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Author : Yujing Li,Xuekun Li,Zhao-Qian Teng,Shunliang Xu
Publisher : Frontiers Media SA
Page : 190 pages
File Size : 42,7 Mb
Release : 2023-04-05
Category : Science
ISBN : 9782832518175
Author : Tapas Kumar Kundu
Publisher : Springer Science & Business Media
Page : 698 pages
File Size : 54,6 Mb
Release : 2012-11-13
Category : Medical
ISBN : 9789400745254
Epigenetics fine-tunes the life processes dictated by DNA sequences, but also kick-starts pathophysiological processes including diabetes, AIDS and cancer. This volume tracks the latest research on epigenetics, including work on new-generation therapeutics.
Author : Trygve Tollefsbol
Publisher : Academic Press
Page : 617 pages
File Size : 55,5 Mb
Release : 2012-07-26
Category : Medical
ISBN : 9780123884169
Epigenetics is one of the fastest growing fields of sciences, illuminating studies of human diseases by looking beyond genetic make-up and acknowledging that outside factors play a role in gene expression. The goal of this volume is to highlight those diseases or conditions for which we have advanced knowledge of epigenetic factors such as cancer, autoimmune disorders and aging as well as those that are yielding exciting breakthroughs in epigenetics such as diabetes, neurobiological disorders and cardiovascular disease. Where applicable, attempts are made to not only detail the role of epigenetics in the etiology, progression, diagnosis and prognosis of these diseases, but also novel epigenetic approaches to the treatment of these diseases. Chapters are also presented on human imprinting disorders, respiratory diseases, infectious diseases and gynecological and reproductive diseases. Since epigenetics plays a major role in the aging process, advances in the epigenetics of aging are highly relevant to many age-related human diseases. Therefore, this volume closes with chapters on aging epigenetics and breakthroughs that have been made to delay the aging process through epigenetic approaches. With its translational focus, this book will serve as valuable reference for both basic scientists and clinicians alike. Comprehensive coverage of fundamental and emergent science and clinical usage Side-by-side coverage of the basis of epigenetic diseases and their treatments Evaluation of recent epigenetic clinical breakthroughs
Author : Gurbachan Singh Miglani
Publisher : I K International Pvt Ltd
Page : 710 pages
File Size : 54,9 Mb
Release : 2023-06-13
Category : Medical
ISBN : 9789390620722
Epigenomics deals in detail with the concepts, principles, procedures, developments, limitations, advantages, applications and future prospects of different areas of epigenomics in a comprehensive manner. It provides concise yet complete knowledge on the many aspects of the basic and most recent methods and applications in epigenomics, a branch of epigenetics that deals with the mechanisms such as DNA modifications, histone modifications, RNA modifications, small and long non-coding RNAs, chromatin remodeling, which are involved in epigenetic control of gene expression without involving variations in DNA sequences. These regulatory mechanisms lead to phenotypic variations. These epigenetic mechanisms can be exploited for crop improvement and cure of human diseases. Epigenomics strives to understand the role of epigenetic marks (chemical tags) in the development of phenotype. This understanding provides epigeneticists to apply epigenomics in medicine and agriculture. Self-explanatory adequately labelled figures have been the special emphasis throughout. This book is primarily designed for senior undergraduate and graduate level (M.Sc. and Ph.D.) students studying epigenetics in conventional, agricultural and medicinal universities. This book will be a useful reference text for teachers and researcher in any discipline of life sciences, agricultural sciences, medicine, and biotechnology.
Author : Stefan Jurga,Jan Barciszewski
Publisher : Springer Nature
Page : 632 pages
File Size : 48,7 Mb
Release : 2021-07-28
Category : Science
ISBN : 9783030716127
This book reviews a novel and exciting field of cellular and molecular biology called epitranscriptomics, which focuses on changes in an organism’s cells resulting from the posttranscriptional modification of cellular RNA. RNA-binding proteins (RBPs) play a crucial role in these posttranscriptional modifications and also support several cellular processes necessary for maintaining RNA homeostasis. Exploring the mechanisms underlying RNA modifications and RBP function is an emerging area of biomedical research, taking the study of gene regulation a step beyond epigenetics. This book reveals that the RNA molecule is not just an information-carrying molecule with some secondary structures. Accordingly, how RNA is modified, regulated, packaged, and controlled is an important aspect. Leading experts address questions such as where the over 170 distinct posttranscriptional RNA modifications are located on the genome, what percentage of mRNAs and noncoding RNAs these modifications include, and how an RNA modification impacts a person’s biology. In closing, the book reviews the role of RNA modifications and RBPs in a variety of diseases and their pathogenesis. Addressing some of the most exciting challenges in epitranscriptomics, this book provides a valuable and engaging resource for researchers in academia and industry studying the phenomena of RNA modification.
Author : Chunfu Wu,Lihui Wang
Publisher : Academic Press
Page : 146 pages
File Size : 48,7 Mb
Release : 2021-06-26
Category : Science
ISBN : 9780128236857
Epigenetic Regulation in Overcoming Chemoresistance, Volume 19, explains how epigenetic agents can enhance the chemotherapy sensitivity of diverse types of cancers. The book provides a comprehensive delineation and the recent development of the scientific studies on the epigenetic regulation in enhancing chemo-sensitivity. In addition, it discusses several topics such as DNA methyltransferase inhibitors (DNMTi), Histone deacetylases inhibitors (HDACi), Histone lysine demethylases inhibitors (HDMi), Histone lysine methyltransferases inhibitors (HMTi) and drugs regulating the microRNA, long non-coding RNA (lncRNA) or RNA methylation. Finally, recent and future developments of the field of epigenetic regulation are explored. This is a valuable resource for cancer researchers, clinicians, graduate students and several members of biomedical field who are interested in learning about epigenetic regulation methods to reverse chemo-resistance in cancers. Presents detailed diagrams of the mechanisms of epigenetic regulation for easy consult Encompasses multiple clinical trial summary diagrams to help readers quickly and clearly get information from clinical trials Provides future perspectives in each section to inspire readers to use epigenetic regulation to overcome chemo-resistance
Author : Xiao Wang,Ying Yu,Lingzhao Fang
Publisher : Frontiers Media SA
Page : 170 pages
File Size : 42,8 Mb
Release : 2023-07-21
Category : Science
ISBN : 9782832526705
Author : Beverly A. Teicher
Publisher : Springer Science & Business Media
Page : 611 pages
File Size : 40,5 Mb
Release : 2007-11-09
Category : Medical
ISBN : 9781597450355
Leading experts summarize and synthesize the latest discoveries concerning the changes that occur in tumor cells as they develop resistance to anticancer drugs, and suggest new approaches to preventing and overcoming it. The authors review physiological resistance based upon tumor architecture, cellular resistance based on drug transport, epigenetic changes that neutralize or bypass drug cytotoxicity, and genetic changes that alter drug target molecules by decreasing or eliminating drug binding and efficacy. Highlights include new insights into resistance to antiangiogenic therapies, oncogenes and tumor suppressor genes in therapeutic resistance, cancer stem cells, and the development of more effective therapies. There are also new findings on tumor immune escape mechanisms, gene amplification in drug resistance, the molecular determinants of multidrug resistance, and resistance to taxanes and Herceptin.
Author : Trygve O. Tollefsbol
Publisher : Springer Science & Business Media
Page : 462 pages
File Size : 43,8 Mb
Release : 2009-11-11
Category : Medical
ISBN : 9781441906397
Recent studies have indicated that epigenetic processes may play a major role in both cellular and organismal aging. These epigenetic processes include not only DNA methylation and histone modifications, but also extend to many other epigenetic mediators such as the polycomb group proteins, chromosomal position effects, and noncoding RNA. The topics of this book range from fundamental changes in DNA methylation in aging to the most recent research on intervention into epigenetic modifications to modulate the aging process. The major topics of epigenetics and aging covered in this book are: 1) DNA methylation and histone modifications in aging; 2) Other epigenetic processes and aging; 3) Impact of epigenetics on aging; 4) Epigenetics of age-related diseases; 5) Epigenetic interventions and aging: and 6) Future directions in epigenetic aging research. The most studied of epigenetic processes, DNA methylation, has been associated with cellular aging and aging of organisms for many years. It is now apparent that both global and gene-specific alterations occur not only in DNA methylation during aging, but also in several histone alterations. Many epigenetic alterations can have an impact on aging processes such as stem cell aging, control of telomerase, modifications of telomeres, and epigenetic drift can impact the aging process as evident in the recent studies of aging monozygotic twins. Numerous age-related diseases are affected by epigenetic mechanisms. For example, recent studies have shown that DNA methylation is altered in Alzheimer’s disease and autoimmunity. Other prevalent diseases that have been associated with age-related epigenetic changes include cancer and diabetes. Paternal age and epigenetic changes appear to have an effect on schizophrenia and epigenetic silencing has been associated with several of the progeroid syndromes of premature aging. Moreover, the impact of dietary or drug intervention into epigenetic processes as they affect normal aging or age-related diseases is becoming increasingly feasible.
Author : Ritu Kulshreshtha,Aniruddha Chatterjee
Publisher : Frontiers Media SA
Page : 207 pages
File Size : 41,5 Mb
Release : 2022-11-30
Category : Science
ISBN : 9782832507940
Author : Xiao Han,Jia Meng,Giovanni Nigita
Publisher : Frontiers Media SA
Page : 387 pages
File Size : 45,6 Mb
Release : 2022-05-05
Category : Science
ISBN : 9782889761067
Author : Mojgan Rastegar,Dag H. Yasui
Publisher : Frontiers Media SA
Page : 182 pages
File Size : 40,7 Mb
Release : 2021-10-20
Category : Science
ISBN : 9782889715145
Author : Fushun Wang,Jason H. Huang,Fang Pan,Yi-Yuan Tang
Publisher : Frontiers Media SA
Page : 138 pages
File Size : 49,9 Mb
Release : 2021-08-09
Category : Science
ISBN : 9782889711536
Author : Christiane Pienna Soares,Jean Leandro Dos Santos,Ângela Sousa
Publisher : Frontiers Media SA
Page : 260 pages
File Size : 48,9 Mb
Release : 2021-06-02
Category : Science
ISBN : 9782889668359
Author : Yun Dai,Yafeng He,Dong Ren,Huanfa Yi
Publisher : Frontiers Media SA
Page : 156 pages
File Size : 54,8 Mb
Release : 2023-10-25
Category : Medical
ISBN : 9782832536544
