Drug Resistance As A Biochemical Target In Cancer Chemotherapy

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Drug Resistance As a Biochemical Target in Cancer Chemotherapy

Makoto Ogawa
Drug Resistance As a Biochemical Target in Cancer Chemotherapy Book PDF

Author : Makoto Ogawa
Publisher : Academic Press
Page : 371 pages
File Size : 43,5 Mb
Release : 1991-11-12
Category : Medical
ISBN : 9780323153881

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Drug Resistance As a Biochemical Target in Cancer Chemotherapy by Makoto Ogawa Pdf

Drug Resistance as a Biochemical Target in Cancer Chemotherapy covers the proceedings of the 13th Bristol-Myers Squibb Symposium on Cancer Research, entitled ""Drug Resistance as a Biochemical Target in Cancer Chemotherapy"", hosted by the Japanese Foundation for Cancer Research in Tokyo. This book is divided into four parts encompassing 18 chapters that summarize the results of both preclinical and clinical research on circumvention of drug resistance. The first two parts discuss the genetic aspects of multidrug resistance and the proteins involved in drug resistance. These parts also examine the structure, function, and expression of P-glycoproteins, with an emphasis on the role of these proteins as targets for cancer chemotherapy. The third part describes the methods for detection of P-glycoprotein and its antagonists to counter clinical drug resistance. This topic is followed by a discussion on the interactions among steroid hormones, steroid hormone receptors, antiandrogens, biological-response modifiers, and cytotoxic drugs in human breast cancer. The concluding part explores the clinical applications of chemosensitizers in cancer therapy. This part also considers the alternative clinical approaches against drug failure, including non-crosss-resistant therapies, autologous bone marrow transplantation, dose-intensive therapy, and high-dose chemotherapy. Biomedical scientists and researchers and clinicians will find this book invaluable.

Multiple Drug Resistance in Cancer 2

Martin Clynes
Multiple Drug Resistance in Cancer 2 Book PDF

Author : Martin Clynes
Publisher : Springer Science & Business Media
Page : 343 pages
File Size : 49,8 Mb
Release : 2013-04-17
Category : Medical
ISBN : 9789401723749

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Multiple Drug Resistance in Cancer 2 by Martin Clynes Pdf

Resistance to chemotherapy, and especially multi-drug resistance, represents a significant barrier to the successful treatment of cancer. This multi-author volume brings together a wide range of up-to-date reviews on different aspects of our knowledge of drug-resistance mechanisms, written by experts in the different areas. Particular attention is paid to recently discovered mechanisms relating to oncogene expression and in particular to proteins involved in regulation and execution of apoptosis. Other important topics covered include DNA repair, topoisomerases, cell cycle control, oxygenation and vascularisation of tumours, LRP, intermediate filament proteins and low-level resistance. Recent developments in understanding the role of efflux pumps (P-170, MRP) in multi-drug resistance are also reviewed. This book will be useful to clinicians and scientists working in the areas of chemotherapy, drug resistance, DNA repair and apoptosis research.

Cancer Drug Resistance

Beverly A. Teicher
Cancer Drug Resistance Book PDF

Author : Beverly A. Teicher
Publisher : Springer Science & Business Media
Page : 611 pages
File Size : 45,8 Mb
Release : 2007-11-09
Category : Medical
ISBN : 9781597450355

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Cancer Drug Resistance by Beverly A. Teicher Pdf

Leading experts summarize and synthesize the latest discoveries concerning the changes that occur in tumor cells as they develop resistance to anticancer drugs, and suggest new approaches to preventing and overcoming it. The authors review physiological resistance based upon tumor architecture, cellular resistance based on drug transport, epigenetic changes that neutralize or bypass drug cytotoxicity, and genetic changes that alter drug target molecules by decreasing or eliminating drug binding and efficacy. Highlights include new insights into resistance to antiangiogenic therapies, oncogenes and tumor suppressor genes in therapeutic resistance, cancer stem cells, and the development of more effective therapies. There are also new findings on tumor immune escape mechanisms, gene amplification in drug resistance, the molecular determinants of multidrug resistance, and resistance to taxanes and Herceptin.

Biochemistry of Drug Resistance

Sarfraz Ahmed,Suvash Chandra Ojha,Muhammad Najam-ul-Haq,Muhammad Younus,Muhammad Zaffar Hashmi
Biochemistry of Drug Resistance Book PDF

Author : Sarfraz Ahmed,Suvash Chandra Ojha,Muhammad Najam-ul-Haq,Muhammad Younus,Muhammad Zaffar Hashmi
Publisher : Springer Nature
Page : 559 pages
File Size : 48,8 Mb
Release : 2021-08-05
Category : Medical
ISBN : 9783030763206

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Biochemistry of Drug Resistance by Sarfraz Ahmed,Suvash Chandra Ojha,Muhammad Najam-ul-Haq,Muhammad Younus,Muhammad Zaffar Hashmi Pdf

This book provides a comprehensive discussion on the current information and evidence on the latest developments in the field of drugs resistance. Drug resistance is the reduction in effectiveness of a medication such as an antimicrobial or an antineoplastic in treating a disease or condition. This leads to negative outcomes at great risk of public health; therefore, increasing efforts are dedicated to the development of a new generation of medications that will help deal with this phenomenon. Decades of technological innovations in drug design have demonstrated the potential of resistance. Enormous information on various aspects of antibiotics resistance is available. However, literature on drug resistance specifically related to infectious and non-infectious diseases is rarely presented, particularly those focusing on the mechanisms, biochemistry, kinetics, dynamics, and management of drug resistance. Therefore, there is an immense need for a systematic compilation on the available information about this issue. All the chapters are logically selected and arranged to provide state-of-the-art information about all aspects of drugs resistance. After an introductory chapter, four chapters are dedicated to infectious microbial diseases, whereas two other chapters are complimenting this theme and focusing on drugs resistance in ear, nose and throat, and skin diseases. The recent advances in the understanding of drugs resistance in lung, neurological, kidney, heart, and liver diseases are also covered. Biochemistry of drugs resistance in cancer, HIV, ocular, reproductive, and diabetes diseases is also discussed. Finally, a chapter dedicated to the “management of drug resistance” has been included.

Molecular Mechanisms of Tumor Cell Resistance to Chemotherapy

Benjamin Bonavida
Molecular Mechanisms of Tumor Cell Resistance to Chemotherapy Book PDF

Author : Benjamin Bonavida
Publisher : Springer Science & Business Media
Page : 271 pages
File Size : 49,9 Mb
Release : 2013-07-04
Category : Medical
ISBN : 9781461470700

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Molecular Mechanisms of Tumor Cell Resistance to Chemotherapy by Benjamin Bonavida Pdf

​​​​​This volume gives the latest developments in on the mechanisms of cancer cell resistance to apoptotic stimuli, which eventually result in cancer progression and metastasis. One of the main challenges in cancer research is to develop new therapies to combat resistant tumors. The development of new effective therapies will be dependent on delineating the biochemical, molecular, and genetic mechanisms that regulate tumor cell resistance to cytotoxic drug-induced apoptosis. These mechanisms should reveal gene products that directly regulate resistance in order to develop new drugs that target these resistance factors and such new drugs may either be selective or common to various cancers. If successful, new drugs may not be toxic and may be used effectively in combination with subtoxic conventional drugs to achieve synergy and to reverse tumor cell resistance. The research developments presented in this book can be translated to produce better clinical responses to resistant tumors.

Drug Resistance in Cancer Cells

Kapil Mehta,Zahid H. Siddik
Drug Resistance in Cancer Cells Book PDF

Author : Kapil Mehta,Zahid H. Siddik
Publisher : Springer Science & Business Media
Page : 372 pages
File Size : 43,8 Mb
Release : 2009-06-12
Category : Medical
ISBN : 9780387894454

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Drug Resistance in Cancer Cells by Kapil Mehta,Zahid H. Siddik Pdf

It was estimated that in 2008, 1,437,180 patients would receive a new cancer diagnosisand 565,650individualswould die of cancer (Jemal et al. 2008).Since the vast majority of patients dying of cancer will have had anticancer therapy, both c- ventional chemotherapy and novel targeted therapy, it can be concluded that these patients are dying with drug resistant cancer. The term multidrug resistance is also apt – in that these patients die after having undergone multiple rounds of different and structurally unrelated cancer therapies. However, for some, the concept of m- tidrug resistance is a worn out idea, stemming from disappointment with the drug resistancereversalstrategiesthatwerecarriedoutinthe1990susingpumpinhibitors to block drug resistance mediated by P-glycoprotein, product of the MDR-1 gene. However, if one takes the larger de?nition – multidrug resistance as simultaneous resistance to multiple structurally unrelated anticancer therapies – its existence c- not be denied. The purpose of this book is to explore new concepts related to drug resistance in cancer, including resistance to the new molecularly targeted agents. Perhaps new terminology is needed for resistance that occurs following therapy with the targeted agents: Novel Targeted Agent Resistance (NTR). Alternatively, we can return to the original de?nition of multidrug resistance as simply the res- tance to multipleagents that occurs in the course of normalcancer progression.This resistance is likely to be mediated by many factors.

Cancer Drug Resistance Research Perspectives

Liman S. Torres
Cancer Drug Resistance Research Perspectives Book PDF

Author : Liman S. Torres
Publisher : Nova Publishers
Page : 242 pages
File Size : 43,6 Mb
Release : 2007
Category : Drug resistance in cancer cells
ISBN : 1600215726

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Cancer Drug Resistance Research Perspectives by Liman S. Torres Pdf

One of the main causes of failure in the treatment of cancer is the development of drug resistance by the cancer cells. The design of cancer chemotherapy has become increasingly sophisticated, yet there is no cancer treatment that is 100% effective against disseminated cancer. Resistance to treatment with anticancer drugs results from a variety of factors including individual variations in patients and somatic cell genetic differences in tumours, even those from the same tissue of origin. Frequently resistance is intrinsic to the cancer, but as therapy becomes more and more effective, acquired resistance has also become common. The most common reason for acquisition of resistance to a broad range of anticancer drugs is expression of one or more energy-dependent transporters that detect and eject anticancer drugs from cells, but other mechanisms of resistance including insensitivity to drug-induced apoptosis and induction of drug-detoxifying mechanisms probably play an important role in acquired anticancer drug resistance. Studies on mechanisms of cancer drug resistance have yielded important information about how to circumvent this resistance to improve cancer chemotherapy and have implications for pharmacokinetics of many commonly used drugs. This book presents new and important research in this field.

Progress in Cancer Drug Resistance Research

Robert A. Parsons
Progress in Cancer Drug Resistance Research Book PDF

Author : Robert A. Parsons
Publisher : Nova Publishers
Page : 240 pages
File Size : 43,8 Mb
Release : 2007
Category : Medical
ISBN : 1600218229

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Progress in Cancer Drug Resistance Research by Robert A. Parsons Pdf

One of the main causes of failure in the treatment of cancer is the development of drug resistance by the cancer cells. The design of cancer chemotherapy has become increasingly sophisticated, yet there is no cancer treatment that is 100 percent effective against disseminated cancer. Resistance to treatment with anticancer drugs results from a variety of factors including individual variations in patients and somatic cell genetic differences in tumours, even those from the same tissue of origin. Frequently resistance is intrinsic to the cancer, but as therapy becomes more and more effective, acquired resistance has also become common.The most common reason for acquisition of resistance to a broad range of anticancer drugs is expression of one or more energy-dependent transporters that detect and eject anti-cancer drugs from cells, but other mechanisms of resistance including insensitivity to drug-induced apoptosis and induction of drug-detoxifying mechanisms probably play an important role in acquired anticancer drug resistance. Studies on mechanisms of cancer drug resistance have yielded important information on how to circumvent this resistance to improve cancer chemotherapy and have implications for pharmacokinetics of many commonly used drugs.

Multiple Drug Resistance in Cancer

Martin Clynes
Multiple Drug Resistance in Cancer Book PDF

Author : Martin Clynes
Publisher : Springer Science & Business Media
Page : 396 pages
File Size : 40,7 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9789401108263

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Multiple Drug Resistance in Cancer by Martin Clynes Pdf

This book is an up-to-date review of current knowledge in the field of multiple drug resistance in human cancer. The literature up to the middle of 1993 is surveyed in specialist chapters written by different experts. Topics covered include the molecular genetics, cytogenetics and biochemistry of the mdr genes and P-glycoprotein; alternative transport proteins in MDR; topoisomerases I and II; cytochrome p450-enzymes and glutathione- S-transferases in MDR; cellular models for MDR in solid tumours and haemopoietic tumours; immunochemical and molecular biological techniques for detection of MDR-related gene expression; and clinical and pharmacological strategies to circumvent resistance. The book brings together a new combination of approaches to this serious clinical problem.

Multi-Drug Resistance in Cancer

Rishabha Malviya,Arun Kumar Singh,Deepika Yadav
Multi Drug Resistance in Cancer Book PDF

Author : Rishabha Malviya,Arun Kumar Singh,Deepika Yadav
Publisher : John Wiley & Sons
Page : 228 pages
File Size : 47,7 Mb
Release : 2023-07-18
Category : Medical
ISBN : 9781394209842

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Multi-Drug Resistance in Cancer by Rishabha Malviya,Arun Kumar Singh,Deepika Yadav Pdf

MULTI-DRUG RESISTANCE IN CANCER The book details the mechanisms underlying multi-drug cellular resistance and the targets of novel chemotherapeutic agents. Cancer is a major killer all over the world. Even with all the progress made, chemotherapy is still the mainstay of modern cancer treatment. The progression of the cellular defeat of numerous independent anticancer drugs in terms of their chemical structure is a major barrier to successful chemotherapy. Multi-drug resistance (MDR) is a term for the fact that most cancer patients exhibit this phenomenon. According to the numbers, drug resistance carries the blame for 90% of cancer patient deaths. Refractory cancer and tumor recurrence are common outcomes of prolonged chemotherapy. Because of the prevalence of drug-resistance mutations, the difficulty of treating tumors increases and the therapeutic efficacy of drugs decreases. Multi-Drug Resistance in Cancer: Mechanism and Treatment Strategies contains nine chapters that cover topics such as: studying the mechanics of resistance to drugs by autophagy; studies to delineate the role of efflux transporters; expression of drug transporters; resistance to targeted therapies in breast cancer; advances in metallodrug driven combination treatment for cancer; and use of natural agents for the overcoming of cancer drug resistance. The book aims to provide the latest data on the mechanisms of cellular resistance to anticancer agents currently used in clinical treatment. It provides a better understanding of the mechanisms of MDR and targets of novel chemotherapy agents which should guide future research concerning new effective strategies in cancer treatment. Audience This book is written for pharmaceutical and biomedical scientists and researchers at both the bench and in the clinic who are interested in the mechanisms and strategies for overcoming cancer’s multi-drug resistance.

Cytotoxic Drug Resistance Mechanisms

Robert Brown,Uta Böger-Brown
Cytotoxic Drug Resistance Mechanisms Book PDF

Author : Robert Brown,Uta Böger-Brown
Publisher : Springer Science & Business Media
Page : 241 pages
File Size : 48,9 Mb
Release : 2008-02-01
Category : Medical
ISBN : 9781592596874

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Cytotoxic Drug Resistance Mechanisms by Robert Brown,Uta Böger-Brown Pdf

There is now a range of cytotoxic drugs that have considerable clinical usefulness in producing responses in tumors and even, in a small proportion of cases, cure. However, the acquisition of drug resistance is a major clinical problem and is perhaps the main limiting factor in successful treatment of cancer. Thus, a tumor initially sensitive to chemotherapy will, in the majority of cases, eventually recur as a resistant tumor, which will then progress. Much of our understanding of drug resistance mechanisms comes from the study of tumor cell lines grown in tissue culture. We now understand many of the - lecular mechanisms that can lead to a cell acquiring resistance to antic- cer drugs; however, we still do not know which mechanism(s) are those most relevant to the problem of clinical drug resistance. Indeed, given that many of the cytotoxic anticancer drugs were discovered by random screening, it is - clear what features give a clinically useful anticancer drug a sufficient the- peutic index to be of value. The aim of Cytotoxic Drug Resistance Mechanisms is to provide pro- cols that are appropriate for examining the mechanisms of cellular resistance to anticancer cytotoxics in human tumor samples. Tumor cell lines have been enormously useful as experimental models of drug resistance mechanisms, however they have limitations and we need to address the relevance of such mechanisms in patients’ tumors. Examining drug resistance in tumors is much more problematic than in cell lines.

Drug Resistance

William N. Hait
Drug Resistance Book PDF

Author : William N. Hait
Publisher : Springer Science & Business Media
Page : 421 pages
File Size : 43,6 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461312673

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Drug Resistance by William N. Hait Pdf

Resistance to treatment represents the final common outcome for far too many patients with cancer. Even our most promising new drugs fall victim to drug resistance. Hormones and newer biological therapies, though safe and active, also lose their activity over time. In this volume of Drug Resistance, leading investigators in the field have reviewed the most basic mechanisms of drug resistance, and have proposed ways to modulate resistance. This comprehensive volume should be of value for basic and clinical scientists who wish to delve more deeply into this intriguing problem in the laboratory and devastating problem in the clinic.

Biological Mechanisms and the Advancing Approaches to Overcoming Cancer Drug Resistance

Andrew Freywald,Franco Vizeacoumar
Biological Mechanisms and the Advancing Approaches to Overcoming Cancer Drug Resistance Book PDF

Author : Andrew Freywald,Franco Vizeacoumar
Publisher : Academic Press
Page : 310 pages
File Size : 53,9 Mb
Release : 2020-11-17
Category : Science
ISBN : 9780128213117

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Biological Mechanisms and the Advancing Approaches to Overcoming Cancer Drug Resistance by Andrew Freywald,Franco Vizeacoumar Pdf

Biological Mechanisms and the Advancing Approaches to Overcoming Cancer Drug Resistance, Volume 12, discusses new approaches that are being undertaken to counteract tumor plasticity, understand and tackle the interactions with the microenvironment, and disrupt the rewiring of malignant cells or bypass biological mechanism of resistance by using targeted radionuclide therapies. This book provides a unique opportunity to the reader to understand the fundamental causes of drug resistance and how different approaches are applied. It is a one-stop-shop to understand why it is so difficult to treat cancer, and why only a very few patients respond to therapy and a significant portion develop resistance. Despite a rapid development of more effective anti-cancer drugs and combination therapies, cancer remains the leading cause of lethality in the developed world. The main reason for this is the ability of heterogeneous subpopulations of tumor cells interacting with constantly evolving tumor microenvironment to resist elimination and eventually, trigger cancer relapse. In this book, experts review current concepts explaining molecular and biological mechanisms of cancer drug resistance and discussing advancing approaches for overcoming these therapeutic challenges. Provides the most updated knowledge on the mechanisms of cancer drug resistance and the emerging therapeutic approaches reviewed by experts in the field Brings detailed analyses of most important recently reported developments related to drug resistance and their relevance to overcoming it in cancer patients Discusses in-depth molecular mechanisms and novel concepts of cancer resistance to conventional and advanced therapies

Principles of Cancer Treatment and Anticancer Drug Development

Wolfgang Alexander Link
Principles of Cancer Treatment and Anticancer Drug Development Book PDF

Author : Wolfgang Alexander Link
Publisher : Unknown
Page : 145 pages
File Size : 42,8 Mb
Release : 2019
Category : Cancer
ISBN : 3030187233

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Principles of Cancer Treatment and Anticancer Drug Development by Wolfgang Alexander Link Pdf

This book explains how current medicines against cancer work and how we find new ones. It provides an easy-to-understand overview of current options to treat patients with cancer, which includes Surgery, Radiation therapy, Chemotherapy, Targeted therapy and Immunotherapy. The efficiency of all these treatments is limited by the capacity of cancer cells to escape therapy. This book explains the mechanisms of anti-cancer drug resistance and strategies to overcome it. The discovery and development process of a new drug is detailed beginning with the identification and validation of a therapeutic target, the identification of an inhibitor of the target and its subsequent preclinical and clinical development until its approval by regulatory authorities. Particular emphasis has been given to specific aspects of the development process including lead generation and optimization, pharmacokinetics, ADME analysis, pharmacodynamics, toxicity and efficacy assessment, investigational new drug (IND) and new drug application (NDA) and the design of clinical trial and their phases. The book covers many aspects of modern personalized oncology and discusses economic aspects of our current system of developing new medicines and its impact on our societies and on future drug research. The author of this book, Dr. Link counts with more than 20 years of experience in biomedical research reflected in numerous publications, patents and key note and plenary presentations at international conferences. Interested readers, students and teachers should read this book as it provides a unique way to learn/teach about basic concepts in oncology and anti-cancer drug research.

Drug Resistance in Cancer

James H. Goldie,Andrew J. Coldman
Drug Resistance in Cancer Book PDF

Author : James H. Goldie,Andrew J. Coldman
Publisher : Cambridge University Press
Page : 256 pages
File Size : 47,8 Mb
Release : 2009-06-11
Category : Medical
ISBN : 0521111706

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Drug Resistance in Cancer by James H. Goldie,Andrew J. Coldman Pdf

Drug resistance in cancer, whereby a portion of cancer cells evades chemotherapy, poses a profound and continuing challenge for the effective treatment of cancer. The principles underlying the biological mechanisms behind this phenomenon are clearly explained in this volume. A deeper understanding of drug resistance requires a quantitative appreciation of the dynamic forces that shape tumor growth, including spontaneous mutation and selection processes. The authors seek to explain and to simplify these complex mechanisms, and to place them in a clinical context. Clearly explained mathematical models are used to illustrate the biological principles and provide an insight into tumor development and the effectiveness and limitations of drug treatment. The volume is suitable for those with a nonmathematical background and aims to enhance the effectiveness of cancer therapy. This is the first book to provide such an integrated account, in a form accessible to both doctor and scientist.