Enabling Discovery Development And Translation Of Treatments For Cognitive Dysfunction In Depression

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Enabling Discovery, Development, and Translation of Treatments for Cognitive Dysfunction in Depression

National Academies of Sciences, Engineering, and Medicine,Institute of Medicine,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders
Enabling Discovery Development and Translation of Treatments for Cognitive Dysfunction in Depression Book PDF

Author : National Academies of Sciences, Engineering, and Medicine,Institute of Medicine,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders
Publisher : National Academies Press
Page : 90 pages
File Size : 45,9 Mb
Release : 2015-10-29
Category : Medical
ISBN : 9780309373968

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Enabling Discovery, Development, and Translation of Treatments for Cognitive Dysfunction in Depression by National Academies of Sciences, Engineering, and Medicine,Institute of Medicine,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders Pdf

Major depressive disorder (MDD) is recognized worldwide as a major cause of disability, morbidity, and mortality. According to the World Health Organization, unipolar depressive disorders affect more than 150 million people around the world and represent the leading cause of years lost due to disability among both men and women. In the United States alone, nearly 8 percent of persons over the age of 12 report current depression. MDD has long been defined primarily as a mood disorder. However,more recently people have begun to recognize effects on cognition as a major contributor to the disablement that accompanies depression and to consider this an underrecognized treatment target for depression. To explore how best to enable the discovery, development, and translation of treatments for cognitive dysfunction in depression, including a focus on the regulatory path forward, the Institute of Medicine's Forum on Neuroscience and Nervous Disorders convened key stakeholders at a workshop in February 2015. This report summarizes the presentations from expert speakers and discussions among workshop participants.

Cognitive Dimensions of Major Depressive Disorder

Bernhard T. Baune,Catherine Harmer
Cognitive Dimensions of Major Depressive Disorder Book PDF

Author : Bernhard T. Baune,Catherine Harmer
Publisher : Oxford University Press
Page : 304 pages
File Size : 48,8 Mb
Release : 2019-08-01
Category : Medical
ISBN : 9780192539212

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Cognitive Dimensions of Major Depressive Disorder by Bernhard T. Baune,Catherine Harmer Pdf

Major depressive disorder (MDD) is one of the most prevalent mental disorders worldwide, and is estimated to affect 300 million people. Most research defines MDD as a categorical disorder and investigations on clinical, functional, and biological correlates are assessed by established diagnostic instruments. However, given the phenotypic and biological heterogeneity of depression, a re-focus on the clinical phenotype of MDD is required. Bridging psychiatric and psychological traditions Cognitive Dimensions of Major Depressive Disorder, discusses the characteristics of the dimensional approach of MDD. Focusing on the cognitive and emotional processes of depression, this guide offers extended and novel diagnostic and treatment approaches ranging from pharmacological to psychological interventions targeting dimensions of depression. Edited by pioneers in this field, this resource discusses hot topics such as how to define the dimensional approach to depression, the neurobiological underpinnings of cognitive dysfunction in depression, and the impairment of emotional processing deficits in depression. Cognitive Dimensions of Major Depressive Disorder is suitable for students, trainees, clinicians and scientists in the fields of psychology, neuropsychology, psychiatry, cognitive neuroscience, neurology, general practice and also for various other health care professionals.

Neuropsychology of Depression

Shawn M. McClintock,Jimmy Choi
Neuropsychology of Depression Book PDF

Author : Shawn M. McClintock,Jimmy Choi
Publisher : Guilford Publications
Page : 484 pages
File Size : 42,9 Mb
Release : 2022-02-20
Category : Psychology
ISBN : 9781462549337

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Neuropsychology of Depression by Shawn M. McClintock,Jimmy Choi Pdf

Timely and authoritative, this unique volume focuses on neurocognitive aspects of depression and their implications for assessment, evaluation, clinical management, and research. Experts in the field explore the impact of depression on executive function, learning and memory, working memory, and other critical capacities, and present cutting-edge assessment tools and procedures. The neurocognitive effects of widely used antidepressant treatments are reviewed, from psychotropic medications and evidence-based psychotherapies to established and emerging neuromodulation technologies. Practical aspects of working with adults across the lifespan with depression are addressed, including ways to strengthen treatment engagement and adherence, and to incorporate cultural considerations.

The SAGE Handbook of Clinical Neuropsychology

Gregory J. Boyle,Yaakov Stern,Dan J. Stein,Charles J. Golden,Barbara J. Sahakian,Tatia Mei-Chun Lee,Shen-Hsing Annabel Chen
The SAGE Handbook of Clinical Neuropsychology Book PDF

Author : Gregory J. Boyle,Yaakov Stern,Dan J. Stein,Charles J. Golden,Barbara J. Sahakian,Tatia Mei-Chun Lee,Shen-Hsing Annabel Chen
Publisher : SAGE
Page : 1047 pages
File Size : 48,5 Mb
Release : 2023-05-25
Category : Psychology
ISBN : 9781529765038

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The SAGE Handbook of Clinical Neuropsychology by Gregory J. Boyle,Yaakov Stern,Dan J. Stein,Charles J. Golden,Barbara J. Sahakian,Tatia Mei-Chun Lee,Shen-Hsing Annabel Chen Pdf

Clinical Neuropsychology is a vast and varied field that focuses on the treatment, assessment and diagnosis of a range of cognitive disorders through a study and understanding of neuroanatomy and the relationship between the brain and human behavior. This handbook focuses on the assessment, diagnosis and rehabilitation of cognitive disorders. It provides in-depth coverage on a variety of content, including psychometrics, neuropsychological test batteries (computer based cognitive assessment systems) and assessment applications. This handbook is vital for clinical neuropsychologists and postgraduate students and researchers hoping to apply a knowledge of neuropsychology to clinical settings and effectively assess, diagnose and treat patients suffering from cognitive disorders. PART I BACKGROUND CONSIDERATIONS PART II DOMAIN-SPECIFIC NEUROPSYCHOLOGICAL MEASURES PART III GENERAL COGNITIVE TEST BATTERIES PART IV LEGACY NEUROPSYCHOLOGICAL TEST BATTERIES PART V COMPUTERISED BATTERIES, TECHNOLOGICAL ADVANCES AND TELENEUROPSYCHOLOGY PART VI NEUROPSYCHOLOGICAL ASSESSMENT APPLICATIONS

Charney & Nestler's Neurobiology of Mental Illness

Dennis S. Charney,Pamela B. Sklar,Eric J. Nestler,Joseph D. Buxbaum
Charney Nestler s Neurobiology of Mental Illness Book PDF

Author : Dennis S. Charney,Pamela B. Sklar,Eric J. Nestler,Joseph D. Buxbaum
Publisher : Oxford University Press
Page : 1025 pages
File Size : 47,7 Mb
Release : 2018
Category : Medical
ISBN : 9780190681425

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Charney & Nestler's Neurobiology of Mental Illness by Dennis S. Charney,Pamela B. Sklar,Eric J. Nestler,Joseph D. Buxbaum Pdf

Preceded by Neurobiology of mental illness / edited by Dennis S. Charney ... [et al.]. 4th ed. 2013.

Major Depressive Disorder

Roger S McIntyre
Major Depressive Disorder Book PDF

Author : Roger S McIntyre
Publisher : Elsevier Health Sciences
Page : 202 pages
File Size : 51,7 Mb
Release : 2019-08-25
Category : Medical
ISBN : 9780323581325

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Major Depressive Disorder by Roger S McIntyre Pdf

Get a quick, expert overview of the key issues surrounding best practices and current consensus on major depressive disorder (MDD). This concise resource by Drs. Roger S. McIntyre, Carola Rong, Mehala Subramaniapillai, and Yena Lee consolidates today’s available information on this complex topic into one convenient resource, making it an ideal, easy-to-digest reference for both psychiatrists and primary care physicians. Covers genetics and epigenetics, brain structural abnormalities, cognition, neuroendocrine alterations, and inflammatory abnormalities as they relate to MDD. Contains chapters on psychiatric comorbidity, pharmacological treatments, neuromodulatory treatments, lifestyle interventions, internet-based/technology-based interventions, and glutamate alterations.

Neurobiology of Depression

Francisco Lopez-Munoz,Cecilio Alamo
Neurobiology of Depression Book PDF

Author : Francisco Lopez-Munoz,Cecilio Alamo
Publisher : CRC Press
Page : 526 pages
File Size : 41,7 Mb
Release : 2011-09-09
Category : Medical
ISBN : 9781439838501

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Neurobiology of Depression by Francisco Lopez-Munoz,Cecilio Alamo Pdf

Major depressive disorders have recently been associated with impairments in signaling pathways that regulate neuroplasticity and cell survival. Agents designed to directly target molecules in these pathways hold promise as new therapeutics for depression. With the collaboration of the most prestigious international specialists in biochemistry, molecular biology, genomics, psychiatry, psychology, and pharmacology, Neurobiology of Depression discusses the nature of the central nervous system circuits responsible for the modifications of neuronal functioning that lead to depression. The book begins by discussing animal, neurophysiological, and neuropsychological models of depression as well as neural foundations. It explores genetic factors that contribute to depression and describes the effect of monoaminergic systems in the central nervous system. Next, the book profiles the rise of psychopharmacology in the treatment of depression and the research into serotonin and monoamine reuptake inhibitors. It examines the role of the glutamatergic, endocannabinoid, and opioid systems in the pathophysiology of mood disorders, as well as the effect of biological rhythms on the human body. Later chapters review the role of CRF-related ligands, CRF receptors, HPA axis activity, and glucocorticoid receptors in the regulation of the stress response and depression. They also describe cytokine modulation of molecular mechanisms. They examine the role of neuropeptide Y, nitric oxide, beta-arrestins, BDNF, and phosphodiesterases, and discuss the use of tachykinin antagonists in treatment. Finally, they analyze the neurobiological basis for the development of new antidepressant agents. Exploring myriad aspects of a disease that plagues a large percentage of the population worldwide, this volume captures the state of the science of this debilitating disorder, facilitating further research and discovery.

Oxidative Stress and Neurodegenerative Disorders

G. Ali Qureshi,S. Hasan Parvez
Oxidative Stress and Neurodegenerative Disorders Book PDF

Author : G. Ali Qureshi,S. Hasan Parvez
Publisher : Elsevier
Page : 794 pages
File Size : 46,7 Mb
Release : 2007-03-22
Category : Science
ISBN : 0080489494

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Oxidative Stress and Neurodegenerative Disorders by G. Ali Qureshi,S. Hasan Parvez Pdf

Oxidative stress is the result of an imbalance in pro-oxidant/antioxidant homeostasis that leads to the generation of toxic reactive oxygen species. Brain cells are continuously exposed to reactive oxygen species generated by oxidative metabolism, and in certain pathological conditions defense mechanisms against oxygen radicals may be weakened and/or overwhelmed. DNA is a potential target for oxidative damage, and genomic damage can contribute to neuropathogenesis. It is important therefore to identify tools for the quantitative analysis of DNA damage in models on neurological disorders. This book presents detailed information on various neurodegenerative disorders and their connection with oxidative stress. This information will provide clinicians with directions to treat these disorders with appropriate therapy and is also of vital importance for the drug industries for the design of new drugs for treatment of degenerative disorders. * Contains the latest information on the subject of neurodegenerative disorders * Reflects on various factors involved in degeneration and gives suggestions for how to tackle these problems

Animal Models of Cognitive Impairment

Edward D. Levin,Jerry J. Buccafusco
Animal Models of Cognitive Impairment Book PDF

Author : Edward D. Levin,Jerry J. Buccafusco
Publisher : CRC Press
Page : 400 pages
File Size : 44,7 Mb
Release : 2006-06-22
Category : Science
ISBN : 9781420004335

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Animal Models of Cognitive Impairment by Edward D. Levin,Jerry J. Buccafusco Pdf

The costs associated with a drug’s clinical trials are so significant that it has become necessary to validate both its safety and efficacy in animal models prior to the continued study of the drug in humans. Featuring contributions from distinguished researchers in the field of cognitive therapy research, Animal Models of Cognitive Impairment examines some of the most popular and successful animal archetypes used in the context of drug discovery. It provides integrated coverage of the latest research concerning neuronal systems relevant to cognitive function and dysfunction, assimilating reviews of this research within the context of each chapter. This approach is unique in that it brings together molecular and neurochemical methodologies, behavioral applications in translational models, and clinical applications. The book comprehensively discusses a wide variety of animal models of cognitive impairment, including genetic, lesion, pharmacological, and aging related impairments. It also explores the significance of this research in regards to the treatment of various addictions and disorders such as stroke, autism, Alzheimer’s, schizophrenia, and ADHD. Edited by two renowned authorities in the field, Animal Models of Cognitive Impairment is a timely book that provides integrated coverage of cutting-edge research that concerns neuronal systems relevant to cognitive function and dysfunction.

Personalized Psychiatry

Bernhard Baune
Personalized Psychiatry Book PDF

Author : Bernhard Baune
Publisher : Academic Press
Page : 604 pages
File Size : 42,5 Mb
Release : 2019-10-16
Category : Medical
ISBN : 9780128131770

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Personalized Psychiatry by Bernhard Baune Pdf

Personalized Psychiatry presents the first book to explore this novel field of biological psychiatry that covers both basic science research and its translational applications. The book conceptualizes personalized psychiatry and provides state-of-the-art knowledge on biological and neuroscience methodologies, all while integrating clinical phenomenology relevant to personalized psychiatry and discussing important principles and potential models. It is essential reading for advanced students and neuroscience and psychiatry researchers who are investigating the prevention and treatment of mental disorders. Combines neurobiology with basic science methodologies in genomics, epigenomics and transcriptomics Demonstrates how the statistical modeling of interacting biological and clinical information could transform the future of psychiatry Addresses fundamental questions and requirements for personalized psychiatry from a basic research and translational perspective

Translational Neuroimaging

Robert A. McArthur
Translational Neuroimaging Book PDF

Author : Robert A. McArthur
Publisher : Academic Press
Page : 464 pages
File Size : 55,7 Mb
Release : 2012-10-05
Category : Medical
ISBN : 9780123869975

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Translational Neuroimaging by Robert A. McArthur Pdf

Translational Neuroimaging: Tools for CNS Drug Discovery, Development and Treatment combines the experience of academic, clinical and industrial neuroimagers in a unique collaborative approach to provide an integrated perspective of the use of small animal and human brain imaging in developing and validating translational models and biomarkers for the study and treatment of neuropsychiatric disorders. Translational Neuroimaging: Tools for CNS Drug Discovery, Development and Treatment examines the translational role of neuroimaging in model development from preclinical animal models, to human experimental medicine, and finally to clinical studies. The focus of this book is to identify and provide common endpoints between species that can serve to inform both the clinic and the bench with the information needed to accelerate clinically-effective CNS drug discovery. This book covers methodical issues in human and animal neuroimaging translational research as well as detailed applied examples of the use of neuroimaging in neuropsychiatric disorders and the development of drugs for their treatment. Offering an accompanying website with illustrations and text available for further knowledge and presentations, Translational Neuroimaging: Tools for CNS Drug Discovery, Development and Treatment appeals to non-clinical and clinical neuroscientists working in and studying neuropsychiatric disorders and their treatment as well as providing the novice researcher or researcher outside of his/her expertise the opportunity to understand the background of translational research and the use of imaging in this field. Provides a background to translational research and the use of brain imaging in neuropsychiatric disorders Critical discussion of the potential and limitations of neuroimaging as a translational tool for identifying and validating biomarkers Identifies cross species neurosystems and common endpoints necessary to help accelerate CNS drug discovery and development for the treatment of neuropsychiatric disorders Features an accompanying website with additional images and text

Neuroprogression in Psychiatry

Flávio Kapczinski,Michael Berk,Pedro Vieira da Silva Magalhães
Neuroprogression in Psychiatry Book PDF

Author : Flávio Kapczinski,Michael Berk,Pedro Vieira da Silva Magalhães
Publisher : Oxford University Press
Page : 272 pages
File Size : 48,8 Mb
Release : 2019-03-05
Category : Medical
ISBN : 9780191090882

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Neuroprogression in Psychiatry by Flávio Kapczinski,Michael Berk,Pedro Vieira da Silva Magalhães Pdf

Recent studies regarding the neuropathology of specific neurological disorders suggest that both neurodevelopmental and neurodegenerative processes may play a role. However, in contrast to the neurodegeneration seen in neurological disorders such as Parkinson's and Alzheimer's disease, the term "neuroprogression" has been used to describe the neurodevelopmental aspect of pathological brain re-wiring that takes place in the context of severe psychiatric disorders, such as schizophrenia or bipolar disorder. Within psychiatry, patients with severe psychopathology, such as those depressed patients who eventually commit suicide, have been shown to present with increased inflammatory markers in the brain. A similar increase in inflammatory markers is also found in patients with bipolar disorders and schizophrenia. Thus, oxidative stress, inflammation, and changes in growth factors are thought to be the pathways of neuroprogression. Neuroprogression in Psychiatry provides a comprehensive summary of the current developments in the emerging field of neuroprogression. With contributions by leading researchers in the field, this book examines the role of neuroprogression across a wide range of specific psychiatric disorders, with chapters included on major depressive disorder, anxiety disorder, post-traumatic stress disorder, substance abuse, schizophrenia, and bipolar disorder.

The Neurobiological Basis of Suicide

Yogesh Dwivedi
The Neurobiological Basis of Suicide Book PDF

Author : Yogesh Dwivedi
Publisher : CRC Press
Page : 485 pages
File Size : 41,6 Mb
Release : 2012-06-25
Category : Medical
ISBN : 9781439838815

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The Neurobiological Basis of Suicide by Yogesh Dwivedi Pdf

With recent studies using genetic, epigenetic, and other molecular and neurochemical approaches, a new era has begun in understanding pathophysiology of suicide. Emerging evidence suggests that neurobiological factors are not only critical in providing potential risk factors but also provide a promising approach to develop more effective treatment and prevention strategies. The Neurobiological Basis of Suicide discusses the most recent findings in suicide neurobiology. Psychological, psychosocial, and cultural factors are important in determining the risk factors for suicide; however, they offer weak prediction and can be of little clinical use. Interestingly, cognitive characteristics are different among depressed suicidal and depressed nonsuicidal subjects, and could be involved in the development of suicidal behavior. The characterization of the neurobiological basis of suicide is in delineating the risk factors associated with suicide. The Neurobiological Basis of Suicide focuses on how and why these neurobiological factors are crucial in the pathogenic mechanisms of suicidal behavior and how these findings can be transformed into potential therapeutic applications.

Memory and Emotion

Daniel Reisberg,Paula Hertel
Memory and Emotion Book PDF

Author : Daniel Reisberg,Paula Hertel
Publisher : Affective Science
Page : 428 pages
File Size : 46,7 Mb
Release : 2004
Category : FAMILY & RELATIONSHIPS
ISBN : 9780195158564

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Memory and Emotion by Daniel Reisberg,Paula Hertel Pdf

And lastly, why is remembering a creative act that can, and often does, produce faulty memories of our experiences?"--BOOK JACKET.

Financial Incentives to Encourage Development of Therapies That Address Unmet Medical Needs for Nervous System Disorders

Institute of Medicine,Board on Health Sciences Policy,Forum on Drug Discovery, Development, and Translation,Forum on Neuroscience and Nervous System Disorders
Financial Incentives to Encourage Development of Therapies That Address Unmet Medical Needs for Nervous System Disorders Book PDF

Author : Institute of Medicine,Board on Health Sciences Policy,Forum on Drug Discovery, Development, and Translation,Forum on Neuroscience and Nervous System Disorders
Publisher : National Academies Press
Page : 128 pages
File Size : 54,8 Mb
Release : 2015-10-22
Category : Medical
ISBN : 9780309373265

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Financial Incentives to Encourage Development of Therapies That Address Unmet Medical Needs for Nervous System Disorders by Institute of Medicine,Board on Health Sciences Policy,Forum on Drug Discovery, Development, and Translation,Forum on Neuroscience and Nervous System Disorders Pdf

The Institute of Medicine (IOM) Forum on Neuroscience and Nervous System Disorders, in collaboration with the IOM Forum on Drug Discovery, Development, and Translation, convened a workshop on January 20-21, 2015, to explore policy changes that might increase private sector investment in research and development innovation that fills unmet medical needs for central nervous system (CNS) disorders. Workshop participants strategized about how to incentivize companies to fortify their CNS drug development programs, shrinking obstacles that currently deter ventures. Representatives from academia, government agencies, patient groups, and industry gathered to share information and viewpoints, and to brainstorm about budget-neutral policy changes that could help widen the pipeline toward drugs that address unmet needs for CNS disorders. This report summarizes the presentations and discussion of the workshop.