Diagnostic Criteria In Autoimmune Diseases

Author : Yehuda Shoenfeld,Ricard Cervera,M. Eric Gershwin
Publisher : Springer Science & Business Media
Page : 593 pages
File Size : 53,5 Mb
Release : 2010-06-08
Category : Medical
ISBN : 9781603272858

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Diagnostic Criteria in Autoimmune Diseases by Yehuda Shoenfeld,Ricard Cervera,M. Eric Gershwin Pdf

According to the Autoimmune Diseases Coordinating Committee (ADCC), between 14.7 and 23.5 million people in the USA – up to eight percent of the population are affected by autoimmune disease. Autoimmune diseases are a family of more than 100 chronic, and often disabling, illnesses that develop when underlying defects in the immune system lead the body to attack its own organs, tissues, and cells. In Handbook of Autoimmune Disease, the editors have gathered in a comprehensive handbook a critical review, by renowned experts, of more than 100 autoimmune diseases, divided into two main groups, namely systemic and organ-specific autoimmune diseases. A contemporary overview of these conditions with special emphasis on diagnosis is presented. Each chapter contains the essential information required by attending physicians as well as bench scientists to understand the definition of a specific autoimmune disease, the diagnostic criteria, and the treatment.

Author : Yehuda Shoenfeld
Publisher : Unknown
Page : 8 pages
File Size : 43,9 Mb
Release : 2014
Category : Electronic
ISBN : OCLC:1074909583

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Diagnostic Criteria in Autoimmune Diseases by Yehuda Shoenfeld Pdf

Author : Kenan Demir,Selim Görgün
Publisher : Cambridge Scholars Publishing
Page : 562 pages
File Size : 50,6 Mb
Release : 2021-06-17
Category : Medical
ISBN : 9781527571198

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Autoimmune Diseases and Diagnostic Approaches by Kenan Demir,Selim Görgün Pdf

The collection of essays reviews, explores, and reports state-of-the-art autoimmune diseases and their diagnostics. It provides a comprehensive presentation of autoimmune diseases, diagnostic approaches with current trends, and possible developments in health sciences. As such, it is a unique resource for medical educators, medical practitioners, and academics.

Author : Marinos C Dalakas
Publisher : Butterworth-Heinemann
Page : 360 pages
File Size : 49,7 Mb
Release : 2013-10-22
Category : Health & Fitness
ISBN : 9781483163048

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Polymyositis and Dermatomyositis by Marinos C Dalakas Pdf

Polymyositis and Dermatomyositis provides extensive information regarding Polymyositis and Dermatomyositis (PM/DM), which is described as a heterogeneous disease complex. This book is divided into four sections: Part I (Clinical Features) covers the classification of PM/DM, details of the clinical presentation, and the disease's association with the other connective tissue disorders and malignancies. Part II (Etiology and Mechanisms) covers advances in the immunopathology and viral etiology of PM/DM along with a frequently recognized entity: inclusion body myositis. Part III (Diagnosis and Treatment) covers the histologic, muscle enzyme histochemical, electron microscopic, and resin histology features of PM/DM along with those electromyographic features that could help make a more accurate diagnosis. Part IV (Overview) summarizes the issues that may not have been clear and highlights differing and unsettled views or present available data. This text is directed to clinicians in private practice or in academic institutions concerned with PM/DM patients, including neurologists, rheumatologists, pediatricians, dermatologists, physiatrists, and neuromuscular investigators. This book is intended as well for neuromuscular pathologists who interpret muscle biopsy specimens and electromyographers who perform EMG studies to help determine the clinical diagnosis. Researchers in immunology and immunopathology of neuromuscular diseases will find discussions in this book invaluable.

Author : Terumi Kamisawa,Myung-Hwan Kim
Publisher : Springer
Page : 142 pages
File Size : 42,9 Mb
Release : 2018-07-31
Category : Medical
ISBN : 9789811045486

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IgG4-Related Sclerosing Cholangitis by Terumi Kamisawa,Myung-Hwan Kim Pdf

This book aims to raise awareness of IgG4-related sclerosing cholangitis among practicing physicians and to equip readers with a sound understanding of the principles of diagnosis and treatment. Clinical, serological, and histopathological features are clearly described and imaging appearances on all relevant modalities are illustrated, covering the bile duct and other involved organs. Differential diagnosis from other diseases, including primary sclerosing cholangitis and cholangiocarcinoma, is precisely explained. Information is then presented on all significant current and emerging therapeutic strategies, including steroids, immunosuppressive drugs, and rituximab. Finally, attention is drawn to significant prognostic features. While IgG4-related sclerosing cholangitis is now a widely acknowledged condition, most practitioners are still liable to misdiagnose it owing to a lack of familiarity with its presenting features. This book should help to rectify the situation and will be an asset for all who may encounter the disease in clinical practice.

Author : Michael Hertl
Publisher : Springer Science & Business Media
Page : 593 pages
File Size : 45,9 Mb
Release : 2011-02-24
Category : Medical
ISBN : 9783211992258

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Autoimmune Diseases of the Skin by Michael Hertl Pdf

Autoimmune disorders of the skin remain an enigma for many clinicians and scientists not familiar with these mostly severe and chronic diseases. The book provides an overview and the latest information on the broad spectrum of cutaneous autoimmune disorders for clinicians, scientists and practitioners in dermatology, medicine, rheumatology, ENT, pediatrics and ophthalmology. The book is unique since it presents the state-of-the-art knowledge on pathophysiology, clinical diagnosis and management of these disorders provided by the world experts in the field. The primary intention is to broaden the understanding of the pathophysiology of cutaneous autoimmune disorders and to provide a practical guide to how to identify and handle these conditions. The book is illustrated with many tables, illustrative figures and clinical color photographs. The third edition has been thoroughly updated and extended by chapters on paraneoplastic cutaneous syndromes, atopic dermatitis and autoimmunity and Skin manifestations of rheumatic diseases.

Author : Takao Saito,John H. Stone,Hitoshi Nakashima,Takako Saeki,Mitsuhiro Kawano
Publisher : Springer
Page : 298 pages
File Size : 52,7 Mb
Release : 2016-11-09
Category : Medical
ISBN : 9784431556879

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IgG4-Related Kidney Disease by Takao Saito,John H. Stone,Hitoshi Nakashima,Takako Saeki,Mitsuhiro Kawano Pdf

This book offers a detailed review of the pathological and imaging features, diagnosis and treatment of IgG4-Related Kidney Disease (IgG4-RKD). IgG4-related disease (IgG4-RD), which is characterized by an elevated serum IgG4 level and infiltration of systemic organs by IgG4 positive plasma cells, is a newly recognized systemic disease. Diverse renal manifestations including specific tubulointerstitial nephritis, membranous nephropathy, and tumor-like urological diseases extending to the pelvis and urinary tract in IgG4-RD have been reported and are recently attracting attention as IgG4-RKD. In this book, leading researchers in the field present the latest insights into the broad spectrum of IgG4-RKD characteristics. In addition, they provide a detailed explanation of the pathology of IgG4-RKD including comparisons between the kidney and other affected organs, such as the lacrimal, salivary glands and pancreas in the histopathological section. IgG4-Related Kidney Disease will have a major impact on future immunological and nephrological studies and offers a useful resource not only for nephrologists but also general physicians and investigators in related fields.

Author : Yehuda Shoenfeld,Pier Luigi Meroni,M. Eric Gershwin
Publisher : Elsevier Science Limited
Page : 855 pages
File Size : 55,6 Mb
Release : 2014-02-11
Category : Medical
ISBN : 0444563784

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Autoantibodies by Yehuda Shoenfeld,Pier Luigi Meroni,M. Eric Gershwin Pdf

Autoimmune diseases are characterized by the occurrence of antibodies reacting with self-constituents of the body. The fully updated third edition of Autoantibodies is an in-depth review of the main autoantibodies identified up to now, with particular emphasis on those that display a diagnostic or prognostic clinical value. The new edition covers recent scientific advances, diagnostic techniques, and therapeutic technologies. Each chapter is focused on a single family of autoantibodies. This important reference contains historical notes, definitions, origins and sources of antigens recognized genetic associations, mediated pathogenic mechanisms, methods of detection, as well as clinical utility (disease prevalence and association, diagnostic value, sensitivity and specificity, prognostic value). This is an ideal reference for anyone involved in the field of autoimmune diseases. Presents all known, important autoantibodies in a single source, focusing on the antibodies needed for autoimmune disorder diagnosis Includes clinical applications for each autoantibody along with general information Organized by disease and disorder type, by autoantibody family, and completely cross-referenced

Author : Michael D. Lockshin,Mary K. Crow,Medha Barbhaiya
Publisher : Springer Nature
Page : 230 pages
File Size : 46,5 Mb
Release : 2022-06-13
Category : Medical
ISBN : 9783031049354

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Diagnoses Without Names by Michael D. Lockshin,Mary K. Crow,Medha Barbhaiya Pdf

Doctors, patients, investigators, administrators, and policymakers who assign diagnoses assume three elements: the name describes an entity with conceptual or evidentiary boundaries, the person setting the name has a high degree of certainty, and the name has a consensus definition. This book challenges this practice and offers an alternative to assigning diagnoses: quantitating diagnostic uncertainty in personal and public medical plans. This book offers the stakeholders' views participating in a workshop, sponsored by the Barbara Volcker Center/Hospital for Special Surgery, taking place in April 2020, about uncertain diagnoses. Chapters examine the circumstances in which diagnosis names are "unassignable", either because patients do not fit within diagnostic "boxes" or because health abnormalities evolve and change over time. In addition, the book deconstructs the processes of diagnosis and explores how different stakeholders used diagnosis names for various purposes. In examining pertinent questions, the book offers a roadmap to achieving consensus definitions or including measures of uncertainty in personal care, research, and policy. Diagnoses Without Names: Challenges for Medical Care, Research, and Policy is an essential resource for physicians and related professionals, residents, fellows, and graduate students in internal medicine, rheumatology, and clinical immunology as well as investigators, administrators, policymakers.

Author : Noel R. Rose,Ian R. Mackay
Publisher : Academic Press
Page : 1532 pages
File Size : 51,6 Mb
Release : 2019-10-15
Category : Medical
ISBN : 9780128122426

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The Autoimmune Diseases by Noel R. Rose,Ian R. Mackay Pdf

The Autoimmune Diseases, Sixth Edition, emphasizes the "3 P’s" of 21st Century medicine: precision, prediction and prevention. Topics cover the modern systems approach to biology that involves large amounts of personalized, ongoing physiologic data ("omics") coupled with advanced methods of analysis, new tests of genetic engineering, such as CRISPR, auto inflammatory diseases, autoimmune responses to tumor immunotherapy, and information on normal immune response and disorders. Each of the major autoimmune disorders is discussed by researchers and clinical investigators experienced in dealing with patients. Chapters emphasize the immunologic basis of the disease as well as the use of immunologic diagnostic methods and treatments. The book also covers several cross-cutting issues related to the recognition and treatment of autoimmune diseases, including chapters on the measurement of autoantibodies and T cells, the use of biomarkers as early predictors of disease, and new methods of treatment. Gives a thorough and important overview on the entire field, framing individual disease chapters with information that compares and contrasts each disorder and its therapy Provides thorough, up-to-date information on specific diseases, along with clinical applications in an easily found reference for clinicians and researchers interested in certain diseases Keeps readers abreast of current trends and emerging areas in the field Ensures that content is not only up-to-date, but applicable and relevant Includes new, updated chapters that emphasize hot topics in the field, e.g., research on auto inflammatory diseases and autoimmune responses following cancer immunotherapy

Author : National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Board on Environmental Studies and Toxicology,Committee on Biologic Markers,Subcommittee on Immunotoxicology
Publisher : National Academies Press
Page : 225 pages
File Size : 46,5 Mb
Release : 1992-02-01
Category : Science
ISBN : 9780309043892

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Biologic Markers in Immunotoxicology by National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Board on Environmental Studies and Toxicology,Committee on Biologic Markers,Subcommittee on Immunotoxicology Pdf

Are environmental pollutants threatening the human immune system? Researchers are rapidly approaching definitive answers to this question, with the aid of biologic markersâ€"sophisticated assessment tools that could revolutionize detection and prevention of certain diseases. This volume, third in a series on biologic markers, focuses on the human immune system and its response to environmental toxicants. The authoring committee provides direction for continuing development of biologic markers, with strategies for applying markers to immunotoxicology in humans and recommended outlines for clinical and field studies. This comprehensive, up-to-date volume will be invaluable to specialists in toxicology and immunology and to biologists and investigators involved in the development of biologic markers.

Author : Philip Conaghan,Chris Denton,Helen Foster,John Isaacs
Publisher : Oxford University Press
Page : 1553 pages
File Size : 50,8 Mb
Release : 2013-10
Category : Medical
ISBN : 9780199642489

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Oxford Textbook of Rheumatology by Philip Conaghan,Chris Denton,Helen Foster,John Isaacs Pdf

A strong clinical emphasis is present throughout this volume from the first section of commonly presenting problems through to the section addressing problems shared with a range of other clinical sub-specialties.

Author : Tomohiro Kurosaki,Jürgen Wienands
Publisher : Springer
Page : 231 pages
File Size : 45,6 Mb
Release : 2015-12-26
Category : Medical
ISBN : 9783319261331

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B Cell Receptor Signaling by Tomohiro Kurosaki,Jürgen Wienands Pdf

This volume details our current understanding of the architecture and signaling capabilities of the B cell antigen receptor (BCR) in health and disease. The first chapters review new insights into the assembly of BCR components and their organization on the cell surface. Subsequent contributions focus on the molecular interactions that connect the BCR with major intracellular signaling pathways such as Ca2+ mobilization, membrane phospholipid metabolism, nuclear translocation of NF-kB or the activation of Bruton’s Tyrosine Kinase and MAP kinases. These elements orchestrate cytoplasmic and nuclear responses as well as cytoskeleton dynamics for antigen internalization. Furthermore, a key mechanism of how B cells remember their cognate antigen is discussed in detail. Altogether, the discoveries presented provide a better understanding of B cell biology and help to explain some B cell-mediated pathogenicities, like autoimmune phenomena or the formation of B cell tumors, while also paving the way for eventually combating these diseases.

Author : Alberta Hoi
Publisher : Springer Nature
Page : 192 pages
File Size : 50,5 Mb
Release : 2021-11-15
Category : Medical
ISBN : 9783030851613

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Pathogenesis of Systemic Lupus Erythematosus by Alberta Hoi Pdf

The scope of this contributed volume is to provide an overview of the latest translational research in the field of lupus pathogenesis, with particular emphasis on how these discoveries progress in parallel with therapeutic drug development. Systemic lupus erythematosus (SLE) is a multifaceted disease with a number of well-defined immune pathways that are dysregulated, resulting in an immune-mediated chronic inflammatory injury at target organs. As knowledge of these pathways evolves to provide opportunities for targeted drug therapy and lays the foundation for personalized medicine, clinicians and researchers need to keep up with the ever-expanding medical literature. This book will critically appraise the current understanding of important immunological pathways that contribute to the pathogenesis of lupus. We will review the role of interferons as part of the innate immune defects that perpetuate the loss of self-tolerance in SLE. B cell hyperactivity, as a defining hallmark of SLE, and different strategies of B cell targeted therapy will be discussed. The role of co-stimulation or immune checkpoint molecules in activating B and T cells will be reviewed, as well as other cytokines that serve in the amplification loop promoting a more proinflammatory Th1 or Th17 responses. Intracellular targets, such as signaling molecules in the JAK/STAT pathway, or a variety of kinases and proteasomes, can cause a cascading downstream effect of transcriptional responses that are important in SLE. Immune homeostasis can also be restored by bolstering the naturally occurring anti-inflammatory mechanisms. Glucocorticoid, as a potent natural anti-inflammatory hormone, can mediate its effects by recruiting histone deacetylase that serve to repress gene transcription. Glucocorticoid-induced leucine zipper is a gene upregulated by glucocorticoid that can be a potential target for development of anti-inflammatory strategy. Finally, T regulatory cells can be utilized to help restore to immune tolerance and are amongst the latest focus of therapeutic development in SLE.

Author : Alessia Alunno,Elena Bartoloni,Roberto Gerli
Publisher : Academic Press
Page : 344 pages
File Size : 50,5 Mb
Release : 2016-06-07
Category : Medical
ISBN : 9780128036327

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Sjogren's Syndrome by Alessia Alunno,Elena Bartoloni,Roberto Gerli Pdf

Sjogren's Syndrome: Novel Insights in Pathogenic, Clinical and Therapeutic Aspects provides the reader with an overview of current knowledge about Sjogren's Syndrome. The book summarizes the huge amount of literature concerning related advances in genetic background, pathogenesis, clinical picture, and therapeutic approaches. It integrates basic immunology concepts, clinical aspects, and pharmacological issues. Scientific progress has allowed us to unmask novel pathogenic mechanisms, to perform genome wide studies, and to identify clinical and serological features associated with different disease subsets and, eventually, different disease prognoses. In addition, the increasing knowledge about SS pathogenesis provides the rationale to employ targeted therapies in SS as has already occurred in rheumatoid arthritis and systemic lupus erythematosus. Discusses heterogeneity of topics and audience, from basic immunology to clinical aspects and therapeutics Provides novel lines of investigation and supports the management of patients requiring novel therapeutic approaches Presents a deeper knowledge on SS clinical management as well as on immunological aspects possibly leading to new lines of investigation Offers a bridge between the clinician and the scientist, and vice versa Provides the reader with most recent and relevant updates due to the novelty of topics