Diagnostic And Therapeutic Antibodies

Author : Andrew J.T. George,Catherine E. Urch
Publisher : Springer Science & Business Media
Page : 471 pages
File Size : 51,6 Mb
Release : 2008-02-02
Category : Medical
ISBN : 9781592590766

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Diagnostic and Therapeutic Antibodies by Andrew J.T. George,Catherine E. Urch Pdf

Soon after the first description of monoclonal antibodies in 1976, there was enormous interest in the clinical application of antibodies, especially in the context of cancer. Antibodies appeared to offer the “magic bullet” that would allow the specific destruction of neoplastic cells. H- ever, many years’ effort resulted in very few cases of successful immu- therapy with antibodies. As a result there was a major backlash against antibody therapy, and the field lost a considerable amount of popularity. Fashion, in science as well as in other things, tends to be cyclical. Antibody-based therapy is once again attracting scientists and clinicians. There are several reasons for the renewed optimism; certainly the expe- ence of the last two decades has provided a wealth of information about problems associated with antibody therapy, and possible solutions to these problems. Recombinant antibody engineering has rejuvenated the field, allowing both the modification of antibodies to improve their in vivo pr- erties and the isolation of novel antibody molecules by such techniques as phage display. The results of recent clinical trials have demonstrated unequivocally the benefit of antibody therapy in a number of settings, and, finally, more careful consideration has been taken of the types of disease best treated using this approach.

Author : National Research Council,Institute for Laboratory Animal Research,Committee on Methods of Producing Monoclonal Antibodies
Publisher : National Academies Press
Page : 74 pages
File Size : 48,7 Mb
Release : 1999-06-06
Category : Medical
ISBN : 9780309064477

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Monoclonal Antibody Production by National Research Council,Institute for Laboratory Animal Research,Committee on Methods of Producing Monoclonal Antibodies Pdf

The American Anti-Vivisection Society (AAVS) petitioned the National Institutes of Health (NIH) on April 23, 1997, to prohibit the use of animals in the production of mAb. On September 18, 1997, NIH declined to prohibit the use of mice in mAb production, stating that "the ascites method of mAb production is scientifically appropriate for some research projects and cannot be replaced." On March 26, 1998, AAVS submitted a second petition, stating that "NIH failed to provide valid scientific reasons for not supporting a proposed ban." The office of the NIH director asked the National Research Council to conduct a study of methods of producing mAb. In response to that request, the Research Council appointed the Committee on Methods of Producing Monoclonal Antibodies, to act on behalf of the Institute for Laboratory Animal Research of the Commission on Life Sciences, to conduct the study. The 11 expert members of the committee had extensive experience in biomedical research, laboratory animal medicine, animal welfare, pain research, and patient advocacy (Appendix B). The committee was asked to determine whether there was a scientific necessity for the mouse ascites method; if so, whether the method caused pain or distress; and, if so, what could be done to minimize the pain or distress. The committee was also asked to comment on available in vitro methods; to suggest what acceptable scientific rationale, if any, there was for using the mouse ascites method; and to identify regulatory requirements for the continued use of the mouse ascites method. The committee held an open data-gathering meeting during which its members summarized data bearing on those questions. A 1-day workshop (Appendix A) was attended by 34 participants, 14 of whom made formal presentations. A second meeting was held to finalize the report. The present report was written on the basis of information in the literature and information presented at the meeting and the workshop.

Author : Stefan Dübel,Janice M. Reichert
Publisher : John Wiley & Sons
Page : 2538 pages
File Size : 50,7 Mb
Release : 2014-12-03
Category : Science
ISBN : 9783527329373

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Handbook of Therapeutic Antibodies by Stefan Dübel,Janice M. Reichert Pdf

Still the most comprehensive reference source on the development, production and therapeutic application of antibodies, this second edition is thoroughly updated and now has 30% more content. Volume 1 covers selection and engineering strategies for new antibodies, while the second volume presents novel therapeutic concepts and antibodies in clinical study, as well as their potential. Volumes 3 and 4 feature detailed and specific information about each antibody approved for therapeutic purposes, including clinical data. This unique handbook concludes with a compendium of marketed monoclonal antibodies and an extensive index. Beyond providing current knowledge, the authors discuss emerging technologies, future developments, and intellectual property issues, such that this handbook meets the needs of academic researchers, decision makers in industry and healthcare professionals in the clinic.

Author : Runjan Chetty,Kumarasen Cooper,Allen M. Gown
Publisher : Cambridge University Press
Page : 525 pages
File Size : 41,9 Mb
Release : 2016-11-28
Category : Medical
ISBN : 9781107077782

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Leong's Manual of Diagnostic Antibodies for Immunohistology by Runjan Chetty,Kumarasen Cooper,Allen M. Gown Pdf

A detailed, A-Z guide and an indispensable source for pathologists ensuring correct application of immunohistochemistry in daily practice.

Author : Anthony Siew-Yin Leong,Kumarasen Cooper,F. Joel W-M. Leong
Publisher : Cambridge University Press
Page : 634 pages
File Size : 52,7 Mb
Release : 2003
Category : Medical
ISBN : 1841101001

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Manual of Diagnostic Antibodies for Immunohistology by Anthony Siew-Yin Leong,Kumarasen Cooper,F. Joel W-M. Leong Pdf

An updated edition provides a comprehensive list of antisera and monoclonal antibodies that have useful diagnostic applications.

Author : Matzku
Publisher : Routledge
Page : 328 pages
File Size : 48,5 Mb
Release : 2019-06-14
Category : Medical
ISBN : 9781351466363

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Antibodies in Diagnosis and Therapy by Matzku Pdf

Monoclonal antibodies have had their impact on biomedical research for more than a decade. Beside their exuberant use as reagents, quite a number of diagnostic and therapeutic approaches have been followed and an impressive number of technological improvements, e.g., humanization, recombinant miniantibodies, have been elaborated to strengthen the principle. With respect to clinical applications, the first generation of antibody 'drugs' is yielding promising results while second and third generation antibody constructs are already underway. The book reviews the status of technological development and brings this into the perspective of clinical results. A rapidly growing amount of clinical data is collected in an expanding number of indications. Hence, the review of clinical study results has been grouped according to the fields of oncology and of chronic and acute inflammation. This book will be of interest to scientists working in the fields of oncology, immunology, internal medicine and clinical chemistry.

Author : Suresh C. Srivastava
Publisher : Springer Science & Business Media
Page : 851 pages
File Size : 47,5 Mb
Release : 2013-03-14
Category : Medical
ISBN : 9781468455380

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Radiolabeled Monoclonal Antibodies for Imaging and Therapy by Suresh C. Srivastava Pdf

The advent of hybridoma technology leading to the successful produc tion of monoclonal antibodies against a variety of tumor-associated antigens has, during the last decade, provided a very powerful tool for research and clinical investigations. These highly specific reagents have essentially replaced the polysera of the earlier days. The successful demonstration of the many wide ranging capabilities of the monoclonal antibody technique has already begun to exert an enormous impact on diverse areas of research in basic science and medicine. In particular, the potential of monoclonal antibodies to serve as carriers for selective targeting of radionuclides to tumors for diagnosis or therapy, has stimulated an intense surge of research interest and even revived hopes of realizing Ehrlich's concept of the "magic bullet". Indeed, the technology appears to be on the threshold of a revolution in diagnosing and treating malignant disease. Much work remains to be done, however, and even though the progress has been impressive, results to date have shown only moderate success. There is no question that the limited success we have achieved thus far is merely a prelude to the many more exciting developments yet to come.

Author : Jeroen van Dijk
Publisher : Unknown
Page : 135 pages
File Size : 44,8 Mb
Release : 1991
Category : Kidneys
ISBN : 9090045651

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Renal Cell Carcinoma by Jeroen van Dijk Pdf

Author : Anonim
Publisher : Academic Press
Page : 288 pages
File Size : 41,8 Mb
Release : 2019-07-13
Category : Medical
ISBN : 9780128173176

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Drug-Induced Liver Injury by Anonim Pdf

Drug-Induced Liver Injury, Volume 85, the newest volume in the Advances in Pharmacology series, presents a variety of chapters from the best authors in the field. Chapters in this new release include Cell death mechanisms in DILI, Mitochondria in DILI, Primary hepatocytes and their cultures for the testing of drug-induced liver injury, MetaHeps an alternate approach to identify IDILI, Autophagy and DILI, Biomarkers and DILI, Regeneration and DILI, Drug-induced liver injury in obesity and nonalcoholic fatty liver disease, Mechanisms of Idiosyncratic Drug-Induced Liver Injury, the Evaluation and Treatment of Acetaminophen Toxicity, and much more. Includes the authority and expertise of leading contributors in pharmacology Presents the latest release in the Advances in Pharmacology series

Author : Robert W Maitta
Publisher : Elsevier Health Sciences
Page : 380 pages
File Size : 55,5 Mb
Release : 2019-08-27
Category : Medical
ISBN : 9780323675109

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Immunologic Concepts in Transfusion Medicine by Robert W Maitta Pdf

Immunological Concepts in Transfusion Medicine provides a thorough discussion of the immune aspects of blood component transfusion, with in-depth information on the intricacies of immune responses to blood components and the immune processes that may be initiated in response to blood exposure. Written to increase knowledge and awareness of immune challenges such as alloimmunization and transfusion-related acute lung injury, this title bridges current basic scientific discoveries and the potential effects seen in blood recipients. Complies the knowledge and expertise of Dr. Robert Maitta, an expert in immune responses and antibody function/structure studies. Helps clinicians in the daily practice of caring for patients in need of transfusion support, as well as physicians in training when considering utilizing blood transfusions in a limited scope or in the setting of massive transfusion. Includes an immunology primer as an introduction to in-depth chapters covering allergic immune reactions to blood components, transfusion-related immunomodulation, fetal and neonatal alloimmune thrombocytopenia and neonatal neuthropenia, complications of haploidentical and mismatched HSC transplantation, chimeric antibody receptor therapies, and much more. Consolidates today’s available information on this timely topic into a single, convenient resource.

Author : Thomas Böldicke
Publisher : BoD – Books on Demand
Page : 314 pages
File Size : 55,6 Mb
Release : 2018-02-21
Category : Medical
ISBN : 9789535138259

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Antibody Engineering by Thomas Böldicke Pdf

Antibody Engineering comprises in vitro selection and modification of human antibodies including humanization of mouse antibodies for therapy, diagnosis, and research. This book comprises an overview about the generation of antibody diversity and essential techniques in antibody engineering: construction of immune, naive and synthetic libraries, all available in vitro display methods, humanization by chain shuffling, affinity maturation techniques, de novo synthesis of antibody genes, colony assays for library screening, construction of scFvs from hybridomas, and purification of monoclonal antibodies by exclusion chromatography. In addition, other topics that are discussed in this book are application and mechanism of single domain antibodies, structural diversity of antibodies, immune-mediated skin reactions induced by TNF-alpha recombinant antibodies, and bioinformatic approaches to select pathogen-derived peptide sequences for antibody targets.

Author : Menotti Ruvo,Annamaria Sandomenico
Publisher : Unknown
Page : 0 pages
File Size : 48,7 Mb
Release : 2022
Category : Electronic
ISBN : 3036531645

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Monoclonal Antibodies and Their Functional Fragments in Research, Diagnosis and Therapy 2.0 by Menotti Ruvo,Annamaria Sandomenico Pdf

Monoclonal antibodies (mAbs) are among the most specialised molecules for the recognition and capture of specific analytes. Hundreds of thousands of mAbs have been generated for a large number of different antigens with increasing affinity and specificity and are available for the most diverse purposes. Many of them have been validated as irreplaceable agents for diagnosis and therapy or as unique reagents for research. Others have been developed using emerging technologies that avoid the need for animal immunisation. This short book strives to gather the perspective view of the various contributing authors and to survey the new strategic assets adopted to generate novel monoclonal antibodies or surrogates, such as Fab, Fab2, ScFv and nanobodies, which have an increasing impact in biomedicine as therapeutic or diagnostic assets in various diseases.

Author : Florian Rüker,Gordana Wozniak-Knopp
Publisher : Springer Nature
Page : 388 pages
File Size : 53,6 Mb
Release : 2021-01-04
Category : Medical
ISBN : 9783030546304

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Introduction to Antibody Engineering by Florian Rüker,Gordana Wozniak-Knopp Pdf

This highly readable textbook serves as a concise and engaging primer to the emerging field of antibody engineering and its various applications. It introduces readers to the basic science and molecular structure of antibodies, and explores how to characterize and engineer them. Readers will find an overview of the latest methods in antibody identification, improvement and biochemical engineering. Furthermore, alternative antibody formats and bispecific antibodies are discussed. The book’s content is based on lectures for the specializations “Protein Engineering” and “Medical Biotechnology” within the Master’s curriculum in “Biotechnology.” The lectures have been held at the University of Natural Resources and Life Sciences, Vienna, in cooperation with the Medical University of Vienna, since 2012 and are continuously adapted to reflect the latest developments in the field. The book addresses Master’s and PhD students in biotechnology, molecular biology and immunology, and all those who are interested in antibody engineering.

Author : Martin Rosenberg,Gordon P. Moore
Publisher : Springer Science & Business Media
Page : 414 pages
File Size : 42,5 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642784323

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The Pharmacology of Monoclonal Antibodies by Martin Rosenberg,Gordon P. Moore Pdf

A sample of the most exciting developments in the cloning, manipulation, expression and application of genetically-engineered monoclonal antibodies. This rapidly-evolving field has witnessed the PCR combinatorial cloning of vast immunological diversity, in vitro mutagenesis of MAbs, MAbs created by transgenic animals, novel expression systems in plants, animals and lower systems, as well as a rich variety of genetically modified MAbs as potential therapeutic agents. Leading scientists from academia and industry present their own findings as well as short reviews of these research areas.

Author : Edgar Haber,Richard M. Krause
Publisher : Unknown
Page : 444 pages
File Size : 45,7 Mb
Release : 1977
Category : Antibodies
ISBN : UCAL:B4492560

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Antibodies in Human Diagnosis and Therapy by Edgar Haber,Richard M. Krause Pdf