Handbook Of Therapeutic Antibodies

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Handbook of Therapeutic Antibodies

Stefan Dübel,Janice M. Reichert
Handbook of Therapeutic Antibodies Book PDF

Author : Stefan Dübel,Janice M. Reichert
Publisher : John Wiley & Sons
Page : 2538 pages
File Size : 40,8 Mb
Release : 2014-12-03
Category : Science
ISBN : 9783527329373

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Handbook of Therapeutic Antibodies by Stefan Dübel,Janice M. Reichert Pdf

Still the most comprehensive reference source on the development, production and therapeutic application of antibodies, this second edition is thoroughly updated and now has 30% more content. Volume 1 covers selection and engineering strategies for new antibodies, while the second volume presents novel therapeutic concepts and antibodies in clinical study, as well as their potential. Volumes 3 and 4 feature detailed and specific information about each antibody approved for therapeutic purposes, including clinical data. This unique handbook concludes with a compendium of marketed monoclonal antibodies and an extensive index. Beyond providing current knowledge, the authors discuss emerging technologies, future developments, and intellectual property issues, such that this handbook meets the needs of academic researchers, decision makers in industry and healthcare professionals in the clinic.

Handbook of Therapeutic Antibodies, 3 Volume Set

Stefan Dübel
Handbook of Therapeutic Antibodies 3 Volume Set Book PDF

Author : Stefan Dübel
Publisher : Wiley-Blackwell
Page : 0 pages
File Size : 49,7 Mb
Release : 2007-03-26
Category : Science
ISBN : 3527314539

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Handbook of Therapeutic Antibodies, 3 Volume Set by Stefan Dübel Pdf

In this most comprehensive reference source for the development, production and therapeutic application of antibodies, Volume I contains general chapters presenting established technologies and clinical applications. Volume II provides a look at emerging technologies, new therapeutic concepts, and clinical studies. The third volume features detailed and specific information about each currently approved type of antibody, including the clinical data. A must-have resource for academic researchers, decision makers in industry and healthcare professionals in the clinic.

Handbook of Therapeutic Antibodies

Stefan Dübel
Handbook of Therapeutic Antibodies Book PDF

Author : Stefan Dübel
Publisher : Wiley-Blackwell
Page : 0 pages
File Size : 53,7 Mb
Release : 2010-08-30
Category : Science
ISBN : 3527329021

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Handbook of Therapeutic Antibodies by Stefan Dübel Pdf

This most comprehensive reference source for the development, production and therapeutic application of antibodies is now available as a competitively priced softcover edition. It includes general chapters presenting established technologies and clinical applications, chapters on emerging technologies, new therapeutic concepts, and clinical studies and detailed and specific information about currently approved therapeutic antibodies, including clinical data. Nearly 100 international experts and researchers from academia, industry, and such regulating bodies as the FDA have contributed to this work. Includes are also information on intellectual property issues, hardly available elsewhere. A must-have resource for academic researchers, decision makers in industry and healthcare professionals in the clinic. From the foreword by Mark Glassy, Chairman & Professor, The Rajko Medenica Research Foundation, and Chief Executive Officer, Shantha West, Inc., San Diego, CA, USA: "After more than a century of intense analysis, antibodies continue to amaze and inspire. This Handbook of Therapeutic Antibodies is not just an assembly of articles but rather a state-of-the-art comprehensive compendium, which will appeal to all those interested in antibodies, whether from academia, industry, or the clinic. It is an unrivalled resource which shows how mature the antibody field has become and how precisely the antibody molecule can be manipulated and utilized." Stefan Dubel studied biology at the universities of Mainz and Heidelberg, initially concentrating on developmental biology. From 1989 onwards he carried out pioneering work on antibody phage display and antibody libraries with randomised CDRs. Further work focussed on antibody fusion proteins and improvements of antibody phage display. Currently he is Director of the Department of Biotechnology at the Technical University of Braunschweig and coordinator of the 'Antibody Factory' within the German National Genome Research Network. Stefan Dubel has co-authored a number of textbooks, about 90 publications and 15 patents in the field of recombinant antibodies and phage display.

Therapeutic Antibodies

Yuti Chernajovsky,Ahuva Nissim
Therapeutic Antibodies Book PDF

Author : Yuti Chernajovsky,Ahuva Nissim
Publisher : Springer Science & Business Media
Page : 380 pages
File Size : 40,5 Mb
Release : 2007-12-11
Category : Medical
ISBN : 9783540732594

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Therapeutic Antibodies by Yuti Chernajovsky,Ahuva Nissim Pdf

This essential work, edited by two researchers at London’s famous Queen Mary’s medical school targets one of the most important areas in medical development today. These days, antibody therapeutics are the treatment of choice for several autoimmune and oncological conditions. They are, indeed, becoming the molecules of choice for further combination therapies and cell engineering. In this timely work, a slew of expert in the field of drug development summarize all the current developments and clinical successes.

Making and Using Antibodies

Gary C. Howard,Matthew R. Kaser
Making and Using Antibodies Book PDF

Author : Gary C. Howard,Matthew R. Kaser
Publisher : CRC Press
Page : 412 pages
File Size : 45,7 Mb
Release : 2006-12-13
Category : Medical
ISBN : 9781420005196

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Making and Using Antibodies by Gary C. Howard,Matthew R. Kaser Pdf

Antibodies are an indispensable tool in the study of biology and medicine. Making and Using Antibodies: A Practical Handbook presents techniques in a single, comprehensive source for the production and use of antibodies. It enables researchers to immediately access lab-tested, proven protocols. Written and edited by an elite team of scienti

Handbook of Therapeutic Antibodies

Stefan Dübel,Janice M. Reichert
Handbook of Therapeutic Antibodies Book PDF

Author : Stefan Dübel,Janice M. Reichert
Publisher : John Wiley & Sons
Page : 2544 pages
File Size : 48,8 Mb
Release : 2014-08-04
Category : Science
ISBN : 9783527682447

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Handbook of Therapeutic Antibodies by Stefan Dübel,Janice M. Reichert Pdf

Still the most comprehensive reference source on the development, production and therapeutic application of antibodies, this second edition is thoroughly updated and now has 30% more content. Volume 1 covers selection and engineering strategies for new antibodies, while the second volume presents novel therapeutic concepts and antibodies in clinical study, as well as their potential. Volumes 3 and 4 feature detailed and specific information about each antibody approved for therapeutic purposes, including clinical data. This unique handbook concludes with a compendium of marketed monoclonal antibodies and an extensive index. Beyond providing current knowledge, the authors discuss emerging technologies, future developments, and intellectual property issues, such that this handbook meets the needs of academic researchers, decision makers in industry and healthcare professionals in the clinic.

Therapeutic Antibodies

Gunnar Houen
Therapeutic Antibodies Book PDF

Author : Gunnar Houen
Publisher : Unknown
Page : 347 pages
File Size : 41,9 Mb
Release : 2022
Category : Immunoglobulins
ISBN : 1071614509

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Therapeutic Antibodies by Gunnar Houen Pdf

This detailed book covers methods for studying, producing, and analyzing therapeutic antibodies, measuring their concentration, developing neutralizing antibodies for them, and for predicting and monitoring their therapeutic efficacy and clinical effects. These biologics are the fastest growing pharmaceutical drug group and have had tremendous clinical and scientific impact in cancer, autoimmune diseases, infectious diseases, and other immune-related diseases, making the content of this volume essential. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible methods, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Therapeutic Antibodies: Methods and Protocols serves as an ideal guide for researchers working with the production of, research on, and development of therapeutic antibodies as well as for clinicians using therapeutic antibodies in daily work with patients.

Antibody Engineering Volume 1

Roland E. Kontermann,Stefan Dübel
Antibody Engineering Volume 1 Book PDF

Author : Roland E. Kontermann,Stefan Dübel
Publisher : Springer Science & Business Media
Page : 788 pages
File Size : 41,8 Mb
Release : 2010-03-10
Category : Medical
ISBN : 9783642011443

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Antibody Engineering Volume 1 by Roland E. Kontermann,Stefan Dübel Pdf

Antibodies are indispensable tools for research, diagnosis, and therapy. Recombinant approaches allow the modification and improvement of nearly all antibody properties, such as affinity, valency, specificity, stability, serum half-life, effector functions, and immunogenicity. "Antibody Engineering" provides a comprehensive toolbox covering the well-established basics but also many exciting new techniques. The protocols reflect the latest "hands on" knowledge of key laboratories in this still fast-moving field. Newcomers will benefit from the proven step-by-step protocols, which include helpful practical advice; experienced antibody engineers will appreciate the new ideas and approaches. The book is an invaluable resource for all those engaged in antibody research and development.

Biosimilars of Monoclonal Antibodies

Cheng Liu,K. John Morrow, Jr.
Biosimilars of Monoclonal Antibodies Book PDF

Author : Cheng Liu,K. John Morrow, Jr.
Publisher : John Wiley & Sons
Page : 720 pages
File Size : 48,5 Mb
Release : 2016-12-19
Category : Medical
ISBN : 9781118662311

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Biosimilars of Monoclonal Antibodies by Cheng Liu,K. John Morrow, Jr. Pdf

Addressing a significant need by describing the science and process involved to develop biosimilars of monoclonal antibody (mAb) drugs, this book covers all aspects of biosimilar development: preclinical, clinical, regulatory, manufacturing. • Guides readers through the complex landscape involved with developing biosimilar versions of monoclonal antibody (mAb) drugs • Features flow charts, tables, and figures that clearly illustrate processes and makes the book comprehensible and accessible • Includes a review of FDA-approved mAb drugs as a quick reference to facts and useful information • Examines new technologies and strategies for improving biosimilar mAbs

The Pharmacology of Monoclonal Antibodies

Martin Rosenberg,Gordon P. Moore
The Pharmacology of Monoclonal Antibodies Book PDF

Author : Martin Rosenberg,Gordon P. Moore
Publisher : Springer Science & Business Media
Page : 414 pages
File Size : 41,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642784323

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The Pharmacology of Monoclonal Antibodies by Martin Rosenberg,Gordon P. Moore Pdf

A sample of the most exciting developments in the cloning, manipulation, expression and application of genetically-engineered monoclonal antibodies. This rapidly-evolving field has witnessed the PCR combinatorial cloning of vast immunological diversity, in vitro mutagenesis of MAbs, MAbs created by transgenic animals, novel expression systems in plants, animals and lower systems, as well as a rich variety of genetically modified MAbs as potential therapeutic agents. Leading scientists from academia and industry present their own findings as well as short reviews of these research areas.

Leong's Manual of Diagnostic Antibodies for Immunohistology

Runjan Chetty,Kumarasen Cooper,Allen M. Gown
Leong s Manual of Diagnostic Antibodies for Immunohistology Book PDF

Author : Runjan Chetty,Kumarasen Cooper,Allen M. Gown
Publisher : Cambridge University Press
Page : 525 pages
File Size : 54,8 Mb
Release : 2016-11-28
Category : Medical
ISBN : 9781107077782

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Leong's Manual of Diagnostic Antibodies for Immunohistology by Runjan Chetty,Kumarasen Cooper,Allen M. Gown Pdf

A detailed, A-Z guide and an indispensable source for pathologists ensuring correct application of immunohistochemistry in daily practice.

Protein Therapeutics, 2 Volume Set

Tristan Vaughan,Jane Osbourn,Bahija Jallal
Protein Therapeutics 2 Volume Set Book PDF

Author : Tristan Vaughan,Jane Osbourn,Bahija Jallal
Publisher : John Wiley & Sons
Page : 762 pages
File Size : 41,8 Mb
Release : 2017-12-04
Category : Medical
ISBN : 9783527340866

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Protein Therapeutics, 2 Volume Set by Tristan Vaughan,Jane Osbourn,Bahija Jallal Pdf

In this practice-oriented two volume handbook, professionals from some of the largest biopharmaceutical companies and top academic researchers address the key concepts and challenges in the development of protein pharmaceuticals for medicinal chemists and drug developers of all trades. Following an introduction tracing the rapid development of the protein therapeutics market over the last decade, all currently used therapeutic protein scaffolds are surveyed, from human and non-human antibodies to antibody mimetics, bispecific antibodies and antibody-drug conjugates. This ready reference then goes on to review other key aspects such as pharmacokinetics, safety and immunogenicity, manufacture, formulation and delivery. The handbook then takes a look at current key clinical applications for protein therapeutics, from respiratory and inflammation to oncology and immune-oncology, infectious diseases and rescue therapy. Finally, several exciting prospects for the future of protein therapeutics are highlighted and discussed.

Monoclonal Antibodies

Harleen Kaur,Dietmar Reusch
Monoclonal Antibodies Book PDF

Author : Harleen Kaur,Dietmar Reusch
Publisher : Elsevier
Page : 260 pages
File Size : 50,8 Mb
Release : 2021-08-03
Category : Medical
ISBN : 9780128223192

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Monoclonal Antibodies by Harleen Kaur,Dietmar Reusch Pdf

Monoclonal antibodies (mAbs) are naturally occurring complex biomolecules. New engineering methods have turned mAbs into a leading therapeutic modality for addressing immunotherapeutic challenges and led to the rise of mAbs as the dominant class of protein therapeutics. mAbs have already demonstrated a great potential in developing safe and reliable treatments for complex diseases and creating more affordable healthcare alternatives. Developing mAbs into well-characterized antibody therapeutics that meet regulatory expectations, however, is extremely challenging. Obstacles to overcome include the determination and development of physiochemical characteristics such as aggregation, fragmentation, charge variants, identity, carbohydrate structure, and higher-order structure (HOS). This book dives deep into mAbs structure and the array of physiochemical testing and characterization methods that need to be developed and validated to establish a mAb as a therapeutic molecule. The main focus of this book is on physiochemical aspects, including the importance of establishing quality attributes such as glycosylation, primary sequence, purity, and HOS and elucidating the structure of new antibody formats by mass spectrometry. Each of the aforementioned quality attributes has been discussed in detail; this will help scientists in researching and developing biopharmaceuticals and biosimilars to find practical solutions to physicochemical testing and characterization. Describes the spectrum of analytical tests and characterization methods necessary for developing and releasing mAb batches Details antibody heterogeneity in terms of size, charge, and carbohydrate content Gives special focus to the structural analysis of mAbs, including mass spectrometry analysis Presents the basic structure of mAbs with clarity and rigor Addresses regulatory guidelines - including ICH Q6B - in relation to quality attributes Lays out characterization and development case studies including biosimilars and new antibody formats

The Antibody Molecule

Anthony R. Rees
The Antibody Molecule Book PDF

Author : Anthony R. Rees
Publisher : Oxford Medical Histories
Page : 385 pages
File Size : 51,9 Mb
Release : 2015
Category : Medical
ISBN : 9780199646579

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The Antibody Molecule by Anthony R. Rees Pdf

'The Antibody Molecule' is a beautifully illustrated review of the remarkable developments within immunology from the discovery of the antibody molecule to its exploitation in medicine and the scientists and pioneers who were involved. This engaging and authoritative history will appeal to a wide audience

Handbook of Pharmaceutical Biotechnology

Jay P Rho,Stan G Louie
Handbook of Pharmaceutical Biotechnology Book PDF

Author : Jay P Rho,Stan G Louie
Publisher : CRC Press
Page : 214 pages
File Size : 43,5 Mb
Release : 2003-03-31
Category : Medical
ISBN : 0789016354

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Handbook of Pharmaceutical Biotechnology by Jay P Rho,Stan G Louie Pdf

Stay up to date with changes in the biopharmaceutical products market! With the growth rate of biopharmaceutical products ascending rapidly since the 1980s, the number of biotechnology companies has risen to more than 1200 new businesses in the Unites States alone. This dramatic increase creates a new set of challenges in education, putting demands on teachers and students to keep pace with innovations in terminology and techniques. The Handbook of Pharmaceutical Biotechnology is essential in meeting those challenges. A practical compendium of biotechnology-produced drugs, the Handbook of Pharmaceutical Biotechnology covers general principles of biotechnology and pharmaceuticals, putting usable information in the hands of those who need it most. The book presents descriptions that break down each pharmaceutical product by pharmacology, pharmacokinetics, clinical applications, toxicities, and dosage guidelines. It also reviews prescription products, discussing clinical uses and trials, adverse reactions, and more. Tables, figures, and extensive references add to each comprehensive summary. The Handbook of Pharmaceutical Biotechnology also includes up-to-date information on: monoclonal antibodies (Abciximab, Muromonab-CD3) enzymes and regulators of enzyme activity (Alteplase, clotting factors, Dornase alpha) anticytokines olgonucleotide and gene therapy hematopoietic growth factors (interleukins, interferons, colony stimulating factors, erythropoietin) As the worldwide production and sales of biotechnology-derived pharmaceuticals and diagnostics continues to grow, teachers, students, and clinical pharmacists need to maintain a clear and current understanding of the field. The Handbook of Pharmaceutical Biotechnology presents a thoughtful and thorough guide to keeping pace in this evolving industry.