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Author : John I. Hubbard,Rodolfo Riascos Llinás,David M. J. Quastel
Publisher : Hodder Education
Page : 444 pages
File Size : 55,7 Mb
Release : 1969
Category : Electrophysiology
ISBN : CORNELL:31924003161613
Author : Nicholas Graziane,Yan Dong
Publisher : Springer Nature
Page : 283 pages
File Size : 48,5 Mb
Release : 2022-08-03
Category : Medical
ISBN : 9781071625897
This second edition volume expands on the previous edition with discussions on the latest techniques used to study synaptic transmissions. The chapters in this book are organized into six parts. Part One looks at the basic concepts, such as extracellular and intracellular recordings, and spatiotemporal effects of synaptic currents. Part Two describes the recording of synaptic currents, such as measuring kinetics of synaptic current and measuring reversal potentials. Part Three discusses basic experimentations of synaptic transmission and covers run-up and run-down, and amplitude. Parts Four and Five cover experimentations with computational components and molecular and visual components, such as measurement of a single synapse and electrophysiological and visual tags. Part Six explores in vivo recordings and talks about general considerations for in vivo exploration of synaptic plasticity. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Authoritative and thorough, Electrophysiological Analysis of Synaptic Transmission, Second Edition is a valuable resource that introduces graduate students and postdoctoral fellows to important topics in this field and also expands these topics to practical electrophysiological approaches.
Author : L. L. Voronin
Publisher : Springer
Page : 332 pages
File Size : 51,8 Mb
Release : 1993-05-27
Category : Medical
ISBN : UOM:39015029850149
Understanding of memory and learning is one of the major goals of neuroscientists and psychologists. The author first introduces the reader into the current state of knowledge of the mechanisms underlying memory by providing extensive reviews of contemporary results including behavioural approaches and molecular studies. He presents results of his group obtained by analysing elec- trical activity - including single neuron meassures. As a major experimental model the phenomenon of hippocampal long- term potentiation was studied. The so-called quantal analy- sis - a quantitative method - was applied to study mammalian brain plasticity. Short- and long-term synaptic plasticities were registered both in vivo and in vitro mammalian brain preparations. Results show the involvement of mainly presynaptic location in memory, however, the possible involvement of postsynaptic mechanisms is indicated by changes in quantal amplitude as shown by the author.
Author : Georgij N. Akoev,Yurij N. Andrianov
Publisher : Springer
Page : 0 pages
File Size : 41,8 Mb
Release : 2011-11-22
Category : Medical
ISBN : 3642779212
This monograph summarizes the results of the authors' own in- vestigations as well as relevant literature data about the mechanism of synaptic transmission in sensory hair cells of the acousticolater- al system. It deals mainly with primary processes in hair cells. Ad- ditionally, data on the properties and selectivity of various ionic channels are presented, with data concerning the mechanism of release of the neurotransmitter from the hair cell and the proper- ties of postsynaptic responses of afferent fibres. The role of ex- citatory amino acids in synaptic transmission is analyzed. This book gives a comprehensive overview of current research on synaptic transmission in sensory hair cells, which should be valuable to both those in the field and neuroscientists of various disciplines. St. Petersburg, January 1993 G.N. Akoev G. N. Andrianov Table of Contents Introduction ...................................... . Chapter 1 Anatomy of the Mecha- and Electroreceptors of the Acousticolateral System 3 1.1 The Organ of Corti ............................ 3 1.2 Semicircular Canals ............................ 8 1.3 The Otolith Organs ............................ 11 1.4 Lateral-Line Organs ............................ 15 1.5 Electroreceptors ............................... 20 1.5.1 Ampullary Receptors ........................... 21 1.5.2 Tuberous Receptors ............................ 26 Chapter 2 Electrophysiological Analysis of Synaptic lhlnsmission in Hair Cells ................ 33 2.1 Electrical Characteristics of Hair Cells.
Author : John I. Hubbard,Rodolfo Riascos Llinás,David M. J. Quastel
Publisher : Unknown
Page : 390 pages
File Size : 48,7 Mb
Release : 1969
Category : Electrophysiology
ISBN : UOM:39015009537435
Author : Wickliffe Abraham
Publisher : Unknown
Page : 158 pages
File Size : 51,5 Mb
Release : 2019-12-08
Category : Medical
ISBN : 0530018683
Abstract: This is a PhD thesis that investigated how chronic ethanol consumption by rats, followed by 2 months of abstinence, affected the functional connectivity of several pathways in the hippocampus. The techniques entailed field potential electrophysiology in anesthetized animals, which was used to investigate basal synaptic transmission, short-term plasticity and long-term potentiaton. Connectivity patterns were assessed using current source density analyses of depth profile data. The findings have been published as 4 papers in 1981, 1982, 1984. Dissertation Discovery Company and the University of Florida are dedicated to making scholarly works more discoverable and accessible throughout the world. This dissertation, "An Electrophysiological Analysis of Chronic Ethanol Effects on Synaptic Distribution and Function in Rat Hippocampus" by Wickliffe Carson Abraham, was obtained from the University of Florida and is being sold with permission from the author. A free digital copy of this work may also be found in the university's institutional repository, the IR@UF. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation.
Author : John R. Heckenlively,Geoffrey B. Arden
Publisher : MIT Press
Page : 1033 pages
File Size : 50,7 Mb
Release : 2006-04-07
Category : Medical
ISBN : 9780262083461
The long-awaited second edition of an authoritative reference on electrophysiologic vision testing, including detailed information on techniques and problems, basic physiology and anatomy, theoretical concepts, and clinical findings; with extensive new material. This authoritative text is the only comprehensive reference available on electrophysiologic vision testing, offering both practical information on techniques and problems as well as basic physiology and anatomy, theoretical concepts, and clinical correlations. The second edition, of the widely used text, offers extensive new material and updated information: 65 of the 84 chapters are completely new, with the changes reflecting recent advances in the field. The book will continue to be an essential resource for practitioners and scholars from a range of disciplines within vision science. The contributions not only cover new information—important material that is likely to become more important in the next decade—but also offer a long-range perspective on the field and its remarkable development in the last century. After discussing the history and background of clinical electrophysiology, the book introduces the anatomy of the retina and principles of cell biology in the visual pathways at the molecular, physiological, and biochemical levels. It relates these new findings to the techniques and interpretations of clinical tests, including the electro-oculogram (EOG), electroretinogram (ERG), and visual evoked potentials (VEP), which are discussed in detail, as are equipment, data acquisition and analysis, principles and protocols for clinical testing, diseases and dysfunction, and animal testing. Notable additions for this edition include chapters on the origin of electroretinogram waveforms, multifocal techniques, testing in standard laboratory animals, recent advances in analysis of abnormalities in disease, and the applications of these techniques to the study of genetic abnormalities.
Author : Virginia M. Pickel,Menahem Segal
Publisher : Elsevier
Page : 512 pages
File Size : 45,8 Mb
Release : 2013-11-16
Category : Science
ISBN : 9780124186828
The Synapse summarizes recent advances in cellular and molecular mechanisms of synaptic transmission and provides new insights into neuronal plasticity and the cellular basis of neurological diseases. Part 1 provides an in-depth look at structural differences and distribution of various pre- and post-synaptic proteins found at glutamatergic synapses. Part 2 is dedicated to dendritic spines and their associated perisynaptic glia, which together constitute the tripartite synapse. The spines are portrayed as major sites for calcium sequestration and local protein synthesis. Part 3 highlights the important regional and cellular differences between glutamatergic transmission and that of neurotransmitters such as dopamine and acetylcholine that are commonly found in axon terminals without synaptic membrane specializations. Part 4 provides an overview of the synapse from the time of formation to degeneration under the powerful influence of aging or hormonal decline that leads to severe deficits in cognitive function. Each chapter is illustrated with drawings and images derived from calcium imaging, electron microscopic immunolabeling, or electrophysiology. This book is a valuable reference for neuroscientists and clinical neurologists in both research and clinical settings. A comprehensive reference focused on the structure and function of the synapse Covers the links between the synapse and neural plasticity and the cellular basis of neurologic disease Detailed coverage of dendritic spines and associated perisynaptic glia—the tripartite synapse Includes in-depth coverage of synapse degeneration due to aging or hormonal decline related to severe cognitive impairment
Author : Jeffrey L. Noebels,Massimo Avoli
Publisher : OUP USA
Page : 1258 pages
File Size : 50,5 Mb
Release : 2012-06-29
Category : Medical
ISBN : 9780199746545
Jasper's Basic Mechanisms, Fourth Edition, is the newest most ambitious and now clinically relevant publishing project to build on the four-decade legacy of the Jasper's series. In keeping with the original goal of searching for "a better understanding of the epilepsies and rational methods of prevention and treatment.", the book represents an encyclopedic compendium neurobiological mechanisms of seizures, epileptogenesis, epilepsy genetics and comordid conditions. Of practical importance to the clinician, and new to this edition are disease mechanisms of genetic epilepsies and therapeutic approaches, ranging from novel antiepileptic drug targets to cell and gene therapies.
Author : Vassilis Cutsuridis,Bruce P. Graham,Stuart Cobb,Imre Vida
Publisher : Unknown
Page : 879 pages
File Size : 46,6 Mb
Release : 2018
Category : Hippocampus (Brain)
ISBN : 3319991043
This is the 2nd edition of a very well received and popular book that reflects the current state-of-the-art of the ongoing research avenues concerning the hippocampus and processing units bridging the gap between single cell activity, network activity and global brain function. It aims to provide a methodology to anyone interested in developing microcircuit level models of the hippocampus. The book is divided into two thematic areas: (I) Experimental background and (II) Computational analysis. In part I, leading experimental neuroscientists discuss the morphological, physiological and molecular characteristics as well as the connectivity and synaptic properties of the various cell types found in the hippocampus. Behaviour-related ensemble activity patterns of morphologically identified neurons in anesthetized and freely moving animals provide insights on the function of the hippocampal areas. In part II, computational neuroscientists present models of the hippocampal microcircuits at various levels of detail (e.g. single cell level, network level, etc.). Synaptomics and connectomics models of hippocampal structures are initially discussed. Then, network models of memory, rhythm generation and spatial navigation are presented, followed by abstract and biophysical models of synaptic plasticity. Network models of hippocampal implicated disorders (epilepsy and schizophrenia) are then detailed and how their network topologies, connectivities and activities change in these diseases. Finally, two chapters are dedicated to describing simulator environments of single neurons and networks currently used by computational neuroscientists in developing their models and modelling tools to parametrically constrain them. This engaging volume is invaluable to experimental and computational neuroscientists, electrical engineers, physicists, mathematicians and others interested in developing microcircuit models of the hippocampus. Graduate level students and trainees in all of these fields can find this book a significant source of information.
Author : Rodolfo Riascos Llinás
Publisher : Oxford University Press, USA
Page : 234 pages
File Size : 40,7 Mb
Release : 1999
Category : Neural transmission
ISBN : 0195116526
Ideal for graduate and undergraduate courses, the book includes PC and Macintosh versions of two programs for simulating and manipulating any aspect of synaptic transmission."--BOOK JACKET.
Author : National Library of Medicine (U.S.)
Publisher : Unknown
Page : 1116 pages
File Size : 49,7 Mb
Release : 1979
Category : Medicine
ISBN : UOM:39015074102479
First multi-year cumulation covers six years: 1965-70.
Author : National Library of Medicine (U.S.)
Publisher : Unknown
Page : 944 pages
File Size : 41,6 Mb
Release : 1965
Category : Medicine
ISBN : MINN:31951M01368061K
Author : R. D. Keynes,D. J. Aidley
Publisher : Cambridge University Press
Page : 196 pages
File Size : 42,9 Mb
Release : 2001-03-15
Category : Medical
ISBN : 0521805848
Essential textbook for all undergraduate students of neurobiology, physiology, cell biology and preclinical medicine.
Author : Anonim
Publisher : Unknown
Page : 1860 pages
File Size : 42,5 Mb
Release : 1997
Category : Medicine
ISBN : MINN:31951D01567139I