because they represent the most immediate concern of the discipline. We expect that this collection of papers will represent a useful source book for behavioral toxicology for some time. For the past few years, the University of Rochester's Department of Radiation Biology and Biophysics has sponsored a series of international conferences on chemical toxicity, partly as a response to concern over the con sequences to health of the rich chemical soup in which we live. This book is based upon presentations made to the fifth of the series. Held in June, 1972, it was the first formal meeting devoted to behavioral toxicology in this country.

International Review of Research in Mental Retardation

Laraine Masters Glidden,Philip W. Davidson,Gary J. Myers,Bernard Weiss
International Review of Research in Mental Retardation Book PDF

Author : Laraine Masters Glidden,Philip W. Davidson,Gary J. Myers,Bernard Weiss
Publisher : Gulf Professional Publishing
Page : 398 pages
File Size : 54,9 Mb
Release : 2005-12-09
Category : Medical
ISBN : 0123662303

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International Review of Research in Mental Retardation by Laraine Masters Glidden,Philip W. Davidson,Gary J. Myers,Bernard Weiss Pdf

Neurotoxicity and Developmental Disabilities is a comprehensive review of the relationship between neurotoxicity and mental retardation. Though individual chapters each focus on a specific toxin, the chapters jointly emphasize that many variables influence the developmental outcomes following exposure to neurotoxicants, including timing of exposure, pattern of exposure, dose, susceptibility, and environmental conditions. Coverage includes the developmental consequences of maternal exposure to methyl mercury, and direct exposure to PCBs and Dioxins, lead, methanol, parental smoking, pthalates and pesticides. Additional chapters review research on environmental agents and autism, and assessment studies of exposure. This thematic volume in the International Review of Research in Mental Retardation begins with forewords by Stephen R. Schroeder, and series editor Laraine Glidden.

Handbook of Neurotoxicology

Edward J. Massaro
Handbook of Neurotoxicology Book PDF

Author : Edward J. Massaro
Publisher : Springer Science & Business Media
Page : 599 pages
File Size : 42,8 Mb
Release : 2002-03-20
Category : Medical
ISBN : 9781592591657

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Handbook of Neurotoxicology by Edward J. Massaro Pdf

N eurotoxicology is a broad and burgeoning field of research. Its growth in recent years can be related, in part, to increased interest in and concern with the fact that a growing number of anthropogenic agents with neurotoxic potential, including pesticides, 1ead, mercury, and the polytypic byproducts of combustion and industrial production, continue to be spewed into and accumulate in the environment. In addition, there is great interest in natural products, including toxins, as sources of therapeutic agents. Indeed, it is well known that many natural toxins ofbroadly differing structure, produced or accumulated for predatory or defensive purposes, and toxic agents, accumulated incidentalIy by numerous species, function to perturb nervous tissue. Components of some of these toxins have been shown to be useful therapeutic agents and/or research reagents. Unfor of some neurotoxicants of anthropogenic ori tunately, the environmental accumulation gin, expecialIy pesticides and metals, has resulted in incidents ofhuman poisoning, some of epidemic proportion, and high levels of morbidity and mortality. Furthermore, an increasing incidence of neurobehavioral disorders, some with baffling symptoms, is confronting clinicians. It is not clear whether this is merely the re suit of increased vigi lance and/or improved diagnostics or a consequence of improved health care. In any case, the role of exposure to environmental and occupational neurotoxicants in the etiology of these phenomena, as well as neurodegenerative diseases, is coming under increasing scrutiny and investigation.

Pediatric Neurotoxicology

Cynthia A. Riccio,Jeremy R. Sullivan
Pediatric Neurotoxicology Book PDF

Author : Cynthia A. Riccio,Jeremy R. Sullivan
Publisher : Springer
Page : 198 pages
File Size : 50,9 Mb
Release : 2018-06-11
Category : Psychology
ISBN : 3319812661

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Pediatric Neurotoxicology by Cynthia A. Riccio,Jeremy R. Sullivan Pdf

This book focuses on children and the impact of neurotoxins on the developing brain to guide the practice of psychologists working with children in clinical and school settings. Each chapter covers a distinct neurotoxin or group of neurotoxins, with particular emphasis on the impact of the neurotoxin exposure on the developing brain and long-term cognitive and psychosocial outcomes. This is more complex than studying neurotoxins with adults because of the rapid development occurring in the child's brain. Further, children are more susceptible than adults to the effects of neurotoxins due to their developmental status. Many of the effects discussed in this volume occur in utero, thus setting the stage for an altered developmental trajectory.

Human Developmental Neurotoxicology

David C. Bellinger
Human Developmental Neurotoxicology Book PDF

Author : David C. Bellinger
Publisher : CRC Press
Page : 0 pages
File Size : 44,7 Mb
Release : 2006-04-06
Category : Medical
ISBN : 0824729889

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Human Developmental Neurotoxicology by David C. Bellinger Pdf

This reference describes the most recent developments in the design, execution, and interpretation of human developmental neurotoxicology studies. Assessing critical issues and controversies in the field, this guide focuses on dose-response/effect relationships and explores challenges in the measurement of exposure to different types of chemicals, including selected metals, organic pollutants, pesticides, and recreational and therapeutic drugs.

Neurotoxicology

Mohamed B. Abou-Donia
Neurotoxicology Book PDF

Author : Mohamed B. Abou-Donia
Publisher : CRC Press
Page : 642 pages
File Size : 55,7 Mb
Release : 1992-07-15
Category : Medical
ISBN : 1439805423

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Neurotoxicology by Mohamed B. Abou-Donia Pdf

Neurotoxicology provides a thorough understanding of neurotoxicology through its integration of multilateral ideas covering several disciplines, including chemistry, biochemistry, anatomy, physiology, and pathology. It discusses neurotoxic agents, describes the methods for studying neurotoxic actions, covers factors affecting neurotoxicity, and inc

OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 426: Developmental Neurotoxicity Study

OECD
OECD Guidelines for the Testing of Chemicals Section 4 Test No 426 Developmental Neurotoxicity Study Book PDF

Author : OECD
Publisher : OECD Publishing
Page : 26 pages
File Size : 43,7 Mb
Release : 2007-10-15
Category : Electronic
ISBN : 9789264067394

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OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 426: Developmental Neurotoxicity Study by OECD Pdf

A developmental neurotoxicity study will provide information on the effects of repeated exposure to a substance during in utero and early postnatal development. The test substance is administered daily, generally orally, to mated females (rats are ...

Neurotoxicology, Third Edition

G. Jean Harry,Hugh A. Tilson
Neurotoxicology Third Edition Book PDF

Author : G. Jean Harry,Hugh A. Tilson
Publisher : CRC Press
Page : 334 pages
File Size : 48,7 Mb
Release : 2016-04-19
Category : Medical
ISBN : 9781420054880

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Neurotoxicology, Third Edition by G. Jean Harry,Hugh A. Tilson Pdf

This new edition presents an integrated approach to neurotoxicology, the study of organisms’ responses to changes in their environment and how interruption of the flow of information by chemical exposure causes a wide range of effects – from learning deficits, sensory disturbances in the extremities, and muscle weakness to seizures and signs similar to neurodegenerative disorders such as Parkinson’s or Alzheimer’s disease. It is an essential resource for understanding the sites and mechanisms of neurotoxicity, for formulating testable hypotheses about the effects of neurotoxicants, and for improving the risk assessment process.