Emerging Roles For Hippocampal Adult Neural Stem Cells In Memory

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Emerging Roles for Hippocampal Adult Neural Stem Cells in Memory

Aaron R. Friedman,Daniela Kaufer
Emerging Roles for Hippocampal Adult Neural Stem Cells in Memory Book PDF

Author : Aaron R. Friedman,Daniela Kaufer
Publisher : Biota Publishing
Page : 41 pages
File Size : 46,5 Mb
Release : 2013-12-01
Category : Science
ISBN : 9781615044771

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Emerging Roles for Hippocampal Adult Neural Stem Cells in Memory by Aaron R. Friedman,Daniela Kaufer Pdf

Approximately 50 years ago, newly generated neurons were discovered in the adult hippocampus of the rat brain. This discovery contradicted a key principle in mammalian developmental neurobiology—that all the neurons of the brain are made during early development—and led to intensive study to find out how new neurons are generated and how the process of neurogenesis is regulated. Since then, a unique population of adult neural stem cells has been identified, and many of the molecular pathways that control their self-renewal, proliferation, and cell fate have been elucidated. However, the presence of new neurons in the adult brain also poses intriguing functional questions that have, as yet, gone largely unanswered. Why is adult neurogenesis restricted to select brain regions? What functional benefit do these new cells confer? Indeed, the field of adult neurogenesis offers a unique opportunity to study naïve neurons as they mature, form connections with existing neural networks, and begin to participate in information processing. We review the basics of adult NSC biology and the maturation of newborn neurons. In particular, we focus on new neurons in the hippocampus, and how they contribute to function in this key memory-forming structure of the brain.

Adult Neurogenesis in the Hippocampus

Juan J. Canales
Adult Neurogenesis in the Hippocampus Book PDF

Author : Juan J. Canales
Publisher : Academic Press
Page : 298 pages
File Size : 44,5 Mb
Release : 2016-05-23
Category : Science
ISBN : 9780128019924

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Adult Neurogenesis in the Hippocampus by Juan J. Canales Pdf

Neurogenesis in the adult brain has emerged as one of the most dynamic and rapidly moving fields in modern neuroscience research. The implications of adult neurogenesis for health and well-being are wide-ranging, with findings in this area having distinct relevance for treatment and rehabilitation in neurology and psychopathology. Adult Neurogenesis in the Hippocampus addresses these implications by providing an up-to-date account on how neurogenesis in the adult hippocampus contributes to critical psychological and physiological processes, such as learning and memory, and how it is modified by life experiences, such as aging, environmental enrichment, exercise, and dieting. The book also provides the most current reviews of how adult hippocampal neurogenesis influences the pathogenesis of mood disorders, addiction, and key neurological disorders. This book is the ideal resource for researchers and advanced graduates seeking focused knowledge on the role of adult neurogenesis in brain health and disease. Provides a unique overview of how adult hippocampal neurogenesis contributes to adaptive processes, brain psychopathology, and disease Includes state-of-the-art reviews by leading world experts in adult neurogenesis

The Hippocampus

Ales Stuchlik
The Hippocampus Book PDF

Author : Ales Stuchlik
Publisher : BoD – Books on Demand
Page : 180 pages
File Size : 51,5 Mb
Release : 2018-07-11
Category : Medical
ISBN : 9781789233568

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The Hippocampus by Ales Stuchlik Pdf

The hippocampus is an important brain region, a true central hub for memory of various kinds and other processes. Neuropsychiatric disorders such as Alzheimer's disease, drug addiction, and schizophrenia are characterized by hippocampal alterations. The dentate gyrus of the hippocampus is a site exhibiting adult neurogenesis. This book covers the topic of the hippocampus from various perspectives. It discusses adult neurogenesis, effect of enriched environments on hippocampal plasticity, and long-term potentiation-associated gene expression. The book also addresses multiscale representations of complex environments and strategies in the hippocampus-dependent spatial tasks. Finally, insight into the hippocampus as a link between negative affect and relapse to psychostimulants is provided. The book collects evidence of various hippocampal functions in healthy and disordered brain.

Stress in the Modern World [2 volumes]

Serena Wadhwa
Stress in the Modern World 2 volumes Book PDF

Author : Serena Wadhwa
Publisher : Bloomsbury Publishing USA
Page : 464 pages
File Size : 44,6 Mb
Release : 2017-01-23
Category : Self-Help
ISBN : 9798216150305

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Stress in the Modern World [2 volumes] by Serena Wadhwa Pdf

An engaging exploration of the scientific theories and medical conditions relating to stress and an examination of case studies that suggest ways to manage, reduce, and prevent stress in everyday life. Tension and anxiety are normal aspects of modern life, but ineffective stress management can lead to stress disorders, psychological distress, and physical ailments. An ideal resource for students researching the impact of stress on both physical and psychological health, this comprehensive two-volume set addresses scientific theories about stress, describes common symptoms and effects, identifies various sources of stress, explains how to identify and assess stress levels, and shares effective coping skills as well as strategies for preventing, managing, and reducing stress. More than two dozen contributors share their combined expertise, covering topics such as cognitive and behavioral theories and explanations of stress, the physical symptoms and effects of being subjected to stress, factors involving lifestyle and parenting styles, effective and ineffective coping methods, and finding support in mitigating stress. The set also supplies 20 personal accounts of stress, offers sidebars throughout its pages that present additional information about interesting related topics, and presents primary sources and statistics to encourage students to use their research and critical thinking skills.

The Neurobiology of Olfaction

Anna Menini
The Neurobiology of Olfaction Book PDF

Author : Anna Menini
Publisher : CRC Press
Page : 448 pages
File Size : 53,6 Mb
Release : 2009-11-24
Category : Science
ISBN : 1420071998

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The Neurobiology of Olfaction by Anna Menini Pdf

Comprehensive Overview of Advances in Olfaction The common belief is that human smell perception is much reduced compared with other mammals, so that whatever abilities are uncovered and investigated in animal research would have little significance for humans. However, new evidence from a variety of sources indicates this traditional view is likely overly simplistic. The Neurobiology of Olfaction provides a thorough analysis of the state-of-the-science in olfactory knowledge and research, reflecting the growing interest in the field. Authors from some of the most respected laboratories in the world explore various aspects of olfaction, including genetics, behavior, olfactory systems, odorant receptors, odor coding, and cortical activity. Until recently, almost all animal research in olfaction was carried out on orthonasal olfaction (inhalation). It is only in recent years, especially in human flavor research, that evidence has begun to be obtained regarding the importance of retronasal olfaction (exhalation). These studies are beginning to demonstrate that retronasal smell plays a large role to play in human behavior. Highlighting common principles among various species – including humans, insects, Xenopus laevis (African frog), and Caenorhabditis elegans (nematodes) – this highly interdisciplinary book contains chapters about the most recent discoveries in odor coding from the olfactory epithelium to cortical centers. It also covers neurogenesis in the olfactory epithelium and olfactory bulb. Each subject-specific chapter is written by a top researcher in the field and provides an extensive list of reviews and original articles for students and scientists interested in further readings.

50th Anniversary of Adult Neurogenesis: Olfaction, Hippocampus and beyond

Alino Martinez-Marcos,José L.Trejo,Laura López-Mascaraque
50th Anniversary of Adult Neurogenesis Olfaction Hippocampus and beyond Book PDF

Author : Alino Martinez-Marcos,José L.Trejo,Laura López-Mascaraque
Publisher : Frontiers Media SA
Page : 245 pages
File Size : 44,6 Mb
Release : 2016-09-21
Category : Neurosciences. Biological psychiatry. Neuropsychiatry
ISBN : 9782889199631

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50th Anniversary of Adult Neurogenesis: Olfaction, Hippocampus and beyond by Alino Martinez-Marcos,José L.Trejo,Laura López-Mascaraque Pdf

In the mid-sixties, the discovery by Altman and co-workers of neurogenesis in the adult brain changed the previous conception of the immutability of this organ during adulthood sustained among others by Cajal. This discovery was ignored up to eighty’s when Nottebohm demonstrated neurogenesis in birds. Subsequently, two main neurogenic zones were characterized: the subventricular zone of the lateral ventricle and the subgranular layer of the dentate gyrus. Half century later, the exact role of new neurons in the adult brain is not completely understand. This book is composed by a number of articles by leaders in the filed covering from an historic perspective to potential therapeutic opportunities.

Translational Research in Traumatic Brain Injury

Daniel Laskowitz,Gerald Grant
Translational Research in Traumatic Brain Injury Book PDF

Author : Daniel Laskowitz,Gerald Grant
Publisher : CRC Press
Page : 412 pages
File Size : 50,5 Mb
Release : 2015-12-01
Category : Medical
ISBN : 9781498766579

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Translational Research in Traumatic Brain Injury by Daniel Laskowitz,Gerald Grant Pdf

Traumatic brain injury (TBI) remains a significant source of death and permanent disability, contributing to nearly one-third of all injury related deaths in the United States and exacting a profound personal and economic toll. Despite the increased resources that have recently been brought to bear to improve our understanding of TBI, the development of new diagnostic and therapeutic approaches has been disappointingly slow. Translational Research in Traumatic Brain Injury attempts to integrate expertise from across specialties to address knowledge gaps in the field of TBI. Its chapters cover a wide scope of TBI research in five broad areas: Epidemiology Pathophysiology Diagnosis Current treatment strategies and sequelae Future therapies Specific topics discussed include the societal impact of TBI in both the civilian and military populations, neurobiology and molecular mechanisms of axonal and neuronal injury, biomarkers of traumatic brain injury and their relationship to pathology, neuroplasticity after TBI, neuroprotective and neurorestorative therapy, advanced neuroimaging of mild TBI, neurocognitive and psychiatric symptoms following mild TBI, sports-related TBI, epilepsy and PTSD following TBI, and more. The book integrates the perspectives of experts across disciplines to assist in the translation of new ideas to clinical practice and ultimately to improve the care of the brain injured patient.

Neurobiology of Chemical Communication

Carla Mucignat-Caretta
Neurobiology of Chemical Communication Book PDF

Author : Carla Mucignat-Caretta
Publisher : CRC Press
Page : 614 pages
File Size : 55,8 Mb
Release : 2014-02-14
Category : Medical
ISBN : 9781466553415

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Neurobiology of Chemical Communication by Carla Mucignat-Caretta Pdf

Intraspecific communication involves the activation of chemoreceptors and subsequent activation of different central areas that coordinate the responses of the entire organism—ranging from behavioral modification to modulation of hormones release. Animals emit intraspecific chemical signals, often referred to as pheromones, to advertise their presence to members of the same species and to regulate interactions aimed at establishing and regulating social and reproductive bonds. In the last two decades, scientists have developed a greater understanding of the neural processing of these chemical signals. Neurobiology of Chemical Communication explores the role of the chemical senses in mediating intraspecific communication. Providing an up-to-date outline of the most recent advances in the field, it presents data from laboratory and wild species, ranging from invertebrates to vertebrates, from insects to humans. The book examines the structure, anatomy, electrophysiology, and molecular biology of pheromones. It discusses how chemical signals work on different mammalian and non-mammalian species and includes chapters on insects, Drosophila, honey bees, amphibians, mice, tigers, and cattle. It also explores the controversial topic of human pheromones. An essential reference for students and researchers in the field of pheromones, this is also an ideal resource for those working on behavioral phenotyping of animal models and persons interested in the biology/ecology of wild and domestic species.

Recent Developments in Neuroanatomical Terminology

Hans J. ten Donkelaar,Luis Puelles
Recent Developments in Neuroanatomical Terminology Book PDF

Author : Hans J. ten Donkelaar,Luis Puelles
Publisher : Frontiers Media SA
Page : 220 pages
File Size : 45,5 Mb
Release : 2019-11-01
Category : Electronic
ISBN : 9782889631261

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Recent Developments in Neuroanatomical Terminology by Hans J. ten Donkelaar,Luis Puelles Pdf

The present series of papers are meant to provoke discussion on neuroanatomical terminology. After publication of the Terminologia Neuroanatomica (TNA 2017; http://FIPAT.library.dal.ca) and its recent ratification by the International Federation of Associations of Anatomists (IFAA), August 9 in London (UK), several neuroscientists were invited to give their views on this new official IFAA terminology. This resulted in 12 papers and one commentary on the following topics: (A) Further development of a developmental ontology; (B) Common terminology for cerebral cortex and thalamus; (C) White matter tracts; and (D) Neuron types. The suggestions made to improve the TNA will be considered in the next version of the TNA. Neuroanatomical terminology should remain an actively ongoing endeavor and concerns all using this nomenclature, whether in Latin, English or other languages.

Neuronal Networks of the Hippocampus

Roger D. Traub,Richard Miles
Neuronal Networks of the Hippocampus Book PDF

Author : Roger D. Traub,Richard Miles
Publisher : Cambridge University Press
Page : 306 pages
File Size : 53,6 Mb
Release : 1991-05-31
Category : Medical
ISBN : 9780521364812

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Neuronal Networks of the Hippocampus by Roger D. Traub,Richard Miles Pdf

The questions of how a large population of neurons in the brain functions, how synchronized firing of neurons is achieved, and what factors regulate how many and which neurons fire under different conditions form the central theme of this book. Important neurological techniques for the physiological reconstruction of a large biological neural network are presented.

Associative Memory Cells: Basic Units of Memory Trace

Jin-Hui Wang
Associative Memory Cells Basic Units of Memory Trace Book PDF

Author : Jin-Hui Wang
Publisher : Springer Nature
Page : 275 pages
File Size : 49,6 Mb
Release : 2019-09-10
Category : Medical
ISBN : 9789811395017

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Associative Memory Cells: Basic Units of Memory Trace by Jin-Hui Wang Pdf

This book focuses on associative memory cells and their working principles, which can be applied to associative memories and memory-relevant cognitions. Providing comprehensive diagrams, it presents the author's personal perspectives on pathology and therapeutic strategies for memory deficits in patients suffering from neurological diseases and psychiatric disorders. Associative learning is a common approach to acquire multiple associated signals, including knowledge, experiences and skills from natural environments or social interaction. The identification of the cellular and molecular mechanisms underlying associative memory is important in furthering our understanding of the principles of memory formation and memory-relevant behaviors as well as in developing therapeutic strategies that enhance memory capacity in healthy individuals and improve memory deficit in patients suffering from neurological disease and psychiatric disorders. Although a series of hypotheses about neural substrates for associative memory has been proposed, numerous questions still need to be addressed, especially the basic units and their working principle in engrams and circuits specific for various memory patterns. This book summarizes the developments concerning associative memory cells reported in current and past literature, providing a valuable overview of the field for neuroscientists, psychologists and students.

Jasper's Basic Mechanisms of the Epilepsies

Jeffrey L. Noebels,Massimo Avoli
Jasper s Basic Mechanisms of the Epilepsies Book PDF

Author : Jeffrey L. Noebels,Massimo Avoli
Publisher : OUP USA
Page : 1258 pages
File Size : 55,5 Mb
Release : 2012-06-29
Category : Medical
ISBN : 9780199746545

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Jasper's Basic Mechanisms of the Epilepsies by Jeffrey L. Noebels,Massimo Avoli Pdf

Jasper's Basic Mechanisms, Fourth Edition, is the newest most ambitious and now clinically relevant publishing project to build on the four-decade legacy of the Jasper's series. In keeping with the original goal of searching for "a better understanding of the epilepsies and rational methods of prevention and treatment.", the book represents an encyclopedic compendium neurobiological mechanisms of seizures, epileptogenesis, epilepsy genetics and comordid conditions. Of practical importance to the clinician, and new to this edition are disease mechanisms of genetic epilepsies and therapeutic approaches, ranging from novel antiepileptic drug targets to cell and gene therapies.

From Neurons to Neighborhoods

National Research Council,Institute of Medicine,Board on Children, Youth, and Families,Committee on Integrating the Science of Early Childhood Development
From Neurons to Neighborhoods Book PDF

Author : National Research Council,Institute of Medicine,Board on Children, Youth, and Families,Committee on Integrating the Science of Early Childhood Development
Publisher : National Academies Press
Page : 610 pages
File Size : 46,5 Mb
Release : 2000-11-13
Category : Social Science
ISBN : 9780309069885

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From Neurons to Neighborhoods by National Research Council,Institute of Medicine,Board on Children, Youth, and Families,Committee on Integrating the Science of Early Childhood Development Pdf

How we raise young children is one of today's most highly personalized and sharply politicized issues, in part because each of us can claim some level of "expertise." The debate has intensified as discoveries about our development-in the womb and in the first months and years-have reached the popular media. How can we use our burgeoning knowledge to assure the well-being of all young children, for their own sake as well as for the sake of our nation? Drawing from new findings, this book presents important conclusions about nature-versus-nurture, the impact of being born into a working family, the effect of politics on programs for children, the costs and benefits of intervention, and other issues. The committee issues a series of challenges to decision makers regarding the quality of child care, issues of racial and ethnic diversity, the integration of children's cognitive and emotional development, and more. Authoritative yet accessible, From Neurons to Neighborhoods presents the evidence about "brain wiring" and how kids learn to speak, think, and regulate their behavior. It examines the effect of the climate-family, child care, community-within which the child grows.

Metabolic and Bioenergetic Drivers of Neurodegenerative Disease: Treating Neurodegenerative Diseases as Metabolic Diseases

Anonim
Metabolic and Bioenergetic Drivers of Neurodegenerative Disease Treating Neurodegenerative Diseases as Metabolic Diseases Book PDF

Author : Anonim
Publisher : Academic Press
Page : 322 pages
File Size : 50,9 Mb
Release : 2020-08-25
Category : Medical
ISBN : 9780128231227

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Metabolic and Bioenergetic Drivers of Neurodegenerative Disease: Treating Neurodegenerative Diseases as Metabolic Diseases by Anonim Pdf

Metabolic Drivers and Bioenergetic Components of Neurodegenerative Disease reviews how the different aspects of metabolic dysfunction and consequent pathology associated with neurodegenerative diseases, including Alzheimer’s and Parkinson’s, can be targeted by novel treatment approaches. Topics covered include Cellular Senescence in Aging and Age-Related Disorders: Implications for Neurodegenerative Diseases; Repurposing GLP1 agonists for Neurodegenerative Diseases; Ketotherapeutics for Neurodegenerative Diseases; Enhancing Mitophagy as a Therapeutic Approach for Neurodegenerative Diseases; Harnessing Neurogenesis in the Adult Brain – A Role in Type 2 Diabetes Mellitus and Alzheimer’s disease; and much more. Summarizes the impact of the metabolic hypothesis on underlying mechanisms of neurodegenerative diseases Presents novel, potential treatment strategies based on the metabolic hypothesis for neurodegenerative diseases

Neuroscience in the 21st Century

Donald W. Pfaff,Nora D. Volkow
Neuroscience in the 21st Century Book PDF

Author : Donald W. Pfaff,Nora D. Volkow
Publisher : Springer
Page : 0 pages
File Size : 45,9 Mb
Release : 2016-10-27
Category : Medical
ISBN : 1493934732

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Neuroscience in the 21st Century by Donald W. Pfaff,Nora D. Volkow Pdf

Edited and authored by a wealth of international experts in neuroscience and related disciplines, this key new resource aims to offer medical students and graduate researchers around the world a comprehensive introduction and overview of modern neuroscience. Neuroscience research is certain to prove a vital element in combating mental illness in its various incarnations, a strategic battleground in the future of medicine, as the prevalence of mental disorders is becoming better understood each year. Hundreds of millions of people worldwide are affected by mental, behavioral, neurological and substance use disorders. The World Health Organization estimated in 2002 that 154 million people globally suffer from depression and 25 million people from schizophrenia; 91 million people are affected by alcohol use disorders and 15 million by drug use disorders. A more recent WHO report shows that 50 million people suffer from epilepsy and 24 million from Alzheimer’s and other dementias. Because neuroscience takes the etiology of disease—the complex interplay between biological, psychological, and sociocultural factors—as its object of inquiry, it is increasingly valuable in understanding an array of medical conditions. A recent report by the United States’ Surgeon General cites several such diseases: schizophrenia, bipolar disorder, early-onset depression, autism, attention deficit/ hyperactivity disorder, anorexia nervosa, and panic disorder, among many others. Not only is this volume a boon to those wishing to understand the future of neuroscience, it also aims to encourage the initiation of neuroscience programs in developing countries, featuring as it does an appendix full of advice on how to develop such programs. With broad coverage of both basic science and clinical issues, comprising around 150 chapters from a diversity of international authors and including complementary video components, Neuroscience in the 21st Century in its second edition serves as a comprehensive resource to students and researchers alike.