Drugs Lipid Metabolism And Atherosclerosis

Author : David Kritchevsky
Publisher : Springer Science & Business Media
Page : 433 pages
File Size : 50,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781468409673

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Drugs, Lipid Metabolism, and Atherosclerosis by David Kritchevsky Pdf

This volume comprises the proceedings of the sixth International Symposium on Drugs Affecting Lipid Meta bolism. Since the first of these symposia in 1960 these triennial meetings have been devoted to the exploration of new ideas, new data and new concepts related to lipid metabolism and atherosclerosis. The sixth Meeting was particularly stimulating in this regard. The concept of the "protective" action of HDL was thoroughly explored within the framework of its molecular biology with data on its epidemiological as well as its in vitro mechan ism(s) of action being discussed. The action of drugs on arterial and HDL metabolism was also discussed as were newer aspects of platelet aggregation, especially as related to prostaglandins. New ground was also broken in discussions of lipid mobilization and mechan isms of hypocholesteremia. We are indebted to the many organizations who con tributed generously to the support of this meeting. Among the sponsors, the assistance of the Lorenzini Foundation was especially helpful. As in all meetings of this type, the hard work of the local organizing committee was instrumental in its success. We are grateful to Mrs. Caroline Hyatt and Mr. Ralph Hollerorth for their invaluable help in the secretariat. We are also deeply indebted to Miss Jane T. Kolimaga for her expert assistance in the preparation of this volume. David Kritchevsky Rodolfo Paoletti William L. Holmes vii Contents LIPOPROTEINS AND DRUGS Lipoprotein Metabolism - New Insights from Cell Biology. . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 D. Steinberg Lipoprotein Metabolism in Man. . . . . . . . . . . . . . . . . . . .

Author : David Kritchevsky
Publisher : Springer
Page : 456 pages
File Size : 51,6 Mb
Release : 2014-01-15
Category : Electronic
ISBN : 1468409689

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Drugs, Lipid Metabolism, and Atherosclerosis by David Kritchevsky Pdf

Author : David Kritchevsky
Publisher : Springer Science & Business Media
Page : 503 pages
File Size : 44,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461324591

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Drugs Affecting Lipid Metabolism VIII by David Kritchevsky Pdf

The Proceedings of the Eight International Symposium on Drugs Affecting Lipid Metabolism (8th D.A.L.M.) is the subject of this volume. Since the first symposium in 1960, each successive meeting has broken new ground in the field of pharmacological control of lipid levels - offering new and stimulating insights and exposing the audience to the state of the art. The field has progressed sufficiently to permit discussion of the cellular biology of athero sclerosis. The opening session was devoted to pathology, macrophages, lipoproteins and their receptors and choles terol ester metabolism. Because of the recent emergence of new apolipoprotein technology, a workshop devoted sole ly to apolipoprotein methodology was introduced followed by a plenary session devoted to their metabolism and structure. Another rapidly developing area of atherosclerosis research is non-invasive assessment of this condition. Accordingly, a session was devoted to new techniques for this research modality. The final plenary sessions were devoted to the roles of drugs and diet in athero~ scl~rosis - cause, treatment and mechanisms of action. The meeting was summarized by Dr. O.J. Pollak, one of the "founding fathers" of this field. There were nine sessions of proffered papers whose abstracts appear in this volume. In addition, special workshops (to be reported elsewhere) were devoted to several drugs including Oiyzanol, Probucol and Etofibrate.

Author : David Kritchevsky,Rodolfo Paoletti,Daniel Steinberg
Publisher : Unknown
Page : 520 pages
File Size : 49,9 Mb
Release : 1965
Category : Drugs
ISBN : OCLC:397057596

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Drugs Affecting Lipid Metabolism by David Kritchevsky,Rodolfo Paoletti,Daniel Steinberg Pdf

Author : Alberico L. Catapano,Antonio M. Gotto Jr.,Louis C. Smith,Rodolfo Paoletti
Publisher : Springer Science & Business Media
Page : 510 pages
File Size : 44,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9789401117036

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Drugs Affecting Lipid Metabolism by Alberico L. Catapano,Antonio M. Gotto Jr.,Louis C. Smith,Rodolfo Paoletti Pdf

A great deal of experimental, clinical and epidemiological data have been gathered to confirm the strict and causal correlation between plasma lipoproteins and coronary heart disease. However, as usually happens in research, many more interesting issues are being studied, opening new fields of research for the future. These new advances, together with the combined efforts of cell biologists and lipoprotein chemists, have set the pace for an exciting period of research and clinical applications of diets and drugs affecting plasma and cell lipids. This volume, which includes the work of many of the leading world labortories, represents an authoritative and up-to-date appraisal of the status of the art and a stimulus to future research at the laboratory and clinical level in a fascinating area of clinical and preventive medicine.

Author : William L. Holmes,Lars A. Carlson,Rodolfo Paoletti
Publisher : Unknown
Page : 704 pages
File Size : 50,9 Mb
Release : 1969
Category : Drugs
ISBN : UCAL:B4532419

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Drugs Affecting Lipid Metabolism by William L. Holmes,Lars A. Carlson,Rodolfo Paoletti Pdf

Author : David Kritchevsky,Rodolfo Paoletti,D. Steinberg
Publisher : Unknown
Page : 520 pages
File Size : 50,7 Mb
Release : 1967
Category : Electronic
ISBN : OCLC:641622982

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Drugs affecting lipid metabolism by David Kritchevsky,Rodolfo Paoletti,D. Steinberg Pdf

Author : Anonim
Publisher : Unknown
Page : 0 pages
File Size : 51,6 Mb
Release : 1967
Category : Electronic
ISBN : OCLC:933996806

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Drugs Affecting Lipid Metabolism by Anonim Pdf

Author : Antonio M. Gotto Jr.,Rodolfo Paoletti,Louis C. Smith,Alberico L. Catapano
Publisher : Springer
Page : 710 pages
File Size : 49,5 Mb
Release : 2011-10-14
Category : Medical
ISBN : 9401066256

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Drugs Affecting Lipid Metabolism by Antonio M. Gotto Jr.,Rodolfo Paoletti,Louis C. Smith,Alberico L. Catapano Pdf

Even a brief scan of the table of contents of the present volume is enough to disclose the diversity of research interests and opinions in the field of lipidology. It is precisely this diversity that is the strength of our field and that was showcased by the XII International Symposium of DRUGS AFFECTING LIPID METABOLISM (DALM). The papers published here from these proceedings may be divided into three categories: those that define-and refine---our understanding ofthe clinical benefit of aggressive lipid management, those that develop our knowledge of ris!. assessment, and those that discuss the genetic, bio~hemical, and biophysical mechanisms underlying the pathology of coronary heart disease. On the clinical front, further analysis of the results of the Scandinavian Simvastatin Survival Study (4S) has indicated the cost-effectiveness of therapy in patients with established coronary heart disease. The West of Scotland Coronary Prevention Study (WOSCOPS), whose methodology was described at the DALM XII symposium, has demonstrated in a mostly primary-prevention population what 4S demonstrated for secondary prevention the year before: aggressive lipid-regulating therapy reduces coronary heart disease morbidity and mortality rates without concurrently increasing mortality from noncardiovascular causes. In the future, important considerations will be to develop protocols that maximize benefit in groups underrepresented in traditional clinical research for example, women and the elderly-and to improve compliance to existing treatment regimens. Furthermore, antioxidant, omega-3 fatty acid, and gene therapies warrant further investigation.

Author : G.V. Marinetti
Publisher : Springer Science & Business Media
Page : 235 pages
File Size : 44,9 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461595649

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Disorders of Lipid Metabolism by G.V. Marinetti Pdf

For the past 30 years I have been teaching lipid biochemistry to'inedical students, graduate students, and undergraduate students. The major topics covered in my courses were fatty acids, prostaglandins, leukotrienes, phospholipids, glyco lipids, triacylglycerols, cholesterol, bile acids, and plasma lipoproteins. Empha sis was placed on the regulation and disorders of lipid metabolism. The latter included hyperlipidemias, atherosclerosis, and alcohol-induced liver damage. In this volume, I have chosen to focus on the disorders of lipid metabolism at a level appropriate both for medical students and for graduate and undergradu ate students majoring in the biological sciences. The biochemistry, nutrition, genetics, and cell biology aspects of lipids and lipid metabolism will be covered as they relate to lipid disorders. I am not aware of any textbook that integrates the disorders of lipid metabolism in this manner. Chapter 1 includes a brief discussion of the basic structures, properties, and metabolism of lipids. This chapter is not very detailed, since the material covered is available in basic textbooks on biochemistry. The major fpcus of this volume is the various lipid disorders, with emphasis on polyunsaturated fatty acids, the molecular biology and pathogenesis of the hyperlipidemias, dietary and drug therapy for the hyperlipidemias, and alcohol-induced liver damage. The material presented has been obtained from several textbooks on biochemistry and from a variety of recent articles in the scientific literature.

Author : Gerd Assmann
Publisher : Unknown
Page : 264 pages
File Size : 45,7 Mb
Release : 1982
Category : Arteriosclerosis
ISBN : UOM:39015008079140

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Lipid Metabolism and Atherosclerosis by Gerd Assmann Pdf

Author : Scott M. Grundy
Publisher : Springer Science & Business Media
Page : 308 pages
File Size : 55,5 Mb
Release : 2011-03-14
Category : Medical
ISBN : 9781441958396

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Atlas of Atherosclerosis and Metabolic Syndrome by Scott M. Grundy Pdf

This new edition is an integral source of information on Atherosclerosis. It covers topics such as newer coronary risk factors, high-density lipoprotein metabolism, lipid-lowering drugs, endothelium and thrombosis in atherogenesis, and contributing risk factors. With over 500 exceptional photographs, diagrams, and charts, each chapter illustrates an important facet of diagnosing and treating this common and often fatal disease.

Author : David Kritchevky,Rodolfo Paoletti,William L. Holmes
Publisher : Springer
Page : 536 pages
File Size : 42,5 Mb
Release : 1975
Category : Medical
ISBN : UCAL:B4532421

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Lipids, Lipoproteins, and Drugs by David Kritchevky,Rodolfo Paoletti,William L. Holmes Pdf

The First International Symposium on Drugs Affecting Lipid Metabolism was held in Milan in 1960. In the succeeding symposia, as in the first, new data and new ideas emerged which stimulated further research in the field. The present volume comprises the proceedings of the Fifth Symposium. In the area of lipoproteins, we have progressed from descriptions of their chemistry to discussion of their physiology and of their control of cholesterol metabolism at the cellular level. Workshop sessions explored thrombosis as affected by drugs, risk factors other than diet, animal models for atherosclerosis research and the organization of lipid clinics and clinical trials. All these topics represent advances in knowledge over the last decade. In the area of drugs a number of new compounds were introduced, many of them offering new structural concepts for hypocholesteremic activity. We expect that the next Symposium will offer as many new hypotheses and avenues of approach as did this one.

Author : Rodlfo Paoletti
Publisher : Elsevier
Page : 553 pages
File Size : 44,7 Mb
Release : 2012-12-02
Category : Medical
ISBN : 9780323155113

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Lipid Pharmacology by Rodlfo Paoletti Pdf

Medicinal Chemistry: Lipid Pharmacology, Volume 2 focuses on the effects of drugs on lipid metabolism. This book explores the methodology in lipid chemistry by which transport and release mechanisms can be investigated very effectively by the use of drugs. Organized into 12 chapters, this book starts with an overview of the total lipid fraction that can be isolated from tissues by any one of many solvent extraction procedures. This text then defines atherosclerosis disease and explores the studies in experimental atherosclerosis, which are designed to better understand the progression of this disease in humans. Other chapters discuss the inhibitors of cholesterol biosynthesis and examine the pathways involved in the synthesis of other classes of lipids. This book describes as well all drugs known to influence steroid metabolism in humans and other mammals. The final chapter deals with the biological activity of a substance, which is determined by several factors. Chemists, biochemists, and pharmacologists will find this book extremely useful.

Author : Chris J. Packard,Daniel J. Rader
Publisher : CRC Press
Page : 254 pages
File Size : 49,7 Mb
Release : 2005-09-08
Category : Medical
ISBN : 9780203492444

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Lipids and Atherosclerosis by Chris J. Packard,Daniel J. Rader Pdf

New discoveries in genetics, molecular, and cell biology are not only enhancing our understanding of the etiology and progression of disease, but are finding applications in the development of new drugs or the implementation of new kinds of therapy. This book provides an in-depth review of emerging areas in biomedical research at the interface of s