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Discovery And Development Of Drugs For Neglected Diseases Chagas Disease Human African Trypanosomiasis And Leishmaniasis Book in PDF, ePub and Kindle version is available to download in english. Read online anytime anywhere directly from your device. Click on the download button below to get a free pdf file of Discovery And Development Of Drugs For Neglected Diseases Chagas Disease Human African Trypanosomiasis And Leishmaniasis book. This book definitely worth reading, it is an incredibly well-written.
Author : Gildardo Rivera,Navin B. Patel,Debasish Bandyopadhyay
Publisher : Frontiers Media SA
Page : 171 pages
File Size : 48,7 Mb
Release : 2021-12-20
Category : Science
ISBN : 9782889717927
Author : World Health Organization
Publisher : Unknown
Page : 0 pages
File Size : 48,9 Mb
Release : 2012
Category : Electronic books
ISBN : 9240689990
The Disease Reference Group on Chagas Disease Human AfricanTrypanosomiasis and Leishmaniasis (DRG3) was part of an independent thinktankof international experts established by the Special Programme for Researchand Training in Tropical Diseases (TDR) to identify key research prioritiesthrough systematic review of research evidence and input from stakeholders. These three distinct insect-borne diseases while caused by related kinetoplastidprotozoan pathogens have dissimilar geographical distributions a reflection oftheir different insect vectors and range of vector contact with humans. Thedisease.
Author : World Health Organization
Publisher : World Health Organization
Page : 153 pages
File Size : 41,9 Mb
Release : 2013
Category : Medical
ISBN : 9789241564540
"Produced under the overall direction and supervision of Dr. Lorenzo Savioli (Director) and Dr. Denis Daumerie (Programme Manager), WHO Department of Control of Neglected Tropical Diseases"--Back of title page.
Author : David C. Swinney,Michael P. Pollastri
Publisher : John Wiley & Sons
Page : 426 pages
File Size : 42,9 Mb
Release : 2019-07-25
Category : Medical
ISBN : 9783527808649
A drug discovery reference to the crippling tropical diseases that affect more than 1 billion people. Neglected Tropical Diseases is the first book of its kind to offer a guide that follows the World Health Organization?s list of neglected tropical diseases. The authors?all are experts on the topic?address the development of effective treatments for 12 crippling infectious diseases that affect almost 20% of the world?s popluation. The book includes information on the common approaches and the most important factors that lead to the development of new drugs for treating tropical diseases. Individual chapters review 12 neglected tropical diseases that are grouped by infectious agent, from viruses to bacteria to eukaryotic parasites. For each of these diseases, the book explains the unmet medical need and explores the current and potential drug discovery strategies. The book also includes information on potential drug compounds derived from natural products. This important book: -Ties together information from different sources for developing novel treatsments forneglected tropical diseases -Is aligned with WHO?s initiative to eradicate tropical diseases -Outlines current and potential drugs for treating tropical diseases -Provides a standard reference for the entire field Written for medicinal chemists, pharmaceutical chemists, pharmaceutical industry, virologists, parasitologists, and specialists on tropics medicine, Neglected Tropical Diseases offers an essential guide and a systematic reference for the development of successful treatments for 12 crippling infectious diseases.
Author : Katherine Elliott,Maeve O'Connor,G. E. W. Wolstenholme
Publisher : John Wiley & Sons
Page : 192 pages
File Size : 42,5 Mb
Release : 2009-09-16
Category : Medical
ISBN : 9780470717707
The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world.
Author : Luis Rivas,Carmen Gil
Publisher : Royal Society of Chemistry
Page : 422 pages
File Size : 51,5 Mb
Release : 2017-10-26
Category : Science
ISBN : 9781788012584
For human health, leishmaniasis is among the most important protozoan diseases, superseded only by malaria. Globally, 10 to 12 million people are infected with 1.5 million new cases every year. The development of cheaper new drugs is urgently needed for this neglected disease that is developing resistance to current treatments. Chemotherapy remains the only treatment option for the bulk of patients. However, this is largely unaffordable for most. In the past three years numerous advances in drug discovery have been made for treating this disease by exploiting diverging metabolic pathways between the Leishmania enzymes and their hosts, using nanotechnology to target the immune cell phagolysosomes where Leishmania resides. Drug Discovery for Leishmaniasis aims to provide a perspective of the current treatments and their challenges, blended with the emerging strategies and methodologies that will drive new target appraisals and drug developments, as well as addressing the molecular basis of resistance in Leishmania. Recent studies have shown that leishmaniasis affects some of the poorest people in the world, with 95% of fatal cases occurring in only 6 countries. With the WHO goal of eliminating this public health problem in the South-east Asia Region by 2020, this book will be important for anyone who is interested in neglected tropical diseases.
Author : World Health Organization. Department of Control of Neglected Tropical Diseases
Publisher : Unknown
Page : 0 pages
File Size : 47,5 Mb
Release : 2015
Category : Communicable diseases
ISBN : 924069384X
"This report repositions a group of 17 neglected tropical diseases on the global development agenda at a time of profound transitions in the economies of endemic countries and in thinking about the overarching objectives of development. In doing so it reinvigorates the drive to prevent control eliminate or eradicate diseases that blind maim and disfigure making life miserable for more than a billion people. Undetected and untreated several almost invariably kill. The burden of these diseases is further amplified by the fact that many require chronic and costly care underscoring the economic as well as the health benefits of preventive chemotherapy and early detection and care. The report brings a new dimension to long-term thinking about the future approach to these diseases. For the first time it sets out financing needs options and targets for meeting WHO Roadmap goals by 2020 but also for reaching universal coverage of all people in need by 2030. The report makes one investment case for cost-effectiveness and a second investment case where equity is the focus. It sets targets for ending catastrophic health expenditures and as part of the drive to strengthen health systems for getting services closer to where people live"--Provided by publisher.
Author : Timo Jäger,Oliver Koch,Leopold Flohé
Publisher : John Wiley & Sons
Page : 850 pages
File Size : 55,5 Mb
Release : 2013-03-19
Category : Medical
ISBN : 9783527670406
This is the first resource to provide researchers in academia and industry with an urgently needed update on drug intervention against trypanosomatides. As such, it covers every aspect of the topic from basic research findings, via current treatments to translational approaches in drug development and includes both human and livestock diseases. The outstanding editor and contributor team reads like a Who?s Who of the field, thus guaranteeing the outstanding quality of this ready reference.
Author : King K. Holmes,Stefano Bertozzi,Barry R. Bloom,Prabhat Jha
Publisher : World Bank Publications
Page : 506 pages
File Size : 53,7 Mb
Release : 2017-11-06
Category : Medical
ISBN : 9781464805257
Infectious diseases are the leading cause of death globally, particularly among children and young adults. The spread of new pathogens and the threat of antimicrobial resistance pose particular challenges in combating these diseases. Major Infectious Diseases identifies feasible, cost-effective packages of interventions and strategies across delivery platforms to prevent and treat HIV/AIDS, other sexually transmitted infections, tuberculosis, malaria, adult febrile illness, viral hepatitis, and neglected tropical diseases. The volume emphasizes the need to effectively address emerging antimicrobial resistance, strengthen health systems, and increase access to care. The attainable goals are to reduce incidence, develop innovative approaches, and optimize existing tools in resource-constrained settings.
Author : Hanem Khater,M. Govindarajan,Giovanni Benelli
Publisher : BoD – Books on Demand
Page : 250 pages
File Size : 49,5 Mb
Release : 2017-07-12
Category : Medical
ISBN : 9789535132899
This book emphasizes past and current research efforts about principles of natural control of major parasites affecting humans, animals, and crops. Each chapter is a complete and integrated subject that presents a problem and confers on the safe alternatives to chemicals. This book discusses and updates information about three major topics of natural remedies. The first topic is represented in a chapter outlining important information on biological control of parasites, the second topic is represented in three chapters dealing with botanicals as promising antiparasitic agents, and the last four chapters deal with miscellaneous control strategies against parasites. This easily readable book is designed precisely for students as well as professors linked with the field of parasitic control. We enhanced words with breathing areas in the form of graphical abstracts, figures, photographs, and tables.
Author : B.E. Maryanoff,A.B. Reitz
Publisher : Elsevier
Page : 321 pages
File Size : 43,5 Mb
Release : 1999-04-01
Category : Science
ISBN : 0080526373
Volume 4 of Advances in Medicinal Chemistry is comprised of six chapters on a wide range of topics in medicinal chemistry, including molecular modeling, structure-based drug design, organic synthesis, peptide conformational analysis, biological assessment, structure-activity correlation, and lead optimization. Chapter 1 presents an account about amino acid-based peptide mimetics corresponding to b-turn, loop, helical motifs in proteins as a probe of ligand-receptor and ligand-enzyme molecular interactions. Chapter 2 addresses new facets of the medicinal chemistry of the important anticancer drug Taxol® (paclitaxel). Chapter 3 relates an account of the search for new drugs for the treatment of malaria based on the natural product artemisinin. Chapter 4 applies computational chemistry to the evaluation of compound libraries for biological testing. Chapter 5 describes the construction of a 3-dimensional molecular model of the human thrombin receptor, the first protease-activated G-protein coupled receptor (PAR-1), as a means to explore the intermolecular contacts involved in agonist peptide recognition. Finally, Chapter 6 describes the research conducted at Merck on inhibitors of farnesyl transferase as a potential treatment for human cancers.
Author : Paul M. Selzer
Publisher : John Wiley & Sons
Page : 511 pages
File Size : 50,8 Mb
Release : 2009-06-08
Category : Medical
ISBN : 9783527323272
Aus erster Hand berichten die Autoren der Beiträge dieses Bandes, mit welchen Strategien in der kommerziellen Forschung nach Wirkstoffen gegen Infektionskrankheiten gesucht wird. Dabei konzentrieren sie sich in erster Linie auf Parasitosen, berücksichtigen aber auch bakterielle Infektionen. Hochinteressante Informationen, die man in dieser Form nirgends findet!
Author : Veeranoot Nissapatorn,Helieh S. Oz
Publisher : Unknown
Page : 0 pages
File Size : 42,5 Mb
Release : 2018
Category : Chagas' disease
ISBN : 1838813691
Author : World Health Organization. Department of Control of Neglected Tropical Diseases,World Health Organization
Publisher : World Health Organization
Page : 184 pages
File Size : 47,9 Mb
Release : 2010
Category : Medical
ISBN : 9789241564090
"Neglected tropical diseases (NTDs) blight the lives of a billion people worldwide and threaten the health of millions more. These ancient companions of poverty weaken impoverished populations, frustrate the achievement of health in the Millennium Development Goals and impede global health and economies has convinced governments, donors, the pharmaceutical industry and other agencies, including nongovernmental organizations (NGOs), to invest in preventing and controlling this diverse group of diseases. Global efforts to control "hidden" diseases, such as dracunculiasis (guinea-worm disease), leprosy, gains including the imminent eradication of dracunculiasis. Since 1989 (when most endemic countries began reporting monthly from each endemic village), the number of new dracunculiasis cases has fallen from 892 055 in 12 endemic countries to 3190 in 4 countries in 2009, a decrease of more than 99%. The World Health Organization (WHO) recommends five public-health strategies for the prevention and control of NTDs: preventive chemotherapy; intensified case-management; vector control; the provision of safe water, sanitation and hygiene; and veterinary public health (that is, applying veterinary sciences to ensure the health and well-being of humans). Although one approach and delivered locally." - p. vii
Author : Venkatesan Jayaprakash,Daniele Castagnolo,Yusuf Özkay
Publisher : CRC Press
Page : 461 pages
File Size : 52,6 Mb
Release : 2019-08-15
Category : Medical
ISBN : 9781351011631
Medicinal Chemistry of Neglected and Tropical Diseases: Advances in the Design and Synthesis of Antimicrobial Agents consolidates and describes modern drug discovery and development approaches currently employed to identify effective chemotherapeutic agents for the treatment of Neglected Tropical Diseases (NTDs) from a medicinal chemistry perspective. Chapters are designed to cater to the needs of medicinal chemists who work with chemotherapeutic developments for NTDs, as well as serve as a guide to budding medicinal chemists who wish to work in this area. It will introduce rational drug design approaches adopted in designing chemotherapeutics and validated targets available for the purpose.
