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Author : Joseph H. Porter,Adam J. Prus Publisher : Springer Page : 324 pages File Size : 43,9 Mb Release : 2018-08-30 Category : Medical ISBN : 9783319985619
The Behavioral Neuroscience of Drug Discrimination by Joseph H. Porter,Adam J. Prus Pdf
The goal for this volume is to provide an up-to-date review of the discriminative stimulus properties of major psychoactive drug classes with an emphasis on how this paradigm enhances our understanding of these drugs and how these findings translate from animals to humans. The drug discrimination paradigm applies to both drugs of abuse and drugs for treating mental illnesses, and research from these studies has provided immense translational value for learning about the mechanisms responsible for drug effects in humans.
National Academies of Sciences, Engineering, and Medicine,Division of Behavioral and Social Sciences and Education,Board on Behavioral, Cognitive, and Sensory Sciences,Committee on the Science of Changing Behavioral Health Social Norms
Author : National Academies of Sciences, Engineering, and Medicine,Division of Behavioral and Social Sciences and Education,Board on Behavioral, Cognitive, and Sensory Sciences,Committee on the Science of Changing Behavioral Health Social Norms Publisher : National Academies Press Page : 171 pages File Size : 54,8 Mb Release : 2016-09-03 Category : Social Science ISBN : 9780309439121
Ending Discrimination Against People with Mental and Substance Use Disorders by National Academies of Sciences, Engineering, and Medicine,Division of Behavioral and Social Sciences and Education,Board on Behavioral, Cognitive, and Sensory Sciences,Committee on the Science of Changing Behavioral Health Social Norms Pdf
Estimates indicate that as many as 1 in 4 Americans will experience a mental health problem or will misuse alcohol or drugs in their lifetimes. These disorders are among the most highly stigmatized health conditions in the United States, and they remain barriers to full participation in society in areas as basic as education, housing, and employment. Improving the lives of people with mental health and substance abuse disorders has been a priority in the United States for more than 50 years. The Community Mental Health Act of 1963 is considered a major turning point in America's efforts to improve behavioral healthcare. It ushered in an era of optimism and hope and laid the groundwork for the consumer movement and new models of recovery. The consumer movement gave voice to people with mental and substance use disorders and brought their perspectives and experience into national discussions about mental health. However over the same 50-year period, positive change in American public attitudes and beliefs about mental and substance use disorders has lagged behind these advances. Stigma is a complex social phenomenon based on a relationship between an attribute and a stereotype that assigns undesirable labels, qualities, and behaviors to a person with that attribute. Labeled individuals are then socially devalued, which leads to inequality and discrimination. This report contributes to national efforts to understand and change attitudes, beliefs and behaviors that can lead to stigma and discrimination. Changing stigma in a lasting way will require coordinated efforts, which are based on the best possible evidence, supported at the national level with multiyear funding, and planned and implemented by an effective coalition of representative stakeholders. Ending Discrimination Against People with Mental and Substance Use Disorders: The Evidence for Stigma Change explores stigma and discrimination faced by individuals with mental or substance use disorders and recommends effective strategies for reducing stigma and encouraging people to seek treatment and other supportive services. It offers a set of conclusions and recommendations about successful stigma change strategies and the research needed to inform and evaluate these efforts in the United States.
Author : Richard A. Glennon,Richard Young Publisher : John Wiley & Sons Page : 534 pages File Size : 46,9 Mb Release : 2011-08-23 Category : Medical ISBN : 9780470433522
Drug Discrimination by Richard A. Glennon,Richard Young Pdf
Drug discrimination: a practical guide to its contributions to the invention of new chemical entities and evaluations of new or known pharmacological agents Drug discrimination can be described as a "drug detection" procedure that uses a pharmacologically active agent as the subjective stimulus. Although the procedure does require some effort to implement, it can be an extremely important tool for understanding drug action. Whereas medicinal chemists should come to learn the types of information that drug discrimination studies can offer, pharmacologists and psychologists might come to realize how medicinal chemists can apply the types of information that the paradigm routinely provides. Drug Discrimination: Applications to Medicinal Chemistry and Drug Studies provides in-depth analyses of the nature and use of drugs as discriminative stimuli and bridges some of the numerous gaps between medicinal chemistry, pharmacology, and psychology. Stressing the practical aspects of drug discrimination, including types of procedures, study design, data, and interpretation, the book details the advantages and limitations of drug discrimination studies versus other pharmacologic evaluations. Practical information from leading researchers in the field addresses specific topics and techniques that are of interest in drug discovery, evaluation, and development. A groundbreaking new guide to the applications of drug discrimination studies for medicinal chemistry and neuroscience, Drug Discrimination is essential for any scientist, researcher, or student whose interests involve the design, development, and/or action of drugs acting at the level of the central nervous system.
Methods of Behavior Analysis in Neuroscience by Jerry J. Buccafusco Pdf
Using the most well-studied behavioral analyses of animal subjects to promote a better understanding of the effects of disease and the effects of new therapeutic treatments on human cognition, Methods of Behavior Analysis in Neuroscience provides a reference manual for molecular and cellular research scientists in both academia and the pharmaceutic
Nonclinical Assessment of Abuse Potential for New Pharmaceuticals by Carrie Markgraf,Thomas Hudzik,David Compton Pdf
Nonclinical Assessment of Abuse Potential for New Pharmaceuticals offers a complete reference on the current international regulatory guidelines and details best practice methodology for the three standard animal models used to evaluate abuse potential: physical dependence, self-administration and drug discrimination. This book also includes chapters on alternative models and examples of when you should use these alternatives. Case histories are provided at the end of the book to show how the data generated from the animal models play a pivitol role in the submission package for a new drug. By incorporating all of this information into one book, Nonclinical Assessment of Abuse Potential for New Pharmaceuticals is your single resource for everything you need to know to understand and implement the assessment of abuse liability. Provides a consolidated overview of the complex regulatory landscape Offers best practice methodology for conducting animal studies, including selection of doses and positive control agents that will help you improve your own abuse potential studies Includes real-life examples to illustrate how nonclinical data fit into the submission strategy
Author : Francis C. Colpaert,Robert L. Balster Publisher : Springer Science & Business Media Page : 236 pages File Size : 47,8 Mb Release : 2012-12-06 Category : Medical ISBN : 9783642732232
Transduction Mechanisms of Drug Stimuli by Francis C. Colpaert,Robert L. Balster Pdf
In this book the latest data available on transduction mechanisms of drug stimuli are presented. A common theme underlying the chapter in this volume is the recognition that drugs can act as stimuli, in much the same manner as external events do. Accordingly, the papers focus on the mechanisms by which these stimuli are transduced at different levels of analysis, such as the behavioral, pharmacological, and molecular levels. Some chapters discuss the mechanisms of transduction of the discriminative effects of several important classes of drugs, while others deal with the methods and research strategies by which these mechanisms can be analyzed. Collectively, the papers in this volume reflect the current status of knowledge in the rapidly expanding field of behavioral pharmacology.
Discriminative Stimulus Properties of Drugs by Harbans Lal Pdf
As one who has gone down the wayward path from "pure" organic chemistry to biochemistry to pharmacology, I was not quite prepared to go all the way - into the field of discriminable stimuli. The organizer of the symposium on discriminable stimuli induced by drugs, Dr. Harbans Lal, did seduce me into attending. Having lost my behavioral virginity, I now stare with open eyes at the field. One item in particular at this meeting exemplifies to me the power of such techniques. Dr. Albert Weissman mentioned the problem he tackled with getting rats to discriminate between saline and dilute solutions of aspirin. Under ordinary circumstances, the animals could not perform this task. However, if the animals were sensitized by injection of prostaglan din into their foot pads, then they were capable of discriminating even very dilute solutions of aspirin. In a sense, Al had created a model of the human arthritic who can jolly well tell if you have given him an aspirin or a salt tablet. The reader of this volume will find it a good introduction to the utilization of discriminable stimuli induced by drugs. After a preface by the organizer, two experts discuss basic principles in separate chapters. One of these chapters places emphasis on the drugs; the other places emphasis on the induced cues and states.
Author : Michael A. Bozarth Publisher : Springer Science & Business Media Page : 658 pages File Size : 50,5 Mb Release : 2012-12-06 Category : Medical ISBN : 9781461248125
Methods of Assessing the Reinforcing Properties of Abused Drugs by Michael A. Bozarth Pdf
Methods of Assessing the Reinforcing Properties of Abused Drugs presents a synopsis of the preclinical procedures used to assess drug reinforcement. Researchers using one technique are provided with an overview of the other available methods, and clinicians who wish to evaluate drug abuse research reports can gain the necessary background from this volume. Although emphasis is placed on the methodological aspects of assessing drug reinforcement, some of the scientific conclusions derived from using these techniques are also presented. This edited collection offers a lasting framework for interpreting the results of current experimental findings.
Drug Discovery and Evaluation by H. Gerhard Vogel,Jochen Maas Pdf
This book is a landmark in the continuously changing world of drugs. It is essential reading for scientists and managers in the pharmaceutical industry who are involved in drug finding, drug development and decision making in the development process.
Drugs Are Not the Devil's Tools - Vol.2, Black & White Edition: How Discrimination and Greed Created a Dysfunctional Drug Policy and How It Can Be Fix by David Bearman M D Pdf
"Drugs are NOT the Devil’s Tools is a[n] ... examination into the origin of United States drug laws. Dr. David Bearman shows how, through intertwining motives of discrimination and greed, often under the guise of morality, they have created a drug policy that is completely dysfunctional. As he points out, our drug laws have been very effective in further marginalizing discriminated-against groups and a total failure in every other respect. In his new book, Dr. Bearman shows that there has rarely been a civilization in the history of mankind that has not used some form of man-altering substance. He also demonstrates that the very real medical properties of cannabis were recognized thousands of years ago, as were the medicinal uses of opium, coca, alcohol and spices..."--Back cover.
Author : Doris Marie Provine Publisher : University of Chicago Press Page : 432 pages File Size : 47,9 Mb Release : 2008-09-15 Category : Social Science ISBN : 9780226684789
Race is clearly a factor in government efforts to control dangerous drugs, but the precise ways that race affects drug laws remain difficult to pinpoint. Illuminating this elusive relationship, Unequal under Law lays out how decades of both manifest and latent racism helped shape a punitive U.S. drug policy whose onerous impact on racial minorities has been willfully ignored by Congress and the courts. Doris Marie Provine’s engaging analysis traces the history of race in anti-drug efforts from the temperance movement of the early 1900s to the crack scare of the late twentieth century, showing how campaigns to criminalize drug use have always conjured images of feared minorities. Explaining how alarm over a threatening black drug trade fueled support in the 1980s for a mandatory minimum sentencing scheme of unprecedented severity, Provine contends that while our drug laws may no longer be racist by design, they remain racist in design. Moreover, their racial origins have long been ignored by every branch of government. This dangerous denial threatens our constitutional guarantee of equal protection of law and mutes a much-needed national discussion about institutionalized racism—a discussion that Unequal under Law promises to initiate.
