Dynamics Of Proteins And Nucleic Acids

Author : J. Andrew McCammon,Stephen C. Harvey
Publisher : Cambridge University Press
Page : 256 pages
File Size : 50,6 Mb
Release : 1988-04-29
Category : Science
ISBN : 0521356520

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Dynamics of Proteins and Nucleic Acids by J. Andrew McCammon,Stephen C. Harvey Pdf

This book is a self-contained introduction to the theory of atomic motion in proteins and nucleic acids. An understanding of such motion is essential because it plays a crucially important role in biological activity. The authors, both of whom are well known for their work in this field, describe in detail the major theoretical methods that are likely to be useful in the computer-aided design of drugs, enzymes and other molecules. A variety of theoretical and experimental studies is described and these are critically analyzed to provide a comprehensive picture of dynamic aspects of biomolecular structure and function. The book will be of interest to graduate students and research workers in structural biochemistry (X-ray diffraction and NMR), theoretical chemistry (liquids and polymers), biophysics, enzymology, molecular biology, pharmaceutical chemistry, genetic engineering and biotechnology.

Author : E. Clementi,S. Chin
Publisher : Springer Science & Business Media
Page : 454 pages
File Size : 47,8 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781468453089

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Structure and Dynamics of Nucleic Acids, Proteins, and Membranes by E. Clementi,S. Chin Pdf

This volume collects a number of the invited lectures and a few selected contrib utions presented at the International Symposium on Structure and Dynamics of Nucleic Acids, Proteins and Membranes held August 31st through September 5th, 1986, in Riva del Garda, Italy. The title of the conference as well as a number of the topics covered represent a continuation of two previous conferences, the first held in 1982 at the University of California in San Diego, and the second in 1984 in Rome at the Accademia dei Lincei. These two earlier conferences have been documented in Structure and Dynamics: Nucleic Acids and Proteins, edited by E. Clementi and R. H. Sarma, Adenine Press, New York, 1983, and Structure and Motion: Membranes, Nucleic Acids and Proteins, edited by E. Clementi, G. Corongiu, M. H. Sarma and R. H. Sarma, Adenine Press, New York, 1985. At this conference in Riva del Garda we were very hesitant to keep the name of the conference the same as the two previous ones. Indeed, a number of topics discussed in this conference were not included in the previous ones and even the emphasis of this gathering is only partly reflected in the conference title. An alternative title would have been Structure and Dynamics of Nucleic Acids, Proteins, and Higher Functions, or, possibly, "higher components" rather than "higher functions.

Author : Anonim
Publisher : Elsevier
Page : 368 pages
File Size : 41,5 Mb
Release : 2013-08-14
Category : Science
ISBN : 9780124116276

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Dynamics of Proteins and Nucleic Acids by Anonim Pdf

Published continuously since 1944, Advances in Protein Chemistry and Structural Biology has been a continuous, essential resource for protein chemists. Covering reviews of methodology and research in all aspects of protein chemistry, including purification/expression, proteomics, modeling and structural determination and design, each volume brings forth new information about protocols and analysis of proteins while presenting the most recent findings from leading experts in a broad range of protein-related topics. Covers reviews of methodology and research in all aspects of protein chemistry Brings forth new information about protocols and analysis of proteins while presenting the most recent findings from leading experts in a broad range of protein-related topics

Author : Enrico Clementi,Ramaswamy H. Sarma
Publisher : Unknown
Page : 520 pages
File Size : 43,5 Mb
Release : 1983
Category : Science
ISBN : UOM:39015016021506

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Structure and Dynamics, Nucleic Acids and Proteins by Enrico Clementi,Ramaswamy H. Sarma Pdf

Author : E. Clementi,S. Chin
Publisher : Unknown
Page : 455 pages
File Size : 44,7 Mb
Release : 1986
Category : Electronic
ISBN : OCLC:989592377

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Structure and Dynamics of Nucleic Acids, Proteins, and Membranes : Proceedings of the International Symposium, Held August 31 - September 5, 1986, in Riva Del Garda, Italy by E. Clementi,S. Chin Pdf

Author : Monika Fuxreiter
Publisher : CRC Press
Page : 458 pages
File Size : 40,6 Mb
Release : 2014-12-24
Category : Science
ISBN : 9781482297867

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Computational Approaches to Protein Dynamics by Monika Fuxreiter Pdf

The Latest Developments on the Role of Dynamics in Protein FunctionsComputational Approaches to Protein Dynamics: From Quantum to Coarse-Grained Methods presents modern biomolecular computational techniques that address protein flexibility/dynamics at all levels of theory. An international contingent of leading researchers in chemistry, physics, an

Author : Enrico Clementi
Publisher : Unknown
Page : 600 pages
File Size : 45,5 Mb
Release : 1985
Category : Science
ISBN : UOM:39015010167800

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Structure and Motion by Enrico Clementi Pdf

Author : Oleg Jardetzky,Jean-François Lefèvre
Publisher : Springer Science & Business Media
Page : 308 pages
File Size : 41,8 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781461558392

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Dynamics and the Problem of Recognition in Biological Macromolecules by Oleg Jardetzky,Jean-François Lefèvre Pdf

From within complex structures of organisms and cells down to the molecular level, biological processes all involve movement. Muscular fibers slide on each other to activate the muscle, as polymerases do along nucleic acids for replicating and transcribing the genetic material. Cells move and organize themselves into organs by recognizing each other through macromolecular surface-specific interactions. These recognition processes involve the mu tual adaptation of structures that rely on their flexibility. All sorts of conformational changes occur in proteins involved in through-membrane signal transmission, showing another aspect of the flexibility of these macromolecules. The movement and flexibility are inscribed in the polymeric nature of essential biological macromolecules such as proteins and nucleic acids. For instance, the well-defined structures formed by the long protein chain are held together by weak noncovalent interac tions that design a complex potential well in which the protein floats, permanently fluctuating between several micro- or macroconformations in a wide range of frequencies and ampli tudes. The inherent mobility of biomolecular edifices may be crucial to the adaptation of their structures to particular functions. Progress in methods for investigating macromolecular structures and dynamics make this hypothesis not only attractive but more and more testable.

Author : Ruth Porter,Maeve O'Connor,Julie Whelan
Publisher : John Wiley & Sons
Page : 192 pages
File Size : 40,8 Mb
Release : 2009-09-14
Category : Science
ISBN : 9780470718445

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Mobility and Function in Proteins and Nucleic Acids by Ruth Porter,Maeve O'Connor,Julie Whelan Pdf

The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world.

Author : Adam Liwo
Publisher : Springer
Page : 851 pages
File Size : 47,7 Mb
Release : 2018-12-19
Category : Technology & Engineering
ISBN : 9783319958439

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Computational Methods to Study the Structure and Dynamics of Biomolecules and Biomolecular Processes by Adam Liwo Pdf

This book provides a comprehensive overview of modern computer-based techniques for analyzing the structure, properties and dynamics of biomolecules and biomolecular processes. It is organized in four main parts; the first one deals with methodology of molecular simulations; the second one with applications of molecular simulations; the third one introduces bioinformatics methods and the use of experimental information in molecular simulations; the last part reports on selected applications of molecular quantum mechanics. This second edition has been thoroughly revised and updated to include the latest progresses made in the respective field of research.

Author : G. Vergoten,T. Theophanides
Publisher : Springer Science & Business Media
Page : 327 pages
File Size : 41,7 Mb
Release : 2012-12-06
Category : Science
ISBN : 9789401154840

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Biomolecular Structure and Dynamics by G. Vergoten,T. Theophanides Pdf

Biomolecular Structure and Dynamics describes recent fundamental advances in the experimental and theoretical study of molecular dynamics and stochastic dynamic simulations, X-ray crystallography and NMR of biomolecules, the structure of proteins and its prediction, time resolved Fourier transform IR spectroscopy of biomolecules, the computation of free energy, applications of vibrational CD of nucleic acids, and solid state NMR. Further presentations include recent advances in UV resonance Raman spectroscopy of biomolecules, semiempirical MO methods, empirical force fields, quantitative studies of the structure of proteins in water by Fourier transform IR, and density functional theory. Metal-ligand interactions, DFT treatment of organometallic and biological systems, and simulation vs. X-ray and far IR experiments are also discussed in some detail. The book provides a broad perspective of the current theoretical aspects and recent experimental findings in the field of biomolecular dynamics, revealing future research trends, especially in areas where theoreticians and experimentalists could fruitfully collaborate.

Author : A. Pullman,Joshua Jortner
Publisher : Springer Science & Business Media
Page : 567 pages
File Size : 49,9 Mb
Release : 2012-12-06
Category : Science
ISBN : 9789400972254

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Nucleic Acids: The Vectors of Life by A. Pullman,Joshua Jortner Pdf

Proceedings of the Sixteenth Jerusalem Symposium on Quantum Chemistry and Biochemistry held in Jerusalem, Israel, May 2-5, 1983

Author : Igor A. Kaltashov,Stephen J. Eyles
Publisher : John Wiley & Sons
Page : 312 pages
File Size : 51,5 Mb
Release : 2012-03-02
Category : Science
ISBN : 9781118232118

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Mass Spectrometry in Structural Biology and Biophysics by Igor A. Kaltashov,Stephen J. Eyles Pdf

The definitive guide to mass spectrometry techniques in biology and biophysics The use of mass spectrometry (MS) to study the architecture and dynamics of proteins is increasingly common within the biophysical community, and Mass Spectrometry in Structural Biology and Biophysics: Architecture, Dynamics, and Interaction of Biomolecules, Second Edition provides readers with detailed, systematic coverage of the current state of the art. Offering an unrivalled overview of modern MS-based armamentarium that can be used to solve the most challenging problems in biophysics, structural biology, and biopharmaceuticals, the book is a practical guide to understanding the role of MS techniques in biophysical research. Designed to meet the needs of both academic and industrial researchers, it makes mass spectrometry accessible to professionals in a range of fields, including biopharmaceuticals. This new edition has been significantly expanded and updated to include the most recent experimental methodologies and techniques, MS applications in biophysics and structural biology, methods for studying higher order structure and dynamics of proteins, an examination of other biopolymers and synthetic polymers, such as nucleic acids and oligosaccharides, and much more. Featuring high-quality illustrations that illuminate the concepts described in the text, as well as extensive references that enable the reader to pursue further study, Mass Spectrometry in Structural Biology and Biophysics is an indispensable resource for researchers and graduate students working in biophysics, structural biology, protein chemistry, and related fields.

Author : Ramaswamy H. Sarma,Mukti H. Sarma
Publisher : Unknown
Page : 416 pages
File Size : 52,6 Mb
Release : 1996
Category : Science
ISBN : 0940030470

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Biological Structure and Dynamics by Ramaswamy H. Sarma,Mukti H. Sarma Pdf

Author : Yogambigai Velmurugu
Publisher : Springer
Page : 199 pages
File Size : 45,8 Mb
Release : 2016-11-29
Category : Science
ISBN : 9783319451299

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Dynamics and Mechanism of DNA-Bending Proteins in Binding Site Recognition by Yogambigai Velmurugu Pdf

Using a novel approach that combines high temporal resolution of the laser T-jump technique with unique sets of fluorescent probes, this study unveils previously unresolved DNA dynamics during search and recognition by an architectural DNA bending protein and two DNA damage recognition proteins. Many cellular processes involve special proteins that bind to specific DNA sites with high affinity. How these proteins recognize their sites while rapidly searching amidst ~3 billion nonspecific sites in genomic DNA remains an outstanding puzzle. Structural studies show that proteins severely deform DNA at specific sites and indicate that DNA deformability is a key factor in site-specific recognition. However, the dynamics of DNA deformations have been difficult to capture, thus obscuring our understanding of recognition mechanisms. The experiments presented in this thesis uncover, for the first time, rapid (~100-500 microseconds) DNA unwinding/bending attributed to nonspecific interrogation, prior to slower (~5-50 milliseconds) DNA kinking/bending/nucleotide-flipping during recognition. These results help illuminate how a searching protein interrogates DNA deformability and eventually “stumbles” upon its target site. Submillisecond interrogation may promote preferential stalling of the rapidly scanning protein at cognate sites, thus enabling site-recognition. Such multi-step search-interrogation-recognition processes through dynamic conformational changes may well be common to the recognition mechanisms for diverse DNA-binding proteins.