Dna Repair And Cancer

Author : Mark R. Kelley,Melissa L. Fishel
Publisher : Academic Press
Page : 464 pages
File Size : 50,6 Mb
Release : 2016-06-07
Category : Medical
ISBN : 9780128035993

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DNA Repair in Cancer Therapy by Mark R. Kelley,Melissa L. Fishel Pdf

DNA Repair and Cancer Therapy: Molecular Targets and Clinical Applications, Second Edition provides a comprehensive and timely reference that focuses on the translational and clinical use of DNA repair as a target area for the development of diagnostic biomarkers and the enhancement of cancer treatment. Experts on DNA repair proteins from all areas of cancer biology research take readers from bench research to new therapeutic approaches. This book provides a detailed discussion of combination therapies, in other words, how the inhibition of repair pathways can be coupled with chemotherapy, radiation, or DNA damaging drugs. Newer areas in this edition include the role of DNA repair in chemotherapy induced peripheral neuropathy, radiation DNA damage, Fanconi anemia cross-link repair, translesion DNA polymerases, BRCA1-BRCA2 pathway for HR and synthetic lethality, and mechanisms of resistance to clinical PARP inhibitors. Provides a comprehensive overview of the basic and translational research in DNA repair as a cancer therapeutic target Includes timely updates from the earlier edition, including Fanconi Anemia cross-link repair, translesion DNA polymerases, chemotherapy induced peripheral neuropathy, and many other new areas within DNA repair and cancer therapy Saves academic, medical, and pharma researchers time by allowing them to quickly access the very latest details on DNA repair and cancer therapy Assists researchers and research clinicians in understanding the importance of the breakthroughs that are contributing to advances in disease-specific research

Author : Srinivasan Madhusudan,David M. Wilson III
Publisher : CRC Press
Page : 718 pages
File Size : 40,5 Mb
Release : 2013-01-22
Category : Medical
ISBN : 9781466577442

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DNA Repair and Cancer by Srinivasan Madhusudan,David M. Wilson III Pdf

DNA repair is a rapidly advancing field in biology and these systems represent a major defense mechanism against environmental and intracellular damaging agents such as sunlight, ionizing radiation, and reactive oxygen species. With contributions from eminent researchers, this book explores the basics and current trends in this critical field. Topics include carcinogenesis as a predictive and/or prognostic biomarker for cancer therapy, nucleotide excision repair, and tumor genetics and personalized medicine. The contributions provide essential information to scientists, pharmaceutical investigators, and clinicians interested in cancer therapy.

Author : Lawrence C. Panasci,Moulay A. Alaoui-Jamali
Publisher : Springer Science & Business Media
Page : 378 pages
File Size : 41,9 Mb
Release : 2004-03-19
Category : Medical
ISBN : 9781592597352

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DNA Repair in Cancer Therapy by Lawrence C. Panasci,Moulay A. Alaoui-Jamali Pdf

A comprehensive review of the recent developments in DNA repair that have potential for translational and clinical applications. The authors explain in detail the various mechanisms by which cancer cells can circumvent anticancer therapy and limits its usefulness in patients. They also review the clinical impact of such novel inhibitors of DNA repair mechanisms as methylguanine-DNA-methyltransferase. Also examined are inhibitors of other DNA repair enzymes such as PARP and DNA-PK, now under development and close to clinical trials. The book captures-for both cancer researchers and practicing oncologists dealing with hallmark "relapse" or "drug resistance" phenomena on a daily basis-the many exciting new uses of DNA repair inhibitors, either alone or in combination with anticancer therapies.

Author : Kum Kum Khanna,Yosef Shiloh
Publisher : Springer Science & Business Media
Page : 450 pages
File Size : 40,7 Mb
Release : 2009-09-18
Category : Medical
ISBN : 9789048125616

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The DNA Damage Response: Implications on Cancer Formation and Treatment by Kum Kum Khanna,Yosef Shiloh Pdf

The ?eld of cellular responses to DNA damage has attained widespread recognition and interest in recent years commensurate with its fundamental role in the ma- tenance of genomic stability. These responses, which are essential to preventing cellular death or malignant transformation, are organized into a sophisticated s- tem designated the “DNA damage response”. This system operates in all living organisms to maintain genomic stability in the face of constant attacks on the DNA from a variety of endogenous by-products of normal metabolism, as well as exogenous agents such as radiation and toxic chemicals in the environment. The response repairs DNA damage via an intricate cellular signal transduction network that coordinates with various processes such as regulation of DNA replication, tr- scriptional responses, and temporary cell cycle arrest to allow the repair to take place. Defects in this system result in severe genetic disorders involving tissue degeneration, sensitivity to speci?c damaging agents, immunode?ciency, genomic instability, cancer predisposition and premature aging. The ?nding that many of the crucial players involved in DNA damage response are structurally and functionally conserved in different species spurred discoveries of new players through similar analyses in yeast and mammals. We now understand the chain of events that leads to instantaneous activation of the massive cellular responses to DNA lesions. This book summarizes several new concepts in this rapidly evolving ?eld, and the advances in our understanding of the complex network of processes that respond to DNA damage.

Author : Lesley A Mathews,Stephanie M Cabarcas,Elain Hurt
Publisher : Springer Science & Business Media
Page : 180 pages
File Size : 45,7 Mb
Release : 2012-07-26
Category : Medical
ISBN : 9789400745902

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DNA Repair of Cancer Stem Cells by Lesley A Mathews,Stephanie M Cabarcas,Elain Hurt Pdf

The existence of ‘cancer stem cells’ (CSCs) has been a topic of heated debate for the last few years within the field of cancer biology. Their continuous characterization in a variety of solid tumors has lead to an abundance of evidence supporting their existence. CSCs are believed to be responsible for resistance against conventional treatment regimes of chemotherapy and radiation, ultimately, leading to metastasis and patient demise. To help aid clinicians, pharmaceutical companies and academic labs investigating how to better kill these highly aggressive cells we have summarized the DNA repair mechanism(s) and their role in the maintenance and regulation of both normal and cancer stem cells. Our book represents a comprehensive investigation into the highly effective DNA repair mechanisms of CSCs and what we need to understand in order to develop more advanced therapies to eradicate them from patients. Currently, there are no other published works entirely on DNA repair and Cancer Stem Cells. In addition, our book provides a comprehensive overview of CSC isolation and characterization from a variety of solid tumor types.

Author : Anonim
Publisher : Unknown
Page : 128 pages
File Size : 41,6 Mb
Release : 2024-06-02
Category : Electronic
ISBN : 9789814477116

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DNA Repair, Genetic Instability, and Cancer by Anonim Pdf

Author : Lawrence Panasci,Raquel Aloyz,Moulay Alaoui-Jamali
Publisher : Springer Science & Business Media
Page : 317 pages
File Size : 49,5 Mb
Release : 2012-12-09
Category : Medical
ISBN : 9781461447412

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Advances in DNA Repair in Cancer Therapy by Lawrence Panasci,Raquel Aloyz,Moulay Alaoui-Jamali Pdf

​A comprehensive review of the recent developments in DNA repair research that have potential for translational applications. The book explains in detail the various biological mechanisms by which cancer cells can circumvent anticancer therapy and limits its usefulness in patients. They also review the impact of such novel inhibitors of DNA repair mechanisms as methylguanine-DNA-methyltransferase. Also examined are inhibitors of other DNA repair enzymes such as PARP and DNA-PK. The book captures-for both cancer researchers and oncologists dealing with hallmark "relapse" or "drug resistance" phenomena on a daily basis-the many exciting new uses of DNA repair inhibitors, either alone or in combination with anticancer therapies.​

Author : Qingyi Wei,Dr. Lei Li,Dr. David Chen
Publisher : World Scientific
Page : 374 pages
File Size : 51,5 Mb
Release : 2007
Category : Medical
ISBN : 9789812700148

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DNA Repair, Genetic Instability, and Cancer by Qingyi Wei,Dr. Lei Li,Dr. David Chen Pdf

This volume describes the elaborate surveillance systems and various DNA repair mechanisms that ensure accurate passage of genetic information onto daughter cells. In particular, it narrates how the cell cycle checkpoint and DNA repair machineries detect and restore DNA damages that are embedded in millions to billions of normal base pairs. The scope of the book ranges from biochemical analyses and structural details of DNA repair proteins, to integrative genomics and population-based studies. It provides a snapshot of current understanding about some of the major DNA repair pathways, including base-excision repair, nucleotide excision repair, mismatch repair, homologous recombination, and non-homologous end-joining as well as cell cycle checkpoints and translesion DNA synthesis. One of the particular emphases of the book is the link between inherited DNA repair deficiencies and susceptibility to cancer in the general population. For the first time, the book brings together a collection of review articles written by a group of active and laboratory-based investigators who have a clear understanding of the recent advances in the fields of DNA damage repair and genomic stability and their implications in carcinogenesis, new approaches in cancer therapy, and cancer prevention.

Author : Jac A. Nickoloff,Merl F. Hoekstra
Publisher : Springer Science & Business Media
Page : 639 pages
File Size : 45,8 Mb
Release : 1998-08-12
Category : Science
ISBN : 9781592594559

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DNA Damage and Repair by Jac A. Nickoloff,Merl F. Hoekstra Pdf

Cutting edge reviews by leading researchers illuminate key aspects of DNA repair in mammalian systems and its relationship to human genetic disease and cancer. Major topics include UV and X-Ray repair, repair of chemical damage, recombinational repair, mismatch repair, transcription-repair coupling, and the role of DNA repair in disease prevention. Extensive up-to-date references and rigorous peer-review of each chapter make this volume definitive and bring it to the active frontiers of research.

Author : Ashis K. Basu, Takehiko Nohmi
Publisher : MDPI
Page : 275 pages
File Size : 46,8 Mb
Release : 2018-08-27
Category : Electronic
ISBN : 9783038971290

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Chemically-Induced DNA Damage, Mutagenesis, and Cancer by Ashis K. Basu, Takehiko Nohmi Pdf

This book is a printed edition of the Special Issue " Chemically-Induced DNA Damage, Mutagenesis, and Cancer" that was published in IJMS

Author : Clark Chen
Publisher : BoD – Books on Demand
Page : 498 pages
File Size : 49,7 Mb
Release : 2015-11-18
Category : Medical
ISBN : 9789535122098

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Advances in DNA Repair by Clark Chen Pdf

This book edition is intended to provide a concise summary for select topics in DNA repair, a field that is ever-expanding in complexity and biologic significance. The topics reviewed ranged from fundamental mechanisms of DNA repair to the interface between DNA repair and a spectrum on cellular process to the clinical relevance of DNA repair in oncologic paradigms. The information in this text should provide a foundation from which one can explore the various topics in depth. The book serve as a supplementary text in seminar courses with focus on DNA repair as well as a general reference for scholars with an interest in DNA repair.

Author : Anonim
Publisher : Unknown
Page : 103 pages
File Size : 44,6 Mb
Release : 1987
Category : DNA repair
ISBN : OCLC:19466368

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DNA-repair and Cancer by Anonim Pdf

Author : Clark Chen
Publisher : BoD – Books on Demand
Page : 676 pages
File Size : 46,6 Mb
Release : 2013-05-22
Category : Medical
ISBN : 9789535111146

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New Research Directions in DNA Repair by Clark Chen Pdf

This book is intended for students and scientists working in the field of DNA repair. Select topics are presented here to illustrate novel concepts in DNA repair, the cross-talks between DNA repair and other fundamental cellular processes, and clinical translational efforts based on paradigms established in DNA repair. The book should serve as a supplementary text in courses and seminars as well as a general reference for biologists with an interest in DNA repair.

Author : Timothy A. Yap,Geoffrey I. Shapiro
Publisher : Springer Nature
Page : 333 pages
File Size : 54,6 Mb
Release : 2023-12-19
Category : Medical
ISBN : 9783031300653

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Targeting the DNA Damage Response for Cancer Therapy by Timothy A. Yap,Geoffrey I. Shapiro Pdf

This book discusses the latest developments in Poly (ADP-ribose) polymerase (PARP) inhibitor drug development. It focuses on the translational and clinical development of the latest drugs, as well as the evidence for regulatory approval of PARP inhibitors in multiple different molecular subtypes and tumor indications. The most-up-to-date information on basic scientific research on DNA repair pathways and the DNA Damage Response (DDR) is also covered. Every chapter contains insight into the preclinical, translational along with clinical aspects of a specific DDR inhibitor with key and expert opinion points reinforcing the most important concepts detailed to enable the reader to develop a deep understanding of the topic. Targeting the DNA Damage Response for Cancer Therapy comprehensively reviews the application of PARP and other DDR inhibitors across oncology disciplines. Therefore, it is a valuable resource for all medical professionals and researchers who use or who are researching the use of these inhibitors on a day-to-day basis.

Author : Yitzhak Zimmer,Christian Reinhardt,Michaela Medová
Publisher : Frontiers Media SA
Page : 114 pages
File Size : 42,9 Mb
Release : 2020-12-11
Category : Medical
ISBN : 9782889662159

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Exploiting DNA Damage Response in the Era of Precision Oncology by Yitzhak Zimmer,Christian Reinhardt,Michaela Medová Pdf

Topic Editor Christian Reinhardt has received funding from companies Gilead, and lecture fees from Abbvie, Merck, and AstraZeneca. All other topic editors declare no competing interests with regards to the Research Topic subject.