Epi Informatics

Author : Jose Medina-Franco
Publisher : Academic Press
Page : 440 pages
File Size : 53,9 Mb
Release : 2016-02-24
Category : Medical
ISBN : 9780128028094

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Epi-Informatics by Jose Medina-Franco Pdf

Epi-Informatics: Discovery and Development of Small Molecule Epigenetic Drugs and Probes features multidisciplinary strategies with strong computational approaches that have led to the successful discovery and/or optimization of compounds that act as modulators of epigenetic targets. This book is intended for all those using or wanting to learn more about computational methodologies in epigenetic drug discovery, including molecular modelers, informaticians, pharmaceutical scientists, and medicinal chemists. With a better understanding of different molecular modeling and cheminformatic approaches, readers can incorporate these techniques into their own drug discovery projects that may involve chemical synthesis and medium- or high-throughput screening. In addition, this book highlights the significance of epigenetic targets to the public health for molecular modelers and chemoinformatians. The goal of this reference is to stimulate ongoing multidisciplinary research and to further improve current computational methodologies and workflows in order to accelerate the discovery and development of epi-drugs and epi-probes. Focuses on the discovery of epi-drugs as candidates to be used in therapy including combined therapies Describes new computational methodologies and screening assays utilizing recent and emerging novel structural data Highlights the discovery, development and optimization of epi-probes, which are molecular probes that elucidate epigenetic mechanisms Includes important topics such as computational-guided optimization of epi-hits, virtual screening to identify novel compounds for epigenetic targets, development and mining of epigenetic molecular databases, SAR modeling of screening data and much more

Author : Thomas Engel,Johann Gasteiger
Publisher : John Wiley & Sons
Page : 660 pages
File Size : 47,8 Mb
Release : 2018-06-05
Category : Science
ISBN : 9783527342013

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Applied Chemoinformatics by Thomas Engel,Johann Gasteiger Pdf

Edited by world-famous pioneers in chemoinformatics, this is a clearly structured and applications-oriented approach to the topic, providing up-to-date and focused information on the wide range of applications in this exciting field. The authors explain methods and software tools, such that the reader will not only learn the basics but also how to use the different software packages available. Experts describe applications in such different fields as structure-spectra correlations, virtual screening, prediction of active sites, library design, the prediction of the properties of chemicals, the development of new cosmetics products, quality control in food, the design of new materials with improved properties, toxicity modeling, assessment of the risk of chemicals, and the control of chemical processes. The book is aimed at advanced students as well as lectures but also at scientists that want to learn how chemoinformatics could assist them in solving their daily scientific tasks. Together with the corresponding textbook Chemoinformatics - Basic Concepts and Methods (ISBN 9783527331093) on the fundamentals of chemoinformatics readers will have a comprehensive overview of the field.

Author : Anonim
Publisher : Academic Press
Page : 152 pages
File Size : 50,5 Mb
Release : 2018-08-24
Category : Science
ISBN : 9780128139172

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Computational Molecular Modelling in Structural Biology by Anonim Pdf

Computational Molecular modelling in Structural Biology, Volume 113, the latest release in the Advances in Protein Chemistry and Structural Biology, highlights new advances in the field, with this new volume presenting interesting chapters on charting the Bromodomain BRD4: Towards the Identification of Novel Inhibitors with Molecular Similarity and Receptor Mapping, and Computational Methods to Discover Compounds for the Treatment of Chagas Disease. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Advances in Protein Chemistry and Structural Biology series Updated, with the latest information on Computational Molecular Modelling in Structural Biology

Author : Kunal Roy
Publisher : Springer
Page : 555 pages
File Size : 54,7 Mb
Release : 2017-05-22
Category : Science
ISBN : 9783319568508

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Advances in QSAR Modeling by Kunal Roy Pdf

The book covers theoretical background and methodology as well as all current applications of Quantitative Structure-Activity Relationships (QSAR). Written by an international group of recognized researchers, this edited volume discusses applications of QSAR in multiple disciplines such as chemistry, pharmacy, environmental and agricultural sciences addressing data gaps and modern regulatory requirements. Additionally, the applications of QSAR in food science and nanoscience have been included – two areas which have only recently been able to exploit this versatile tool. This timely addition to the series is aimed at graduate students, academics and industrial scientists interested in the latest advances and applications of QSAR.

Author : Alma D. Campos-Parra,Carlos Pérez-Plasencia,Teresita Padilla-Benavides,Eduardo López-Urrutia
Publisher : Frontiers Media SA
Page : 158 pages
File Size : 40,5 Mb
Release : 2021-08-26
Category : Medical
ISBN : 9782889712397

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Repurposed Drugs Targeting Cancer Signaling Pathways: Clinical Insights to Improve Oncologic Therapies by Alma D. Campos-Parra,Carlos Pérez-Plasencia,Teresita Padilla-Benavides,Eduardo López-Urrutia Pdf

Author : Anonim
Publisher : Academic Press
Page : 212 pages
File Size : 42,9 Mb
Release : 2016-08-24
Category : Science
ISBN : 9780128052419

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Insights into Enzyme Mechanisms and Functions from Experimental and Computational Methods by Anonim Pdf

Insights into Enzyme Mechanisms and Functions from Experimental and Computational Methods is the latest volume in the popular Advances in Protein Chemistry and Structural Biology series, an essential resource for protein chemists. Each volume brings forth new information about protocols and analysis of proteins, with each thematically organized volume guest edited by leading experts in a broad range of protein-related topics. Provides cutting-edge developments in protein chemistry and structural biology Written by authorities in their respective fields Targeted to a wide audience of researchers, specialists, and students

Author : Anonim
Publisher : Academic Press
Page : 332 pages
File Size : 46,7 Mb
Release : 2020-09-21
Category : Science
ISBN : 9780128177631

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Enzymes – Mechanisms, Dynamics and Inhibition by Anonim Pdf

Enzymes – Mechanisms, Dynamics and Inhibition, Volume 122, the latest release in the Advances in Protein Chemistry and Structural Biology series, highlights new advances in the field, with this new volume presenting new and interesting chapters on the topics. Each chapter is written by an international board of authors. Provides a targeted approach to a very wide audience of specialists, researchers and students Contains timely chapters written by well-renowned authorities in their field Includes a number of high quality illustrations, figures and tables

Author : José L. Medina-Franco
Publisher : MDPI
Page : 158 pages
File Size : 42,8 Mb
Release : 2019-07-01
Category : Medical
ISBN : 9783039211043

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New Approaches for the Discovery of Pharmacologically-Active Natural Compounds by José L. Medina-Franco Pdf

A major source of active compounds, natural products from different sources supply a large variety of molecules that have been approved for clinical use or used as the starting points of optimization programs. This book features nine papers (eight full articles and one review paper) written by more than 45 scientists from around the world. These papers illustrate the development and application of a broad range of computational and experimental techniques applied to natural product research. On behalf of the contributors to the book, our hope is that the research presented here contributes to advancements in the field, and encourages multidisciplinary teams, young scientists, and students to further advance in the discovery of pharmacologically-active natural compounds

Author : Anonim
Publisher : Hotcourses
Page : 614 pages
File Size : 44,8 Mb
Release : 2008
Category : Graduate students
ISBN : 1904735312

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Postgraduate UK study and funding guide by Anonim Pdf

Features information on studying at Postgraduate level in the UK, what is involved, what opportunities there are, lists details £75 million of funding available to Postgraduate students.

Author : Harish Garg,Jyotir Moy Chatterjee
Publisher : Elsevier
Page : 402 pages
File Size : 42,7 Mb
Release : 2023-07-20
Category : Computers
ISBN : 9780443194146

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Deep Learning in Personalized Healthcare and Decision Support by Harish Garg,Jyotir Moy Chatterjee Pdf

Deep Learning in Personalized Healthcare and Decision Support discusses the potential of deep learning technologies in the healthcare sector. The book covers the application of deep learning tools and techniques in diverse areas of healthcare, such as medical image classification, telemedicine, clinical decision support system, clinical trials, electronic health records, precision medication, Parkinson disease detection, genomics, and drug discovery. In addition, it discusses the use of DL for fraud detection and internet of things. This is a valuable resource for researchers, graduate students and healthcare professionals who are interested in learning more about deep learning applied to the healthcare sector. Although there is an increasing interest by clinicians and healthcare workers, they still lack enough knowledge to efficiently choose and make use of technologies currently available. This book fills that knowledge gap by bringing together experts from technology and clinical fields to cover the topics in depth. Discusses the application of deep learning in several areas of healthcare, including clinical trials, telemedicine and health records management Brings together experts in the intersection of deep learning, medicine, healthcare and programming to cover topics in an interdisciplinary way Uncovers the stakes and possibilities involved in realizing personalized healthcare services through efficient and effective deep learning technologies

Author : Pulok K. Mukherjee
Publisher : Elsevier
Page : 858 pages
File Size : 44,6 Mb
Release : 2022-07-12
Category : Business & Economics
ISBN : 9780323984560

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Evidence-Based Validation of Herbal Medicine by Pulok K. Mukherjee Pdf

Evidence-Based Validation of Herbal Medicines: Translational Research on Botanicals brings together current thinking and practice in the characterization and validation of natural products. The book describes different approaches and techniques for evaluating the quality, safety and efficacy of herbal medicine, particularly methods to assess their activity and understand compounds responsible and their probable underlying mechanisms of action. This book brings together the views, expertise and experiences of scientific experts in the field of medicinal plant research, hence it will be useful for researcher who want to know more about the natural lead with their validation and also useful to exploit traditional medicines. Includes state-of-the-art methods for detecting, isolating and performing structure elucidation by degradation and spectroscopic techniques Highlights the trends in validation and value addition of herbal medicine with different scientific approaches used in therapeutics Contains several all-new chapters on topics such as traditional-medicine-inspired drug development to treat emerging viral diseases, medicinal plants in antimicrobial resistance, TLC bio profiling, botanicals as medicinal foods, bioprospecting and bioassay-guided isolation of medicinal plants, immunomodulators from medicinal plants, and more

Author : Madhumita Roy,Jaydip Biswas,Amitava Datta
Publisher : Springer Nature
Page : 96 pages
File Size : 52,7 Mb
Release : 2023-05-10
Category : Medical
ISBN : 9789811999253

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Genetics and Epigenetics of Breast Cancer by Madhumita Roy,Jaydip Biswas,Amitava Datta Pdf

This book discusses the contribution of genetics and epigenetics alterations in the initiation, development, and recurrence of breast cancer. It also reviews the potential of translating the epigenetic alterations into diagnosis, prognosis, and breast cancer therapy. The initial chapters explore the epigenetics, etiology, and conventional treatment strategies for breast cancer. The subsequent chapters discuss the genetic landscape and cover three main epigenetic modulation mechanisms; histone modification, DNA methylation, and miRNA silencing. Further, the book explores the potential of epigenetic drugs in treating breast cancer. Lastly, it covers the phytochemicals targeting epigenetic modulators in breast cancer treatment. This book is an essential source for researchers and practitioners interested in exploring the potential of epigenetics modulators in breast cancer treatment. ​

Author : Rudy Schreiber
Publisher : Springer Nature
Page : 285 pages
File Size : 50,9 Mb
Release : 2021-06-17
Category : Medical
ISBN : 9783030623517

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Modern CNS Drug Discovery by Rudy Schreiber Pdf

This textbook provides a comprehensive overview of the currently used concepts, approaches and technologies in the discovery and development of new treatments for the full spectrum of disorders of the central nervous system. It guides the reader through all essential steps, from finding an innovative idea, to the registration of a new drug. Divided into four sections, the book starts by presenting a broad perspective on current approaches in central nervous system (CNS) drug discovery. The second section addresses the generation of ideas for the identification of targets and novel treatment strategies; covers core functions in early discovery, and provides an example of a novel treatment paradigm: brain stimulation. The third section highlights strategies and technologies in translational CNS drug discovery. In an effort to bridge the gap between discovery and clinical development, it also covers brain imaging, EEG and cognitive testing approaches. The fourth section extensively discusses the clinical phase of drug development, covering the basics of early clinical testing for psychopharmacological drugs. The book’s final chapter addresses the registration for newly developed drugs. Written by experts from academia and industry, the book covers important basics and best practices, as well as recent developments in drug discovery. Offering in-depth insights into the world of drug development, it represents essential reading for early researchers who want to prepare for a career in drug discovery in academia or industry.

Author : Albert Jeltsch,Renata Z. Jurkowska
Publisher : Springer Nature
Page : 562 pages
File Size : 55,5 Mb
Release : 2022-11-09
Category : Science
ISBN : 9783031114540

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DNA Methyltransferases - Role and Function by Albert Jeltsch,Renata Z. Jurkowska Pdf

This 2nd edition of the book on DNA methyltransferases has been comprehensively updated to reflect many novel research findings regarding the structure, function, and technology of these enzymes that have emerged over the past 6 years. Like the previous edition, this 2nd edition explains the biochemical properties of DNA methyltransferases, describing their structures, mechanisms and biological roles in bacteria, humans and plants. It also discusses the biological processes of reading DNA methylation and the mechanisms of DNA demethylation. This volume highlights the newest findings on DNA methyltransferase inhibitors and their use in cancer therapy as well as the latest epigenome editing systems based on these enzymes. Overall, this 2nd edition comprehensively summarizes the current state of research in the field of DNA methylation and DNA methyltransferase and is essential reading for early career and advanced researchers in this exciting field.

Author : Simon Jones,Richard Beamish
Publisher : John Wiley & Sons
Page : 554 pages
File Size : 53,7 Mb
Release : 2011-08-02
Category : Technology & Engineering
ISBN : 9780470961544

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Salmon Lice by Simon Jones,Richard Beamish Pdf

The salmon louse Lepeophtheirus salmonis is adapted to survive in hostile marine environments of the northern hemisphere, including an ability to parasitize several species of salmon. Salmonids are some of the most economically important and sought after fish for human consumption, and louse parasitism has a significant impact both on cultured and wild fish populations. Salmon Lice is a timely collection of the latest research on the cause and spread of lice infestations and management techniques being designed and implemented to combat this issue. Salmon Lice provides a thorough single volume review of Lepeophtheirus salmonis, the key parasite standing in the way of sustainable and profitable production of salmonid fishes including salmon, trout and charr. Opening with a review of the biology, morphology, life cycle, and larval behavior of the parasite, Salmon Lice proceeds to review the distribution of planktonic larvae of salmon lice, addresses management techniques used in salmonid aquaculture and capture fisheries, provides a practical assessment of the salmon lice issue and explores potential solutions to the problem. With comprehensive coverage of the biology and distribution of this harmful and ubiquitous parasite, Salmon Lice will be of value to fish health researchers, aquaculture and fisheries professionals, and seafood industry personnel to inform the management of both cultured and wild salmonid populations. Key Features: In-depth coverage of a key parasite impacting viability and sustainability of salmonid fisheries and aquaculture Integrates parasite biology and hydrodynamic models in diverse coastal ecosystems Provides a practical assessment of the salmon louse issue Reviews international salmon louse monitoring and management techniques used in salmonid fisheries and aquaculture