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Author : Paul M. Selzer Publisher : John Wiley & Sons Page : 511 pages File Size : 52,7 Mb Release : 2009-06-08 Category : Medical ISBN : 9783527323272
Antiparasitic and Antibacterial Drug Discovery by Paul M. Selzer Pdf
Aus erster Hand berichten die Autoren der Beiträge dieses Bandes, mit welchen Strategien in der kommerziellen Forschung nach Wirkstoffen gegen Infektionskrankheiten gesucht wird. Dabei konzentrieren sie sich in erster Linie auf Parasitosen, berücksichtigen aber auch bakterielle Infektionen. Hochinteressante Informationen, die man in dieser Form nirgends findet!
Antimicrobial drugs include those medicines which use antimicrobial agents in the prevention and treatment of infections in humans. An antimicrobial agent is a drug used to prevent and treat the pathogenicity of microorganisms. There are different types of antimicrobial drugs, including antibacterial drugs, antifungal drugs, antiviral agents and antiparasitic drugs. There is increased antimicrobial resistance (AMR) in a variety of human pathogenic microorganisms, which includes Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp. The discovery and development of the antimicrobial drugs is aimed at enhancing the pharmacokinetic properties, overcoming pathogen resistance, and extending the spectrum of microorganisms targeted. The five key areas of research in antimicrobial drug discovery are molecular genetics and systems microbiology; synthetic and computational chemistry, and chemoinformatics; high throughput screening (HTS); non-vertebrate model hosts; and light- and nano-based technologies. This book aims to shed light on some of the unexplored aspects of antimicrobial drug discovery. It includes contributions of experts and scientists which will provide innovative insights into this field.
This handbook is the first dealing with the discovery of drugs directed against apicomplexan parasites. Amongst others, this group of endoparasites includes the causative agents of Malaria, Toxoplasmosis, and Babesiosis, the latter occurring mainly in animals. Written by renowned scientific experts from academia and industry, the book focuses on currentdrug development approaches for all apicomplexan diseases making it appealing to a large audience, ranging from research labs in academia to the human and veterinarian pharmaceutical industry. This work is the second volume of the new book series 'Drug Discovery in Infectious Diseases', edited by Prof. Dr Paul M. Selzer.
This third volume in the successful 'Drug Discovery in Infectious Diseases' series is the first to deal with drug discovery in helminthic infections in human and animals. The result is a broad overview of different drug target evaluation methods, including specific examples of successful drug development against helminthes, and with a whole section devoted to vaccine development. With its well-balanced mix of high-profile contributors from academia and industry, this handbook and reference will appeal to a wide audience, including parasitologists, pharmaceutical industry, epidemiologists, and veterinary scientists.
National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Population Health and Public Health Practice
Author : National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Population Health and Public Health Practice Publisher : National Academies Press Page : 427 pages File Size : 54,7 Mb Release : 2020-04-24 Category : Medical ISBN : 9780309672108
Assessment of Long-Term Health Effects of Antimalarial Drugs When Used for Prophylaxis by National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Population Health and Public Health Practice Pdf
Among the many who serve in the United States Armed Forces and who are deployed to distant locations around the world, myriad health threats are encountered. In addition to those associated with the disruption of their home life and potential for combat, they may face distinctive disease threats that are specific to the locations to which they are deployed. U.S. forces have been deployed many times over the years to areas in which malaria is endemic, including in parts of Afghanistan and Iraq. Department of Defense (DoD) policy requires that antimalarial drugs be issued and regimens adhered to for deployments to malaria-endemic areas. Policies directing which should be used as first and as second-line agents have evolved over time based on new data regarding adverse events or precautions for specific underlying health conditions, areas of deployment, and other operational factors At the request of the Veterans Administration, Assessment of Long-Term Health Effects of Antimalarial Drugs When Used for Prophylaxis assesses the scientific evidence regarding the potential for long-term health effects resulting from the use of antimalarial drugs that were approved by FDA or used by U.S. service members for malaria prophylaxis, with a focus on mefloquine, tafenoquine, and other antimalarial drugs that have been used by DoD in the past 25 years. This report offers conclusions based on available evidence regarding associations of persistent or latent adverse events.
Toxins and Drug Discovery by P. Gopalakrishnakone,Lourdes J. Cruz,Sulan Luo Pdf
In recent years, the field of Toxinology has expanded substantially. On the one hand it studies venomous animals, plants and micro organisms in detail to understand their mode of action on targets. While on the other, it explores the biochemical composition, genomics and proteomics of toxins and venoms to understand their three interaction with life forms (especially humans), development of antidotes and exploring their pharmacological potential. Therefore, Toxinology has deep linkages with biochemistry, molecular biology, anatomy and pharmacology. In addition, there is a fast developing applied subfield, clinical toxinology, which deals with understanding and managing medical effects of toxins on human body. Given the huge impact of toxin-based deaths globally, and the potential of venom in generation of drugs for so-far incurable diseases (for example, Diabetes, Chronic Pain), the continued research and growth of the field is imminent. This has led to the growth of research in the area and the consequent scholarly output by way of publications in journals and books. Despite this ever growing body of literature within biomedical sciences, there is still no all-inclusive reference work available that collects all of the important biochemical, biomedical and clinical insights relating to Toxinology. The Handbook of Toxinology aims to address this gap and cover the field of Toxinology comprehensively.
Chemical Drug Design by Girish Kumar Gupta,Vinod Kumar Pdf
Chemical Drug Design provides a compact overview on recent advances in this rapidly developing field. With contributions on in silico drug design, natural product based compounds, as well as on ligand- and structure-based approaches, the authors present innovative methods and techniques for identifying and synthetically designing novel drugs.
Kucers' The Use of Antibiotics by M. Lindsay Grayson,Sara E. Cosgrove,Suzanne Crowe,William Hope,James S. McCarthy,John Mills,Johan W. Mouton,David L. Paterson Pdf
Kucers’ The Use of Antibiotics is the definitive, internationally-authored reference, providing everything that the infectious diseases specialist and prescriber needs to know about antimicrobials in this vast and rapidly developing field. The much-expanded Seventh Edition comprises 4800 pages in 3 volumes in order to cover all new and existing therapies, and emerging drugs not yet fully licensed. Concentrating on the treatment of infectious diseases, the content is divided into four sections - antibiotics, anti-fungal drugs, anti-parasitic drugs, and anti-viral drugs - and is highly structured for ease of reference. Each chapter is organized in a consistent format, covering susceptibility, formulations and dosing (adult and pediatric), pharmacokinetics and pharmacodynamics, toxicity, and drug distribution, with detailed discussion regarding clinical uses - a feature unique to this title. Compiled by an expanded team of internationally renowned and respected editors, with expert contributors representing Europe, Africa, Asia, Australia, South America, the US, and Canada, the Seventh Edition adopts a truly global approach. It remains invaluable for anyone using antimicrobial agents in their clinical practice and provides, in a systematic and concise manner, all the information required when prescribing an antimicrobial to treat infection.
Medicinal Chemistry by Norma K Dunlap,Donna M Huryn Pdf
Medicinal Chemistry begins with the history of the field, starting from the serendipitous use of plant preparations to current practice of design- and target-based screening methods. Written from the perspective of practicing medicinal chemists, the text covers key drug discovery activities such as pharmacokinetics and patenting, as well as the classes and structures of drug targets (receptors, enzymes, nucleic acids, and protein-protein and lipid interactions) with numerous examples of drugs acting at each type. Selected therapeutic areas include drugs to treat cancer, infectious diseases, and central nervous system disorders. Throughout the book, historical and current examples illustrate the progress to market and case studies explore the applications of concepts discussed in the text. Each chapter features a Journal Club, as well as review and application questions to enhance and test comprehension. This textbook is ideal for upper-level undergraduates and graduate students taking a one-semester survey course on medicinal chemistry and/or drug discovery, as well as scientists entering the pharmaceutical industry.
Research Topics in Bioactivity, Environment and Energy by Carlton A. Taft,Sergio R. de Lazaro Pdf
This book covers edge-point applications in science and engineering. The chapters discuss the functional properties of advanced engineering materials and biomolecules, improving the comprehension of their chemical physical properties and potential for new technological and medicinal applications. The book presents a small number of experimental techniques and computational simulation models from basic concepts of classical/quantum mechanics, physics, chemistry, biology, statistical methods that can predict important applications and properties of these materials/biomolecules. The content shows how improving design of new systems helps in addressing future world problems (health, energy, food, environment, transportation, housing, clothing, etc.), i.e., almost every aspects of our daily lives.
Principles and Practices of Canine and Feline Clinical Parasitic Diseases by Tanmoy Rana Pdf
A comprehensive reference guide for specialists highlighting the parasitic diseases of dogs and cats with appropriate therapeutic strategy Parasitic diseases are a scourge for dogs and cats, and the impact of the numerous maladies associated with these diseases cannot be underestimated. For the clinician or researcher attempting to alleviate these symptoms, Principles and Practices of Canine and Feline Clinical Parasitic Diseases is a helpful, introductory practical guidebook that helps identify the parasites infecting these animals and suggests useful treatment strategies based on an appropriate diagnosis. Principles and Practices of Canine and Feline Clinical Parasitic Diseases comprehensively details its topic from symbiosis and parasitism, to therapeutics measures and control strategies, to the deleterious effect of parasites in various organs in dogs and cats. The book offers extensive information on management approaches, the most significant clinical findings, diagnostic approaches, disease prevention, and drug evaluation. As a reference, the guide provides systems for the identification of the pathogens and recognizes the severity and exhibition of disease manifestation. Principles and Practices of Canine and Feline Clinical Parasitic Diseases readers will also find: Preventative measures that can be utilized to prophylactically assure the continued health of the patient Chapters written by contributors with specialized knowledge in each particular subject presented The most up-to-date advanced research in the field of parasitic diseases Each chapter covers treatment schedules, details about the disease, and a management approach, using figures and line figures to aid in identification and treatment Principles and Practices of Canine and Feline Clinical Parasitic Diseases is ideal for undergraduates, postgraduates, researchers, academics, and industrialists interested in the various parasitic diseases and treatments. It is also extremely useful as a ready reference for scientists seeking to develop new anti-parasitic drugs.
The book "Drug Selectivity - An Evolving Concept in Medicinal Chemistry" provides a current overview and comprehensive compilation for medicinal chemists that discusses the effects of aiming for multiple targets on the entire drug development process. The result is a broad survey of current and future strategies for drug selectivity in medicinal chemistry with theoretical but also practical aspects. Different strategies are presented and evaluated, such as various design approaches, merged multiple ligands, discovery technologies and a broad range of successful examples of unselective drugs taken from all major disease areas. With its wide-ranging view of an emerging new paradigm in drug development, this handbook is of prime importance for every medicinal and pharmaceutical chemist.
Ectoparasites by Charles Q. Meng,Ann E. Sluder Pdf
This first book specifically dedicated to ectoparasite drug discovery is unique in providing insights from the veterinary as well as the medical perspective, covering research from both industry and academia while paving the way for new synergies between the two research communities. Edited by a team combining 80 years of experience in academic research and industrial antiparasitic drug discovery, this volume of Drug Discovery in Infectious Diseases summarizes current knowledge in this rapidly expanding field. Comprehensive yet concise, this ready reference blends solid background information on ectoparasite biology with the very latest methods in ectoparasite drug discovery. Three major parts cover current ectoparasite control strategies and the threat of drug resistance, screening and drug evaluation, and the new isoxazoline class of ectoparasiticides. The future potential of mechanism-based approaches for repellents and parasiticides is thoroughly discussed, as are strategies for vaccines against ectoparasites, making the book ideal for parasitologists in academia as well as researchers working in the pharmaceutical industry.
Human and Animal Filariases by Ronald Kaminsky,Timothy G. Geary Pdf
Human and Animal Filariases The rational approach to controlling human and animal diseases caused by nematodes Filariae are a family of parasitic worms which infect animals and humans, causing severe diseases such as elephantiasis (lymphatic filariasis) and river blindness (onchocerciasis) in humans, as well as heartworm disease (dirofilariasis) in dogs and cats. While the human diseases are rarely fatal, the blindness and disfiguration resulting from these infections constitute a severe burden for the affected individuals and to the healthcare systems in many tropical countries. In 2017, the World Health Organization classified several filariases as neglected tropical diseases and announced a new program seeking to eradicate these infections, which has in turn sparked a new push to develop antifilarial drugs. Considering the current and future import of this topic, Human and Animal Filariases takes a comprehensive look at infections by filarial parasites in humans and in animals. It begins by reviewing the current state of diagnosis and chemotherapy, before addressing the increasing resistance to available antifilarial drugs. This is followed by strategies and approaches for the discovery of novel drugs and finally by looking at alternative and supplementary approaches to combat the parasites, including vector control and vaccination. Human and Animal Filariases readers will find: A comprehensive approach that integrates current chemotherapy with recent advances in antifilarial drug discovery Practical information on assay development, target validation, and required drug product profiles Insights from global experts from leading academic institutions as well as from pharma and healthcare companies Human and Animal Filariases is a unique reference for parasitologists, veterinarians, as well as professionals in the pharmaceutical industry and in public health agencies.
Comprehensive Analysis of Parasite Biology by Sylke Müller,Rachel Cerdan,Ovidiu Radulescu Pdf
Written and edited by experts in the field, this book brings together the current state of the art in phenotypic and rational, target-based approaches to drug discovery against pathogenic protozoa. The chapters focus particularly on virtual compounds and high throughput screening, natural products, computer-assisted drug design, structure-based drug design, mechanism of action identification, and pathway modelling. Furthermore, state-of the art "omics" technologies are described and currently studied enzymatic drug targets are discussed. Mathematical, systems biology-based approaches are introduced as new methodologies for dissecting complex aspects of pathogen survival mechanisms and for target identification. In addition, recently developed anti-parasitic agents targeting particular pathways, which serve as lead compounds for further drug development, are presented.