Endocellular Selection

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Endocellular Selection

Author : John A Rush
Publisher : Independently Published
Page : 134 pages
File Size : 50,9 Mb
Release : 2021-09-29
Category : Electronic
ISBN : 9798486707162

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Endocellular Selection by John A Rush Pdf

Darwinism is the greatest hoax ever perpetrated by the academic community. Not only was Darwin wrong - random events don't build functional codes and natural selection is a circular argument (survival of the fittest; it is the fit that survive), there is no definition of "fit," and circular arguments are meaningless. Moreover, Darwin was a racist, a champion of eugenics, and he believed men to be superior to women in every way. Organisms alter their own DNA in preparation for the next generation and there is nothing random about it. Educators who continue to preach the Darwinian model are, quite simply, lying to their students. In Endocellular Selection: Evolution without Darwin, and the companion volume, What Darwin and Dawkins didn't Know, I present scientific studies pointing to the real origin of species. There are two concepts Charles Darwin presented to the world over 170 years ago, neither of which has been scientifically verified. The first is the concept of random mutations, or alterations to the genetic code, that accumulate, and, over time, result in the creation of new species. There is no science available that indicates how random acts can create codes, without researcher interference, let along the complex DNA code and all the other enzymes, etc. that support it. The second concept is natural selection and the belief that nature can pick and choose a specific sequence of the genetic code thus leading to the survival of the fittest. This sound like a good idea, that is, the survival of the fittest means it is the fit who survive. However, there is no definition of what it means to be "fit," along with the fact this is a circular argument, not allowed in science; it is meaningless. These two concepts, neither of which has been verified by materialistic science (math, physics, and chemistry), are accepted as scientific fact by the academic community. The reasons for this are twofold. First, the Myth of Darwin has been told over and over again, in textbook after textbook, implying it is scientific fact without critical analysis. The second is political and the need to remove any suggestion of an energy guiding the universe and the development of life within; there is a fear of returning to deities and demons. Dr. Rush takes the reader through the research and presents the real science for the origin of species. Basically, through endocellular selection, cells alter their coding in response to environmental issues. Moreover, lifeforms also get new information through symbiosis and hybridization. Lifeforms are not at the mercy of nature; they think and decide in order to stay ahead of Nature and anticipate the future. Life's survival depends on the cell's ability to alter itself, not on chance happenings, that is, random mutations and natural selection. Nature is information only; the cell has to decide what to do with it.

Cats

Author : John A. Rush
Publisher : Simon and Schuster
Page : 251 pages
File Size : 41,6 Mb
Release : 2023-10-03
Category : Body, Mind & Spirit
ISBN : 9781644117477

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Cats by John A. Rush Pdf

Explores our intertwined spiritual history with cats • Examines spiritual and occult beliefs connected to cats from Mayan, Aztec, and Native American mythology as well as from ancient India, Samaria, Babylon, Japan, and Egypt • Looks at spiritual behaviors attributed to cats as well as modern biological research into cat behavior and their highly sophisticated sensory systems • Reveals the similarities between cat and human emotions and the deep connection between cats and meditation We have been connected to cats for more than 30 million years. To our prehistoric ancestors cats were deadly predators of the night, and because of this ancient memory etched onto our DNA, cats epitomize our fear of the dark. Yet in addition to their connection to the dark and the shadows, their intelligence, sophisticated physical abilities, and finely tuned senses also led many cultures to view cats as connected to the spirit world. Exploring the spiritual nature of cats, John A. Rush looks at humanity’s fascination and fear of cats through the ages. He examines spiritual and occult beliefs connected to cats from Mayan, Aztec, and Native American mythology as well as from ancient India, Samaria, Babylon, Japan, and Egypt, including how ancient Egyptians used cats to send messages to the gods. He reveals why the Catholic Church demonized cats and how cats are symbols of both Good and Evil. Examining cat evolution, the author looks at spiritual behaviors attributed to cats as well as modern biological research into cat behavior and their highly sophisticated sensory systems, which, unlike most other animals, have changed very little over millions of years. He explores their “psychic” ability to sense what humans cannot and the origins of their glowing eyes, which has connected cats, through myth, to both the Underworld and the World of Light. He also explores similarities between cat and human emotions, cat communications with us, and the deep connection between cats and meditation. Revealing the spiritual journey of the cat from fearsome predator to occult symbol to household companion, the author shows how, in many ways, cats are mirrors of us, reflecting our conflicting dual nature that is at once loving yet distant, magical yet vengeful, and above all, deeply connected to the spirit world.

Mitochondrial DNA Mutations in Aging, Disease and Cancer

Author : Keshav K. Singh
Publisher : Springer Science & Business Media
Page : 417 pages
File Size : 55,8 Mb
Release : 2013-03-09
Category : Science
ISBN : 9783662125090

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Mitochondrial DNA Mutations in Aging, Disease and Cancer by Keshav K. Singh Pdf

Many human genetic diseases associated with blood, brain, colon, ear, eye, heart, kidney, liver, muscle, and pancreas are caused by mutations in mitochondrial DNA. Mutations in DNA can result in defects of the electron transport complexes, intermediates of the tricarboxylic acid cycle and substrate transport. The clinical manifestation of these diseases often involves muscle and the nervous system. Mitochondrial DNA mutations have now been associated with aging as well as age-related degenerative diseases such as Parkinson's, Alzheimer's, and Huntington's diseases. Changes in structure, function, and a number of mitochondria play an important role in carcinogenesis. Furthermore, the role of mitochondria in the execution of programmed cell death or apoptosis has been recognized recently.

Natural Selection

Author : Mario A. Fares
Publisher : CRC Press
Page : 276 pages
File Size : 54,8 Mb
Release : 2014-11-21
Category : Science
ISBN : 9781482263725

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Natural Selection by Mario A. Fares Pdf

This book summarizes the knowledge in the field of methods to identify signatures of natural selection. A number of mathematical models and methods have been designed to identify the fingerprints of natural selection on genes and genomes. Such methods are provided in a simple and direct way so that students of different disciplines can navigate through molecular fitness landscapes using complex methods with a basic knowledge on bioinformatics. A collection of the main methods to detect selection in protein-coding genes and amino acid sequences is given at different levels of complexity, from nucleotides to proteins and molecular networks. The importance of identifying natural selection in genes and genomes through the methods described in this book transcends the bioinformatics and computational biology fields, presenting applications for experimental biologists in a straightforward and understandable way.

Antibody Expression and Production

Author : Mohamed Al-Rubeai
Publisher : Springer Science & Business Media
Page : 349 pages
File Size : 50,7 Mb
Release : 2011-05-16
Category : Medical
ISBN : 9789400712577

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Antibody Expression and Production by Mohamed Al-Rubeai Pdf

Engineered antibodies currently represent over 30% of biopharmaceuticals in clinical trials and their total worldwide sales continue to increase significantly. The importance of antibody applications is reflected in their increasing clinical and industrial applications as well as in the progression of established and emerging production strategies. This volume provides detailed coverage of the generation, optimization, characterization, production and applications of antibody. It provides the necessary theoretical background and description of methods for the expression of antibody in microbial and animal cell cultures and in transgenic animals and plants. There is a strong focus on those issues related to the production of intrabodies, bispecific antibody and antibody fragments and also to novel applications in cancer immunotherapy.

Immunoproteins—Advances in Research and Application: 2013 Edition

Author : Anonim
Publisher : ScholarlyEditions
Page : 752 pages
File Size : 40,6 Mb
Release : 2013-06-21
Category : Medical
ISBN : 9781481676694

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Immunoproteins—Advances in Research and Application: 2013 Edition by Anonim Pdf

Immunoproteins—Advances in Research and Application: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about ZZZAdditional Research. The editors have built Immunoproteins—Advances in Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about ZZZAdditional Research in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Immunoproteins—Advances in Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

The Role of Behavior in Evolution

Author : Henry C. Plotkin
Publisher : MIT Press
Page : 222 pages
File Size : 47,8 Mb
Release : 1988
Category : Psychology
ISBN : 0262161079

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The Role of Behavior in Evolution by Henry C. Plotkin Pdf

These six original essays focus on a potentially important aspect of evolutionary biology, the possible causal role of phenotypic behavior in evolution. Balancing theory with actual or potential empiricism, they provide the first full examination of this topic. Plotkin's opening chapter outlines the "conceptual minefields" that the contributors attempt to negotiate: What is an adequate theory of evolution? What is behavior and is it possible to maintain a distinction between behavior and other attributes of the phenotype? is all, or only a special subset, of behavior both a cause and a consequence of evolution? And what do the theoretical issues mean in empirical terms? He concludes that any attempt to understand the causal role of behavior in evolution requires a more complicated theoretical structure than that of orthodox neoDarwinism, a conceptualization of behavior as a distinctive set of phenotypic attributes, and the accumulation of more data. David L. Hull (Northwestern University) provides an alternative account of the evolutionary process by developing a hierarchy of replicators-interactors-lineages to replace the traditional one of genes-organisms-species. Robert N. Brandon (Duke University) also posits hierarchy as an appropriate architecture for the theoretical complexity needed to support an examination of the role of behavior in evolution. F. J. Odling-Smee (Brunei University) outlines a theoretical structure to encompass the behavior of phenotypes, concentrating on the unrestricted definition of behavior (everything that an animal does). The remaining chapters are as much concerned with evidence as with theory. Plotkin concentrates on a restricted definition of behavior (behavior that is a product of choosing intelligence), reviewing our empirical knowledge of how learning might influence evolution. R.I.M. Dunbar (University College, London) uses empirical studies of vertebrate social behavior to deal with the question of how the social systems, especially of primates, might have a causal role in species evolution. A Bradford Book

One Long Argument

Author : Ernst Mayr
Publisher : Harvard University Press
Page : 228 pages
File Size : 43,5 Mb
Release : 1991
Category : Science
ISBN : 0674639065

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One Long Argument by Ernst Mayr Pdf

The great evolutionist Mayr elucidates the subtleties of Darwin’s thought and that of his contemporaries and intellectual heirs—A. R. Wallace, T. H. Huxley, August Weisman, Asa Gray. Mayr has achieved a remarkable distillation of Darwin’s scientific thought and his legacy to twentieth-century biology.

Concepts and Methods in Evolutionary Biology

Author : Robert N. Brandon
Publisher : Cambridge University Press
Page : 252 pages
File Size : 49,9 Mb
Release : 1996
Category : Philosophy
ISBN : 0521498880

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Concepts and Methods in Evolutionary Biology by Robert N. Brandon Pdf

This collection of Professor Brandon's recent essays covers all the traditional topics in the philosophy of evolutionary biology.

A Portrait of the Immune System

Author : Ivan Lefkovits
Publisher : World Scientific
Page : 878 pages
File Size : 48,6 Mb
Release : 1996-12-05
Category : Medical
ISBN : 9789814499200

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A Portrait of the Immune System by Ivan Lefkovits Pdf

Using the published work of Nobel Laureate Niels Kaj Jerne, this book shows how he developd his ideas. The book is a compilation of his published work, but in fact it is much more than that. Whether the reader wants to read the book systematically, or only browse, it opens a fascinating world of hypotheses, theories, facts and vistas. His selection theory, his view of how immunological diversity is created, and his concept of lymphocytes interacting as a network, reveals Jerne's revolutionary spirit. The book ought to be a rich source of inspiration for everyone interested in science and how science is made. Contents:Preface:The Master and His Atelier (G Stent)Overview:A Portrait of the Immune System (I Lefkovits)On the Writing of a Paper with N K Jerne by Antonio et al.BibliographyFacsimiles of Selected Publications:A Study of Avidity Based on Rabbit Skin Responses to Diphtheria Toxin-Antioxin Mixtures (N K Jerne)The Natural-Selection Theory of Antibody Formation (N K Jerne)Immunological Speculations (N K Jerne)Plaque Formation in Agar by Single Antibody-Producing Cells (N K Jerne & A A Nordin)The Natural Selection Theory of Antibody FormationTen Years Later, in: “Phage and the Origins of Molecular Biology” (N K Jerne)The Somatic Generation of Immune Recognition (N K Jerne)The Immune System (N K Jerne)Towards a Network Theory of the Immune System (N K Jerne)Idiotypic Networks and Other Preconceived Ideas (N K Jerne)The Generative Grammar of the Immune System (N K Jerne)and other papersIntroductions to the BII Annual ReportsHandwritten LettersPostscript (I Lefkovits) Readership: Biological scientists, immunologists and medical doctors. keywords:Antibody Diversity;Clonal Selection;Idiotype Network;Immune Response;Theoretical Immunology;Plaque Forming Cell(s);Antibody Specificity;T and B lymphocyte(s);Antibody Repertoire;Bacteriophages “This volume will be welcomed by the whole immunological community but in particular by all those immunologists who had the luck to have been co-workers of Niels Jerne or simply to have been acquainted with him. His exceptional personality and his capacity for original thinking, have made an enormous impact on modern immunology.” Immunological Investigation

Gene Transfer and Expression in Mammalian Cells

Author : S.C. Makrides
Publisher : Newnes
Page : 722 pages
File Size : 50,9 Mb
Release : 2003-10-24
Category : Science
ISBN : 9780080930350

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Gene Transfer and Expression in Mammalian Cells by S.C. Makrides Pdf

The production of proteins in mammalian cells is an important tool in numerous scientific and commercial areas. For example, proteins for human therapy, vaccination or diagnostic applications are typically produced in mammalian cells. Gene cloning, protein engineering, biochemical and biophysical characterization of proteins also require the use of gene expression in mammalian cells. Other applications in widespread use involve screening of libraries of chemical compounds in drug discovery, and the development of cell-based biosensors. This book presents a state-of-the-art comprehensive coverage of the technical aspects of gene expression in mammalian cells, written by experienced scientists working at the forefront of the field.

Molecular Technology, Volume 2

Author : Hisashi Yamamoto,Takashi Kato
Publisher : John Wiley & Sons
Page : 400 pages
File Size : 48,9 Mb
Release : 2018-12-10
Category : Science
ISBN : 9783527341627

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Molecular Technology, Volume 2 by Hisashi Yamamoto,Takashi Kato Pdf

Edited by foremost leaders in chemical research together with a number of distinguished international authors, Volume 2 presents the most important and promising recent chemical developments in life sciences, neatly summarized in one book. Interdisciplinary and application-oriented, this ready reference focuses on methods and processes with a high practical aspect, covering new trends in drug delivery, in-vivo analysis, structure formation and much more. Of great interest to chemists and life scientists in academia and industry.

Biosimilars and Interchangeable Biologics

Author : Sarfaraz K. Niazi
Publisher : CRC Press
Page : 575 pages
File Size : 42,7 Mb
Release : 2016-01-05
Category : Medical
ISBN : 9781498743501

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Biosimilars and Interchangeable Biologics by Sarfaraz K. Niazi Pdf

What’s the Deal with Biosimilars? Biosimilars are gaining momentum as new protein therapeutic candidates that can help fill a vital need in the healthcare industry. The biological drugs are produced by recombinant DNA technology that allows for large-scale production and an overall reduction time in costs and development. Part of a two-volume set that covers varying aspects of biosimilars, Biosimilars and Interchangeable Biologics: Tactical Elements explores the development and manufacturing of biosimilars and targets challenges surrounding the creation of these products. This includes manufacturing, production costs, and intellectual property barriers, particularly in regulated markets (regulatory agencies are still in the process of developing guidelines). It addresses the complexity of biological drugs, and it discusses specific structural elements vital to the functionality, immunogenicity, and safety of biosimilar products. Of specific interest to practitioners, researchers, and scientists in the biopharmaceutical industry, this volume provides an overall understanding of the hurdles, difficulties, and practicalities of developing a strong plan. It introduces a step-by-step approach for creating a strategy that helps develop and manufacture a biosimilar product while reducing overall production costs and meeting the requirements of biosimilarity based on analytical and functional, pharmacokinetic, pharmacodynamic (where applicable), and nonclinical toxicology or toxicokinetic similarity (where appropriate) while remaining competitive in the market.

Antibody Phage Display

Author : Philippa M. O’Brien,Robert Aitken
Publisher : Springer Science & Business Media
Page : 391 pages
File Size : 47,7 Mb
Release : 2008-02-05
Category : Science
ISBN : 9781592592401

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Antibody Phage Display by Philippa M. O’Brien,Robert Aitken Pdf

The closing years of the 19th century and the start of the 20th century witnessed the emergence of microbiology and immunology as discrete sci- tific disciplines, and in the work of Roux and Yersin, perhaps the first benefits of their synergy—immunotherapy against bacterial infection. As we advance into the new millennium, microbiology and immunology again offer a c- ceptual leap forward as antibody phage display gains increasing acceptance as the definitive technology for monoclonal production and unleashes new - portunities in immunotherapy, drug discovery, and functional genomics. In assembling Antibody Phage Display: Methods and Protocols, we have aimed to produce a resource of real value for scientists who have followed the development of phage display technology over the past decade. The founding principles of phage display have always held an elegant simplicity. We hope that readers will find similar clarity in the technical guidance offered by the book’s contributors. In meeting our objectives, we have tried to cover the broad scope of the technology and the key areas of library construction, scre- ing, antibody modification, and expression. Of course, the technology cont- ues to advance apace, but we trust that readers will be able to gage the potential of phage display from our coverage, that some of its subtleties will emerge, and that our selection of methods will prove appealing. We are indebted to all the contributing authors for sharing their expertise with the wider scientific community.

From Gene to Protein: Translation into Biotechnology

Author : Fazal Ahmad
Publisher : Elsevier
Page : 612 pages
File Size : 43,9 Mb
Release : 2012-12-02
Category : Science
ISBN : 9780323144612

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From Gene to Protein: Translation into Biotechnology by Fazal Ahmad Pdf

From Gene to Protein: Translation into Biotechnology is the 15th volume in the continuing series under the title ""Miami Winter Symposia"". The theme of the symposium is the translation of the basic research findings into the practical application of biotechnology. This book summarizes methodology and its applications that lie behind the practical innovations. The book starts with reviews of techniques of eukaryotic cell culture, hybridoma technology and uses, and the in vitro synthesis of DNA and its use in the generation of protein analogs. Considerable space is devoted to development of monoclonal antibodies that promises to be the dominating tool of medical technology, both for diagnosis and therapy. Cloning into eukaryotic cells and methods of increasing the levels of gene expression are included. These topics reflect areas of intensive research that have important commercial and clinical value. Core chapters describe biological activities of cloned gene products, including reports on trials with human subjects of interferon, human insulin, and growth hormone. A panel session on horizons in biotechnology is also provided, looking forward to the directions of future research and its applications. Biotechnologists, cell biologists, scientists, researchers, teachers, and students will greatly benefit from this book.