Egfr Signaling Networks In Cancer Therapy

Author : John D. Haley,William John Gullick
Publisher : Springer Science & Business Media
Page : 393 pages
File Size : 52,9 Mb
Release : 2009-03-01
Category : Medical
ISBN : 9781597453561

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EGFR Signaling Networks in Cancer Therapy by John D. Haley,William John Gullick Pdf

The epidermal gro wth factor (EGF ) receptor and its downstream signal transduction networks have been implicated in the ontology and maintenance of tumor tissues, which has motivated the discovery and development of molecularly targeted anti-EGF receptor therapies. Over decades of study, the EGF receptor structure, its ligand binding domains, the physical biochemistry underlying its intrinsic tyrosine kinase catalytic function and the modular interactions with SH2, PTB, and SH3 domain containing signaling adaptor p- teins required for signal transduction, have been extensively dissected. Not only is the EGF receptor the nexus of many streams of information, but it also forms one part of a calcul- ing device by forming dimers and oligomers with the other three receptors in its family in response to at least eleven ligands (some of which are expressed in multiple forms with overlapping or quite distinct functions). This phenomenon, while recruiting to the inner surface of the cell membrane and activating multiple second messenger proteins, also allows the possibility of cross talk between these systems, permitting a further layer of information to be exchanged. Less well described are the cross re gulation of the EGF receptor and other anti-apoptotic, mitogenic and metabolic signaling systems. The study of these systems has yielded new surprises. One hurdle in these efforts has been that signal transduction pathways have frequently been defined in the generic absence of their tissue-specific or cell-interaction specific context.

Author : Christoph Wagener,Carol Stocking,Oliver Müller
Publisher : John Wiley & Sons
Page : 360 pages
File Size : 49,9 Mb
Release : 2017-01-27
Category : Science
ISBN : 9783527800476

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Cancer Signaling, Enhanced Edition by Christoph Wagener,Carol Stocking,Oliver Müller Pdf

Cancer, which has become the second-most prevalent health issue globally, is essentially a malfunction of cell signaling. Understanding how the intricate signaling networks of cells and tissues allow cancer to thrive - and how they can be turned into potent weapons against it - is the key to managing cancer in the clinic and improving the outcome of cancer therapies. In their ground-breaking textbook, the authors provide a compelling story of how cancer works on the molecular level, and how targeted therapies using kinase inhibitors and other modulators of signaling pathways can contain and eventually cure it. The first part of the book gives an introduction into the cell and molecular biology of cancer, focusing on the key mechanisms of cancer formation. The second part of the book introduces the main signaling transduction mechanisms responsible for carcinogenesis and compares their function in healthy versus cancer cells. In contrast to the complexity of its topic, the text is easy to read. 32 specially prepared teaching videos on key concepts and pathways in cancer signaling are available online.

Author : Christoph Wagener,Carol Stocking,Oliver Müller
Publisher : John Wiley & Sons
Page : 356 pages
File Size : 48,8 Mb
Release : 2016-12-12
Category : Science
ISBN : 9783527336586

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Cancer Signaling by Christoph Wagener,Carol Stocking,Oliver Müller Pdf

Cancer, which has become the second-most prevalent health issue globally, is essentially a malfunction of cell signaling. Understanding how the intricate signaling networks of cells and tissues allow cancer to thrive - and how they can be turned into potent weapons against it - is the key to managing cancer in the clinic and improving the outcome of cancer therapies. In their ground-breaking textbook, the authors provide a compelling story of how cancer works on the molecular level, and how targeted therapies using kinase inhibitors and other modulators of signaling pathways can contain and eventually cure it. The first part of the book gives an introduction into the cell and molecular biology of cancer, focusing on the key mechanisms of cancer formation. The second part of the book introduces the main signaling transduction mechanisms responsible for carcinogenesis and compares their function in healthy versus cancer cells. In contrast to the complexity of its topic, the text is easy to read. 32 specially prepared teaching videos on key concepts and pathways in cancer signaling are available online for users of the print edition and have been integrated into the text in the enhanced e-book edition.

Author : Daniel Gioeli
Publisher : Springer Science & Business Media
Page : 211 pages
File Size : 45,7 Mb
Release : 2011-06-02
Category : Medical
ISBN : 9781607614784

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Targeted Therapies by Daniel Gioeli Pdf

This volume explores the mechanisms of resistance to targeted therapeutics. The focus is on the cancer cell signaling network, although other mechanisms of resistance including target mutation, and new areas of study such as cancer stem cells are included. Targeted Therapies: Mechanisms of Resistance highlights examples of changes in the signaling network in response to inhibition of a signaling event and underscores the importance in having a mechanistic understanding of the signaling network in cancer for developing effective targeted cancer therapies. Moreover, cutting edge tools to analyze the cell signaling network will be discussed. This includes the leading edge of techniques as well as computational biology and systems theory. This volume provides the reader with both an overview as well as a detailed perspective on the mechanisms of resistance to targeted therapeutics and will be of great value to the oncologist, the physician-scientist treating patients and the translational scientist working on any aspect of targeted therapeutics.

Author : Sanjay Srivastava
Publisher : BoD – Books on Demand
Page : 328 pages
File Size : 41,9 Mb
Release : 2012-03-28
Category : Medical
ISBN : 9789535103943

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Pancreatic Cancer by Sanjay Srivastava Pdf

This book covers pancreatic cancer risk factors, treatment and clinical procedures. It provides an outline of pancreatic cancer genetic risk factors, biomarkers and systems biology for the better understanding of disease. As pancreatic cancer suffers from lack of early diagnosis or prognosis markers, this book encompasses stem cell and genetic makers to identify the disease in early stages. The book uncovers the rationale and effectiveness of monotherapy and combination therapy in combating the devastating disease. As immunotherapy is emerging as an attractive approach to cease pancreatic cancer progression, the present book covers various aspects of immunotherapy including innate, adaptive, active, passive and bacterial approaches. Management of anesthesia during surgery and pain after surgery has been discussed. Book also takes the reader through the role of endoscopy and fine needle guided biopsies in diagnosing and observing the disease progression.

Author : Richard G. Pestell,Marja T. Nevalainen
Publisher : Springer Science & Business Media
Page : 456 pages
File Size : 45,8 Mb
Release : 2008-02-26
Category : Medical
ISBN : 9781603270793

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Prostate Cancer by Richard G. Pestell,Marja T. Nevalainen Pdf

Award winning authors present a comprehensive review of new perspectives in prostate cancer research and open up new directions in the clinical management of prostate cancer. The authors focus on the biology, genetics, molecular signaling networks in the disease process, and recent advances in the treatment of prostate cancer. This state-of-the-art title provides key insights into cutting edge advances in prostate cancer and into future, novel treatment strategies.

Author : Rakesh Kumar
Publisher : Springer Science & Business Media
Page : 331 pages
File Size : 55,8 Mb
Release : 2004-04-30
Category : Medical
ISBN : 9781402078224

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Molecular Targeting and Signal Transduction by Rakesh Kumar Pdf

Our limited understanding of cellular regulatory signal-transduction-networks has been a barrier to progress in improving the overall cure-rate of human cancers. Delineation of the physiologic roles of the specific regulatory signaling components, with known association with metastatic phenotypes, is a highly promising area which will likely provide the next generation of targeted strategies in the future of molecular cancer medicine. These signaling components are likely to be used in diagnosis, prognosis, and as novel targets for therapeutic development. This book brings together up-to-date summaries by leading cancer researchers on the major principles of cancer cell biology: survival, apoptosis, adhesion, and cell cycle deregulation. It is directed at clinicians and scientists working in the areas of experimental and molecular therapeutics, molecular medicine, translational cancer research, and bio-medical sciences in general.

Author : Anonim
Publisher : Unknown
Page : 128 pages
File Size : 50,7 Mb
Release : 19??
Category : Electronic
ISBN : 1461464382

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Encyclopedia of Signaling Molecules by Anonim Pdf

Author : John L. Marshall
Publisher : Springer
Page : 0 pages
File Size : 46,7 Mb
Release : 2017-06-17
Category : Medical
ISBN : 1441907165

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Cancer Therapeutic Targets by John L. Marshall Pdf

In the past decade, we have experienced an explosion of new information about cancer therapeutic targets. Many of the targets have been validated by the discovery and approval of new medicines which have been approved for the treatment of cancer. On the heels of these successes, innumerable new targets and new potential therapeutics are being developed by many different groups including government agencies, pharmaceutical companies, biotechnology companies, academic institutions, and individual investigators. Understanding the expanding "universe" of cancer therapies is therefore becoming impossible and no single source exists which serves as a reference for the involved parties. Further, the interested parties have vastly different areas of expertise, from focused laboratory based science, to clinical research, to corporate and regulatory oversight. The text would be updated every two years, more often depending on pace of change, interest and sales. While useful online, this reference book would likely be kept in hard copy as well.

Author : David A. Frank
Publisher : Springer Science & Business Media
Page : 358 pages
File Size : 52,5 Mb
Release : 2002-12-31
Category : Medical
ISBN : 9781402073403

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Signal Transduction in Cancer by David A. Frank Pdf

One of the most exciting areas of cancer research now is the development of agents which can target signal transduction pathways that are activated inappropriately in malignant cells. The understanding of the molecular abnormalities which distinguish malignant cells from their normal counterparts has grown tremendously. This volume summarizes the current research on the role that signal transduction pathways play in the pathogenesis of cancer and how this knowledge may be used to develop the next generation of more effective and less toxic anticancer agents. Series Editor comments: "The biologic behavior of both normal and cancer cells is determined by critical signal transduction pathways. This text provides a comprehensive review of the field. Leading investigators discuss key molecules that may prove to be important diagnostic and/or therapeutic targets."

Author : Bo Zhai,Zhendong Jin,Chen Yang,Gang Tian
Publisher : Frontiers Media SA
Page : 261 pages
File Size : 50,7 Mb
Release : 2024-06-04
Category : Medical
ISBN : 9782832549247

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Targeting Key Cellular Signaling Network for Cancer Chemotherapy and Immunotherapy by Bo Zhai,Zhendong Jin,Chen Yang,Gang Tian Pdf

The cellular signaling network refers to the complex system formed by the interactions between various signaling molecules and receptors within and between cells. It consists of multiple signaling pathways that mediate intricate cellular interactions both internally and externally. The development of cancer is closely associated with the intricate signaling transduction network within cells, where multiple signaling pathways are interconnected and collectively regulate the biological phenotypes of tumor cells.

Author : Federico Cappuzzo
Publisher : Adis
Page : 0 pages
File Size : 46,7 Mb
Release : 2014-10-27
Category : Medical
ISBN : 3319030582

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Guide to Targeted Therapies: EGFR mutations in NSCLC by Federico Cappuzzo Pdf

Guide to Targeted Therapies: EGFR Mutations in NSCLC is a speedy and up-to-date review, which discusses EGFR mutations, testing methods and technology, current and emerging therapies, and resources that clinicians can provide to their patients. Busy healthcare professionals who want a quick review of EGFR gene mutations as well as a summary of current therapies will benefit from this succinct guide.

Author : Ammad Ahmad Farooqi,Muhammad Ismail
Publisher : Springer
Page : 302 pages
File Size : 52,9 Mb
Release : 2017-03-29
Category : Medical
ISBN : 9783319530826

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Molecular Oncology: Underlying Mechanisms and Translational Advancements by Ammad Ahmad Farooqi,Muhammad Ismail Pdf

Cancer is a multifaceted and genomically complex disease and data obtained through high throughput technologies has provided near complete resolution of the landscape of how genomic, genetic and epigenetic mutations in cancerous cells effectively influence homeostasis of signaling networks within these cells, between cancerous cells, tumor microenvironment and at the organ level. Increasingly sophisticated information has helped us in developing a better understanding of the underlying mechanisms of cancer, and it is now known that intra-tumor genetic heterogeneity, cellular plasticity, dysregulation of spatio-temporally controlled signaling cascades, and loss of apoptosis are contributory in cancer development, progression and the development of resistance against different therapeutics. It is becoming progressively more understandable that earlier detection of pre-existing or emerging resistance against different therapeutics may prove to be helpful in personalizing the use of targeted cancer therapy. Despite the fact that there is a continuously increasing list of books, being guest edited by researchers, books on the subject are often composed of invited reviews without proper sequence and continuity and designed for a particular readership. This book progressively shifts and guides the readers from basic underlying mechanisms to translational approaches to treat cancer.

Author : Jinbo Chen,Yin Sun,Meng Zhang
Publisher : Frontiers Media SA
Page : 222 pages
File Size : 51,9 Mb
Release : 2022-04-25
Category : Medical
ISBN : 9782889749904

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Emerging Molecular Signaling Pathways and Therapeutic Targets for Genitourinary Cancer Metastasis by Jinbo Chen,Yin Sun,Meng Zhang Pdf

Author : Adam B. Glick,Carter Van Waes
Publisher : Springer Science & Business Media
Page : 462 pages
File Size : 47,9 Mb
Release : 2010-11-25
Category : Medical
ISBN : 9781441972033

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Signaling Pathways in Squamous Cancer by Adam B. Glick,Carter Van Waes Pdf

Squamous epithelia form the lining surface of tissues in contact with the environment: the skin, oral mucosa, esophagus and respiratory tract, the genital tract, and several other specialized tissues. These tissues are at highest risk for exposure to environmental carcinogens such as UV, tobacco smoke and infectious agents. Cancers that form in squamous epithelia are among the most common human solid tumors and have high morbidity and mortality. These cancers include squamous cell carcinoma of the skin, oral cancer, head and neck and esophageal cancer, certain lung cancers and cervical cancer. We propose to organize the book so that the early chapters will focus on individual pathways and more specific mechanisms in both normal function and cancer, while the later chapters will be more integrative and include overviews of biomarkers and therapeutic development. This should increase interest for clinically oriented researchers. All authors will be encouraged to provide a balanced review in addition to highlighting their own work.