Epigenetics

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Introduction to Epigenetics

Renato Paro,Ueli Grossniklaus,Raffaella Santoro,Anton Wutz
Introduction to Epigenetics Book PDF

Author : Renato Paro,Ueli Grossniklaus,Raffaella Santoro,Anton Wutz
Publisher : Springer Nature
Page : 215 pages
File Size : 42,6 Mb
Release : 2021-03-23
Category : Science
ISBN : 9783030686703

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Introduction to Epigenetics by Renato Paro,Ueli Grossniklaus,Raffaella Santoro,Anton Wutz Pdf

This open access textbook leads the reader from basic concepts of chromatin structure and function and RNA mechanisms to the understanding of epigenetics, imprinting, regeneration and reprogramming. The textbook treats epigenetic phenomena in animals, as well as plants. Written by four internationally known experts and senior lecturers in this field, it provides a valuable tool for Master- and PhD- students who need to comprehend the principles of epigenetics, or wish to gain a deeper knowledge in this field. After reading this book, the student will: Have an understanding of the basic toolbox of epigenetic regulation Know how genetic and epigenetic information layers are interconnected Be able to explain complex epigenetic phenomena by understanding the structures and principles of the underlying molecular mechanisms Understand how misregulated epigenetic mechanisms can lead to disease

Handbook of Epigenetics

Trygve Tollefsbol
Handbook of Epigenetics Book PDF

Author : Trygve Tollefsbol
Publisher : Academic Press
Page : 682 pages
File Size : 44,8 Mb
Release : 2017-07-10
Category : Science
ISBN : 9780128054772

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Handbook of Epigenetics by Trygve Tollefsbol Pdf

Handbook of Epigenetics: The New Molecular and Medical Genetics, Second Edition, provides a comprehensive analysis of epigenetics, from basic biology, to clinical application. Epigenetics is considered by many to be the new genetics in that many biological phenomena are controlled, not through gene mutations, but rather through reversible and heritable epigenetic processes. These epigenetic processes range from DNA methylation to prions. The biological processes impacted by epigenetics are vast and encompass effects in lower organisms and humans that include tissue and organ regeneration, X-chromosome inactivation, stem cell differentiation, genomic imprinting, and aging. The first edition of this important work received excellent reviews; the second edition continues its comprehensive coverage adding more current research and new topics based on customer and reader reviews, including new discoveries, approved therapeutics, and clinical trials. From molecular mechanisms and epigenetic technology, to discoveries in human disease and clinical epigenetics, the nature and applications of the science is presented for those with interests ranging from the fundamental basis of epigenetics, to therapeutic interventions for epigenetic-based disorders. Timely and comprehensive collection of fully up-to-date reviews on epigenetics that are organized into one volume and written by leading figures in the field Covers the latest advances in many different areas of epigenetics, ranging from basic aspects, to technologies, to clinical medicine Written at a verbal and technical level that can be understood by scientists and college students Updated to include new epigenetic discoveries, newly approved therapeutics, and clinical trials

Transgenerational Epigenetics

Trygve Tollefsbol
Transgenerational Epigenetics Book PDF

Author : Trygve Tollefsbol
Publisher : Elsevier
Page : 413 pages
File Size : 41,6 Mb
Release : 2014-05-02
Category : Science
ISBN : 9780124059221

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Transgenerational Epigenetics by Trygve Tollefsbol Pdf

Transgenerational Epigenetics provides a comprehensive analysis of the inheritance of epigenetic phenomena between generations. Recent research points to the existence of biological phenomena that are controlled not through gene mutations, but rather through reversible and heritable epigenetic processes. Epidemiological studies have suggested that environmental factors may be heritable. In fact, environmental factors often play a role in transgenerational epigenetics, which may have selective or adverse effects on the offspring. This epigenetic information can be transferred through a number of mechanisms including DNA methylation, histone modifications or RNA and the effects can persist for multiple generations. This book examines the evolution of epigenetic inheritance, its expression in animal and plant models, and how human diseases, such as metabolic disorders and cardiovascular diseases, appear to be affected by transgenerational epigenetic inheritance. It discusses clinical interventions in transgenerational epigenetic inheritance that may be on the horizon to help prevent diseases before the offspring are born, or to reduce the severity of diseases at the very earliest stages of development in utero, and current controversies in this area of study, as well as future directions for research. Focused discussion of metabolic disorders, cardiovascular diseases and longevity, which appear most affected by reversible and heritable epigenetic processes Encompasses both foundational and clinical aspects including discussions of preventative in utero therapies Covers history, future outlook, disease management and current controversies

The Epigenetics Revolution

Nessa Carey
The Epigenetics Revolution Book PDF

Author : Nessa Carey
Publisher : Columbia University Press
Page : 353 pages
File Size : 54,9 Mb
Release : 2012-03-06
Category : Science
ISBN : 9780231530712

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The Epigenetics Revolution by Nessa Carey Pdf

Epigenetics can potentially revolutionize our understanding of the structure and behavior of biological life on Earth. It explains why mapping an organism's genetic code is not enough to determine how it develops or acts and shows how nurture combines with nature to engineer biological diversity. Surveying the twenty-year history of the field while also highlighting its latest findings and innovations, this volume provides a readily understandable introduction to the foundations of epigenetics. Nessa Carey, a leading epigenetics researcher, connects the field's arguments to such diverse phenomena as how ants and queen bees control their colonies; why tortoiseshell cats are always female; why some plants need cold weather before they can flower; and how our bodies age and develop disease. Reaching beyond biology, epigenetics now informs work on drug addiction, the long-term effects of famine, and the physical and psychological consequences of childhood trauma. Carey concludes with a discussion of the future directions for this research and its ability to improve human health and well-being.

Computational Epigenetics and Diseases

Anonim
Computational Epigenetics and Diseases Book PDF

Author : Anonim
Publisher : Academic Press
Page : 450 pages
File Size : 40,5 Mb
Release : 2019-02-06
Category : Business & Economics
ISBN : 9780128145142

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Computational Epigenetics and Diseases by Anonim Pdf

Computational Epigenetics and Diseases, written by leading scientists in this evolving field, provides a comprehensive and cutting-edge knowledge of computational epigenetics in human diseases. In particular, the major computational tools, databases, and strategies for computational epigenetics analysis, for example, DNA methylation, histone modifications, microRNA, noncoding RNA, and ceRNA, are summarized, in the context of human diseases. This book discusses bioinformatics methods for epigenetic analysis specifically applied to human conditions such as aging, atherosclerosis, diabetes mellitus, schizophrenia, bipolar disorder, Alzheimer disease, Parkinson disease, liver and autoimmune disorders, and reproductive and respiratory diseases. Additionally, different organ cancers, such as breast, lung, and colon, are discussed. This book is a valuable source for graduate students and researchers in genetics and bioinformatics, and several biomedical field members interested in applying computational epigenetics in their research. Provides a comprehensive and cutting-edge knowledge of computational epigenetics in human diseases Summarizes the major computational tools, databases, and strategies for computational epigenetics analysis, such as DNA methylation, histone modifications, microRNA, noncoding RNA, and ceRNA Covers the major milestones and future directions of computational epigenetics in various kinds of human diseases such as aging, atherosclerosis, diabetes, heart disease, neurological disorders, cancers, blood disorders, liver diseases, reproductive diseases, respiratory diseases, autoimmune diseases, human imprinting disorders, and infectious diseases

Epigenetics

C. David Allis,Thomas Jenuwein,Danny Reinberg,Marie-Laure Caparros
Epigenetics Book PDF

Author : C. David Allis,Thomas Jenuwein,Danny Reinberg,Marie-Laure Caparros
Publisher : CSHL Press
Page : 503 pages
File Size : 41,8 Mb
Release : 2007
Category : Epigenesis, Genetic
ISBN : 9780879697242

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Epigenetics by C. David Allis,Thomas Jenuwein,Danny Reinberg,Marie-Laure Caparros Pdf

The regulation of gene expression in many biological processes involves epigenetic mechanisms. In this new volume, 24 chapters written by experts in the field discuss epigenetic effects from many perspectives. There are chapters on the basic molecular mechanisms underpinning epigenetic regulation, discussion of cellular processes that rely on this kind of regulation, and surveys of organisms in which it has been most studied. Thus, there are chapters on histone and DNA methylation, siRNAs and gene silencing; X-chromosome inactivation, dosage compensation and imprinting; and discussion of epigenetics in microbes, plants, insects, and mammals. The last part of the book looks at how epigenetic mechanisms act in cell division and differentiation, and how errors in these pathways contribute to cancer and other human diseases. Also discussed are consequences of epigenetics in attempts to clone animals. This book is a major resource for those working in the field, as well as being a suitable text for advanced undergraduate and graduate courses on gene regulation.

Epigenetics and Systems Biology

Leonie Ringrose
Epigenetics and Systems Biology Book PDF

Author : Leonie Ringrose
Publisher : Academic Press
Page : 286 pages
File Size : 48,5 Mb
Release : 2017-04-25
Category : Medical
ISBN : 9780128030769

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Epigenetics and Systems Biology by Leonie Ringrose Pdf

Epigenetics and Systems Biology highlights the need for collaboration between experiments and theoretical modeling that is required for successful application of systems biology in epigenetics studies. This book breaks down the obstacles which exist between systems biology and epigenetics researchers due to information barriers and segmented research, giving real-life examples of successful combinations of systems biology and epigenetics experiments. Each section covers one type of modeling and one set of epigenetic questions on which said models have been successfully applied. In addition, the book highlights how modeling and systems biology relate to studies of RNA, DNA, and genome instability, mechanisms of DNA damage signaling and repair, and the effect of the environment on genome stability. Presents original research in a wider perspective to reveal potential for synergies between the two fields of study Provides the latest experiments in primary literature for the modeling audience Includes chapters written by experts in systems biology and epigenetics who have vast experience studying clinical applications

Epigenetics Methods

Trygve Tollefsbol
Epigenetics Methods Book PDF

Author : Trygve Tollefsbol
Publisher : Academic Press
Page : 736 pages
File Size : 48,6 Mb
Release : 2020-07-08
Category : Medical
ISBN : 9780128194157

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Epigenetics Methods by Trygve Tollefsbol Pdf

In recent years, the field of epigenetics has grown significantly, driving new understanding of human developmental processes and disease expression, as well as advances in diagnostics and therapeutics. As the field of epigenetics continues to grow, methods and technologies have multiplied, resulting in a wide range of approaches and tools researchers might employ. Epigenetics Methods offers comprehensive instruction in methods, protocols, and experimental approaches applied in field of epigenetics. Here, across thirty-five chapters, specialists offer step-by-step overviews of methods used to study various epigenetic mechanisms, as employed in basic and translational research. Leading the reader from fundamental to more advanced methods, the book begins with thorough instruction in DNA methylation techniques and gene or locus-specific methylation analyses, followed by histone modification methods, chromatin evaluation, enzyme analyses of histone methylation, and studies of non-coding RNAs as epigenetic modulators. Recently developed techniques and technologies discussed include single-cell epigenomics, epigenetic editing, computational epigenetics, systems biology epigenetic methods, and forensic epigenetic approaches. Epigenetics methods currently in-development, and their implication for future research, are also considered in-depth. In addition, as with the wider life sciences, reproducibility across experiments, labs, and subdisciplines is a growing issue for epigenetics researchers. This volume provides consensus-driven methods instruction and overviews. Tollefsbol and contributing authors survey the range of existing methods; identify best practices, common themes, and challenges; and bring unity of approach to a diverse and ever-evolving field. Includes contributions by leading international investigators involved in epigenetic research and clinical and therapeutic application Integrates technology and translation with fundamental chapters on epigenetics methods, as well as chapters on more novel and advanced epigenetics methods Written at verbal and technical levels that can be understood by scientists and students alike Includes chapters on state-of-the-art techniques such as single-cell epigenomics, use of CRISPR/Cas9 for epigenetic editing, and epigenetics methods applied to forensics

Environmental Epigenetics

L. Joseph Su,Tung-chin Chiang
Environmental Epigenetics Book PDF

Author : L. Joseph Su,Tung-chin Chiang
Publisher : Springer
Page : 321 pages
File Size : 43,9 Mb
Release : 2015-05-18
Category : Medical
ISBN : 9781447166788

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Environmental Epigenetics by L. Joseph Su,Tung-chin Chiang Pdf

This book examines the toxicological and health implications of environmental epigenetics and provides knowledge through an interdisciplinary approach. Included in this volume are chapters outlining various environmental risk factors such as phthalates and dietary components, life states such as pregnancy and ageing, hormonal and metabolic considerations and specific disease risks such as cancer cardiovascular diseases and other non-communicable diseases. Environmental Epigenetics imparts integrative knowledge of the science of epigenetics and the issues raised in environmental epidemiology. This book is intended to serve both as a reference compendium on environmental epigenetics for scientists in academia, industry and laboratories and as a textbook for graduate level environmental health courses. Environmental Epigenetics imparts integrative knowledge of the science of epigenetics and the issues raised in environmental epidemiology. This book is intended to serve both as a reference compendium on environmental epigenetics for scientists in academia, industry and laboratories and as a textbook for graduate level environmental health courses.

Epigenetics of Infectious Diseases

Walter Doerfler,Josep Casadesús
Epigenetics of Infectious Diseases Book PDF

Author : Walter Doerfler,Josep Casadesús
Publisher : Springer
Page : 277 pages
File Size : 54,7 Mb
Release : 2017-05-26
Category : Medical
ISBN : 9783319550213

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Epigenetics of Infectious Diseases by Walter Doerfler,Josep Casadesús Pdf

The present volume of Epigenetics and Human Health is devoted to the patho-epigenetics of viral and microbial infections, an exiting new field of disease-related epigenetic research. As recognized during the past years, epigenetic reprogramming of pathogen and host genome functions – the latter frequently induced by pathogens – plays an important role in many infectious processes. Beyond their immediate relevance for pathogen proliferation and obligatorily associated symptoms, such alterations frequently contribute to severe additional complications, such as the development of immunodeficiency, cancer and various chronic disorders. This holds in particular for epigenetic dysregulation of host gene expression induced by latent infections. The present book summarizes current knowledge of the mechanisms underlying epigenetic changes caused by viral, bacterial, fungal and protozoan infections and their impact on human health.

Epigenetic Technological Applications

Yujun George Zheng
Epigenetic Technological Applications Book PDF

Author : Yujun George Zheng
Publisher : Academic Press
Page : 516 pages
File Size : 53,7 Mb
Release : 2015-05-30
Category : Science
ISBN : 9780128013274

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Epigenetic Technological Applications by Yujun George Zheng Pdf

Epigenetic Technological Applications is a compilation of state-of-the-art technologies involved in epigenetic research. Epigenetics is an exciting new field of biology research, and many technologies are invented and developed specifically for epigenetics study. With chapters covering the latest developments in crystallography, computational modeling, the uses of histones, and more, Epigenetic Technological Applications addresses the question of how these new ideas, procedures, and innovations can be applied to current epigenetics research, and how they can keep pushing discovery forward and beyond the epigenetic realm. Discusses technologies that are critical for epigenetic research and application Includes epigenetic applications for state-of-the-art technologies Contains a global perspective on the future of epigenetics

Epigenetics and Regeneration

Anonim
Epigenetics and Regeneration Book PDF

Author : Anonim
Publisher : Academic Press
Page : 541 pages
File Size : 51,8 Mb
Release : 2019-05-24
Category : Science
ISBN : 9780128148808

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Epigenetics and Regeneration by Anonim Pdf

Epigenetics and Regeneration compiles the first foundational reference on epigenetic mechanisms governing tissue development, repair, homeostasis, and regeneration, as well as pathways to employ these mechanisms in clinical practice and translational science. In this book, life science researchers, clinicians, and students will discover an interdisciplinary resource bringing together common themes in the field, background overviews, research methods, recent advances, and opportunities for drug discovery. Throughout this volume, special attention is paid to pre-clinical and first clinical studies aimed at increasing the regenerative potential of damaged tissues by epigenetic drugs, as well as innovative, discipline spanning strategies to enhance cell reprogramming. As an all-inclusive, evidence-based volume, Epigenetics and Regeneration will stimulate discussion and boost new research in this fascinating and impactful area of translational epigenetics. Provides a foundational overview of epigenetics in regenerative medicine Examines epigenetic components of tissue regeneration for a variety of organ systems and tissue types, as well as current attempts to employ these mechanisms in clinical practice Offers researchers, students, clinicians, and pharmacologists the tools they need to enhance tissue development, repair, homeostasis, and regeneration and explore new epigenetic therapeutic pathways Features chapter contributions from leading international researchers and clinicians in the fields of epigenetics and regenerative medicine

Epigenetics: Development and Disease

Tapas Kumar Kundu
Epigenetics Development and Disease Book PDF

Author : Tapas Kumar Kundu
Publisher : Springer Science & Business Media
Page : 689 pages
File Size : 41,9 Mb
Release : 2012-11-13
Category : Medical
ISBN : 9789400745254

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Epigenetics: Development and Disease by Tapas Kumar Kundu Pdf

Epigenetics fine-tunes the life processes dictated by DNA sequences, but also kick-starts pathophysiological processes including diabetes, AIDS and cancer. This volume tracks the latest research on epigenetics, including work on new-generation therapeutics.

Drug Discovery in Cancer Epigenetics

Gerda Egger,Paola Arimondo
Drug Discovery in Cancer Epigenetics Book PDF

Author : Gerda Egger,Paola Arimondo
Publisher : Academic Press
Page : 498 pages
File Size : 45,5 Mb
Release : 2015-11-19
Category : Medical
ISBN : 9780128024928

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Drug Discovery in Cancer Epigenetics by Gerda Egger,Paola Arimondo Pdf

Drug Discovery in Cancer Epigenetics is a practical resource for scientists involved in the discovery, testing, and development of epigenetic cancer drugs. Epigenetic modifications can have significant implications for translational science as biomarkers for diagnosis, prognosis or therapy prediction. Most importantly, epigenetic modifications are reversible and epigenetic players are found mutated in different cancers; therefore, they provide attractive therapeutic targets. There has been great interest in developing and testing epigenetic drugs, which inhibit DNA methyltransferases, histone modifying enzymes or chromatin reader proteins. The first few drugs are already FDA approved and have made their way into clinical settings. This book provides a comprehensive summary of the epigenetic drugs currently available and aims to increase awareness in this area to foster more rapid translation of epigenetic drugs into the clinic. Highlights the potential of epigenetic alterations in cancer for drug development Covers the tools and methods for epigenetic drug discovery, preclinical and clinical testing, and clinical implications of epigenetic therapy Provides important information regarding putative epigenetic targets, epigenetic technologies, networks and consortia for epigenetic drug discovery and routes for translation

Epigenetic Gene Expression and Regulation

Suming Huang,Michael D Litt,C. Ann Blakey
Epigenetic Gene Expression and Regulation Book PDF

Author : Suming Huang,Michael D Litt,C. Ann Blakey
Publisher : Academic Press
Page : 482 pages
File Size : 50,6 Mb
Release : 2015-10-19
Category : Science
ISBN : 9780128004715

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Epigenetic Gene Expression and Regulation by Suming Huang,Michael D Litt,C. Ann Blakey Pdf

Epigenetic Gene Expression and Regulation reviews current knowledge on the heritable molecular mechanisms that regulate gene expression, contribute to disease susceptibility, and point to potential treatment in future therapies. The book shows how these heritable mechanisms allow individual cells to establish stable and unique patterns of gene expression that can be passed through cell divisions without DNA mutations, thereby establishing how different heritable patterns of gene regulation control cell differentiation and organogenesis, resulting in a distinct human organism with a variety of differing cellular functions and tissues. The work begins with basic biology, encompasses methods, cellular and tissue organization, topical issues in epigenetic evolution and environmental epigenesis, and lastly clinical disease discovery and treatment. Each highly illustrated chapter is organized to briefly summarize current research, provide appropriate pedagogical guidance, pertinent methods, relevant model organisms, and clinical examples. Reviews current knowledge on the heritable molecular mechanisms that regulate gene expression, contribute to disease susceptibility, and point to potential treatment in future therapies Helps readers understand how epigenetic marks are targeted, and to what extent transgenerational epigenetic changes are instilled and possibly passed onto offspring Chapters are replete with clinical examples to empower the basic biology with translational significance Offers more than 100 illustrations to distill key concepts and decipher complex science