Insights Into Enzyme Mechanisms And Functions From Experimental And Computational Methods

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Insights into Enzyme Mechanisms and Functions from Experimental and Computational Methods

Anonim
Insights into Enzyme Mechanisms and Functions from Experimental and Computational Methods Book PDF

Author : Anonim
Publisher : Academic Press
Page : 212 pages
File Size : 49,8 Mb
Release : 2016-08-24
Category : Science
ISBN : 9780128052419

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Insights into Enzyme Mechanisms and Functions from Experimental and Computational Methods by Anonim Pdf

Insights into Enzyme Mechanisms and Functions from Experimental and Computational Methods is the latest volume in the popular Advances in Protein Chemistry and Structural Biology series, an essential resource for protein chemists. Each volume brings forth new information about protocols and analysis of proteins, with each thematically organized volume guest edited by leading experts in a broad range of protein-related topics. Provides cutting-edge developments in protein chemistry and structural biology Written by authorities in their respective fields Targeted to a wide audience of researchers, specialists, and students

Structural and Mechanistic Enzymology

Anonim
Structural and Mechanistic Enzymology Book PDF

Author : Anonim
Publisher : Academic Press
Page : 366 pages
File Size : 40,9 Mb
Release : 2017-07-17
Category : Medical
ISBN : 9780128118771

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Structural and Mechanistic Enzymology by Anonim Pdf

Structural and Mechanistic Enzymology, Volume 109, the latest release in the Advances in Protein Chemistry and Structural Biology series, is an essential resource for protein chemists. Chapters in this new volume include Collagenolytic Matrix Metalloproteinase Structure–Function Relationships: Insights from Molecular Dynamics Studies, Computational Glycobiology: Mechanistic Studies of Carbohydrate-Active Enzymes and Implication for Inhibitor Design, Computational Biochemistry─Enzyme Mechanisms Explored, and A Paradigm for C─H Bond Cleavage: Structural and Functional Aspects of Transition State Stabilization by Mandelate Racemase. This series presents new information on protocols and analysis of proteins, with each volume guest edited by leading experts in a broad range of protein-related topics. This volume presents state-of-the-art contributions, providing insights into the relationship between enzyme structure, catalysis, and function. Provides cutting-edge developments in protein chemistry and structural biology Features new information about protocols and analysis of proteins Contains chapters written by authorities in their respective fields Targeted to a wide audience of researchers, specialists and students

Computational Approaches to Biochemical Reactivity

Gábor Náray-Szabó,Arieh Warshel
Computational Approaches to Biochemical Reactivity Book PDF

Author : Gábor Náray-Szabó,Arieh Warshel
Publisher : Springer Science & Business Media
Page : 381 pages
File Size : 49,7 Mb
Release : 2006-04-11
Category : Science
ISBN : 9780306469343

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Computational Approaches to Biochemical Reactivity by Gábor Náray-Szabó,Arieh Warshel Pdf

A quantitative description of the action of enzymes and other biological systems is both a challenge and a fundamental requirement for further progress in our und- standing of biochemical processes. This can help in practical design of new drugs and in the development of artificial enzymes as well as in fundamental understanding of the factors that control the activity of biological systems. Structural and biochemical st- ies have yielded major insights about the action of biological molecules and the mechanism of enzymatic reactions. However it is not entirely clear how to use this - portant information in a consistent and quantitative analysis of the factors that are - sponsible for rate acceleration in enzyme active sites. The problem is associated with the fact that reaction rates are determined by energetics (i. e. activation energies) and the available experimental methods by themselves cannot provide a correlation - tween structure and energy. Even mutations of specific active site residues, which are extremely useful, cannot tell us about the totality of the interaction between the active site and the substrate. In fact, short of inventing experiments that allow one to measure the forces in enzyme active sites it is hard to see how can one use a direct experimental approach to unambiguously correlate the structure and function of enzymes. In fact, in view of the complexity of biological systems it seems that only computers can handle the task of providing a quantitative structure-function correlation.

Proceedings of 8th GACM Colloquium on Computational Mechanics

Tobias Gleim ,Stephan Lange
Proceedings of 8th GACM Colloquium on Computational Mechanics Book PDF

Author : Tobias Gleim ,Stephan Lange
Publisher : kassel university press GmbH
Page : 493 pages
File Size : 44,7 Mb
Release : 2019-09-04
Category : Technology & Engineering
ISBN : 9783737650939

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Proceedings of 8th GACM Colloquium on Computational Mechanics by Tobias Gleim ,Stephan Lange Pdf

This conference book contains papers presented at the 8th GACM Colloquium on Computational Mechanics for Young Scientists from Academia and Industry. The conference was held from August 28th – 30th, 2019 in Kassel, hosted by the Institute of Mechanics and Dynamics of the department for civil and environmental engineering and by the chair of Engineering Mechanics / Continuum Mechanics of the department for mechanical engineering of the University of Kassel. The aim of the conference is, to bring together young scientits who are engaged in academic and industrial research on Computational Mechanics and Computer Methods in Applied Sciences. It provides a plattform to present and discuss recent results from research efforts and industrial applications. In more than 150 presentations, given by young scientists, current scientific developments and advances in engineering practice in this field are presented and discussed. The contributions of the young researchers are supplemented by a poster session and plenary talks from four senior scientists from academia and industry as well as from the GACM Best PhD Award winners 2017 and 2018.

Computational Approaches for Studying Enzyme Mechanism

Anonim
Computational Approaches for Studying Enzyme Mechanism Book PDF

Author : Anonim
Publisher : Academic Press
Page : 514 pages
File Size : 52,7 Mb
Release : 2016-08-03
Category : Medical
ISBN : 9780128111086

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Computational Approaches for Studying Enzyme Mechanism by Anonim Pdf

Computational Approaches for Studying Enzyme Mechanism, Part B is the first of two volumes in the Methods in Enzymology series that focuses on computational approaches for studying enzyme mechanism. The serial achieves the critically acclaimed gold standard of laboratory practices and remains one of the most highly respected publications in the molecular biosciences. Each volume is eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with over 550 volumes, the series remains a prominent and essential publication for researchers in all fields of the life sciences and biotechnology, including biochemistry, chemical biology, microbiology, synthetic biology, cancer research, genetics, and other fields of study. Focuses on computational approaches for studying enzyme mechanism Continues the legacy of this premier serial with quality chapters authored by leaders in the field Covers research methods in intermediate filament associated proteins, and contains sections on such topics as lamin-associated proteins, intermediate filament-associated proteins and plakin, and other cytoskeletal cross-linkers

Molecular Level Atomistic and Structural Insights on Biological Macromolecules, Inhibition, and Dynamics Studies

Chandrabose Selvaraj,Emilia Pedone,Jung-Kul Lee,Sanjeev Kumar Singh
Molecular Level Atomistic and Structural Insights on Biological Macromolecules Inhibition and Dynamics Studies Book PDF

Author : Chandrabose Selvaraj,Emilia Pedone,Jung-Kul Lee,Sanjeev Kumar Singh
Publisher : Frontiers Media SA
Page : 179 pages
File Size : 40,5 Mb
Release : 2024-03-14
Category : Science
ISBN : 9782832546277

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Molecular Level Atomistic and Structural Insights on Biological Macromolecules, Inhibition, and Dynamics Studies by Chandrabose Selvaraj,Emilia Pedone,Jung-Kul Lee,Sanjeev Kumar Singh Pdf

Everything in a living organism relies on biological macromolecules, which have the role of enzymatic chemical transformations, formation of structures, transportation, catalysis, and regulation of biological processes. They are complex biological structures that require an atomistic understanding. A molecular understanding of biological macromolecules has had a massive impact on the pharmaceutical, biotechnological, and chemical industries. Specifically, new enzymatic structures are being discovered through various experimental and computational methods, by describing an atomistic-level insight into function, mechanism, role in reactions and their inhibition. Those atom-level illustrations are mainly focused through enzyme kinetics, enzyme inhibition, mutational and conformational analysis through quantum mechanical and molecular dynamics methods.

Structural and Mechanistic Enzymology

Christo Christov,Tatyana Karabencheva-Christova
Structural and Mechanistic Enzymology Book PDF

Author : Christo Christov,Tatyana Karabencheva-Christova
Publisher : Academic Press
Page : 473 pages
File Size : 41,5 Mb
Release : 2012-05-29
Category : Science
ISBN : 9780123983121

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Structural and Mechanistic Enzymology by Christo Christov,Tatyana Karabencheva-Christova Pdf

Other volumes cataloged as a serial, see LCCN: 2009237250

Contemporary Enzyme Kinetics and Mechanism

Anonim
Contemporary Enzyme Kinetics and Mechanism Book PDF

Author : Anonim
Publisher : Academic Press
Page : 703 pages
File Size : 40,6 Mb
Release : 2009-10-24
Category : Science
ISBN : 9780123847447

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Contemporary Enzyme Kinetics and Mechanism by Anonim Pdf

Kinetic studies of enzyme action provide powerful insights into the underlying mechanisms of catalysis and regulation. These approaches are equally useful in examining the action of newly discovered enzymes and therapeutic agents. Contemporary Enzyme Kinetics and Mechanism, Second Edition presents key articles from Volumes 63, 64, 87, 249, 308 and 354 of Methods in Enzymology. The chapters describe the most essential and widely applied strategies. A set of exercises and problems is included to facilitate mastery of these topics. The book will aid the reader to design, execute, and analyze kinetic experiments on enzymes. Its emphasis on enzyme inhibition will also make it attractive to pharmacologists and pharmaceutical chemists interested in rational drug design.Of the seventeen chapters presented in this new edition, ten did not previously appear in the first edition. Transient kinetic approaches to enzyme mechanisms Designing initial rate enzyme assay Deriving initial velocity and isotope exchange rate equations Plotting and statistical methods for analyzing rate data Cooperativity in enzyme function Reversible enzyme inhibitors as mechanistic probes Transition-state and multisubstrate inhibitors Affinity labeling to probe enzyme structure and function Mechanism-based enzyme inactivators Isotope exchange methods for elucidating enzymatic catalysis Kinetic isotope effects in enzyme catalysis Site-directed mutagenesis in studies of enzyme catalysis

Computational Chemistry Methods in Structural Biology

Anonim
Computational Chemistry Methods in Structural Biology Book PDF

Author : Anonim
Publisher : Academic Press
Page : 360 pages
File Size : 40,8 Mb
Release : 2011-09-13
Category : Science
ISBN : 9780123864864

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Computational Chemistry Methods in Structural Biology by Anonim Pdf

Published continuously since 1944, the Advances in Protein Chemistry and Structural Biology serial has been a continuous, essential resource for protein chemists. Covering reviews of methodology and research in all aspects of protein chemistry, including purification/expression, proteomics, modeling and structural determination and design, each volume brings forth new information about protocols and analysis of proteins while presenting the most recent findings from leading experts in a broad range of protein-related topics. This volume features articles on Computational Chemistry methods in Structural Biology. Essential resource for protein chemists This volume features articles on Computational Chemistry methods in Structural Biology

Human Genome Structure, Function and Clinical Considerations

Luciana Amaral Haddad
Human Genome Structure Function and Clinical Considerations Book PDF

Author : Luciana Amaral Haddad
Publisher : Springer Nature
Page : 367 pages
File Size : 40,7 Mb
Release : 2021-06-07
Category : Medical
ISBN : 9783030731519

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Human Genome Structure, Function and Clinical Considerations by Luciana Amaral Haddad Pdf

This book provides a detailed evidence-based overview of the latest developments in how the structure of the human genome is relevant to the health professional. It features comprehensive reviews of genome science including human chromosomal and mitochondrial DNA structure, protein-coding and noncoding genes, and the diverse classes of repeat elements of the human genome. These concepts are then built upon to provide context as to how they functionally relate to differences in phenotypic traits that can be observed in human populations. Guidance is also provided on how this information can be applied by the medical practitioner in day-to-day clinical practice. Human Genome Structure, Function and Clinical Considerations collates the latest developments in genome science and current methods for genome analysis that are relevant for the clinician, researcher and scientist who utilises precision medicine techniques and is an essential resource for any such practitioner.

Origin and Evolution of Viruses

Esteban Domingo,Colin R. Parrish,John J. Holland
Origin and Evolution of Viruses Book PDF

Author : Esteban Domingo,Colin R. Parrish,John J. Holland
Publisher : Elsevier
Page : 573 pages
File Size : 44,6 Mb
Release : 2008-06-23
Category : Science
ISBN : 9780080564968

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Origin and Evolution of Viruses by Esteban Domingo,Colin R. Parrish,John J. Holland Pdf

New viral diseases are emerging continuously. Viruses adapt to new environments at astounding rates. Genetic variability of viruses jeopardizes vaccine efficacy. For many viruses mutants resistant to antiviral agents or host immune responses arise readily, for example, with HIV and influenza. These variations are all of utmost importance for human and animal health as they have prevented us from controlling these epidemic pathogens. This book focuses on the mechanisms that viruses use to evolve, survive and cause disease in their hosts. Covering human, animal, plant and bacterial viruses, it provides both the basic foundations for the evolutionary dynamics of viruses and specific examples of emerging diseases. NEW - methods to establish relationships among viruses and the mechanisms that affect virus evolution UNIQUE - combines theoretical concepts in evolution with detailed analyses of the evolution of important virus groups SPECIFIC - Bacterial, plant, animal and human viruses are compared regarding their interation with their hosts

Simulating Enzyme Reactivity

Inaki Tunon,Vicent Moliner
Simulating Enzyme Reactivity Book PDF

Author : Inaki Tunon,Vicent Moliner
Publisher : Royal Society of Chemistry
Page : 535 pages
File Size : 47,8 Mb
Release : 2016-11-16
Category : Science
ISBN : 9781782626831

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Simulating Enzyme Reactivity by Inaki Tunon,Vicent Moliner Pdf

The simulation of enzymatic processes is a well-established field within computational chemistry, as demonstrated by the 2013 Nobel Prize in Chemistry. It has been attracting increasing attention in recent years due to the potential applications in the development of new drugs or new environmental-friendly catalysts. Featuring contributions from renowned authors, including Nobel Laureate Arieh Warshel, this book explores the theories, methodologies and applications in simulations of enzyme reactions. It is the first book offering a comprehensive perspective of the field by examining several different methodological approaches and discussing their applicability and limitations. The book provides the basic knowledge for postgraduate students and researchers in chemistry, biochemistry and biophysics, who want a deeper understanding of complex biological process at the molecular level.

Computational Approaches for Studying Enzyme Mechanism

Anonim
Computational Approaches for Studying Enzyme Mechanism Book PDF

Author : Anonim
Publisher : Academic Press
Page : 558 pages
File Size : 52,7 Mb
Release : 2016-08-04
Category : Medical
ISBN : 9780128053638

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Computational Approaches for Studying Enzyme Mechanism by Anonim Pdf

Computational Approaches for Studying Enzyme Mechanism Part A, is the first of two volumes in the Methods in Enzymology series, focusses on computational approaches for studying enzyme mechanism. The serial achieves the critically acclaimed gold standard of laboratory practices and remains one of the most highly respected publications in the molecular biosciences. Each volume is eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with over 550 volumes, the series remains a prominent and essential publication for researchers in all fields of life sciences and biotechnology, including biochemistry, chemical biology, microbiology, synthetic biology, cancer research, and genetics to name a few. Focuses on computational approaches for studying enzyme mechanism Continues the legacy of this premier serial with quality chapters authored by leaders in the field Covers research methods in intermediate filament associated proteins, and contains sections on such topics as lamin-associated proteins, intermediate filament-associated proteins and plakin, and other cytoskeletal cross-linkers

Introduction to Bioorganic Chemistry and Chemical Biology

David Van Vranken,Gregory A. Weiss
Introduction to Bioorganic Chemistry and Chemical Biology Book PDF

Author : David Van Vranken,Gregory A. Weiss
Publisher : Garland Science
Page : 504 pages
File Size : 51,5 Mb
Release : 2018-10-08
Category : Medical
ISBN : 9781135054823

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Introduction to Bioorganic Chemistry and Chemical Biology by David Van Vranken,Gregory A. Weiss Pdf

Introduction to Bioorganic Chemistry and Chemical Biology is the first textbook to blend modern tools of organic chemistry with concepts of biology, physiology, and medicine. With a focus on human cell biology and a problems-driven approach, the text explains the combinatorial architecture of biooligomers (genes, DNA, RNA, proteins, glycans, lipids, and terpenes) as the molecular engine for life. Accentuated by rich illustrations and mechanistic arrow pushing, organic chemistry is used to illuminate the central dogma of molecular biology. Introduction to Bioorganic Chemistry and Chemical Biology is appropriate for advanced undergraduate and graduate students in chemistry and molecular biology, as well as those going into medicine and pharmaceutical science.

Structure and Biophysics - New Technologies for Current Challenges in Biology and Beyond

Joseph D. Puglisi
Structure and Biophysics New Technologies for Current Challenges in Biology and Beyond Book PDF

Author : Joseph D. Puglisi
Publisher : Springer Science & Business Media
Page : 157 pages
File Size : 40,9 Mb
Release : 2007-03-21
Category : Science
ISBN : 9781402059001

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Structure and Biophysics - New Technologies for Current Challenges in Biology and Beyond by Joseph D. Puglisi Pdf

This volume is a collection of articles from the proceedings of the ISSBMR 7th Course: Structure and Biophysics - New Technologies for Current Challenges in Biology and Beyond. This NATO Advanced Institute (ASI) was held in Erice at the Ettore Majorana Foundation and Centre for Scientific Culture in June 2005. It presents state of the art information on NMR spectroscopy and its place in the broader field of biophysics.