Drug Delivery In Dermatology

Author : Célia Luiza Petersen Vitello Kalil,Valéria Campos
Publisher : Springer Nature
Page : 212 pages
File Size : 45,9 Mb
Release : 2021-09-19
Category : Medical
ISBN : 9783030818074

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Drug Delivery in Dermatology by Célia Luiza Petersen Vitello Kalil,Valéria Campos Pdf

Skin accounts for approximately 15% of an adult’s total body weight, with a surface of about 2m2. It provides an entry and exit barrier to various substances, offers effective protection against harmful substances, microorganisms and ultraviolet radiation, and is also paramount in immunology and body homeostasis, preventing dehydration and loss of essential minerals. The topical route has a number of advantages over oral and parenteral routes: no first-pass metabolism, greater convenience resulting in better treatment compliance, lower side-effect frequency, and prompt dosing cessation if required. However, the stratum corneum allows penetration of only 1 to 5% of substances applied topically, making this application route much less efficient. Lipophilic and small molecules (up to 500 Da) can cross the stratum corneum, since keratinocytes are covered by a lipid matrix, while it is virtually impossible for hydrophilic and large drugs to cross intact, normal skin, which means that passive topical delivery is restricted. To address this, techniques have been developed aimed at optimizing drug skin penetration by means of chemical, mechanical and physical methods, such as adding permeating active agents and using occlusion, iontophoresis, microneedling, lasers and intense pulsed light, and it is now possible to deliver medication to different skin layers or transdermally to the systemic circulation. Drug delivery is a hot topic in dermatology, with a Pubmed search generating 203431 articles. Offering a detailed review of this emerging therapeutic option, including the various methods available, this unique book guides physicians and doctors in selecting the correct technologies, technique and products for each patient.

Author : Heather A. E. Benson,Adam C. Watkinson
Publisher : John Wiley & Sons
Page : 393 pages
File Size : 46,5 Mb
Release : 2012-02-03
Category : Medical
ISBN : 9781118140499

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Topical and Transdermal Drug Delivery by Heather A. E. Benson,Adam C. Watkinson Pdf

Practical drug development approaches presented by leading experts Designed to support the development of new, effective therapeutics, Topical and Transdermal Drug Delivery: Principles and Practice explains the principles underlying the field and then demonstrates how these principles are put into practice in the design and development of new drug products. Drawing together and reviewing the latest research findings, the book focuses on practical, tested, and proven approaches that are backed by industry case studies and the authors' firsthand experience. Moreover, the book emphasizes the mechanistic information that is essential for successful drug product development. Topical and Transdermal Drug Delivery: Principles and Practice is divided into two parts: Part One, Current Science, Skin Permeation, and Enhancement Approaches, offers readers a fundamental understanding of the underlying science in the field. It describes the principles and techniques needed to successfully perform experimental approaches, covering such issues as skin permeation, enhancement, and assessment. Part Two, Topical and Transdermal Product Development, guides readers through the complete product development process from concept to approval, offering practical tips and cautions from experts in the field. This part also discusses regulations that are specific to the development of dermal drug products. The final chapter explores current and future trends, forecasting new development techniques and therapeutics. Throughout the book, the authors clearly set forth the basic science and experimental procedures, making it possible for researchers to design their own experimental approaches and accurately interpret their results. With contributions from experienced drug researchers, this text is highly recommended for all researchers involved in topical and transdermal product development who need to know both the state of the science and the standards of practice.

Author : Lionel Trottet,Howard Maibach, MD
Publisher : Springer
Page : 148 pages
File Size : 53,6 Mb
Release : 2017-08-07
Category : Medical
ISBN : 9783319595047

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Dermal Drug Selection and Development by Lionel Trottet,Howard Maibach, MD Pdf

The authors show how the pharmaceutical industry faces the development of dermal drugs and provide the only book of its kind that describes how the industry develops and selects dermal drugs, complete with the challenges and opportunities of the field. Delivery of drugs through the skin has been an attractive and challenging area for research, and advances in modern technologies have resulted in a larger number of drugs being delivered transdermally, including conventional hydrophobic small molecule drugs, hydrophilic drugs and macromolecules. Offering the perspective from the industrial side of selection and development of drugs, the primary audience is geared towards the pharmaceutical industry but can also offer valuable information to clinicians, compounding pharmacists, and similarly pharmacy students. Dermal Drug Selection and Development covers the scientific gaps that exist in terms of dermal pharmacokinetics and the resulting uncertainty by clinicians when choosing a drug candidate.

Author : Jonathan Hadgraft
Publisher : CRC Press
Page : 400 pages
File Size : 49,7 Mb
Release : 2002-10-29
Category : Medical
ISBN : 9780203909683

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Transdermal Drug Delivery Systems by Jonathan Hadgraft Pdf

Presents authoritative state-of-the-art discussions of the key issues pertinent to transdermal drug delivery, examining those topics necessary to enable a critical evaluation of a drug candidate's potential to be delivered across the skin; from physical chemistry and assessment of drug permeability to available enhancement technolgies, to regulator

Author : C. Surber,C. Abels,H. Maibach
Publisher : Karger Medical and Scientific Publishers
Page : 214 pages
File Size : 49,9 Mb
Release : 2018-08-21
Category : Medical
ISBN : 9783318063851

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pH of the Skin: Issues and Challenges by C. Surber,C. Abels,H. Maibach Pdf

The concept of expressing acidity as the negative logarithm of the hydrogen ion concentration was defined and termed pH in the beginning of the 20th century. The general usefulness of the pH concept for life science was recognized and later gained importance to analytical research. Reports on results of pH measurements from living skin established the term acid mantle - the skin's own protective shield that maintains a naturally acid pH. It is invisible to the eye but crucial to the overall wellbeing of skin. Chronic alkalization can throw this acid mantle out of balance, leading to inflammation, dermatitis, and atopic skin diseases. It is therefore no surprise, that skin pH shifts have been observed in various skin pathologies. It is also obvious that the pH in topically applied preparations may play an important role. Optimal pH and buffer capacity within topical preparations not only support stability of active ingredients and auxiliary materials, but may also increase absorption of the non-ionized species of an acidic or a basic active ingredient. They may even open up opportunities to modify and "correct" skin pH and hence accelerate barrier recovery and maintain or enhance barrier integrity. Further efforts are needed to standardize and improve pH measurements in biological media or pharmaceutical/cosmetic vehicles to increase and ensure quality, comparability, and relevance of research data. In this volume, we present a unique collection of papers that address past, present and future issues of the pH of healthy and diseased skin. It is hoped that this collection will foster future efforts in clinical and experimental skin research.

Author : Kenneth A. Walters
Publisher : CRC Press
Page : 592 pages
File Size : 49,6 Mb
Release : 2002-02-20
Category : Medical
ISBN : 9780824743239

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Dermatological and Transdermal Formulations by Kenneth A. Walters Pdf

Containing 350 illustrations, tables, and equations and covering AAPS/FDA guidelines for the experimentation and analysis of in vivo and in vitro percutaneous absorption, this reference provides comprehensive coverage of the development, preparation, and application of topical and transdermal therapeutic systems. Recognized international experts di

Author : J. Comstock,M.H. Gold
Publisher : Karger Medical and Scientific Publishers
Page : 178 pages
File Size : 55,6 Mb
Release : 2021-01-19
Category : Medical
ISBN : 9783318066906

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Cosmeceuticals by J. Comstock,M.H. Gold Pdf

Cosmeceuticals are ingredients or products that provide cosmetic and therapeutic benefits and which can be obtained without a prescription. They are one of the fastest growing segments in the personal care product market. Even in the worst economic climate, sales of cosmetics remain robust. Beauty enhancers are our best means of feel-good escapism, and we are not about to give them up. The ingredients, sales locations, and the regulation of sales are dynamic aspects of the industry. Here we give you a heads-up on where the market is going so you can make strategic decisions for your practice. This book will give you an understanding of facial cosmeceuticals examining the needs of the face, moisturizer formulation, noninvasive testing, and clinical evaluation to establish efficacy. It sheds light on topics such as the delivery mechanisms of active ingredients, vitamin A and C and other antioxidants, growth factors and stem cells, peptides, or amino acids. Topics also include the use of cosmeceuticals for the treatment of acne, rosacea, and hair loss and for hair care as well as the treatment of scars and cosmeceuticals for sun protection and protection from pollution. It also covers aspects of nutraceuticals and diets for healthy skin.

Author : S Narasimha Murthy,Howard I. Maibach
Publisher : CRC Press
Page : 293 pages
File Size : 49,9 Mb
Release : 2012-09-26
Category : Medical
ISBN : 9781439811313

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Topical Nail Products and Ungual Drug Delivery by S Narasimha Murthy,Howard I. Maibach Pdf

Discussing existing techniques, ongoing research, new approaches, and basic concepts in the treatment of nail diseases, Topical Nail Products and Ungual Drug Delivery summarizes the current knowledge and represents a jumping-off point for creating novel techniques of drug delivery across the nail.A growing area of pharmaceutical research, the searc

Author : Keith R Brain,Robert P Chilcott
Publisher : Royal Society of Chemistry
Page : 476 pages
File Size : 54,9 Mb
Release : 2013
Category : Medical
ISBN : 9781849733984

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Advances in Dermatological Sciences by Keith R Brain,Robert P Chilcott Pdf

Readily accessible, yet detailed, this book presents cutting-edge advances in the field of dermatological sciences.

Author : Umesh V. Banakar,David W. Osborne
Publisher : Unknown
Page : 178 pages
File Size : 47,6 Mb
Release : 1993
Category : Dermatologic agents
ISBN : 1566760623

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Dermatological Product Development and Drug Delivery by Umesh V. Banakar,David W. Osborne Pdf

Author : Nina Dragicevic,Howard I. Maibach
Publisher : Springer
Page : 414 pages
File Size : 42,5 Mb
Release : 2017-05-04
Category : Medical
ISBN : 9783662532706

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Percutaneous Penetration Enhancers Drug Penetration Into/Through the Skin by Nina Dragicevic,Howard I. Maibach Pdf

Percutaneous Penetration Enhancers in a mini-series format comprising five volumes, represents the most comprehensive reference on enhancement methods – both well established and recently introduced – in the field of dermal/transdermal drug delivery. In detail the broad range of both chemical and physical methods used to enhance the skin delivery of drugs is described. All aspects of drug delivery and measurement of penetration are covered, and the latest findings are provided on skin structure and function, mathematics in skin permeation, and modern analytical techniques adapted to assess and measure penetration. In offering a detailed description of the methods currently in use for penetration enhancement, this book will be of value for researchers, pharmaceutical scientists, practitioners, students and dermatological scientists or dermatologists​.

Author : Tapash K. Ghosh
Publisher : CRC Press
Page : 463 pages
File Size : 48,5 Mb
Release : 2020-01-21
Category : Medical
ISBN : 9781466582712

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Dermal Drug Delivery by Tapash K. Ghosh Pdf

With the continued advancement of better-quality control and patient outcome reporting systems, changes in the development, control, and regulation of all pharmaceutical delivery systems including transdermal and topical products have been happening on a continuous basis. In light of various quality issues that have been reported by patients and practitioners resulting in the recall or removal of products from the market, both the pharmaceutical industries and regulatory agencies have been adopting new measures to address these issues. With chapters written by experts in this field, this book takes a 21st century multidisciplinary and cross-functional look at these dosage forms to improve the development, design, manufacturing, quality, clinical performance, safety, and regulation of these products. This book offers a wealth of up-to-date information organized in a logical sequence corresponding to various stages of research, development, and commercialization of dermal drug delivery products. The authors have been carefully selected from different sectors of pharmaceutical science for their expertise in their selected areas to present objectively a balanced view of the current state of these products development and commercialization via regulatory approval. Their insights will provide useful information to others to ensure the successful development of the next generation dermal drug products. Key Features: Presents current advancements including new technologies of transdermal and topical dosage forms. Presents challenges in the development of the new generation of transdermal and topical dosage forms. Introduces new technologies and QbD (quality by design) aspects of manufacturing and control strategies. Includes new perspectives on pre-clinical and clinical development, regulatory considerations, safety and quality. Discusses regulatory challenges, gaps, and future considerations for dermal drug delivery systems.

Author : John J. Wille
Publisher : Wiley-Blackwell
Page : 404 pages
File Size : 45,6 Mb
Release : 2006-06-26
Category : Science
ISBN : 0813808480

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Skin Delivery Systems by John J. Wille Pdf

Current interest in drug delivery technologies is exceedingly high. Similarly, a recent upsurge in consumer awareness of the potential antiaging and antiwrinkling benefits of natural products and botanicals has spurred a revolution in the cosmetic industry for better skin care delivery technologies, both to preserve inherent activity as well as to enhance their benefits through novel formulation and delivery methods. With these considerations in mind, Skin Delivery Systems: Transdermals, Dermatologicals and Cosmetic Actives brings together the emerging fields of cosmetic actives with new advances in skin delivery technologies and provides a methodical and systematic explanation of technologies used to transport pharmaceuticals and cosmetic actives through the skin's barriers. After reviewing the basic principles of dermatology and skin penetration, the reference describes and explains the most current methods of transdermal transport. Coverage includes new materials, such as amphiphilic polymers; new formulation methods, such as miniemulsions; and variations on technologies such as sonophoresis and iontophoresis. The authors also show the connections between skin penetration and a variety of active substances, including specialized pharmaceuticals and natural and botanical ingredients used in cosmetics. The book presents critical empirical data and design information intended to assist researchers, product developers, and testers in the pharmaceutical and cosmetics industries.

Author : Maria Claudia Almeida Issa,Bhertha Tamura
Publisher : Springer
Page : 0 pages
File Size : 51,5 Mb
Release : 2017-08-11
Category : Medical
ISBN : 3319125885

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Daily Routine in Cosmetic Dermatology by Maria Claudia Almeida Issa,Bhertha Tamura Pdf

​The series “Clinical Approaches and Procedures in Cosmetic Dermatology” intends to be a practical guide in Cosmetic Dermatology. Procedures in cosmetic dermatology are very popular and useful in medicine, indicated to complement topical and oral treatments not only for photodamaged skin but also for other dermatosis such as acne, rosacea, scars, etc. Also, full-face treatments using peelings, lasers, fillers and toxins are increasingly being used, successfully substituting or postponing the need for plastic surgeries. Altogether, these techniques not only provide immediate results but also help patients to sustain long-term benefits, both preventing/treating dermatological diseases and maintaining a healthy and youthful skin. Throughout this series, different treatments in Cosmetic Dermatology will be discussed in detail covering the use of many pharmacological groups of cosmeceuticals, the new advances in nutraceuticals and emerging technologies and procedures. This volume, entitled “Daily Routine in Cosmetic Dermatology” will be an important tool for aesthetic doctors, practicing dermatologists, plastic surgeons, and all other physicians interested in the field of aesthetic medicine. It discloses in detail the semiology and general treatments in cosmetic dermatology, providing the state-of-the-art regarding patients’ evaluation, photoprotection, nutraceuticals and cosmeceuticals and special prescriptions. Also check the other volumes: Volume II - Chemical and Physical Peelings Volume III - Lasers, Lights and Other Technologies Volume IV - Botulinum Toxins, Fillers and Related Substances

Author : Kenji Sugibayashi
Publisher : Springer
Page : 428 pages
File Size : 53,8 Mb
Release : 2017-11-28
Category : Medical
ISBN : 9784431565260

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Skin Permeation and Disposition of Therapeutic and Cosmeceutical Compounds by Kenji Sugibayashi Pdf

This book reviews skin permeation and disposition of chemical compounds. Skin is utilized as an administration site for transdermal drug delivery systems, topical drug formulations, cosmeceuticals, and cosmetics. Their usefulness is closely related to the permeation and disposition of entrapped active ingredients through and into the skin. Skin permeation, disposition, and metabolism of chemicals are first summarized in the general introduction. Then primary topical formulations are explained in the second part, “Basic Formulations Applied to Skin”. The explanation for the active compounds and formulations are of the most important parts required to fabricate these formulations. Skin absorption of chemicals is generally much lower than oral and the other mucosal absorptions, so that skin-penetration enhancement is a key issue to have good formulations topically applied. Part 3 presents “Skin Penetration Enhancement”. In addition, Part 4, “Selection of Topically Applied Chemical Candidates”, deals with selection methods of topically applied ingredients for transdermal drug delivery systems, topical drug formulations, cosmeceuticals, and cosmetics. Parts 5 and 6, “Safety Assessment of Topically Applied Compounds“ and “Experimental Methods of Skin Permeation“, respectively, show safety issues and experimental methods for topical formulations. The final part consists of comments on therapeutic and cosmetic formulations by medical doctors and pharmacists. Their comments are especially helpful for pharmaceutical and cosmetic researchers who study dermatopharmacokinetics and topical formulations. This volume is particularly useful for those working in R&D, graduate students, and educators in the area of pharmaceutics, cosmetic sciences, dermatological sciences, pharmacology, toxicology, biopharmacy, pharmacokinetics, physical pharmacy, chemical engineering, and related fields.