Down Syndrome From Understanding The Neurobiology To Therapy

Author : Mara Dierssen,Rafa de la Torre
Publisher : Elsevier
Page : 273 pages
File Size : 48,5 Mb
Release : 2012-06-19
Category : Medical
ISBN : 9780444542991

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Down Syndrome: From Understanding the Neurobiology to Therapy by Mara Dierssen,Rafa de la Torre Pdf

Down syndrome (DS) is the most common example of neurogenetic aneuploid disorder leading to mental retardation. In most cases, DS results from an extra copy of chromosome 21 (HSA21) producing deregulated gene expression in brain that gives raise to subnormal intellectual functioning. The topic of this volume is of broad interest for the neuroscience community, because it tackles the concept of neurogenomics, that is, how the genome as a whole contributes to a neurodevelopmental cognitive disorders, such as DS, and thus to the development, structure and function of the nervous system. This volume of Progress in Brain Research discusses comparative genomics, gene expression atlases of the brain, network genetics, engineered mouse models and applications to human and mouse behavioral and cognitive phenotypes. It brings together scientists of diverse backgrounds, by facilitating the integration of research directed at different levels of biological organization, and by highlighting translational research and the application of the existing scientific knowledge to develop improved DS treatments and cures. Leading authors review the state-of-the-art in their field of investigation and provide their views and perspectives for future research Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist

Author : Bani Bandana Ganguly
Publisher : Academic Press
Page : 500 pages
File Size : 49,9 Mb
Release : 2022-08-21
Category : Medical
ISBN : 9780323904575

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Genetics and Neurobiology of Down Syndrome by Bani Bandana Ganguly Pdf

Genetics and Neurobiology of Down Syndrome provides a thorough review of the genetic etiology and mechanisms of trisomy 21. The author discusses the history of the syndrome, along with the clinical features and health consequences, including physical features, cognitive, and neurologic symptoms. Genetic counseling on pros and cons of prenatal screening and testing and associated ethical issues are explored. This unique book also covers the societal and demographic aspects as well as the future direction of therapeutic development. Reviews genetic etiology and mechanisms of trisomy 21 Discusses prenatal screening and genetic counseling, including ethical aspects Explores link between Down Syndrome and susceptibility to Alzheimer’s and early brain aging Covers cognitive and neurological symptoms and other health consequences Identifies future therapeutic developments

Author : Anonim
Publisher : Elsevier
Page : 273 pages
File Size : 48,5 Mb
Release : 2012-10-16
Category : Medical
ISBN : 9780444543004

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Down Syndrome: From Understanding the Neurobiology to Therapy by Anonim Pdf

Down syndrome (DS) is the most common example of neurogenetic aneuploid disorder leading to mental retardation. In most cases, DS results from an extra copy of chromosome 21 (HSA21) producing deregulated gene expression in brain that gives raise to subnormal intellectual functioning. The topic of this volume is of broad interest for the neuroscience community, because it tackles the concept of neurogenomics, that is, how the genome as a whole contributes to a neurodevelopmental cognitive disorders, such as DS, and thus to the development, structure and function of the nervous system. This volume of Progress in Brain Research discusses comparative genomics, gene expression atlases of the brain, network genetics, engineered mouse models and applications to human and mouse behavioral and cognitive phenotypes. It brings together scientists of diverse backgrounds, by facilitating the integration of research directed at different levels of biological organization, and by highlighting translational research and the application of the existing scientific knowledge to develop improved DS treatments and cures. Leading authors review the state-of-the-art in their field of investigation and provide their views and perspectives for future research Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist

Author : Anonim
Publisher : Academic Press
Page : 320 pages
File Size : 54,6 Mb
Release : 2020-02-10
Category : Science
ISBN : 9780444642578

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Preclinical Research in Down Syndrome: Insights for Pathophysiology and Treatments by Anonim Pdf

Preclinical Research in Down Syndrome: From Bench to Bedside, Volume 251, the latest release in the Progress in Brain Research series, highlights new advances in the field. Chapters in this updated release include Exploring genetic and epigenetic mechanisms underlying cognitive deficits in Dow syndrome, The trisomy paradox: gene expression dysregulation domains, the Influence of allelic differences in mouse models of Down syndrome, Modelling Down syndrome in cells: From stem cells to organoids, Modelling Down syndrome in animals from the early stage to the new generation of models, Mapping behavioral landscapes in Down syndrome animal models, and more. Presents content by renowned authors who review the state-of-the-art in preclinical research and provide their views and perspectives for the future of the field Provides extensively referenced chapters, thus giving readers a comprehensive list of resources on topics covered Includes comprehensive and in-depth background information written in a clear form that is accessible to both specialists and non-specialists

Author : Charles J. Epstein
Publisher : Unknown
Page : 280 pages
File Size : 48,7 Mb
Release : 1986
Category : Down syndrome
ISBN : UOM:39015010142654

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The Neurobiology of Down Syndrome by Charles J. Epstein Pdf

Author : Marie-Claude Potier,Roger H. Reeves
Publisher : Frontiers Media SA
Page : 183 pages
File Size : 45,8 Mb
Release : 2017-02-24
Category : Electronic book
ISBN : 9782889450459

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Intellectual Disabilities in Down Syndrome from Birth and throughout Life: Assessment and Treatment by Marie-Claude Potier,Roger H. Reeves Pdf

Research on the multiple aspects of cognitive impairment in Down syndrome (DS), from genes to behavior to treatment, has made tremendous progress in the last decade. The study of congenital intellectual disabilities such as DS is challenging since they originate from the earliest stages of development and both the acquisition of cognitive skills and neurodegenerative pathologies are cumulative. Comorbidities such as cardiac malformations, sleep apnea, diabetes and dementia are frequent in the DS population, as well, and their increased risk provides a means of assessing early stages of these pathologies that is relevant to the general population. Notably, persons with DS will develop the histopathology of Alzheimer’s disease (formation of neuritic plaques and tangles) and are at high risk for dementia, something that cannot be predicted in the population at large. Identification of the gene encoding the amyloid precursor protein, its localization to chromosome 21 in the 90’s and realization that all persons with DS develop pathology identified this as an important piece of the amyloid cascade hypothesis in Alzheimer’s disease. Awareness of the potential role of people with DS in understanding progression and treatment as well as identification of genetic risk factors and also protective factors for AD is reawakening. For the first time since DS was recognized, major pharmaceutical companies have entered the search for ameliorative treatments, and phase II clinical trials to improve learning and memory are in progress. Enriched environment, brain stimulation and alternative therapies are being tested while clinical assessment is improving, thus increasing the chances of success for therapeutic interventions. Researchers and clinicians are actively pursuing the possibility of prenatal treatments for many conditions, an area with a huge potential impact for developmental disorders such as DS. Our goal here is to present an overview of recent advances with an emphasis on behavioral and cognitive deficits and how these issues change through life in DS. The relevance of comorbidities to the end phenotypes described and relevance of pharmacological targets and possible treatments will be considerations throughout.

Author : Anonim
Publisher : Academic Press
Page : 306 pages
File Size : 44,7 Mb
Release : 2019-09-06
Category : Psychology
ISBN : 9780128184554

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State of the Art of Research on Down Syndrome by Anonim Pdf

State of the Art of Research on Down Syndrome, Volume 56, the latest release in the International Review of Research in Developmental Disabilities series, highlights new advances in the field, with this new volume presenting interesting chapters on the Genetics and Genomics of Down Syndrome, Motor Development and Down Syndrome, Cognitive Profiles in Individuals with Down syndrome, Working Memory and Down syndrome, Environment Learning in Individuals with Down syndrome, Reading for Comprehension: The Contribution of Decoding, Linguistic and Cognitive Skills, Number Sense in Down syndrome, Early Starting States in Infants with Down Syndrome: Implications for Research and Practice, and more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the International Review of Research in Developmental Disabilities series Updated release includes the latest information on the State of the Art of Research on Down Syndrome

Author : Anonim
Publisher : Academic Press
Page : 250 pages
File Size : 41,7 Mb
Release : 2016-06-20
Category : Science
ISBN : 9780444636454

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Neurobiology of Epilepsy by Anonim Pdf

Neurobiology of Epilepsy: From Genes to Networks is the latest volume in the Progress in Brain Research series that focuses on new trends and developments. This established international series examines major areas of basic and clinical research within the neurosciences, as well as popular and emerging subfields. Explores new trends and developments in the neurobiology of Epilepsy Enhances the literature of neuroscience by further expanding the established, ongoing international series Progress in Brain Research Examines major areas of basic and clinical research within the field

Author : Anonim
Publisher : Academic Press
Page : 284 pages
File Size : 53,9 Mb
Release : 2022-11-08
Category : Psychology
ISBN : 9780323990974

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International Review Research in Developmental Disabilities by Anonim Pdf

International Review of Research in Developmental Disabilities, Volume 63 highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors, including updates on Theoretical Issues in Adult Siblings, Effects of Challenging Behavior on Others, Transition among Latino Families, Career and Technical Education for adults with IDD, and Emotion Regulation and Social Anxiety in Autism Spectrum Disorders. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the International Review of Research in Developmental Disabilities series

Author : Marcelo Larramendy,Sonia Soloneski
Publisher : BoD – Books on Demand
Page : 206 pages
File Size : 50,8 Mb
Release : 2017-08-30
Category : Medical
ISBN : 9789535134732

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Chromosomal Abnormalities by Marcelo Larramendy,Sonia Soloneski Pdf

This edited book, Chromosomal Abnormalities - A Hallmark Manifestation of Genomic Instability, contains a series of chapters highlighting several aspects related to the generation of chromosomal abnormalities in genetic material. We are extremely grateful to the authors who had contributed with valuable information about the role of genomic instability in pathological disorders as well as in the evolution process.

Author : Anonim
Publisher : Elsevier
Page : 252 pages
File Size : 49,9 Mb
Release : 2013-12-11
Category : Science
ISBN : 9780444633873

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Literature, Neurology, and Neuroscience: Neurological and Psychiatric Disorders by Anonim Pdf

This well-established international series examines major areas of basic and clinical research within neuroscience, as well as emerging and promising subfields. This volume on the neurosciences, neurology, and literature vividly shows how science and the humanities can come together --- and have come together in the past. Its sections provide a new, broad look at these interactions, which have received surprisingly little attention in the past. Experts in the field cover literature as a window to neurological and scientific zeitgeists, theories of brain and mind in literature, famous authors and their suspected neurological disorders, and how neurological disorders and treatments have been described in literature. In addition, a myriad of other topics are covered, including some on famous authors whose important connections to the neurosciences have been overlooked (e.g., Roget, of Thesaurus fame), famous neuroscientists who should also be associated with literature, and some overlooked scientific and medical men who helped others produce great literary works (e,g., Bram Stoker's Dracula). There has not been a volume with this coverage in the past, and the connections it provides should prove fascinating to individuals in science, medicine, history, literature, and various other disciplines. This book looks at literature, medicine, and the brain sciences both historically and in the light of the newest scholarly discoveries and insights

Author : Anonim
Publisher : Elsevier
Page : 368 pages
File Size : 54,8 Mb
Release : 2013-11-25
Category : Science
ISBN : 9780444632753

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Literature, Neurology, and Neuroscience: Historical and Literary Connections by Anonim Pdf

This well-established international series examines major areas of basic and clinical research within neuroscience, as well as emerging and promising subfields. This volume on the neurosciences, neurology, and literature vividly shows how science and the humanities can come together --- and have come together in the past. Its sections provide a new, broad look at these interactions, which have received surprisingly little attention in the past. Experts in the field cover literature as a window to neurological and scientific zeitgeists, theories of brain and mind in literature, famous authors and their suspected neurological disorders, and how neurological disorders and treatments have been described in literature. In addition, a myriad of other topics are covered, including some on famous authors whose important connections to the neurosciences have been overlooked (e.g., Roget, of Thesaurus fame), famous neuroscientists who should also be associated with literature, and some overlooked scientific and medical men who helped others produce great literary works (e,g., Bram Stoker's Dracula). There has not been a volume with this coverage in the past, and the connections it provides should prove fascinating to individuals in science, medicine, history, literature, and various other disciplines. This book looks at literature, medicine, and the brain sciences both historically and in the light of the newest scholarly discoveries and insights

Author : Suzanne "Tink" Martin, PT, PhD,Mary Kessler, MHS, PT
Publisher : Elsevier Health Sciences
Page : 520 pages
File Size : 44,8 Mb
Release : 2015-06-24
Category : Electronic
ISBN : 9781455740208

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Neurologic Interventions for Physical Therapy by Suzanne "Tink" Martin, PT, PhD,Mary Kessler, MHS, PT Pdf

Master the role of the physical therapist or physical therapist assistant in neurologic rehabilitation! Neurologic Interventions for Physical Therapy, 3rd Edition helps you develop skills in the treatment interventions needed to improve the function of patients with neurologic deficits. It provides a solid foundation in neuroanatomy, motor control, and motor development, and offers clear, how-to guidelines to rehabilitation procedures. Case studies help you follow best practices for the treatment of children and adults with neuromuscular impairments caused by events such as spinal cord injuries, cerebral palsy, and traumatic brain injuries. Written by physical therapy experts Suzanne 'Tink' Martin and Mary Kessler, this market-leading text will help you prepare for the neurological portion of the PTA certification exam and begin a successful career in physical therapy practice. Comprehensive coverage of neurologic rehabilitation explores concepts in neuroanatomy, motor control and motor learning, motor development, and evidence-based treatment of adults and children with neuromuscular impairments. Over 700 photos and drawings clarify concepts, show anatomy, physiology, evaluation, and pathology, and depict the most current rehabilitation procedures and technology. Case studies demonstrate the patient examination and treatment process, and show how to achieve consistency in documentation. Proprioceptive Neuromuscular Facilitation chapter describes how PNF can be used to improve a patient's performance of functional tasks by increasing strength, flexibility, and range of motion - key to the treatment of individuals post stroke. Review questions are included at the end of each chapter, with answers at the back of the book. Illustrated step-by-step intervention boxes, tables, and charts highlight important information, and make it easy to find instructions quickly. Use of language of the APTA Guide to Physical Therapist Practice ensures that you understand and comply with best practices recommended by the APTA. NEW photographs of interventions and equipment reflect the most current rehabilitation procedures and technology. UPDATED study resources on the Evolve companion website include an intervention collection, study tips, and additional review questions and interactive case studies.

Author : Anonim
Publisher : Elsevier
Page : 440 pages
File Size : 42,9 Mb
Release : 2015-02-12
Category : Medical
ISBN : 9780444634108

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Music, Neurology, and Neuroscience: Historical Connections and Perspectives by Anonim Pdf

Music, Neurology, and Neuroscience: Historical Connections and Perspectives provides a broad and comprehensive discussion of history and new discoveries regarding music and the brain, presenting a multidisciplinary overview on music processing, its effects on brain plasticity, and the healing power of music in neurological and psychiatric disorders. In this context, the disorders that plagued famous musicians and how they affected both performance and composition are critically discussed, as is music as medicine and its potential health hazard. Additional topics, including the way music fits into early conceptions of localization of function in the brain, its cultural roots in evolution, and its important roles in societies and educational systems are also explored. Examines music and the brain both historically and in the light of the latest research findings The largest and most comprehensive volume on "music and neurology" ever written Written by a unique group of real world experts representing a variety of fields, ranging from history of science and medicine, to neurology and musicology Includes a discussion of the way music has cultural roots in evolution and its important role in societies

Author : Anonim
Publisher : Elsevier
Page : 292 pages
File Size : 48,6 Mb
Release : 2015-03-02
Category : Medical
ISBN : 9780444635525

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Music, Neurology, and Neuroscience: Evolution, the Musical Brain, Medical Conditions, and Therapies by Anonim Pdf

Did you ever ask whether music makes people smart, why a Parkinson patient's gait is improved with marching tunes, and whether Robert Schumann was suffering from schizophrenia or Alzheimer's disease? This broad but comprehensive book deals with history and new discoveries about music and the brain. It provides a multi-disciplinary overview on music processing, its effects on brain plasticity, and the healing power of music in neurological and psychiatric disorders. In this context, the disorders the plagued famous musicians and how they affected both performance and composition are critically discussed, and music as medicine, as well as music as a potential health hazard are examined. Among the other topics covered are: how music fit into early conceptions of localization of function in the brain, the cultural roots of music in evolution, and the important roles played by music in societies and educational systems. Topic: Music is interesting to almost everybody Orientation: This book looks at music and the brain both historically and in the light of the latest research findings Comprehensiveness: This is the largest and most comprehensive volume on "music and neurology" ever written! Quality of authors: This volume is written by a unique group of real world experts representing a variety of fields, ranging from history of science and medicine to neurology and musicology