Genetics Of Colorectal Cancer

Author : John D. Potter,Noralane M. Lindor
Publisher : Springer Science & Business Media
Page : 304 pages
File Size : 40,7 Mb
Release : 2009-02-07
Category : Medical
ISBN : 9780387095684

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Genetics of Colorectal Cancer by John D. Potter,Noralane M. Lindor Pdf

Genetic susceptibility refers to how variations in a person’s genes increase or decrease his or her susceptibility to environmental factors, such as chemicals, radiation and lifestyle (diet and smoking). This volume will explore the latest findings in the area of genetic susceptibility to gastrointestinal cancers, focusing on molecular epidemiology, DNA repair, and gene-environment interactions to identify factors that affect the incidence of GI cancers. Topics will include germline susceptibility, including Mendelian patterns of inheritance and gene-environment interactions that lead to cancer etiology.

Author : John D. Potter,Noralane M. Lindor
Publisher : Springer
Page : 309 pages
File Size : 54,7 Mb
Release : 2008-12-08
Category : Medical
ISBN : 0387095675

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Genetics of Colorectal Cancer by John D. Potter,Noralane M. Lindor Pdf

Genetic susceptibility refers to how variations in a person’s genes increase or decrease his or her susceptibility to environmental factors, such as chemicals, radiation and lifestyle (diet and smoking). This volume will explore the latest findings in the area of genetic susceptibility to gastrointestinal cancers, focusing on molecular epidemiology, DNA repair, and gene-environment interactions to identify factors that affect the incidence of GI cancers. Topics will include germline susceptibility, including Mendelian patterns of inheritance and gene-environment interactions that lead to cancer etiology.

Author : John D. Potter,Noralane M. Lindor
Publisher : Springer
Page : 309 pages
File Size : 45,5 Mb
Release : 2008-11-01
Category : Medical
ISBN : 038756084X

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Genetics of Colorectal Cancer by John D. Potter,Noralane M. Lindor Pdf

Genetic susceptibility refers to how variations in a person’s genes increase or decrease his or her susceptibility to environmental factors, such as chemicals, radiation and lifestyle (diet and smoking). This volume will explore the latest findings in the area of genetic susceptibility to gastrointestinal cancers, focusing on molecular epidemiology, DNA repair, and gene-environment interactions to identify factors that affect the incidence of GI cancers. Topics will include germline susceptibility, including Mendelian patterns of inheritance and gene-environment interactions that lead to cancer etiology.

Author : Fred H. Menko
Publisher : Springer Science & Business Media
Page : 210 pages
File Size : 49,8 Mb
Release : 1993-07-31
Category : Medical
ISBN : 0792321006

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Genetics of Colorectal Cancer for Clinical Practice by Fred H. Menko Pdf

Colorectal cancer is a collective term for a heterogeneous group of diseases. In a large proportion of cases, the condition is attributable to genetic predisposition. Those directly involved in the treatment of patients with cancer of the large bowel are confronted to an increasing degree with the genetic aspects of the disease. In familial and hereditary forms of the disorder periodic screening of the close relatives of the patients can in principle prevent disease and death from colorectal cancer. Presymptomatic diagnosis by means of DNA technology is now possible in many cases of familial adenomatous polyposis. Genetic diagnosis will be increasingly important for the identification of high-risk groups. This book summarizes those aspects of the genetics of colorectal cancer that are important for clinical pracice. It has been stated that clinicians can contribute to the goal of reducing mortality from cancer by asking each patient about his or her family history of cancer. The aim of this book is to provide a guideline for the management of those situations in which the family history of colorectal cancer is found to be positive.

Author : Laura Valle,Stephen B. Gruber,Gabriel Capellá
Publisher : Springer
Page : 505 pages
File Size : 45,9 Mb
Release : 2018-05-04
Category : Medical
ISBN : 9783319742595

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Hereditary Colorectal Cancer by Laura Valle,Stephen B. Gruber,Gabriel Capellá Pdf

This book provides information on a wide variety of issues ranging from genetics to clinical description of the syndromes, genetic testing and counseling, and clinical management including surveillance, surgical and prophylactic interventions, and chemoprevention. Moreover, current hot issues, such as the identification of novel causal genes and the challenges we face, and the relevance of cancer risk modifiers, both genetic and environmental, are also discussed. This reference book is great for geneticists, oncologists, genetic counselors, researchers, clinicians, surgeons and nurses dedicated to, or interested in, hereditary cancer. The best and most recognized experts in the field have contributed to this project, guaranteeing updated information, accuracy and the discussion of topical issues.

Author : C. Richard Boland, MD
Publisher : AuthorHouse
Page : 330 pages
File Size : 46,6 Mb
Release : 2015-08-30
Category : Biography & Autobiography
ISBN : 9781504928670

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Cancer Family by C. Richard Boland, MD Pdf

It is 1946, and a young man stares out his third-story apartment window. He has returned from the war with metastatic cancer and assumes he will die, leaving his wife and infant daughter behind. Instead, he lives another twenty-four years, raising a family of four children, before he succumbs to a second colon cancer. His son, the author, recognizes that there is a hereditary cancer syndrome in the family and resolves to solve the problem as a medical researcher. Eventually, hereditary colorectal cancer is recognized as a medical entity, and multiple genes responsible for this hereditary condition are isolated. However, the mutation responsible in the author’s family escaped detection. In 2001, his laboratory identifies the mutation responsible for the problem and develops a specific test for the family. This permits the mutation carriers to obtain life-saving care, altering the natural history of the disease for his family and others.

Author : Miguel A. Rodriguez-Bigas,Raul Cutait,Patrick M. Lynch,Ian Tomlinson,Hans F.A. Vasen
Publisher : Springer Science & Business Media
Page : 630 pages
File Size : 48,5 Mb
Release : 2010-09-10
Category : Medical
ISBN : 144196603X

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Hereditary Colorectal Cancer by Miguel A. Rodriguez-Bigas,Raul Cutait,Patrick M. Lynch,Ian Tomlinson,Hans F.A. Vasen Pdf

Colorectal cancer is the third most commonly diagnosed cancer in the US and the third most recently linked to cancer deaths. The national annual incidence rate of colorectal cancer is approximately 148,000+, striking slightly more females than males. The lifetime risk of colorectal cancer is 5-6%, however patients with a familial risk (with two or more first or second degree relatives) make up 20% of the patients. Persons who carry genetic mutations linked to hereditary colorectal cancer are the most likely to develop the disease.

Author : Joji Utsunomiya,Henry T. Lynch
Publisher : Springer Science & Business Media
Page : 564 pages
File Size : 50,7 Mb
Release : 2013-11-27
Category : Medical
ISBN : 9784431683377

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Hereditary Colorectal Cancer by Joji Utsunomiya,Henry T. Lynch Pdf

Since the success in chemical induction of cancer in rabbit's ear skin by K. Yamagiwa in 1915, oncologists of the world have come to believe that they can only solve their problems by means of animal experimen tation. The importance of environmental factors became moreevident in 1935 when T. Yoshida and T. Sasaki introduced azodye hepatocarcino genesis in rats. In the domain of the gastrointestinal tract, T. Sugimura has more recently accumulated enough evidence to indicate that locally active chemical mutagens are carcinogenic. In contrast, principal approaches to colorectal tumors have been quite different: emphasis has been placed on gene identification. Long before cancer of the large bowel was recognized, importance of the roles of adenomatosis coli and its familial occurrence attracted the attention of epidemiologists and geneticists. Morphological characteri zation and analysis of hereditary trends of human material have already bad a long history, and recently detailed analysis of genetic material has become feasible in the wake of rapid development in our knowledge of the oncoviruses, oncogenes, suppressor genes, chromosomal and DNA mapping, molecular mutation and so on. lt is true that in colorectal pathology, and in no other field, these areas of research have been explored more extensively and decisively. The identification of previ ously ill-defined lesions such as precancers and benign neoplasms have been improved because sequential changes can be observed in multiple samples spread over a wide area and followed up in due course.

Author : Henry T. Lynch,Takeshi Hirayama
Publisher : CRC Press
Page : 376 pages
File Size : 42,9 Mb
Release : 1989-06-30
Category : Medical
ISBN : 0849367565

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Genetic Epidemiology of Cancer by Henry T. Lynch,Takeshi Hirayama Pdf

This multi-authored book provides a unique accounting of the cancer problem from the standpoint of those primary genetic factors which may be interacting with myriad environmental exposures in cancer etiology. It provides a comprehensive coverage of cancer of all anatomical sites in conjunction with a genetic/environmental thrust. It includes a survey chapter dealing with the role of primary genetic factors in cancer of differing anatomic sites and a similar comprehensive survey chapter tracing the history of epidemiology, with focus upon multiple anatomic sites, including classical epidemiologic cancer models such as cigarette smoking, asbestos, vinyl chloride, and uranium exposure. Chapters are devoted to tumor biomarkers and their applicability to cancer of multiple anatomic sites. Clinical correlation will involve surveillance/management programsand focus on high-risk groups-such as those involving primary genetic or environmental factors and/or their interaction. The development of registries involving families with differing hereditary cancer syndromes are considered. Also, many chapters are devoted to environmental protective measures, as well as the need for more responsibility for coverage of patients at inordinately high risk for cancer by third party carriers. Other chapters address segregation and linkage analysis, oncogenes, cytogenetics, and other biomarkers. This book will be of interest to general clinicians, oncologists, surgeons, geneticists, and carcinogenesis investigators.

Author : Kevin M. Haigis, Ph.D.
Publisher : Springer Science & Business Media
Page : 316 pages
File Size : 46,9 Mb
Release : 2013-10-02
Category : Medical
ISBN : 9781461484127

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Molecular Pathogenesis of Colorectal Cancer by Kevin M. Haigis, Ph.D. Pdf

Colorectal cancer has for more than two decades served as the paradigm for the multi-step concept of cancer initiation and progression. Perhaps more than any other organ site, cancer of the colon is extensively characterized at the molecular level. We are now entering a time when molecular classification, rather than histologic classification, of cancer subtypes is driving the development of clinical trials with emerging targeted therapies. The book will focus on the progression from the identification of mutations that drive colorectal cancer initiation and progression to the search for novel therapies to treat the disease.

Author : James M. Church,Graham Casey
Publisher : Springer Science & Business Media
Page : 174 pages
File Size : 48,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781441993106

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Molecular Genetics of Colorectal Neoplasia by James M. Church,Graham Casey Pdf

Molecular Genetics of Colorectal Neoplasia A Primer for the Clinician provides the latest information on the genetics of colorectal cancer within a context of basic genetics, describing the subject in understandable language and making it clinically relevant. In this way, clinicians can become familiar with genetic terms and techniques related to colorectal neoplasia, providing a background upon which to build an appreciation of future advances and an ability to include them in the practicalities of patient care. This edition is intended for the healthcare provider or industry concerned with colorectal neoplasia: including general and colorectal surgeons, pathologists, oncologists, gastroenterologists, internal medicine and family practice physicians, nurses, geneticists, counsellors, registry co-ordinators, epidemiologists, and statisticians.

Author : Patrick M. Lynch,Henry T. Lynch
Publisher : Unknown
Page : 344 pages
File Size : 48,6 Mb
Release : 1985
Category : Medical
ISBN : UOM:39015009529168

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Colon Cancer Genetics by Patrick M. Lynch,Henry T. Lynch Pdf

Author : Institute of Medicine,Board on Health Sciences Policy,Roundtable on Translating Genomic-Based Research for Health
Publisher : National Academies Press
Page : 109 pages
File Size : 54,8 Mb
Release : 2010-11-29
Category : Medical
ISBN : 9780309184991

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The Value of Genetic and Genomic Technologies by Institute of Medicine,Board on Health Sciences Policy,Roundtable on Translating Genomic-Based Research for Health Pdf

Knowing one's genetic disposition to a variety of diseases, including common chronic diseases, can benefit both the individual and society at large. The IOM's Roundtable on Translating Genomic-Based Research for Health held a workshop on March 22, 2010, to bring together diverse perspectives on the value of genetic testing, and to discuss its use in clinical practice.

Author : B.A. Ponder,M.J. Waring
Publisher : Springer Science & Business Media
Page : 222 pages
File Size : 47,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9789401106771

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The Genetics of Cancer by B.A. Ponder,M.J. Waring Pdf

It has been recognized for almost 200 years that certain families seem to inherit cancer. It is only in the past decade, however, that molecular genetics and epidemiology have combined to define the role of inheritance in cancer more clearly, and to identify some of the genes involved. The causative genes can be tracked through cancer-prone families via genetic linkage and positional cloning. Several of the genes discovered have subsequently been proved to play critical roles in normal growth and development. There are also implications for the families themselves in terms of genetic testing with its attendant dilemmas, if it is not clear that useful action will result. The chapters in The Genetics of Cancer illustrate what has already been achieved and take a critical look at the future directions of this research and its potential clinical applications.

Author : Jose G. Guillem,Garrett Friedman
Publisher : Springer Nature
Page : 213 pages
File Size : 51,5 Mb
Release : 2020-04-02
Category : Medical
ISBN : 9783030262341

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Management of Hereditary Colorectal Cancer by Jose G. Guillem,Garrett Friedman Pdf

This book provides a comprehensive review of the clinical management of hereditary colorectal cancer. The text focuses on six distinct patient groups: patients with early age-of-onset colorectal cancer and adenomas, patients with hamartomatous colorectal polyps, patients afflicted with familial adenomatous polyposis (FAP), patients with attenuated familial adenomatous polyposis (AFAP), patients with MYH associated polyposis (MAP), and patients afflicted with lynch syndrome (LS). Each chapter illustrates how clinicians utilize current technologies in genetic testing, pathological review, and endoscopic, surgical, and chemotherapeutic/immunotherapeutic approaches to manage these patient groups. Topics such as the timing of genetic testing, endoscopic screening and surveillance, prophylactic surgical options and chemo-preventive interventions are also discussed in concise yet precise detail. Written by experts in their fields, Management of Hereditary Colorectal Cancer: A Multidisciplinary Approach is a valuable and timely resource for gastroenterologists, surgeons, genetic counselors, medical oncologists, psychologists, and any health caregivers involved with the management of patients and families afflicted with a hereditary form of colorectal cancer.