Endocrine Disruptors And The Developing Brain

Author : Andrea C. Gore,Sarah Dickerson
Publisher : Biota Publishing
Page : 114 pages
File Size : 41,9 Mb
Release : 2012-05-01
Category : Science
ISBN : 9781615040889

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Endocrine Disruptors and The Developing Brain by Andrea C. Gore,Sarah Dickerson Pdf

The field of endocrine disruption has been the focus of increasing attention from scientists and the general public in the past 30 years, amidst concerns that exposure to environmental chemicals with the potential to alter endocrine system function, known as endocrine disrupting chemicals (EDCs), may be contributing to an overall decline in wildlife populations and the reproductive health of humans. These concerns are based on observations of adverse effects of EDCs on marine and land animals, an increased incidence of reproductive and endocrine disease in humans, epidemiological evidence for links between body burden and disease, and endocrine disruption in laboratory animals following exposure to EDCs. Owing to its role in regulation of endocrine function as well as its responsiveness to hormones, the developing brain is an especially vulnerable target for many classes of EDCs. This book will address the evidence for EDC action on the developing brain, organized into 7 chapters. Topics covered include background about EDCs, evidence for exposures, concerns about EDC effects in the developing organism, and particularly on the developing nervous system, how EDCs perturb the brain's neuroendocrine systems, transgenerational epigenetic effects of EDCs, EDC effects on non-reproductive behaviors, and future perspectives. This is the first book completely dedicated to understanding links between EDCs and the developing brain, an area of emerging importance for human health.

Author : Heather B. Patisaul,Scott M. Belcher
Publisher : Oxford University Press
Page : 336 pages
File Size : 42,5 Mb
Release : 2017-04-10
Category : Psychology
ISBN : 9780190669034

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Endocrine Disruptors, Brain, and Behavior by Heather B. Patisaul,Scott M. Belcher Pdf

Our world and bodies are becoming increasingly polluted with chemicals capable of interfering with our hormones and thus, possibly, our present and future neural and mental health. As authors Heather Patisaul and Scott Belcher outline, there is a large lack of data and evidence in this causal relationship, which begs a need for further study to accelerate progress in the endocrinology and neuroendocrinology fields. Endocrine Disruptors, Brain, and Behavior focuses on if and how these chemicals, known as endocrine disrupting compounds (EDCs), affect the development and function of the brain and might be contributing to neural disorders rapidly rising in prevalence. The book provides an overall synthesis of the EDC field, including its historical roots, major hypotheses, key findings, and research gaps. The authors explain why even the concept of endocrine disruption is controversial in some circles, how differing definitions of endocrine disruption and what constitutes an "adverse" outcome on the brain shape public policy, and where the current capacity by different stakeholders (industry, academia, regulatory agencies) to evaluate chemicals for safety in a regulatory context begins and ends. The book concludes with suggestions for future research needs and a summary of emerging technology which might prove capable of more effectively evaluating existing and emerging chemicals for endocrine disrupting properties. As such, it provides the context for interdisciplinary and innovative input from a broad spectrum of fields, including those well-schooled in neuroscience, evolutionary biology, brain, behavior, sex differences, and neuroendocrinology.

Author : Fumihiko Maekawa,Kazuaki Nakamura,Shoji F. Nakayama
Publisher : Frontiers Media SA
Page : 155 pages
File Size : 40,9 Mb
Release : 2017-05-11
Category : Electronic book
ISBN : 9782889451722

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Chemicals in the Environment and Brain Development: Importance of Neuroendocrinological Approaches by Fumihiko Maekawa,Kazuaki Nakamura,Shoji F. Nakayama Pdf

Mounting evidence shows that increasing numbers of children are being diagnosed with neurodevelopmental disorders, and it is clear that this increase cannot be explained by genetic background alone. A number of studies, including epidemiological studies, have found an association between in-utero and childhood exposure to certain chemicals, such as endocrine disruptors, psychoactive pharmaceuticals, volatile organic chemicals, persistent organic compounds and heavy metals, and children’s brain development. Yet, the mechanisms by which these chemicals impair brain development and function are not fully understood. In addition, little is known about how these chemicals enter and accumulate in the brain. Experimental approaches are essential to understand how those harmful chemicals enter children’s brain and pose discrete effects on specific brain sites. These approaches include the following: improvement of technologies for the detection and measurement of neuroendocrinological and behavioral changes in animal models: development of analytical methods for the identification and quantification of chemicals and their metabolites in the brain; development of in vitro cell line assays; and imaging technologies to illustrate cellular functions. In this research topic, we collected articles that provide state-of-the-art science and technologies that can help us identify environmental chemicals that influence brain development. We also included articles that lead to a better understanding of the actions and dynamics of these chemicals. The articles in this research topics supplied novel information about harmful endpoints of environmental chemicals. The reviews demonstrated the typical and novel interactions between environmental chemicals and the developing brain. We believe that these studies would lead to further understanding of neurodevelopmental disorders caused by environmental factors.

Author : National Research Council,Institute of Medicine,Board on Children, Youth, and Families,Committee on Integrating the Science of Early Childhood Development
Publisher : National Academies Press
Page : 610 pages
File Size : 50,8 Mb
Release : 2000-11-13
Category : Social Science
ISBN : 9780309069885

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From Neurons to Neighborhoods by National Research Council,Institute of Medicine,Board on Children, Youth, and Families,Committee on Integrating the Science of Early Childhood Development Pdf

How we raise young children is one of today's most highly personalized and sharply politicized issues, in part because each of us can claim some level of "expertise." The debate has intensified as discoveries about our development-in the womb and in the first months and years-have reached the popular media. How can we use our burgeoning knowledge to assure the well-being of all young children, for their own sake as well as for the sake of our nation? Drawing from new findings, this book presents important conclusions about nature-versus-nurture, the impact of being born into a working family, the effect of politics on programs for children, the costs and benefits of intervention, and other issues. The committee issues a series of challenges to decision makers regarding the quality of child care, issues of racial and ethnic diversity, the integration of children's cognitive and emotional development, and more. Authoritative yet accessible, From Neurons to Neighborhoods presents the evidence about "brain wiring" and how kids learn to speak, think, and regulate their behavior. It examines the effect of the climate-family, child care, community-within which the child grows.

Author : Evanthia Diamanti-Kandarakis,Andrea C. Gore
Publisher : Springer Science & Business Media
Page : 378 pages
File Size : 49,8 Mb
Release : 2011-12-01
Category : Medical
ISBN : 1607615614

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Endocrine Disruptors and Puberty by Evanthia Diamanti-Kandarakis,Andrea C. Gore Pdf

Endocrine disruption represents one of the most controversial environmental issues of our time. Mounting evidence stemming from more than 10 years of experimental, epidemiological and clinical studies has transformed the once generally discounted subject of endocrine disruptors into an issue of tremendous concern not only within the scientific community but among society as a whole. Following initial evidence from basic research, endocrine disruption in humans has now emerged as a major medical challenge. In this respect, puberty, a crucial developmental stage, has been definitively identified as a key window of vulnerability with regard to endocrine disruptors. Written by leading authorities in the field, Endocrine Disruptors and Puberty offers an engaging and comprehensive overview of this fascinating and rapidly growing problem. An indispensable resource for all clinicians and scientists interested in this challenging endocrinologic topic, Endocrine Disruptors and Puberty is a timely contribution that will help navigate a path toward understanding the problem and developing solutions.

Author : Barbara Demeneix
Publisher : Oxford University Press
Page : 240 pages
File Size : 44,7 Mb
Release : 2017-01-02
Category : Psychology
ISBN : 9780190260958

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Toxic Cocktail by Barbara Demeneix Pdf

In today's world, everyone carries a toxic load of dozens of industrially produced chemicals in their bloodstream. Not only do these adversely affect the health of adults and children, but also, and more worryingly, they damage the development of unborn infants. The amniotic fluid of pregnant women has been found to contain a variety of chemicals, such as pesticides, plasticizers, disinfectant products, flame-retardants, surfactants and UV filters, many of which interfere with fetal physiology, especially thyroid hormone action. Thyroid hormone is vital for brain development, particularly for the fetus during pregnancy and for toddlers. In fact, children born to women who lack this thyroid hormone (or who are unwittingly exposed to thyroid-disrupting chemicals) have lower IQs and more neurodevelopmental problems. Evolution of the human brain has involved multiple changes and processes dependent on thyroid hormone. The urgent question thus arises: Is chemical pollution poisoning brain development and reversing evolution's most outstanding achievement: the human brain? And if so, as this book convincingly illuminates, what can be done about it both collectively and individually? Toxic Cocktail provides a clear view of how many environmental chemicals interfere with brain development. As a result, this book looks at how we define and test IQ, the evidence for IQ loss, and how chemical pollution and thyroid hormone disruption can be actors in this process, as well as increasing neurodevelopmental disease risk.

Author : Marcella Motta
Publisher : Raven Press (ID)
Page : 504 pages
File Size : 46,7 Mb
Release : 1991
Category : Medical
ISBN : UOM:39015021980373

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Brain Endocrinology by Marcella Motta Pdf

This revised edition of The endocrine functions of the brain (1980) presents the most recent findings in the field, with particular emphasis on their clinical significance and applications. Each of the 17 chapters may be read separately to obtain information on specific areas. The primary goal is to provide a comprehensive view of modern basic and clinical neuroendocrinology. For a wide range of investigators, clinicians, and their students, in endocrinology and neuroscience. Annotation copyrighted by Book News, Inc., Portland, OR

Author : Shanna H. Swan,Stacey Colino
Publisher : Simon and Schuster
Page : 304 pages
File Size : 45,7 Mb
Release : 2022-02-08
Category : Health & Fitness
ISBN : 9781982113674

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Count Down by Shanna H. Swan,Stacey Colino Pdf

An award-winning scientist, in this urgent, thought-provoking and meticulously researched book, shows how chemicals in the modern environment are changing--and endangering--human sexuality and fertility on the grandest scale.

Author : Andrea C. Gore
Publisher : Springer Science & Business Media
Page : 361 pages
File Size : 44,5 Mb
Release : 2007-06-08
Category : Medical
ISBN : 9781597451079

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Endocrine-Disrupting Chemicals by Andrea C. Gore Pdf

This book provides comprehensive coverage of the three most important themes in the field of Endocrine Disrupting Chemicals (EDC) research: the basic biology of EDCs, particularly their effects on reproductive systems; EDC effects on humans and wildlife, including biomedical considerations; and potential interventions and practical advice for dealing with the problem of EDCs.

Author : Jones B. Graceli,Leandro Miranda-Alves,Celia Regina Nogueira
Publisher : Frontiers Media SA
Page : 75 pages
File Size : 40,6 Mb
Release : 2020-01-17
Category : Electronic
ISBN : 9782889633432

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Organotins as a Complete Physiologic and Endocrine Disruptor: Role of Disease Development by Jones B. Graceli,Leandro Miranda-Alves,Celia Regina Nogueira Pdf

Author : Rebecca Fett
Publisher : Franklin Fox Publishing LLC
Page : 209 pages
File Size : 53,8 Mb
Release : 2019-08-28
Category : Health & Fitness
ISBN : 9780999676158

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Brain Health From Birth by Rebecca Fett Pdf

Raising a bright and happy child starts during pregnancy and early infancy, when small changes can have a big impact on brain development. ​ By taking advantage of this golden window of opportunity--when millions of new brain cells are formed every single day--you can help support your child's IQ, language development, memory, attention span, and emotional regulation. Importantly, the same strategies that nurture these cognitive abilities can also help reduce the odds of autism and ADHD, conditions that now impact 1 in 10 children. Brain Health from Birth is your guide to this new scientific frontier, explaining which key nutrients may be missing from your prenatal supplement, how to reduce the odds of preterm birth, what to look for in a formula, how to support your baby's microbiome, and much more. With contributions from leading obstetricians and pediatricians, science writer Rebecca Fett (author of the bestselling fertility book It Starts with the Egg) brings you practical advice you can start applying today, to help your baby thrive.

Author : Jerry J. Buccafusco
Publisher : CRC Press
Page : 341 pages
File Size : 46,8 Mb
Release : 2000-08-29
Category : Medical
ISBN : 9781420041811

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Methods of Behavior Analysis in Neuroscience by Jerry J. Buccafusco Pdf

Using the most well-studied behavioral analyses of animal subjects to promote a better understanding of the effects of disease and the effects of new therapeutic treatments on human cognition, Methods of Behavior Analysis in Neuroscience provides a reference manual for molecular and cellular research scientists in both academia and the pharmaceutic

Author : Barbara Demeneix
Publisher : Oxford Behavioral Neuroendocri
Page : 313 pages
File Size : 51,6 Mb
Release : 2014
Category : Medical
ISBN : 9780199917518

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Losing Our Minds by Barbara Demeneix Pdf

"The exponential increases in neurodevelopmental disorders implicate environmental factors as well as genetic causes. Flame-retardants, pesticides, plasticizers, and other every-day products contain chemicals shown to affect thyroid hormone signaling, which, if disrupted, can result in significant impairment in IQ. Across entire populations, such effects spell large-scale social and economic consequences. Barbara Demeneix suggests what can and must be done to halt and reverse this disturbing trend"--

Author : National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Division of Behavioral and Social Sciences and Education,Board on Children, Youth, and Families,Committee on the Neurobiological and Socio-behavioral Science of Adolescent Development and Its Applications
Publisher : National Academies Press
Page : 493 pages
File Size : 52,7 Mb
Release : 2019-07-26
Category : Social Science
ISBN : 9780309490115

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The Promise of Adolescence by National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Division of Behavioral and Social Sciences and Education,Board on Children, Youth, and Families,Committee on the Neurobiological and Socio-behavioral Science of Adolescent Development and Its Applications Pdf

Adolescenceâ€"beginning with the onset of puberty and ending in the mid-20sâ€"is a critical period of development during which key areas of the brain mature and develop. These changes in brain structure, function, and connectivity mark adolescence as a period of opportunity to discover new vistas, to form relationships with peers and adults, and to explore one's developing identity. It is also a period of resilience that can ameliorate childhood setbacks and set the stage for a thriving trajectory over the life course. Because adolescents comprise nearly one-fourth of the entire U.S. population, the nation needs policies and practices that will better leverage these developmental opportunities to harness the promise of adolescenceâ€"rather than focusing myopically on containing its risks. This report examines the neurobiological and socio-behavioral science of adolescent development and outlines how this knowledge can be applied, both to promote adolescent well-being, resilience, and development, and to rectify structural barriers and inequalities in opportunity, enabling all adolescents to flourish.

Author : Donald A. P. Bundy,Nilanthi de Silva,Susan Horton,Dean T. Jamison
Publisher : World Bank Publications
Page : 502 pages
File Size : 50,9 Mb
Release : 2017-11-20
Category : Medical
ISBN : 9781464804397

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Disease Control Priorities, Third Edition (Volume 8) by Donald A. P. Bundy,Nilanthi de Silva,Susan Horton,Dean T. Jamison Pdf

More children born today will survive to adulthood than at any time in history. It is now time to emphasize health and development in middle childhood and adolescence--developmental phases that are critical to health in adulthood and the next generation. Child and Adolescent Health and Development explores the benefits that accrue from sustained and targeted interventions across the first two decades of life. The volume outlines the investment case for effective, costed, and scalable interventions for low-resource settings, emphasizing the cross-sectoral role of education. This evidence base can guide policy makers in prioritizing actions to promote survival, health, cognition, and physical growth throughout childhood and adolescence.