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Grasslands and Herbivore Production in Europe and Effects of Common Policies by Christian Huyghe,Alex De Vliegher,Bert van Gils,Alain Peeters Pdf
Funded by and written during theEuropean Multisward project, this open access ebook presents an inventory of grasslands and forage crops in Europe by placing them in the production system in which they are embedded, and studying the technical, economic and regulatory determinants of past and present trends. Profusely illustrated with maps, it also features many case studies in all European regions and interviews of farmers and key stakeholders.
Sustainable use of Genetic Diversity in Forage and Turf Breeding by Christian Huyghe Pdf
Grassland produces feed for livestock, improves soil fertility and structure, protects water resources and may contribute to climate change mitigation through carbon storage and to biodiversity preservation. It simultaneously maintains sustainable economic outputs for farmers and provides ecosystem services. Turf similarly c- siderably contributes to our environment by adding beauty to our surroundings, providing a safe playing surface for sports and recreation. The species diversity present in most grasslands and turfs is a functional div- sity contributing to the previously mentioned agronomic and environmental bene?ts. The species belong to different functional groups and the adequate species com- sition may maximise the agronomic performance through a higher production and a better quality and the environmental bene?ts through symbiotic nitrogen ?xation or sources of pollen and nectar to pollinators. In a given grassland or turf, the genetic diversity available in each variety contributes to this economic and environmental performance, but also to the stability of these performances including the stability of the resistance against pathogens and pests. Natural grasslands share many species with the sown swards. They may be regarded as favourable sites for in situ preservation of genetic diversity as well as valuable sources of diversity for breeding.
Targeted Radionuclide Tumor Therapy by Torgny Stigbrand,Jorgen Carlsson,Gregory P. Adams Pdf
The last three decades have provided opportunities to explore the potential of treating malignant diseases with antibodies or other targeting molecules labelled with nuclides. While considerable advances have been reported, there is still a signi- cant amount of work left to accomplish before our ambitions can be achieved. It now seems timely to review the accomplishments achieved to date and to clarify the challenges that remain. The choice of radionuclide, the conjugation p- cedure employed, and the selection of suitable targets were early issues that were faced by our field that still persist, however we can now tackle these obstacles with significantly better insight. The expanding array of new targeting molecules (recombinant antibodies, peptides and agents based upon alternate scaffolds) may increase the therapeutic efficacy or even modify the radiation sensitivity of the targeted tumor cell. The title of this book “Targeted Radionuclide Tumour Therapy – Biological Aspects” was selected to reinforce the concept that a major focus of this volume was devoted to understanding the biological effects of targeting and radiation. These important issues have not previously been the primary focus in this context. Furthermore, our rapidly expanding knowledge of different types of cell death and the increasingly likely existence of cancer stem cells suggests to us that even more efficient approaches in targeting might be possible in the future.
Mathematical Modeling of the Immune System in Homeostasis, Infection and Disease by Gennady Bocharov,Burkhard Ludewig,Andreas Meyerhans,Vitaly Volpert Pdf
The immune system provides the host organism with defense mechanisms against invading pathogens and tumor development and it plays an active role in tissue and organ regeneration. Deviations from the normal physiological functioning of the immune system can lead to the development of diseases with various pathologies including autoimmune diseases and cancer. Modern research in immunology is characterized by an unprecedented level of detail that has progressed towards viewing the immune system as numerous components that function together as a whole network. Currently, we are facing significant difficulties in analyzing the data being generated from high-throughput technologies for understanding immune system dynamics and functions, a problem known as the ‘curse of dimensionality’. As the mainstream research in mathematical immunology is based on low-resolution models, a fundamental question is how complex the mathematical models should be? To respond to this challenging issue, we advocate a hypothesis-driven approach to formulate and apply available mathematical modelling technologies for understanding the complexity of the immune system. Moreover, pure empirical analyses of immune system behavior and the system’s response to external perturbations can only produce a static description of the individual components of the immune system and the interactions between them. Shifting our view of the immune system from a static schematic perception to a dynamic multi-level system is a daunting task. It requires the development of appropriate mathematical methodologies for the holistic and quantitative analysis of multi-level molecular and cellular networks. Their coordinated behavior is dynamically controlled via distributed feedback and feedforward mechanisms which altogether orchestrate immune system functions. The molecular regulatory loops inherent to the immune system that mediate cellular behaviors, e.g. exhaustion, suppression, activation and tuning, can be analyzed using mathematical categories such as multi-stability, switches, ultra-sensitivity, distributed system, graph dynamics, or hierarchical control. GB is supported by the Russian Science Foundation (grant 18-11-00171). AM is also supported by grants from the Spanish Ministry of Economy, Industry and Competitiveness and FEDER grant no. SAF2016-75505-R, the “María de Maeztu” Programme for Units of Excellence in R&D (MDM-2014-0370) and the Russian Science Foundation (grant 18-11-00171).
Author : Union of International Associations Staff Publisher : De Gruyter Saur Page : 1464 pages File Size : 55,5 Mb Release : 2010-08-13 Category : Language Arts & Disciplines ISBN : 3110230313
Organization Descriptions and Cross-references by Union of International Associations Staff Pdf
Yearbook of International Organizations is the most comprehensive reference resource and provides current details of international non-governmental (NGO) and intergovernmental organizations (IGO). Collected and documented by the Union of International Associations (UIA), detailed information on international organizations worldwide can be found here. Besides historical and organizational information, details on activities, events or publications, contact details, biographies of the leading individuals as well as the presentation of networks of organizations are included.
Mitogen-activated protein kinase (MAPK) signaling cascades are a group of protein kinases that play a central role in the intracellular transmission of extracellular signals. These cascades operate as major lines of communication within a complicated signaling network that regulates many cellular processes, including proliferation, differentiation, development, stress response, and apoptosis. More than 15,000 papers on MAPKs have been published over the past few years, with the number of publications increasing each year. More and more laboratories embark on the study of MAPK cascades in many d- tinct cellular systems and in particular their role in disease. Future challenges in the study of MAPK cascades remain in understa- ing the role of the various components and isoforms of the cascades in the multiple critical functions that they regulate in the whole organism, as well as the diseases caused by their malfunction. Data from gene-disrupted mice s- gest that inhibition of the MAPK cascades may have serious consequences on the development and growth of the animals. For example, targeted deletion of MEK1 is lethal, owing to developmental problems of placental vasculature and abnormal fibroblast migration. This lethality occurs in spite of the normal expression of MEK2, indicating that although the two MEK isoforms are apparently similar, they do have distinct functions, at least during embryog- esis. The ERK cascade was also shown to play a central role in brain function and in learning and memory.
NorFor is a semi-mechanistic feed evaluation system for cattle, which is used by advisors in Denmark, Iceland, Norway and Sweden. This book describes in detail the system and it covers five main sections. The first is concerned with information on feed characteristics, feed analysis and feed digestion methods. The second section describes the digestion and metabolism in the gastrointestinal tract and the supply and requirement of energy and metabolizable amino acids. The third section considers the prediction of feed intake and physical structure of the diet. The fourth section focuses on model evaluation and the final section provides information on the IT solutions and feed ration formulation by a non-linear economical optimization procedure. This book will be of significant interest to researchers, students and advisors of cattle nutrition and feed evaluation.
Global Re-introduction Perspectives by Pritpal S. Soorae Pdf
"This is the second issue in the Global Re-introduction Perspectives series and has been produced in the same standardized format as the previous one. The case-studies are arranged in the following order: Introduction, Goals, Success Indicators, Project Summary, Major Difficulties Faced, Major Lessons Learned, Success of Project with reasons for success or failure. For this second issue we received a total of 72 case-studies compared to 62 in the last issue. These case studies cover the following taxa as follows: invertebrates (9), fish (6), amphibians (5), reptiles (7), birds (13), mammals (20) and plants (12) ... We hope the information presented in this book will provide a broad global perspective on challenges facing re-introduction projects trying to restore biodiversity."--Pritpal S. Soorae.
How Unified Is the European Union? by Sverker Gustavsson,Lars Oxelheim,Lars Pehrson Pdf
World politics has been surprised recently by two sudden developments. The first took place around the beginning of 2007, when the question of global warming rose abruptly to the top of the agenda, after having been a factor in the background. The second occurred in the autumn of 2008, when the rules for a global economy started inspiring great anxiety, after having been regarded as a source of stability. These two shifts took place independently, but their consequences will require common management. The regulatory structure underlying the world’s economic, legal, and political systems needs to be revised. This presents the EU with the greatest challenge it has ever faced. The point is that this global challenge comes on top of the pr- lems already posed by markets, welfare states, security, energy, and movements of population. The additional challenge is furthermore of such a kind that a deeper discussion of the very structure of the Union is difficult to avoid.
Smad Signal Transduction by Peter Dijke,Carl-Henrik Heldin Pdf
This is the first comprehensive book on Smad signal transduction. Forward looking reviews of Smads are provided in a series of 22 cutting-edge chapters. The book is written for an audience with basic understanding of molecular and cell biology. This volume provides an in-depth review of a rapidly developing field and extensive cross-references between chapters are provided.