Molecular Oncology Underlying Mechanisms And Translational Advancements

Author : Ammad Ahmad Farooqi,Muhammad Ismail
Publisher : Springer
Page : 302 pages
File Size : 47,8 Mb
Release : 2017-03-29
Category : Medical
ISBN : 9783319530826

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Molecular Oncology: Underlying Mechanisms and Translational Advancements by Ammad Ahmad Farooqi,Muhammad Ismail Pdf

Cancer is a multifaceted and genomically complex disease and data obtained through high throughput technologies has provided near complete resolution of the landscape of how genomic, genetic and epigenetic mutations in cancerous cells effectively influence homeostasis of signaling networks within these cells, between cancerous cells, tumor microenvironment and at the organ level. Increasingly sophisticated information has helped us in developing a better understanding of the underlying mechanisms of cancer, and it is now known that intra-tumor genetic heterogeneity, cellular plasticity, dysregulation of spatio-temporally controlled signaling cascades, and loss of apoptosis are contributory in cancer development, progression and the development of resistance against different therapeutics. It is becoming progressively more understandable that earlier detection of pre-existing or emerging resistance against different therapeutics may prove to be helpful in personalizing the use of targeted cancer therapy. Despite the fact that there is a continuously increasing list of books, being guest edited by researchers, books on the subject are often composed of invited reviews without proper sequence and continuity and designed for a particular readership. This book progressively shifts and guides the readers from basic underlying mechanisms to translational approaches to treat cancer.

Author : Miguel H. Bronchud
Publisher : Springer Science & Business Media
Page : 477 pages
File Size : 53,9 Mb
Release : 2000-02-14
Category : Medical
ISBN : 9781592592227

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Principles of Molecular Oncology by Miguel H. Bronchud Pdf

At the midpoint of the 20th century, our knowledge of cancer was based on epide- ology and pathology, and treatment consisted of surgery and radiation therapy. At mid-century, Medawar and colleagues initiated the understanding of transplantation immunology, Farber described the first use of an antifolic drug to treat leukemia, and Jacobson and coworkers described the irradiation-protection effect of spleen cells. These observations opened the door to the development of chemotherapy and tra- plantation in the treatment of cancer. Despite the rapid development of these new disciplines, progress was usually based on empiric observations and clinical trials. The rapid advances in molecular biology at the end of the 20th century mark a new era in our knowledge of cancer. Molecular immunology, molecular genetics, mole- lar pharmacology, and the Human Genome Project are in the process of providing a level of understanding of cancer undreamed of in the past. Optimism is based on the firm belief that understanding at the molecular level will lead to better and earlier di- nosis, to new forms of treatment, and, most importantly, eventually to prevention of many types of cancer.

Author : Alexzander A. A. Asea,Punit Kaur
Publisher : Springer Nature
Page : 307 pages
File Size : 51,8 Mb
Release : 2019-10-30
Category : Science
ISBN : 9783030242855

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Heat Shock Proteins in Neuroscience by Alexzander A. A. Asea,Punit Kaur Pdf

The book Heat Shock Proteins in Neuroscience provides the most comprehensive review on contemporary knowledge on the role of HSP in signaling pathways relevant to a number of diseases. Using an integrative approach, the contributors provide a synopsis of novel mechanisms, signal transduction pathways. To enhance the ease of reading and comprehension, this book has been subdivided into various section including; Section I, reviews current progress on our understanding of Neurological Aspects of HSP; Section II, focuses on Aspects of HSP in Neurodegenerative Diseases and Disorders, Section III, emphasizes the importance of HSP in Multiple Sclerosis; Section IV, reviews critical Aspects of HSP in Alzheimer’s Disease and Section V, gives a comprehensive update of the Development of HSP-Based Therapies for Neurological Disorders. Key basic and clinical research laboratories from major universities, academic medical hospitals, biotechnology and pharmaceutical laboratories around the world have contributed chapters that review present research activity and importantly project the field into the future. The book is a must read for starters and professionals in the fields of Neurology and Neurosciences, Translational Medicine, Clinical Research, Human Physiology, Biotechnology, Cell & Molecular Medicine, Pharmaceutical Scientists and Researchers involved in Drug Discovery.

Author : Sapna Malviya,Neelesh Malviya
Publisher : CRC Press
Page : 294 pages
File Size : 47,5 Mb
Release : 2023-10-03
Category : Health & Fitness
ISBN : 9781000923131

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Medicinal Plants and Cancer Chemoprevention by Sapna Malviya,Neelesh Malviya Pdf

Cancer is the second leading cause of death globally. Medicinal Plants and Cancer Chemoprevention provides information on the use of various herbal plants used as anticancer agents. It discusses the traditional system of medicine and focuses on plant-derived compounds for cancer therapy with integrated approaches. Chapters present information on various medicinal plants that covers background and history, ethnomedical considerations, morphology, phytochemistry, and pharmacological properties. The book presents a scientific investigation on medicinal plants in managing cancer, reported mechanisms of action as anticancer activity, as well as covering the toxicological aspects of certain plants. KEY FEATURES: · Details information on plant-derived compounds for cancer therapy. · Features information on methods of extraction and isolation of various phytoconstituents responsible for anticancer activity. · Discusses herbal formulations and alternative approaches used for the management and treatment of cancer. · Demonstrates the importance of alternative approaches including yoga, acupuncture, and dietary supplements to be effective in the management of cancer. This book is helpful to botanists, researchers and practitioners in alternative and complementary medicine, and the herbal medicine research community.

Author : Giulia Pasello,Emanuela Felley-Bosco,Jordi Remon
Publisher : Frontiers Media SA
Page : 163 pages
File Size : 54,7 Mb
Release : 2022-03-28
Category : Medical
ISBN : 9782889748181

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Understanding the Interplay Between the Tumor Immune Microenvironment and Genetic Alterations in Thoracic Malignancies by Giulia Pasello,Emanuela Felley-Bosco,Jordi Remon Pdf

Author : Aamir Shahzad
Publisher : Academic Press
Page : 196 pages
File Size : 44,5 Mb
Release : 2015-11-24
Category : Medical
ISBN : 9780128034941

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Translational Medicine: Tools And Techniques by Aamir Shahzad Pdf

Translational Medicine: Tools and Techniques provides a standardized path from basic research to the clinic and brings together various policy and practice issues to simplify the broad interdisciplinary field. With discussions from academic and industry leaders at international institutions who have successfully implemented translational medicine techniques and tools in various settings, readers will be guided through implementation strategies relevant to their own needs and institutions. The book also addresses regulatory processes in USA, EU, Japan and China. By providing details on omics sciences techniques, biomarkers, data mining and management approaches, case reports from industry, and tools to assess the value of different technologies and techniques, this book is the first to provide a user-friendly go-to guide for key opinion leaders (KOLs), industry administrators, faculty members, clinicians, researchers, and students interested in translational medicine. Includes detailed and standardized information about the techniques and tools used in translational medicine Provides specific industry case scenarios Explains how to use translational medicine tools and techniques to plan and improve infrastructures and capabilities while reducing cost and optimizing resources

Author : Pratap Chandra Acharya,Michio Kurosu
Publisher : Academic Press
Page : 688 pages
File Size : 54,5 Mb
Release : 2023-03-09
Category : Medical
ISBN : 9780323907019

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Medicinal Chemistry of Chemotherapeutic Agents by Pratap Chandra Acharya,Michio Kurosu Pdf

Medicinal Chemistry of Chemotherapeutic Agents: A Comprehensive Resource of Anti-infective and Anti-cancer Drugs focuses on the basics and fundamentals of chemistry involved in chemotherapeutic agents. Each chapter comprises distinct chemical classifications that include structure and IUPAC nomenclature, synthetic schemes and routes for each drug, mechanism of the drug action, metabolic pathway and structure–activity relationship (SAR) studies. The book covers current research focused on drug resistance and methods to overcome it, the development of newer drugs belonging to each category of the chemotherapeutic agents, molecules currently under clinical trials, and newly approved drugs, if any. This book will be a valuable resource for academics and researchers, helping them to understand the fundamentals of the medicinal chemistry of the chemotherapeutic agents. Includes current research focused on drug resistance and methods to overcome problems Outlines synthetic schemes and metabolic pathways of chemotherapeutic agents Discusses molecules under clinical trials and newly approved drugs

Author : Anonim
Publisher : Academic Press
Page : 468 pages
File Size : 48,8 Mb
Release : 2022-08-10
Category : Science
ISBN : 9780323983938

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Hepatobiliary Cancers: Translational Advances and Molecular Medicine by Anonim Pdf

Hepatobiliary cancer refers to primary malignant tumors originating in cells of the liver, bile ducts, and gallbladder. Globally, primary liver cancer, which includes hepatocellular carcinoma (~75 % of all cases) and intrahepatic biliary cancer or cholangiocarcinoma (~10-15 % 0f all cases) is the 6th most commonly diagnosed cancer and 3rd leading cause of cancer deaths worldwide. The vast majority of these highly malignant cancers are diagnosed at an advanced stage where treatment options are limited and patient survival outcomes are poor. The biological and therapeutic challenges posed by hepatobililiary cancers such as hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA) are daunting, emphasizing a critical need to review and assess current and evolving basic, translational, and clinical research focused on addressing the critical obstacles that continue to limit progress towards achieving significant improvements in HCC and CCA clinical management and patient survival outcomes. Towards this goal, this special edition of Advances in Cancer Research is focused on providing a comprehensive, timely and authoritative reviews covering such topics of significant scientific and clinical relevance, including hepatobiliary cancer risk mechanisms and risk-predictive molecular biomarkers; causes and functional intricacies of inter- and intratumor heterogeneity; novel insights into the role of tumor microenvironment and key signaling pathways in promoting hepatobiliary cancer progression, therapeutic resistance and immunosuppression; emerging biomarkers of HCC and CCA prognosis; advances in molecular genomics for personalizing tumor classification and targeted therapies; innovative preclinical cell culture modeling for hepatobiliary cancer drug discovery; and current and emerging trends in hepatobiliary cancer molecular therapeutic targeting and immunotherapies. Up-to date review of hepatobiliary cancers molecular genetics, novel predictive molecular biomarkers, and distinct mechanisms of inter-and intratumor heterogeneity Novel insights into the role of tumor microenvironment as a promoter of hepatobiliary cancer progression and therapeutic resistance, as well as an emerging therapeutic target Current and emerging approaches and strategies for advancing personalized molecular therapeutic targeting and immunotherapy of hepatobiliary cancers

Author : Fiona Roberts,Chee Koon Thum
Publisher : Springer Nature
Page : 501 pages
File Size : 54,9 Mb
Release : 2021-08-14
Category : Medical
ISBN : 9783030765255

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Lee's Ophthalmic Histopathology by Fiona Roberts,Chee Koon Thum Pdf

Completely revised and updated third edition of Lee’s Ophthalmic Histopathology, this well-illustrated and practically-oriented text has retained its general layout and style and division into specimen-based chapters. The visual image remains key to explaining the pathological processes - facilitated by full colour photography throughout the text. The text and illustrations are also provided as a searchable CD-ROM. The book emphasizes pertinent recent advances, particularly in the molecular basis of disease and in the diagnosis and classification of tumours. including improvements in immunohistochemistry and cytogenetic and molecular biological studies. This book is an invaluable source of reference for ophthalmic pathologists, general pathologists and ophthalmologists.

Author : Vivek Verma,Catherine Sautes-Fridman,Anna Dimberg
Publisher : Frontiers Media SA
Page : 178 pages
File Size : 54,5 Mb
Release : 2022-04-06
Category : Medical
ISBN : 9782889748624

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Tertiary Lymphoid Structures: from Basic Biology to Translational Impact in Cancer by Vivek Verma,Catherine Sautes-Fridman,Anna Dimberg Pdf

Author : Kamal Dua,Meenu Mehta,Terezinha de Jesus Andreoli Pinto,Lisa G. Pont,Kylie A. Williams,Michael Rathbone
Publisher : Elsevier
Page : 572 pages
File Size : 46,6 Mb
Release : 2021-06-24
Category : Business & Economics
ISBN : 9780323900799

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Advanced Drug Delivery Systems in the Management of Cancer by Kamal Dua,Meenu Mehta,Terezinha de Jesus Andreoli Pinto,Lisa G. Pont,Kylie A. Williams,Michael Rathbone Pdf

Advanced Drug Delivery Systems in the Management of Cancer discusses recent developments in nanomedicine and nano-based drug delivery systems used in the treatment of cancers affecting the blood, lungs, brain, and kidneys. The research presented in this book includes international collaborations in the area of novel drug delivery for the treatment of cancer. Cancer therapy remains one of the greatest challenges in modern medicine, as successful treatment requires the elimination of malignant cells that are closely related to normal cells within the body. Advanced drug delivery systems are carriers for a wide range of pharmacotherapies used in many applications, including cancer treatment. The use of such carrier systems in cancer treatment is growing rapidly as they help overcome the limitations associated with conventional drug delivery systems. Some of the conventional limitations that these advanced drug delivery systems help overcome include nonspecific targeting, systemic toxicity, poor oral bioavailability, reduced efficacy, and low therapeutic index. This book begins with a brief introduction to cancer biology. This is followed by an overview of the current landscape in pharmacotherapy for the cancer management. The need for advanced drug delivery systems in oncology and cancer treatment is established, and the systems that can be used for several specific cancers are discussed. Several chapters of the book are devoted to discussing the latest technologies and advances in nanotechnology. These include practical solutions on how to design a more effective nanocarrier for the drugs used in cancer therapeutics. Each chapter is written with the goal of informing readers about the latest advancements in drug delivery system technologies while reinforcing understanding through various detailed tables, figures, and illustrations. Advanced Drug Delivery Systems in the Management of Cancer is a valuable resource for anyone working in the fields of cancer biology and drug delivery, whether in academia, research, or industry. The book will be especially useful for researchers in drug formulation and drug delivery as well as for biological and translational researchers working in the field of cancer. Presents an overview of the recent perspectives and challenges within the management and diagnosis of cancer Provides insights into how advanced drug delivery systems can effectively be used in the management of a wide range of cancers Includes up-to-date information on diagnostic methods and treatment strategies using controlled drug delivery systems

Author : Karel Pacak,David Taïeb
Publisher : MDPI
Page : 380 pages
File Size : 47,8 Mb
Release : 2019-11-20
Category : Medical
ISBN : 9783039216543

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Pheochromocytoma (PHEO) and Paraganglioma (PGL) by Karel Pacak,David Taïeb Pdf

This book outlines some new advances in genetics, clinical evaluation, localization, therapy (newly including immunotherapy) of pheochromocytoma and paraganglioma including their metastatic counterparts. Well-known and experienced clinicians and scientists contributed to this book to include some novel approaches to these tumors. This book will serve to various health care professionals from different subspecialties, but mainly oncologists, endocrinologists, endocrine surgeons, pediatricians, and radiologists. This book shows that the field of pheochromocytoma/paraganglioma is evolving and a significant progress has been made in last 5 years requiring that health care professionals and scientists will learns new information and implement it in their clinical practice or scientific work, respectively. This book should not be missed by anybody who is focusing on neuroendocrine tumors, their newest evaluation and treatment.

Author : Matthew Gregory Cable,Robert Lawrence Randall
Publisher : BoD – Books on Demand
Page : 132 pages
File Size : 46,5 Mb
Release : 2019-12-04
Category : Medical
ISBN : 9781839680144

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Osteosarcoma by Matthew Gregory Cable,Robert Lawrence Randall Pdf

This book is titled Osteosarcoma - Diagnosis, Mechanisms, and Translational Developments, and focuses on recent advancements and novel ideas in osteosarcoma research. In a manner of speaking, we have taken the multidisciplinary mindset essential for treating osteosarcoma and broadened it to include other areas of cancer research. By learning from gains in other areas of oncology, such as new lncRNAs, the understanding of cancer metabolism and oxidative phosphorylation, and new chemotherapy agents, we can apply them to the niche of osteosarcoma for treatment development. By drawing more attention to these novel and clever discoveries, we hope to continue this enthusiasm for advancements in basic and translational research in the field of osteosarcoma.

Author : Hailiang Tang,Allen Ho
Publisher : Frontiers Media SA
Page : 409 pages
File Size : 44,8 Mb
Release : 2021-12-29
Category : Medical
ISBN : 9782889718702

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Meningioma: From Basic Research to Clinical Translational Study by Hailiang Tang,Allen Ho Pdf

Author : Kumar, Sumit,Rizvi, Moshahid Alam,Verma, Saurabh
Publisher : IGI Global
Page : 913 pages
File Size : 46,7 Mb
Release : 2020-11-27
Category : Medical
ISBN : 9781799865315

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Handbook of Research on Advancements in Cancer Therapeutics by Kumar, Sumit,Rizvi, Moshahid Alam,Verma, Saurabh Pdf

The complexity of cancer demands an integrated approach from both a cancer biology standpoint and a pharmaceutical basis to understand the different anticancer modalities. Current research has been focused on conventional and newer anticancer modalities, recent discoveries in cancer research, and also the advancements in cancer treatment. There is a current need for more research on the advances in cancer therapeutics that bridge the gap between basic research (pharmaceutical drug development processes, regulatory issues, and translational experimentation) and clinical application. Recent promising discoveries such as immunotherapies, promising therapies undergoing clinical trials, synthetic lethality, carbon beam radiation, and other exciting targeted therapies are being studied to improve and advance the studies of modern cancer treatment. The Handbook of Research on Advancements in Cancer Therapeutics serves as a comprehensive guide in modern cancer treatment by combining and merging the knowledge from both cancer biology and the pharmacology of anticancer modalities. The chapters come from multi-disciplinary backgrounds, including scientists and clinicians from both academia and various industries, to discuss nascent personalized therapies and big data-driven cancer treatment. While highlighting topic areas that include cancer prevention, cancer therapeutics, and cancer treatments through the lenses of technology, medicine/drugs, and alternate therapies, this book is ideally intended for oncologists, radiation oncologists, surgical oncologists, and cancer biologists, along with practitioners, stakeholders, researchers, academicians, and students who are interested in understanding the most fundamental aspects of cancer and the available therapeutic opportunities.