Dynamics Of Immune Activation In Viral Diseases

Author : Pallaval Veera Bramhachari
Publisher : Springer Nature
Page : 283 pages
File Size : 49,5 Mb
Release : 2020-02-24
Category : Medical
ISBN : 9789811510458

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Dynamics of Immune Activation in Viral Diseases by Pallaval Veera Bramhachari Pdf

This book discusses various components of the innate and adaptive immune response in combating viral infections, presenting the recent advances in our understanding of innate immunity recognition of viruses and highlighting the important role of inflammation, cytokines such as interferon, toll-like receptors and leukocytes in the initial detection of invading viruses and subsequent activation of adaptive immunity. It also summarizes the role of the adaptive immunity against viral infections through clearance of virus and establishment of memory response that protects against the recurrent infections. In addition, the book examines the role of DNA and RNA sensors in viral recognition and in controlling viral infection. Lastly, it reviews the latest developments in the development of the rational viral vaccines. As such it is a useful resource book for postgraduate and early researchers wanting to gain insights into the immune response to viral infections.

Author : Martin Nowak,Robert M. May
Publisher : Oxford University Press, UK
Page : 253 pages
File Size : 52,8 Mb
Release : 2000-11-23
Category : Electronic
ISBN : 9780191588518

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Virus Dynamics : Mathematical Principles of Immunology and Virology by Martin Nowak,Robert M. May Pdf

This groundbreaking book describes the emerging field of theoretical immunology, in particular the use of mathematical models to describe the spread of infectious diseases within patients. It reveals fascinating insights into the dynamics of viral and other infections, and the interactions between infectious agents and immune responses. Structured around the examples of HIV/AIDS and hepatitis B, Nowak and May show how mathematical models can help researchers to understand the detailed dynamics of infection and the effects of antiviral therapy. Models are developed to describe the dynamics of drug resistance, immune responses, viral evolution and mutation, and to optimise the design of therapy and vaccines. - ;We know, down to the tiniest details, the molecular structure of the human immunodeficiency virus (HIV). Yet despite this tremendous accomplishment, and despite other remarkable advances in our understanding of individual viruses and cells of the immune system, we still have no agreed understanding of the ultimate course and variability of the pathogenesis of AIDS. Gaps in our understanding like these impede our efforts towards developing effective therapies and preventive vaccines. Martin Nowak and Robert M May describe the emerging field of theoretical immunology in this accessible and well- written text. Using mathematical modelling techniques, the authors set out their ideas about how populations of viruses and populations of immune system cells may interact in various circumstances, and how infectious diseases spread within patients. They explain how this approach to understanding infectious diseases can reveal insights into the dynamics of viral and other infections, and the interactions between infectious agents and immune responses. The book is structured around the examples of HIV/AIDS and Hepatitis B virus, although the approaches described will be more widely applicable. The authors use mathematical tools to uncover the detailed dynamics of the infection and the effects of antiviral therapy. Models are developed to describe the emergence of drug resistance, and the dynamics of immune responses, viral evolution, and mutation. The practical implications of this work for optimisation of the design of therapy and vaccines are discussed. The book concludes with a glance towards the future of this fascinating, and potentially highly useful, field of study. - ;... an excellent introduction to a field that has the potential to advance substantially our understanding of the complex interplay between virus and host - Nature

Author : Martin A. Nowak,Robert M. May
Publisher : Oxford University Press
Page : 253 pages
File Size : 52,9 Mb
Release : 2000-11-23
Category : Mathematics
ISBN : 9780198504177

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Virus Dynamics by Martin A. Nowak,Robert M. May Pdf

This text describes the emerging field of theoretical immunology, in particular the use of mathematical models to describe the spread of infectious diseases within patients. It reveals insights into the dynamics of viral & other infections.

Author : B.A. Askonas,B. Moss,G. Torrigiani,S. Gorini
Publisher : Springer Science & Business Media
Page : 298 pages
File Size : 41,9 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781468457124

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The Immune Response to Viral Infections by B.A. Askonas,B. Moss,G. Torrigiani,S. Gorini Pdf

Virus diseases continue to represent serious health problems in most parts of the world. In spite of the fact that diseases such as polio myelitis and measles have been controlled in the industrialized countries by vaccination, vaccines now in use in tropical countries have proved not to be optimal. Further research is needed to develop new vaccines that will be effective in all countries. To do so we need to understand better the immune response to different viruses so that we may be able to maxi mize the protective response of new vaccines and minimize their potential immunopathologic effect. An exciting new discovery which is now being further developed is the possibility of being able to use some viruses (e.g. vaccinia, adenoviruses, etc.), as carriers for other antigens. This may open up the way for the production of vaccines that will be inexpensive and that will confer long lasting immunity after only one injection. This meeting has also served to review our present knowledge of virus diseases which are still of great importance such as hepatitis, dengue and influenza.

Author : R. Ahmed,Irvin Chen
Publisher : Wiley-Blackwell
Page : 754 pages
File Size : 51,5 Mb
Release : 1999
Category : Medical
ISBN : UOM:39015041993448

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Persistent Viral Infections by R. Ahmed,Irvin Chen Pdf

Persistent Viral Infections Edited by Rafi Ahmed Emory Vaccine Center, Atlanta, USA and Irvin S. Y. Chen UCLA School of Medicine, Los Angeles, USA During the past decade much of our attention has focused on diseases associated with viral persistence. Major breakthroughs in immunology, and the advent of molecular approaches to study pathogenesis have increased our understanding of the complex virus-host interactions that occur during viral persistence. Persistent Viral Infections focuses on: * The pathogenesis and immunology of chronic infections * Animal models that provide, or have the potential to provide, major insights This volume will be essential reading for virologists, immunologists, oncologists and neurologists.

Author : Dominik Wodarz
Publisher : Springer Science & Business Media
Page : 226 pages
File Size : 44,7 Mb
Release : 2007-04-05
Category : Mathematics
ISBN : 9780387687339

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Killer Cell Dynamics by Dominik Wodarz Pdf

This book reviews how mathematical and computational approaches can be useful to help us understand how killer T-cell responses work to fight viral infections. It also demonstrates, in a writing style that exemplifies the point, that such mathematical and computational approaches are most valuable when coupled with experimental work through interdisciplinary collaborations. Designed to be useful to immunoligists and viroligists without extensive computational background, the book covers a broad variety of topics, including both basic immunological questions and the application of these insights to the understanding and treatment of pathogenic human diseases.

Author : Christopher J. Burrell,Colin R. Howard,Frederick A. Murphy
Publisher : Academic Press
Page : 604 pages
File Size : 51,9 Mb
Release : 2016-11-09
Category : Science
ISBN : 9780123751577

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Fenner and White's Medical Virology by Christopher J. Burrell,Colin R. Howard,Frederick A. Murphy Pdf

Fenner and White's Medical Virology, Fifth Edition provides an integrated view of related sciences, from cell biology, to medical epidemiology and human social behavior. The perspective represented by this book, that of medical virology as an infectious disease science, is meant to provide a starting point, an anchor, for those who must relate the subject to clinical practice, public health practice, scholarly research, and other endeavors. The book presents detailed exposition on the properties of viruses, how viruses replicate, and how viruses cause disease. These chapters are then followed by an overview of the principles of diagnosis, epidemiology, and how virus infections can be controlled. The first section concludes with a discussion on emergence and attempts to predict the next major public health challenges. These form a guide for delving into the specific diseases of interest to the reader as described in Part II. This lucid and concise, yet comprehensive, text is admirably suited to the needs of not only advanced students of science and medicine, but also postgraduate students, teachers, and research workers in all areas of virology. Features updated and expanded coverage of pathogenesis and immunity Contains the latest laboratory diagnostic methods Provides insights into clinical features of human viral disease, vaccines, chemotherapy, epidemiology, and control

Author : Neal Nathanson,Rafi Ahmed
Publisher : Unknown
Page : 240 pages
File Size : 55,8 Mb
Release : 2002
Category : Medical
ISBN : UOM:39015053761865

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Viral Pathogenesis and Immunity by Neal Nathanson,Rafi Ahmed Pdf

This text provides a coherent and concise introduction to the field of viral pathogenesis and immunity. The text is divided into four sections which highlight the fundamental principles within this field of study. Section 1, Essentials of Viral Pathogenesis, describes the sequential events in viral infection, the localization of viral infections and the variety of virus-cell interactions. Section 2, Host Responses to Viral Infection, examines immune responses including virus-induced immunopathology and immunosuppression. Section 3, Virus-Host Interactions, covers virulence, viral persistence, virus-induced oncogenesis and host susceptibility. Section 4, Prevention of Viral Infections, explains the key principles of vaccine development.

Author : Kenneth Murphy,Paul Travers,Mark Walport,Peter Walter
Publisher : Garland Science
Page : 128 pages
File Size : 41,9 Mb
Release : 2010-06-22
Category : Medical
ISBN : 0815344570

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Janeway's Immunobiology by Kenneth Murphy,Paul Travers,Mark Walport,Peter Walter Pdf

The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.

Author : Sudhir Gupta,Alan Sher,Rafi Ahmed
Publisher : Springer
Page : 0 pages
File Size : 55,9 Mb
Release : 2012-10-23
Category : Medical
ISBN : 146137443X

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Mechanisms of Lymphocyte Activation and Immune Regulation VII by Sudhir Gupta,Alan Sher,Rafi Ahmed Pdf

Proceedings of the Seventh International Conference held in New Port Beach, California, February 6-8, 1998

Author : Anthony S. Fauci,Guiseppe Pantaleo
Publisher : Springer Science & Business Media
Page : 159 pages
File Size : 44,5 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642608674

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Immunopathogenesis of HIV Infection by Anthony S. Fauci,Guiseppe Pantaleo Pdf

During the last 5 years, major advances have been made in our understanding of the pathogenesis of human immunodeficiency virus (HIV) disease and in the development of new potent antiviral agents. With regard to HIV pathogenesis, several recent observations have not only changed our perspectives of HIV disease, but have been critical for the design of therapeutic strategies.

Author : Vittorio Cristini,Eugene Koay,Zhihui Wang
Publisher : CRC Press
Page : 204 pages
File Size : 50,5 Mb
Release : 2017-06-26
Category : Mathematics
ISBN : 9781466551367

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An Introduction to Physical Oncology by Vittorio Cristini,Eugene Koay,Zhihui Wang Pdf

Physical oncology has the potential to revolutionize cancer research and treatment. The fundamental rationale behind this approach is that physical processes, such as transport mechanisms for drug molecules within tissue and forces exchanged by cancer cells with tissue, may play an equally important role as biological processes in influencing progression and treatment outcome. This book introduces the emerging field of physical oncology to a general audience, with a focus on recent breakthroughs that help in the design and discovery of more effective cancer treatments. It describes how novel mathematical models of physical transport processes incorporate patient tissue and imaging data routinely produced in the clinic to predict the efficacy of many cancer treatment approaches, including chemotherapy and radiation therapy. By helping to identify which therapies would be most beneficial for an individual patient, and quantifying their effects prior to actual implementation in the clinic, physical oncology allows doctors to design treatment regimens customized to each patient’s clinical needs, significantly altering the current clinical approach to cancer treatment and improving the outcomes for patients.

Author : Melvin Madsen
Publisher : Unknown
Page : 132 pages
File Size : 52,9 Mb
Release : 1983
Category : HLA class II antigens
ISBN : UCAL:B3700899

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HLA-DR Antigens by Melvin Madsen Pdf

Author : National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Committee on New Directions in the Study of Antimicrobial Therapeutics: Immunomodulation,Committee on New Directions in the Study of Antimicrobial Therapeutics: New Classes of Antimicrobials
Publisher : National Academies Press
Page : 102 pages
File Size : 54,6 Mb
Release : 2006-01-03
Category : Medical
ISBN : 9780309180689

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Treating Infectious Diseases in a Microbial World by National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Committee on New Directions in the Study of Antimicrobial Therapeutics: Immunomodulation,Committee on New Directions in the Study of Antimicrobial Therapeutics: New Classes of Antimicrobials Pdf

Humans coexist with millions of harmless microorganisms, but emerging diseases, resistance to antibiotics, and the threat of bioterrorism are forcing scientists to look for new ways to confront the microbes that do pose a danger. This report identifies innovative approaches to the development of antimicrobial drugs and vaccines based on a greater understanding of how the human immune system interacts with both good and bad microbes. The report concludes that the development of a single superdrug to fight all infectious agents is unrealistic.

Author : Susu M. Zughaier,Erik Lubberts,Abdulbari Bener
Publisher : Frontiers Media SA
Page : 177 pages
File Size : 41,6 Mb
Release : 2020-12-16
Category : Medical
ISBN : 9782889661749

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Immune-Modulatory Effects of Vitamin D by Susu M. Zughaier,Erik Lubberts,Abdulbari Bener Pdf

This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.