Download Full eBooks in PDF
Drug Discrimination Applications To Drug Abuse Research Research Monograph 116 1991 Book in PDF, ePub and Kindle version is available to download in english. Read online anytime anywhere directly from your device. Click on the download button below to get a free pdf file of Drug Discrimination Applications To Drug Abuse Research Research Monograph 116 1991 book. This book definitely worth reading, it is an incredibly well-written.
Author : Anonim
Publisher : Unknown
Page : 420 pages
File Size : 48,8 Mb
Release : 1991
Category : Electronic
ISBN : 8210379456XXX
Author : Richard A. Glennon,Torbjörn U. C. Järbe,Jerry Frankenheim
Publisher : Unknown
Page : 408 pages
File Size : 45,7 Mb
Release : 1991
Category : Discrimination learning
ISBN : 0160360358
Author : Richard A. Glennon,Richard Young
Publisher : John Wiley & Sons
Page : 534 pages
File Size : 54,7 Mb
Release : 2011-08-23
Category : Medical
ISBN : 9780470433522
Drug discrimination: a practical guide to its contributions to the invention of new chemical entities and evaluations of new or known pharmacological agents Drug discrimination can be described as a "drug detection" procedure that uses a pharmacologically active agent as the subjective stimulus. Although the procedure does require some effort to implement, it can be an extremely important tool for understanding drug action. Whereas medicinal chemists should come to learn the types of information that drug discrimination studies can offer, pharmacologists and psychologists might come to realize how medicinal chemists can apply the types of information that the paradigm routinely provides. Drug Discrimination: Applications to Medicinal Chemistry and Drug Studies provides in-depth analyses of the nature and use of drugs as discriminative stimuli and bridges some of the numerous gaps between medicinal chemistry, pharmacology, and psychology. Stressing the practical aspects of drug discrimination, including types of procedures, study design, data, and interpretation, the book details the advantages and limitations of drug discrimination studies versus other pharmacologic evaluations. Practical information from leading researchers in the field addresses specific topics and techniques that are of interest in drug discovery, evaluation, and development. A groundbreaking new guide to the applications of drug discrimination studies for medicinal chemistry and neuroscience, Drug Discrimination is essential for any scientist, researcher, or student whose interests involve the design, development, and/or action of drugs acting at the level of the central nervous system.
Author : National Clearinghouse for Alcohol and Drug Information (U.S.).
Publisher : Unknown
Page : 116 pages
File Size : 45,8 Mb
Release : 2001
Category : Government publications
ISBN : RUTGERS:39030032861223
Author : Anonim
Publisher : Unknown
Page : 318 pages
File Size : 45,8 Mb
Release : 1997
Category : Alcoholism
ISBN : UOM:39015040503818
Author : Kenneth Blum,Ernest P. Noble
Publisher : CRC Press
Page : 530 pages
File Size : 50,6 Mb
Release : 1996-10-29
Category : Science
ISBN : 0849344867
Psychiatric genetics is an exciting new discipline that explores how our minds and behavior are influenced by our genes. Increased interest in this area of medical genetics has been sparked by advances in molecular genetic techniques, the genome project, the neurosciences, the role of genes in somatic diseases, and the linking of specific genes with complex mental disorders. This Handbook is the definitive resource on this complex, and sometimes controversial, new field.
Author : Louis W. Chang,William Slikker Jr.
Publisher : Elsevier
Page : 875 pages
File Size : 55,8 Mb
Release : 1995-04-20
Category : Science
ISBN : 9780080537474
Neurotoxicology: Approaches and Methods provides a unique and comprehensive presentation of the current concepts and state-of-the-art methods for the assessment of neurotoxicity. The book analyzes various techniques available and discusses their strengths and weaknesses. This volume will serve as an excellent desk companion and laboratory guide for all investigators, researchers, clinicians, and students interested in neurotoxicology. The internationally knowngroup of editors divide the book into seven sections: Neuromorphological and Neuropathological Approaches; Neurophysiological Approaches; Neurobehavioral Toxicology; Neurochemical and Biomolecular Approaches; In-Vitro Models; Clinical Neurotoxicology; and Risk Assessment of Neurotoxicity. Each section yields the most up-to-date information by experts in their fields. Meticulously organized and edited, Neurotoxicology: Approaches and Methods is the most authoritative and well-planned neurotoxicology book on the market. Discusses neurobehavioral testing methods for assessment of neural dysfunctions Explains state-of-the-art diagnostic methods, such as clinico-neuropsychological and neurophysiological methods, for patients confronted by neurotoxic problems Discusses In Vitro methods, including aggregating brain cell methods, organotypic cultures, and the use of human neuronal cell lines for the assessment of neurotoxicity Presents step-by-step procedures for many methods Provides state-of-the-art neuromorphological and biomolecular methods and approaches for neurotoxicity investigation
Author : Godfrey Tunnicliff,Christopher D. Cash
Publisher : CRC Press
Page : 316 pages
File Size : 46,7 Mb
Release : 2002-08-01
Category : Medical
ISBN : 9780203300992
Gamma-hydroxybutyrate (GHB) has come a long way since early experiments in animals where it was found to induce a sleep-like state and from its use in general anaesthesia in human subjects. It has been found to be a naturally-occurring compound in the brain, a metabolite of GABA, the emerging ubiquitous inhibitory neurotransmitter. This has opened
Author : Anonim
Publisher : Unknown
Page : 696 pages
File Size : 54,9 Mb
Release : 1976
Category : Drug abuse
ISBN : COLUMBIA:HR01752251
Author : Joseph H. Porter,Adam J. Prus
Publisher : Springer
Page : 324 pages
File Size : 45,8 Mb
Release : 2018-08-30
Category : Medical
ISBN : 9783319985619
The goal for this volume is to provide an up-to-date review of the discriminative stimulus properties of major psychoactive drug classes with an emphasis on how this paradigm enhances our understanding of these drugs and how these findings translate from animals to humans. The drug discrimination paradigm applies to both drugs of abuse and drugs for treating mental illnesses, and research from these studies has provided immense translational value for learning about the mechanisms responsible for drug effects in humans.
Author : College on Problems of Drug Dependence (U.S.). Scientific Meeting
Publisher : Unknown
Page : 564 pages
File Size : 48,8 Mb
Release : 1993
Category : Drug abuse
ISBN : UOM:39015035689952
Author : Anonim
Publisher : Unknown
Page : 568 pages
File Size : 41,6 Mb
Release : 1993
Category : Drug abuse
ISBN : MINN:31951D009510473
Author : Anonim
Publisher : Unknown
Page : 568 pages
File Size : 54,6 Mb
Release : 1993
Category : Research
ISBN : NWU:35558003396930
Author : Julie A. Marusich,Timothy W. Lefever,Scott P. Novak,Bruce E. Blough,Jenny L. Wiley
Publisher : RTI Press
Page : 16 pages
File Size : 40,9 Mb
Release : 2013-07-22
Category : Medical
ISBN : 8210379456XXX
In 2011, the prevalence of prescription drug abuse exceeded that of any other illicit drug except marijuana. Consequently, efforts to curtail abuse of new medications should begin during the drug development process, where abuse liability can be identified and addressed before a candidate medication has widespread use. The first step in this process is scheduling with the Drug Enforcement Agency so that legal access is appropriately restricted, dependent upon levels of abuse risk and medical benefit. To facilitate scheduling, the Food and Drug Administration (FDA) has published guidance for industry that describes assessment of abuse liability. The purpose of this paper is to review methods that may be used to satisfy the FDA's regulatory requirements for animal behavioral and dependence pharmacology. Methods include psychomotor activity, self-administration (an animal model of the rewarding effects of a drug), drug discrimination (an animal model of the subjective effects of a drug), and evaluation of tolerance and dependence. Data from tests with known drugs of abuse illustrate typical results. While the use of preclinical data to predict abuse liability is an imperfect process, these methods have substantial predictive validity. The ultimate goal is to increase consumer safety through appropriate scheduling of new medications.
Author : United States. Superintendent of Documents
Publisher : Unknown
Page : 12 pages
File Size : 52,7 Mb
Release : 1992
Category : Alcoholism
ISBN : UFL:31262049461667
