Endocrine Tumor Syndromes And Their Genetics

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Endocrine Tumor Syndromes and Their Genetics

C.A. Stratakis
Endocrine Tumor Syndromes and Their Genetics Book PDF

Author : C.A. Stratakis
Publisher : Karger Medical and Scientific Publishers
Page : 202 pages
File Size : 43,7 Mb
Release : 2013-03-20
Category : Medical
ISBN : 9783318023312

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Endocrine Tumor Syndromes and Their Genetics by C.A. Stratakis Pdf

In these times, a book should aspire to present the most significant advances in the field, reflect the themes of the moment, and provide a useful compendium for future reference. This book accomplishes all three objectives by discussing the changing world of modern genetics in endocrine tumors and its impact on clinical practice. Clinicians have to incorporate modern genetics and systems biology in their daily practice. Educators and researchers have to introduce molecular pathways and their genetic variability in their teaching, as well as understanding of classic physiology and pathophysiology.Taking these aspects into account, the chapters in this book cover both the classic multiple endocrine neoplasia (MEN) syndromes, as well as newly described ones, such as Carney triad and Carney-Stratakis syndrome. Furthermore, the genetics of paragangliomas as well as thyroid, parathyroid, and pituitary tumors are examined. Outlining the latest research and its obvious implications for our understanding the genetics of endocrine tumor formation and molecular biology of cancer and their potential therapeutic implications, this book is not only useful for researchers but even more so for practicing clinicians, in particular internists, endocrinologists, oncologists, pediatricians, surgeons, pathologists, geneticists, and genetic counselors.

Endocrine Tumor Syndromes and Their Genetics

Constantine A. Stratakis
Endocrine Tumor Syndromes and Their Genetics Book PDF

Author : Constantine A. Stratakis
Publisher : Karger Medical and Scientific Publishers
Page : 202 pages
File Size : 54,9 Mb
Release : 2013
Category : Medical
ISBN : 9783318023305

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Endocrine Tumor Syndromes and Their Genetics by Constantine A. Stratakis Pdf

From classic MEN syndromes to various germline and somatic mutations in sporadic tumors In these times, a book should aspire to present the most significant advances in the field, reflect the themes of the moment, and provide a useful compendium for future reference. This book accomplishes all three objectives by discussing the changing world of modern genetics in endocrine tumors and its impact on clinical practice. Clinicians have to incorporate modern genetics and systems biology in their daily practice. Educators and researchers have to introduce molecular pathways and their genetic variability in their teaching, as well as understanding of classic physiology and pathophysiology. Taking these aspects into account, the chapters in this book cover both the classic multiple endocrine neoplasia (MEN) syndromes, as well as newly described ones, such as Carney triad and Carney- Stratakis syndrome. Furthermore, the genetics of paragangliomas as well as thyroid, parathyroid, and pituitary tumors are examined. Outlining the latest research and its obvious implications for our understanding the genetics of endocrine tumor formation and molecular biology of cancer and their potential therapeutic implications, this book is not only useful for researchers but even more so for practicing clinicians, in particular internists, endocrinologists, oncologists, pediatricians, surgeons, pathologists, geneticists, and genetic counselors.

Genetic Disorders of Endocrine Neoplasia

Patricia L. M. Dahia,Charis Eng
Genetic Disorders of Endocrine Neoplasia Book PDF

Author : Patricia L. M. Dahia,Charis Eng
Publisher : Karger Medical and Scientific Publishers
Page : 226 pages
File Size : 40,7 Mb
Release : 2001-01-01
Category : Medical
ISBN : 9783805572033

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Genetic Disorders of Endocrine Neoplasia by Patricia L. M. Dahia,Charis Eng Pdf

The genetics of endocrine cancers is clearly an area where new scientific discoveries that have occurred in the past few years have already been translated into clinical practice. This volume attempts to provide a state-of-the-art review of some of the most relevant inherited syndromes that share a higher susceptibility to the development of endocrine tumors. It focuses on familial tumor syndromes for which the primary gene defect has been well characterized or recently identified. An overview of cloning strategies and gene characterization in cancer is combined with detailed discussions of clinical aspects and molecular features of heritable endocrine neoplastic diseases, such as MEN 1 and MEN 2 and Von Hippel-Lindau Disease. Studies on the PTEN gene, the first known phosphatase to lead to cancer when disrupted, are discussed in detail. Also included is the recent identification and partial characterization of one of at least two genes for Carney Complex, PRKARIA. The authors place special emphasis on testing and screening strategies which now allow a much earlier identification of family members at risk. The challenge for the 21st century will be to develop equal progress in pharmacological prevention and cure based on the knowledge of the function of these susceptibility genes and their targets.

Hot Topics in Endocrine and Endocrine-Related Diseases

Monica Fedele
Hot Topics in Endocrine and Endocrine Related Diseases Book PDF

Author : Monica Fedele
Publisher : BoD – Books on Demand
Page : 278 pages
File Size : 53,5 Mb
Release : 2013-05-08
Category : Medical
ISBN : 9789535110804

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Hot Topics in Endocrine and Endocrine-Related Diseases by Monica Fedele Pdf

This book covers a selected number of hot topics in endocrine and hormone-related pathologies, discussed by eminent scientists and clinicians coming from different countries of the world. It deals with advanced recent trends in the field, including neuroendocrine and pituitary tumors, thyroid dysfunctions, diabetes and a series of endocrine-related diseases, such as those related to the anabolic effects of testosterone, obesity, cancer, the liver complications of diabetes and the pediatric nonalcoholic fatty liver disease. The readers should be able to have a basic, as well as critic and advanced, overview of these selected hot pathologies of the endocrine system.

Genetics of Endocrine Diseases and Syndromes

Peter Igaz,Attila Patócs
Genetics of Endocrine Diseases and Syndromes Book PDF

Author : Peter Igaz,Attila Patócs
Publisher : Springer Nature
Page : 476 pages
File Size : 48,5 Mb
Release : 2019-10-06
Category : Science
ISBN : 9783030259051

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Genetics of Endocrine Diseases and Syndromes by Peter Igaz,Attila Patócs Pdf

This book provides a comprehensive overview of the genetic basis underlying endocrine diseases. It covers both the molecular and clinical consequences of these genetic defects, as well as the relevance for clinical care, highlighting issues of genetic counseling. Several endocrine diseases have a genetic background, and contemporary research in the field plays a crucial role in the clinical care of endocrine diseases. In recent years, there have been major developments in our understanding of the genetic basis of endocrine diseases. Several novel genes and mutations predisposing individuals to monogenic endocrine diseases have been discovered, and with the advent of next generation sequencing, a huge amount of new data has become available. Further, novel molecular mechanisms, such as genomic imprinting, have been implicated in the pathogenesis of endocrine diseases. A better understanding of the genetic background of these diseases is relevant not only from the research perspective, but also in terms of clinical care. As such, this book is an essential read for both researchers and clinicians working in the field.

Genetic Diagnosis of Endocrine Disorders

Roy E. Weiss,Samuel Refetoff
Genetic Diagnosis of Endocrine Disorders Book PDF

Author : Roy E. Weiss,Samuel Refetoff
Publisher : Academic Press
Page : 472 pages
File Size : 52,9 Mb
Release : 2015-10-09
Category : Medical
ISBN : 9780128011348

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Genetic Diagnosis of Endocrine Disorders by Roy E. Weiss,Samuel Refetoff Pdf

Genetic Diagnosis of Endocrine Disorders, Second Edition provides users with a comprehensive reference that is organized by endocrine grouping (i.e., thyroid, pancreas, parathyroid, pituitary, adrenal, and reproductive and bone), discussing the genetic and molecular basis for the diagnosis of various disorders. The book emphasizes the practical nature of diagnosing a disease, including which tests should be done for the diagnosis of diabetes mellitus in adults and children, which genes should be evaluated for subjects with congenital hypothyroidism, which genetic tests should be ordered in obese patients or for those with parathyroid carcinoma, and the rationale behind testing for multiple endocrine neoplasias. Offers a clear presentations of pharmacogenetics and the actual assays used in detecting endocrine diseases Teaches the essentials of the genetic basis of disease in each major endocrine organ system Offers expert advice from genetic counselors on how to use genetic information in counseling patients Includes new chapters on the genetics of lipid disorders and glycogen storage diseases, genetics of hypoglycemia, and whole genome/exome sequencing

Pathology and Genetics of Tumours of Endocrine Organs

Ronald A. DeLellis
Pathology and Genetics of Tumours of Endocrine Organs Book PDF

Author : Ronald A. DeLellis
Publisher : IARC
Page : 324 pages
File Size : 48,5 Mb
Release : 2004
Category : Medical
ISBN : 9283224167

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Pathology and Genetics of Tumours of Endocrine Organs by Ronald A. DeLellis Pdf

This vol. was produced in collaboration with the International Academy of Pathology (IAP). - This publication reflects the views of a working group that convened for an editorial and consensus conference in Lyon, France, April 23-26, 2003

Epidemiology of Endocrine Tumors

Jahangir Moini,Craig Badolato,Raheleh Ahangari
Epidemiology of Endocrine Tumors Book PDF

Author : Jahangir Moini,Craig Badolato,Raheleh Ahangari
Publisher : Elsevier
Page : 570 pages
File Size : 42,8 Mb
Release : 2021-03-03
Category : Medical
ISBN : 9780128232668

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Epidemiology of Endocrine Tumors by Jahangir Moini,Craig Badolato,Raheleh Ahangari Pdf

Epidemiology of Endocrine Tumors brings current data and clinical research into one source for a multidisciplinary audience. The book discusses the prevalence, incidence, etiology, pathology, diagnosis and treatment of various endocrine tumors. With clear and focused writing, it is essential reading for healthcare professionals, endocrinologists, oncologists, and public health professionals. Users will be able to bridge the knowledge gap that exists in the comprehensive coverage surrounding the epidemiology of endocrine tumors. Globally, the prevalence and incidence of endocrine tumors is high. This audience needs a treatise where they can gain a broad overview of endocrine tumors with a focus on epidemiology. Supplies information about the epidemiology of various endocrine tumors, both benign and malignant, to endocrinologists, oncologists and related health care professionals Focuses on the impact upon costs and patient deaths due to complications of these tumors Describes how endocrine tumors affect various age groups and ethnicities, discussing the prevention of endocrine tumors Presents chapters on Cancer Problem, Specific Endocrine Tumors, Prevention, Detection and Diagnosis, and Treatment of Endocrine Tumors Provides review questions with an answer key and detailed glossary

The Pancreas

Hans G. Beger,Andrew L. Warshaw,Ralph H. Hruban,Markus W. Buchler,Markus M. Lerch,John P. Neoptolemos,Tooru Shimosegawa,David C. Whitcomb
The Pancreas Book PDF

Author : Hans G. Beger,Andrew L. Warshaw,Ralph H. Hruban,Markus W. Buchler,Markus M. Lerch,John P. Neoptolemos,Tooru Shimosegawa,David C. Whitcomb
Publisher : John Wiley & Sons
Page : 1218 pages
File Size : 45,6 Mb
Release : 2018-04-23
Category : Medical
ISBN : 9781119188391

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The Pancreas by Hans G. Beger,Andrew L. Warshaw,Ralph H. Hruban,Markus W. Buchler,Markus M. Lerch,John P. Neoptolemos,Tooru Shimosegawa,David C. Whitcomb Pdf

This brand new updated edition of the most comprehensive reference book on pancreatic disease details the very latest knowledge on genetics and molecular biological background in terms of anatomy, physiology, pathology, and pathophysiology for all known disorders. Included for the first time, are two brand new sections on the key areas of Autoimmune Pancreatitis and Benign Cystic Neoplasms. In addition, this edition is filled with over 500 high-quality illustrations, line drawings, and radiographs that provide a step-by-step approach to all endoscopic techniques and surgical procedures. Each of these images can be downloaded via an online image bank for use in scientific presentations. Every existing chapter in The Pancreas: An Integrated Textbook of Basic Science, Medicine and Surgery, 3rd Edition has been thoroughly revised and updated to include the many changes in clinical practice since publication of the current edition. The book includes new guidelines for non-surgical and surgical treatment; new molecular biologic pathways to support clinical decision making in targeted treatment of pancreatic cancer; new minimally invasive surgical approaches for pancreatic diseases; and the latest knowledge of neuroendocrine tumors and periampullary tumors. The most encyclopedic book on the pancreas—providing outstanding and clear guidance for the practicing clinician Covers every known pancreatic disorder in detail including its anatomy, physiology, pathology, pathophysiology, diagnosis, and management Completely updated with brand new chapters Over 500 downloadable illustrations An editor and author team of high international repute who present global best-practice The Pancreas: An Integrated Textbook of Basic Science, Medicine and Surgery, 3rd Edition is an important book for gastroenterologists and gastrointestinal surgeons worldwide.

Pheochromocytoma (PHEO) and Paraganglioma (PGL)

Karel Pacak,David Taïeb
Pheochromocytoma PHEO and Paraganglioma PGL Book PDF

Author : Karel Pacak,David Taïeb
Publisher : MDPI
Page : 380 pages
File Size : 52,5 Mb
Release : 2019-11-20
Category : Medical
ISBN : 9783039216543

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Pheochromocytoma (PHEO) and Paraganglioma (PGL) by Karel Pacak,David Taïeb Pdf

This book outlines some new advances in genetics, clinical evaluation, localization, therapy (newly including immunotherapy) of pheochromocytoma and paraganglioma including their metastatic counterparts. Well-known and experienced clinicians and scientists contributed to this book to include some novel approaches to these tumors. This book will serve to various health care professionals from different subspecialties, but mainly oncologists, endocrinologists, endocrine surgeons, pediatricians, and radiologists. This book shows that the field of pheochromocytoma/paraganglioma is evolving and a significant progress has been made in last 5 years requiring that health care professionals and scientists will learns new information and implement it in their clinical practice or scientific work, respectively. This book should not be missed by anybody who is focusing on neuroendocrine tumors, their newest evaluation and treatment.

Pheochromocytoma

Karel Pacak,Graeme Eisenhofer,Jacques Lenders
Pheochromocytoma Book PDF

Author : Karel Pacak,Graeme Eisenhofer,Jacques Lenders
Publisher : John Wiley & Sons
Page : 184 pages
File Size : 46,8 Mb
Release : 2008-04-15
Category : Medical
ISBN : 9780470766385

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Pheochromocytoma by Karel Pacak,Graeme Eisenhofer,Jacques Lenders Pdf

Pheochromocytomas are rare but treacherous catecholamine-producing tumors, which if missed or not properly treated, will almost invariably prove fatal. Prompt diagnosis is, therefore, essential for effective treatment, usually by surgical resection. The manifestations are diverse and the tumor can mimic a variety of conditions, often resulting in either erroneous diagnoses or a delayed diagnosis. Reflecting the recent leaps in understanding this condition, Pheochromocytoma: Diagnosis, Localization, and Treatment provides a comprehensive update on the improvements in the diagnosis, localization, management and treatment of pheochromocytomas – providing you with the latest cutting edge science alongside best clinical practice. Written by the leading names in the field, the text details the significant developments in understanding the genetics and biology of the tumors, coupled with technological advances in the fields of analytical chemistry, genomics, molecular biology and nuclear medicine. The most comprehensive book on pheochromocytoma Provides cutting edge science and clinical guidance Written by the leading names in the field Authors present their recently developed novel biochemical test for the diagnosis of Pheochromocytoma

Oxford Handbook of Endocrinology and Diabetes

Helen Turner,John Wass
Oxford Handbook of Endocrinology and Diabetes Book PDF

Author : Helen Turner,John Wass
Publisher : Oxford University Press, USA
Page : 954 pages
File Size : 51,8 Mb
Release : 2009-03-26
Category : Medical
ISBN : 9780198567394

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Oxford Handbook of Endocrinology and Diabetes by Helen Turner,John Wass Pdf

This handbook in endocrinology and diabetes discusses clinical investigation and management in a convenient way, including both the protocols and explicit clinical information necessary for the management of individual patients.

Genetics of Colorectal Cancer

John D. Potter,Noralane M. Lindor
Genetics of Colorectal Cancer Book PDF

Author : John D. Potter,Noralane M. Lindor
Publisher : Springer
Page : 309 pages
File Size : 41,6 Mb
Release : 2008-12-08
Category : Medical
ISBN : 0387095675

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Genetics of Colorectal Cancer by John D. Potter,Noralane M. Lindor Pdf

Genetic susceptibility refers to how variations in a person’s genes increase or decrease his or her susceptibility to environmental factors, such as chemicals, radiation and lifestyle (diet and smoking). This volume will explore the latest findings in the area of genetic susceptibility to gastrointestinal cancers, focusing on molecular epidemiology, DNA repair, and gene-environment interactions to identify factors that affect the incidence of GI cancers. Topics will include germline susceptibility, including Mendelian patterns of inheritance and gene-environment interactions that lead to cancer etiology.

Genetics in Endocrinology

John D. Baxter,Shlomo Melmed,Maria I. New
Genetics in Endocrinology Book PDF

Author : John D. Baxter,Shlomo Melmed,Maria I. New
Publisher : Lippincott Raven
Page : 792 pages
File Size : 49,5 Mb
Release : 2002
Category : Medical
ISBN : UOM:39015054255024

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Genetics in Endocrinology by John D. Baxter,Shlomo Melmed,Maria I. New Pdf

An extensive body of evidence highlights the crucial importance of endocrine genetics. Examples range from human growth disorders and obesity to cancers of the prostate and breast. A pivotal part of the Modern Endocrinology Series, this book presents major biological studies underlining the significance of data obtained from knock-out mice, as well as from transgenic animals. Gene therapy and laboratory evaluation and screening of genetic endocrine diseases are covered, as are many of the classical endocrine diseases.

Cancer Cytogenetics

Sverre Heim,Felix Mitelman
Cancer Cytogenetics Book PDF

Author : Sverre Heim,Felix Mitelman
Publisher : John Wiley & Sons
Page : 642 pages
File Size : 43,5 Mb
Release : 2015-08-17
Category : Medical
ISBN : 9781118795538

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Cancer Cytogenetics by Sverre Heim,Felix Mitelman Pdf

The first three editions of this acclaimed book presented a much-needed conceptual synthesis of this rapidly moving field. Now, Cancer Cytogenetics, Fourth Edition, offers a comprehensive, expanded, and up-to-date review of recent dramatic advances in this area, incorporating a vast amount of new data from the latest basic and clinical investigations. New contributors reflecting broader international authorship and even greater expertise Greater emphasis throughout on the clinical importance and application of information about cytogenetic and molecular aberrations Includes a complete coverage of chromosome aberrations in cancer based on an assessment of the 60,000 neoplasms cytogenetically investigated to date Now produced in full color for enhanced clarity Covers how molecular genetic data (PCR-based and sequencing information) are collated with the cytogenetic data where pertinent Discusses how molecular cytogenetic data (based on studies using FISH, CGH, SNP, etc) are fused with karyotyping data to enable an as comprehensive understanding of cancer cytogenetics as is currently possible