Epigenetics And Chromatin

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Chromatin and Epigenetics

Colin Logie,Tobias Aurelius Knoch
Chromatin and Epigenetics Book PDF

Author : Colin Logie,Tobias Aurelius Knoch
Publisher : BoD – Books on Demand
Page : 296 pages
File Size : 54,7 Mb
Release : 2020-01-29
Category : Science
ISBN : 9781789844924

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Chromatin and Epigenetics by Colin Logie,Tobias Aurelius Knoch Pdf

Genomics has gathered broad public attention since Lamarck put forward his top-down hypothesis of 'motivated change' in 1809 in his famous book "Philosophie Zoologique" and even more so since Darwin published his famous bottom-up theory of natural selection in "The Origin of Species" in 1859. The public awareness culminated in the much anticipated race to decipher the sequence of the human genome in 2002. Over all those years, it has become apparent that genomic DNA is compacted into chromatin with a dedicated 3D higher-order organization and dynamics, and that on each structural level epigenetic modifications exist. The book "Chromatin and Epigenetics" addresses current issues in the fields of epigenetics and chromatin ranging from more theoretical overviews in the first four chapters to much more detailed methodologies and insights into diagnostics and treatments in the following chapters. The chapters illustrate in their depth and breadth that genetic information is stored on all structural and dynamical levels within the nucleus with corresponding modifications of functional relevance. Thus, only an integrative systems approach allows to understand, treat, and manipulate the holistic interplay of genotype and phenotype creating functional genomes. The book chapters therefore contribute to this general perspective, not only opening opportunities for a true universal view on genetic information but also being key for a general understanding of genomes, their function, as well as life and evolution in general.

Epigenetics and Chromatin

Philippe Jeanteur
Epigenetics and Chromatin Book PDF

Author : Philippe Jeanteur
Publisher : Springer Science & Business Media
Page : 284 pages
File Size : 55,6 Mb
Release : 2008-09-10
Category : Science
ISBN : 3540852360

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Epigenetics and Chromatin by Philippe Jeanteur Pdf

Epigenetics refers to heritable patterns of gene expression which do not depend on alterations of genomic DNA sequence. This book provides a state-of-the-art account of a few selected hot spots by scientists at the edge in this extremely active field. It puts special emphasis on two main streams of research. One is the role of post-translational modifications of proteins, mostly histones, on chromatin structure and accessibility. The other one deals with parental genomic imprinting, a process which allows to express a few selected genes from only one of the parental allele while extinguishing the other.

Chromatin And Epigenetics: An Introduction To Epigenetic Mechanisms

Vincenzo Pirrotta
Chromatin And Epigenetics An Introduction To Epigenetic Mechanisms Book PDF

Author : Vincenzo Pirrotta
Publisher : World Scientific
Page : 525 pages
File Size : 41,7 Mb
Release : 2023-07-05
Category : Science
ISBN : 9789811257643

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Chromatin And Epigenetics: An Introduction To Epigenetic Mechanisms by Vincenzo Pirrotta Pdf

This book is an introduction to epigenetics, a controversial term that denotes the mechanisms that instruct the genome on how to express the purely genetic information that encodes proteins. Starting with the discovery of repressor proteins in the 1960s, epigenetics evolved into a kind of user manual for the genetic information, telling the genome if, when, how much and in what cells to read genes. Advances in epigenetics in the past 15 years have revealed how it lies at the heart of virtually every branch of biological and medical sciences and an understanding of its basic principles is therefore essential for every student in this field.The field of chromatin and epigenetics has developed very rapidly in the past 15-20 years. The pace in the field of epigenetics has now slowed down, the basic outlines of the mechanisms and implications have solidified and a consensus has been achieved among the researchers in the field. At the same time, these mechanisms and implications are now an integral part of how we think about the genome. Genes are more than just DNA and more than just protein-coding sequences and this realization has revolutionized our understanding of the genome, gene expression and its regulation in development, health and disease. It is time, therefore, for a textbook to help train a new generation of biologists and health scientists as well as providing a basic competence among practitioners in allied fields. The present book has grown out of a course given for the past 13 years to advanced undergraduates at Rutgers University. In keeping with the experience in that course, the book is abundantly illustrated, presents a wealth of specific examples, and includes a chapter describing a number of methods and techniques that have driven the advances in the field.

Human Epigenetics: How Science Works

Carsten Carlberg,Ferdinand Molnár
Human Epigenetics How Science Works Book PDF

Author : Carsten Carlberg,Ferdinand Molnár
Publisher : Springer Nature
Page : 153 pages
File Size : 46,7 Mb
Release : 2019-09-24
Category : Medical
ISBN : 9783030229078

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Human Epigenetics: How Science Works by Carsten Carlberg,Ferdinand Molnár Pdf

The view “It’s all in our genes and we cannot change it” developed in the past 150 years since Gregor Mendel’s experiments with flowering pea plants. However, there is a special form of genetics, referred to as epigenetics, which does not involve any change of our genes but regulates how and when they are used. In the cell nucleus our genes are packed into chromatin, which is a complex of histone proteins and genomic DNA, representing the molecular basis of epigenetics. Our environment and lifestyle decisions influence the epigenetics of our cells and organs, i.e. epigenetics changes dynamically throughout our whole life. Thus, we have the chance to change our epigenetics in a positive as well as negative way and present the onset of diseases, such a type 2 diabetes or cancer. This textbook provides a molecular explanation how our genome is connected with environmental signals. It outlines that epigenetic programming is a learning process that results in epigenetic memory in each of the cells of our body. The central importance of epigenetics during embryogenesis and cellular differentiation as well as in the process of aging and the risk for the development of cancer are discussed. Moreover, the role of the epigenome as a molecular storage of cellular events not only in the brain but also in metabolic organs and in the immune system is described. The book represents an updated but simplified version of our textbook “Human Epigenomics” (ISBN 978-981-10-7614-8). The first five chapters explain the molecular basis of epigenetics, while the following seven chapters provide examples for the impact of epigenetics in human health and disease.

Chromatin and Gene Regulation

Bryan M. Turner
Chromatin and Gene Regulation Book PDF

Author : Bryan M. Turner
Publisher : John Wiley & Sons
Page : 288 pages
File Size : 55,7 Mb
Release : 2008-04-15
Category : Science
ISBN : 9780470751671

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Chromatin and Gene Regulation by Bryan M. Turner Pdf

Written in an informal and accessible style, Chromatin and Gene Regulation enables the reader to understand the science of this rapidly moving field. Chromatin is a fundamental component in the network of controls that regulates gene expression. Many human diseases have been linked to disruption of these control processes by genetic or environmental factors, and unravelling the mechanisms by which they operate is one of the most exciting and rapidly developing areas of modern biology. Chromatin is central both to the rapid changes in gene transcription by which cells respond to changes in their environment and also to the maintenance of gene expression patterns from one cell generation to the next. This book will be an invaluable guide to undergraduate and postgraduate students in the biological sciences and all those with an interest in the medical implications of aberrant gene expression.

Introduction to Epigenetics

Renato Paro,Ueli Grossniklaus,Raffaella Santoro,Anton Wutz
Introduction to Epigenetics Book PDF

Author : Renato Paro,Ueli Grossniklaus,Raffaella Santoro,Anton Wutz
Publisher : Springer Nature
Page : 215 pages
File Size : 46,8 Mb
Release : 2021-03-23
Category : Science
ISBN : 9783030686703

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Introduction to Epigenetics by Renato Paro,Ueli Grossniklaus,Raffaella Santoro,Anton Wutz Pdf

This open access textbook leads the reader from basic concepts of chromatin structure and function and RNA mechanisms to the understanding of epigenetics, imprinting, regeneration and reprogramming. The textbook treats epigenetic phenomena in animals, as well as plants. Written by four internationally known experts and senior lecturers in this field, it provides a valuable tool for Master- and PhD- students who need to comprehend the principles of epigenetics, or wish to gain a deeper knowledge in this field. After reading this book, the student will: Have an understanding of the basic toolbox of epigenetic regulation Know how genetic and epigenetic information layers are interconnected Be able to explain complex epigenetic phenomena by understanding the structures and principles of the underlying molecular mechanisms Understand how misregulated epigenetic mechanisms can lead to disease

Chromatin Regulation and Dynamics

Anita Göndör
Chromatin Regulation and Dynamics Book PDF

Author : Anita Göndör
Publisher : Academic Press
Page : 496 pages
File Size : 55,5 Mb
Release : 2016-10-25
Category : Science
ISBN : 9780128034026

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Chromatin Regulation and Dynamics by Anita Göndör Pdf

Chromatin Regulation and Dynamics integrates knowledge on the dynamic regulation of primary chromatin fiber with the 3D nuclear architecture, then connects related processes to circadian regulation of cellular metabolic states, representing a paradigm of adaptation to environmental changes. The final chapters discuss the many ways chromatin dynamics can synergize to fundamentally contribute to the development of complex diseases. Chromatin dynamics, which is strategically positioned at the gene-environment interface, is at the core of disease development. As such, Chromatin Regulation and Dynamics, part of the Translational Epigenetics series, facilitates the flow of information between research areas such as chromatin regulation, developmental biology, and epidemiology by focusing on recent findings of the fast-moving field of chromatin regulation. Presents and discusses novel principles of chromatin regulation and dynamics with a cross-disciplinary perspective Promotes crosstalk between basic sciences and their applications in medicine Provides a framework for future studies on complex diseases by integrating various aspects of chromatin biology with cellular metabolic states, with an emphasis on the dynamic nature of chromatin and stochastic principles Integrates knowledge on the dynamic regulation of primary chromatin fiber with 3D nuclear architecture, then connects related processes to circadian regulation of cellular metabolic states, representing a paradigm of adaptation to environmental changes

Epigenetic Mechanisms of Gene Regulation

Vincenzo E. A. Russo,Robert A. Martienssen,Arthur D. Riggs
Epigenetic Mechanisms of Gene Regulation Book PDF

Author : Vincenzo E. A. Russo,Robert A. Martienssen,Arthur D. Riggs
Publisher : Unknown
Page : 716 pages
File Size : 55,8 Mb
Release : 1996
Category : Medical
ISBN : UOM:39015047449171

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Epigenetic Mechanisms of Gene Regulation by Vincenzo E. A. Russo,Robert A. Martienssen,Arthur D. Riggs Pdf

Many inheritable changes in gene function are not explained by changes in the DNA sequence. Such epigenetic mechanisms are known to influence gene function in most complex organisms and include effects such as transposon function, chromosome imprinting, yeast mating type switching and telomeric silencing. In recent years, epigenetic effects have become a major focus of research activity. This monograph, edited by three well-known biologists from different specialties, is the first to review and synthesize what is known about these effects across all species, particularly from a molecular perspective, and will be of interest to everyone in the fields of molecular biology and genetics.

Chromatin, Epigenetics and Plant Physiology

Jiří Fajkus,Miloslava Fojtová
Chromatin Epigenetics and Plant Physiology Book PDF

Author : Jiří Fajkus,Miloslava Fojtová
Publisher : MDPI
Page : 190 pages
File Size : 51,9 Mb
Release : 2021-01-20
Category : Science
ISBN : 9783039360284

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Chromatin, Epigenetics and Plant Physiology by Jiří Fajkus,Miloslava Fojtová Pdf

This eBook focuses on current progress in understanding the role of chromatin structure, its modifications and remodeling in developmental and physiological processes. Eukaryotic genomes are packed into the supramolecular nucleoprotein structure of chromatin. Therefore, our understanding of processes such as DNA replication and repair, transcription, and cell differentiation requires an understanding of the structure and function of chromatin. While the nucleotide sequence of the DNA component of chromatin constitutes the genetic material of the cell, the other chromatin components (and also modifications of bases in the DNA itself) participate in so-called epigenetic processes. These processes are essential, e.g., in ontogenesis or adaptation to environmental changes. Therefore, epigenetics is particularly important (and elaborated) in plants that show a high developmental plasticity and, as sessile organisms, display an enormous capacity to cope with environmental stress. In these processes, epigenetic mechanisms show a crosstalk with plant signaling pathways mediated by phytohormones and redox components. You are welcome to read examples of current research and review articles in this hot research topic.

Fundamentals of Chromatin

Jerry L. Workman,Susan M. Abmayr
Fundamentals of Chromatin Book PDF

Author : Jerry L. Workman,Susan M. Abmayr
Publisher : Springer Science & Business Media
Page : 587 pages
File Size : 49,6 Mb
Release : 2013-12-04
Category : Medical
ISBN : 9781461486244

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Fundamentals of Chromatin by Jerry L. Workman,Susan M. Abmayr Pdf

​​​​​​​​​​​​​While there has been an increasing number of books on various aspects of epigenetics, there has been a gap over the years in books that provide a comprehensive understanding of the fundamentals of chromatin. ​Chromatin is the combination of DNA and proteins that make up the genetic material of chromosomes. Its primary function is to package DNA to fit into the cell, to strengthen the DNA to prevent damage, to allow mitosis and meiosis, and to control the expression of genes and DNA replication. The audience for this book is mainly newly established scientists ​and graduate students. Rather than going into the more specific areas of recent research on chromatin the chapters in this book give a strong, updated groundwork about the topic. Some the fundamentals that this book will cover include the structure of chromatin and biochemistry and the enzyme complexes that manage it.

Epigenetics

C. David Allis,Thomas Jenuwein,Danny Reinberg,Marie-Laure Caparros
Epigenetics Book PDF

Author : C. David Allis,Thomas Jenuwein,Danny Reinberg,Marie-Laure Caparros
Publisher : CSHL Press
Page : 503 pages
File Size : 42,9 Mb
Release : 2007
Category : Epigenesis, Genetic
ISBN : 9780879697242

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Epigenetics by C. David Allis,Thomas Jenuwein,Danny Reinberg,Marie-Laure Caparros Pdf

The regulation of gene expression in many biological processes involves epigenetic mechanisms. In this new volume, 24 chapters written by experts in the field discuss epigenetic effects from many perspectives. There are chapters on the basic molecular mechanisms underpinning epigenetic regulation, discussion of cellular processes that rely on this kind of regulation, and surveys of organisms in which it has been most studied. Thus, there are chapters on histone and DNA methylation, siRNAs and gene silencing; X-chromosome inactivation, dosage compensation and imprinting; and discussion of epigenetics in microbes, plants, insects, and mammals. The last part of the book looks at how epigenetic mechanisms act in cell division and differentiation, and how errors in these pathways contribute to cancer and other human diseases. Also discussed are consequences of epigenetics in attempts to clone animals. This book is a major resource for those working in the field, as well as being a suitable text for advanced undergraduate and graduate courses on gene regulation.

Epigenetics: Development and Disease

Tapas Kumar Kundu
Epigenetics Development and Disease Book PDF

Author : Tapas Kumar Kundu
Publisher : Springer Science & Business Media
Page : 689 pages
File Size : 54,5 Mb
Release : 2012-11-13
Category : Medical
ISBN : 9789400745254

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Epigenetics: Development and Disease by Tapas Kumar Kundu Pdf

Epigenetics fine-tunes the life processes dictated by DNA sequences, but also kick-starts pathophysiological processes including diabetes, AIDS and cancer. This volume tracks the latest research on epigenetics, including work on new-generation therapeutics.

Epigenetics Methods

Trygve Tollefsbol
Epigenetics Methods Book PDF

Author : Trygve Tollefsbol
Publisher : Academic Press
Page : 736 pages
File Size : 54,6 Mb
Release : 2020-07-08
Category : Medical
ISBN : 9780128194157

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Epigenetics Methods by Trygve Tollefsbol Pdf

In recent years, the field of epigenetics has grown significantly, driving new understanding of human developmental processes and disease expression, as well as advances in diagnostics and therapeutics. As the field of epigenetics continues to grow, methods and technologies have multiplied, resulting in a wide range of approaches and tools researchers might employ. Epigenetics Methods offers comprehensive instruction in methods, protocols, and experimental approaches applied in field of epigenetics. Here, across thirty-five chapters, specialists offer step-by-step overviews of methods used to study various epigenetic mechanisms, as employed in basic and translational research. Leading the reader from fundamental to more advanced methods, the book begins with thorough instruction in DNA methylation techniques and gene or locus-specific methylation analyses, followed by histone modification methods, chromatin evaluation, enzyme analyses of histone methylation, and studies of non-coding RNAs as epigenetic modulators. Recently developed techniques and technologies discussed include single-cell epigenomics, epigenetic editing, computational epigenetics, systems biology epigenetic methods, and forensic epigenetic approaches. Epigenetics methods currently in-development, and their implication for future research, are also considered in-depth. In addition, as with the wider life sciences, reproducibility across experiments, labs, and subdisciplines is a growing issue for epigenetics researchers. This volume provides consensus-driven methods instruction and overviews. Tollefsbol and contributing authors survey the range of existing methods; identify best practices, common themes, and challenges; and bring unity of approach to a diverse and ever-evolving field. Includes contributions by leading international investigators involved in epigenetic research and clinical and therapeutic application Integrates technology and translation with fundamental chapters on epigenetics methods, as well as chapters on more novel and advanced epigenetics methods Written at verbal and technical levels that can be understood by scientists and students alike Includes chapters on state-of-the-art techniques such as single-cell epigenomics, use of CRISPR/Cas9 for epigenetic editing, and epigenetics methods applied to forensics

Epigenetic Technological Applications

Yujun George Zheng
Epigenetic Technological Applications Book PDF

Author : Yujun George Zheng
Publisher : Academic Press
Page : 516 pages
File Size : 52,5 Mb
Release : 2015-05-30
Category : Science
ISBN : 9780128013274

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Epigenetic Technological Applications by Yujun George Zheng Pdf

Epigenetic Technological Applications is a compilation of state-of-the-art technologies involved in epigenetic research. Epigenetics is an exciting new field of biology research, and many technologies are invented and developed specifically for epigenetics study. With chapters covering the latest developments in crystallography, computational modeling, the uses of histones, and more, Epigenetic Technological Applications addresses the question of how these new ideas, procedures, and innovations can be applied to current epigenetics research, and how they can keep pushing discovery forward and beyond the epigenetic realm. Discusses technologies that are critical for epigenetic research and application Includes epigenetic applications for state-of-the-art technologies Contains a global perspective on the future of epigenetics

Epigenetics in Society

Windsor Epigenetics Study Group
Epigenetics in Society Book PDF

Author : Windsor Epigenetics Study Group
Publisher : University of Windsor
Page : 338 pages
File Size : 55,5 Mb
Release : 2015-10-26
Category : Science
ISBN : 9780920233726

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Epigenetics in Society by Windsor Epigenetics Study Group Pdf

This is a book written by students of diverse disciplines, and intended for students and educated lay people. We intend this book to serve several functions. First, we want to make the field of epigenetics accessible to lay readers. Second, and more importantly, we want to excite further interest and concern regarding the social, ethical, legal, health, and policy implications that this field will have for all arenas of our lives. Third, we want to arm our readers with knowledge and wariness so that they can understand and critique the nuanced debates that will inevitably arise when costs and benefits must be weighed: while the effects of epigenetics upon us as individuals may be subtle, the demographic implications and costs are huge.